Grantee Research Project Results

Temporal Models for Biomarker Based Exposure Inference

EPA Grant Number: U915829
Title: Temporal Models for Biomarker Based Exposure Inference
Investigators: Bartell, Scott M.
Institution: University of California - Davis
EPA Project Officer: Lee, Sonja
Project Period: September 1, 2000 through September 1, 2003
Project Amount: $82,484
RFA: STAR Graduate Fellowships (2000) RFA Text | Recipients Lists
Research Category: Fellowship - Molecular Biology/Genetics , Biology/Life Sciences , Academic Fellowships

Objective:

The objective of the research project is to develop appropriate toxicokinetic/toxicodynamic based statistical methods for exposure inferences based on biomarker measurements.

Approach:

In many toxicokinetic models, exposures may be reasonably treated as discrete events occurring daily with randomly distributed magnitudes. Biomarker measurements appropriate for this model, such as blood mercury concentrations, can be written as time-weighted linear combinations of all prior exposure events. Classic mathematical statistics methods can then be used to develop equations describing the statistical properties of the biomarker measurements and their relationship to exposure history.

Expected Results:

By using classic mathematical statistics methods, equations can be developed to describe the statistical properties of biomarker measurements.

Supplemental Keywords:

human health, risk, mercury, methodology, population, variability., Health, Scientific Discipline, Toxics, National Recommended Water Quality, Health Risk Assessment, Risk Assessments, HAPS, 33/50, Applied Math & Statistics, Toxicology, mercury & mercury compounds, human exposure, statistical methods, toxicokinetic models, Mercury Compounds, risk, toxicokinetic, population, temporal models, biomarker measurements, human health risk, biomarker, biomarker based exposure inference

Progress and Final Reports:

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.