Developmental Effects of Dietary Soy Phytoestrogens

EPA Grant Number: R825721
Title: Developmental Effects of Dietary Soy Phytoestrogens
Investigators: Hughes, Claude L. , Shively, Carol , Bullock, Bill , Lewis, Carole
Current Investigators: Hughes, Claude L. , Tyrey, Lee , Davis, Vickie
Institution: Duke University , Davidson College
Current Institution: Duke University Medical Center
EPA Project Officer: Aja, Hayley
Project Period: November 1, 1996 through October 30, 1999
Project Amount: $574,747
RFA: Endocrine Disruptors (1996) RFA Text |  Recipients Lists
Research Category: Endocrine Disruptors , Human Health , Safer Chemicals


The purpose of the project is to conduct a series of experiments to determine whether developmental exposure to dietary phytochemicals that have estrogenic activity will affect central nervous system and reproductive system functions later in life. The basic design is, in addition to a control group, dietary exposure of pregnant rats to three different levels of soy phytoestrogens or the reference estrogen diethylstilbestrol during late preganancy, the neonatal interval, lactation and ending with weaning. The groups of exposed progeny, particularly the females, will be studied. Outcomes will include adolescent behavior, age of onset of puberty, initial ovarian cyclicity, age-associated cessation of ovarian cyclicity, ovarian follicle numbers and brain histomorphometry/histochemistry to assess sexually dimorphic endpoints. These observations will provide substantial insight regarding the effects or lack of effect of these naturally-occuring dietary estrogens on several subtle but important developmental outcomes.

Publications and Presentations:

Publications have been submitted on this project: View all 2 publications for this project

Supplemental Keywords:

endocrine disruption, rodent, reproduction, development, female., RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Susceptibility/Sensitive Population/Genetic Susceptibility, Children's Health, genetic susceptability, Biology, Endocrine Disruptors - Human Health, adverse outcomes, central nervous system, puberty, sensitive populations, adolescence, childhood development, epidemiology, health risks, females, exposure studies, exposure, gender, brain chemistry, children, animal models, developmental processes, phytochemicals, growth and development, reproductive processes, environmentally caused disease, biological effects, dietary soy phytoestrogens, female, dietary exposure, pregnancy, rodent, developmental toxicants, endocrine disruption, environmental hazard exposures

Relevant Websites:

Progress and Final Reports:

  • 1997
  • 1998 Progress Report
  • Final Report