The Michigan PBB Cohort 20 Years: Endocrine Disruption?

EPA Grant Number: R825300
Title: The Michigan PBB Cohort 20 Years: Endocrine Disruption?
Investigators: Marcus, Michele
Current Investigators: Marcus, Michele , Blanck, Heidi Michels , Henderson, Alden , Rubin, Carol , Cameron, Lorraine , Tolbert, Paige , Hertzberg, Vicki
Institution: Emory University
Current Institution: Emory University , Centers for Disease Control and Prevention , Michigan Department of Community Health
EPA Project Officer: Chung, Serena
Project Period: November 29, 1996 through November 28, 1999 (Extended to December 14, 2004)
Project Amount: $360,005
RFA: Endocrine Disruptors (1996) RFA Text |  Recipients Lists
Research Category: Environmental Justice , Endocrine Disruptors , Human Health , Safer Chemicals


This project will examine the cohort of women and their offspring who were exposed to polybrominated biphenyls (PBB) as a contaminant of cattle feed in l973. The Michigan Department of Community Health has followed this cohort for more than 20 years. The project will ascertain the occurrence of a number of outcomes in the women and their offspring in order to determine if there is evidence of endocrine disruption associated with PBB exposure.

The study will include the administration of a telephone interview to the approximately 1900 women currently in the cohort to ascertain the cumulative incidence since exposure of endocrine sensitive endpoints such as endometriosis, benign breast disease, abnormal Pap smears, uterine fibroids, thyroid dysfunction and infertility. We will ascertain time to pregnancy for each pregnancy following exposure. Medical records will be obtained and reviewed to verify each of the clinical conditions. The occurrence of each of these outcomes will be modeled by multivariate methods as a function of PBB serum level in l976 controlling for potentially confounding variables.

This cohort, by virtue of its well-characterized exposure to PBB and the long follow-up period, can provide valuable data on the potential endocrine disrupting effects of halogenated hydrocarbons.

Publications and Presentations:

Publications have been submitted on this project: View all 18 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 8 journal articles for this project

Supplemental Keywords:

endocrine disruption, human, epidemiology, reproduction, PBB, female,, RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Endocrine Disruptors - Environmental Exposure & Risk, Risk Assessments, endocrine disruptors, Children's Health, Biology, Endocrine Disruptors - Human Health, adverse outcomes, thyroid dysfunction, breast cancer, uterine fibroids, endocrine disrupting chemicals, exposure studies, fertility, human exposure, developmental processes, human growth and development, biochemistry, sensitive endpoints, biological effects, endometriosis, polybrominated biphenyls (PBB), cattle feed

Progress and Final Reports:

  • 1997
  • 1998
  • 1999
  • 2000
  • 2001
  • 2002 Progress Report
  • 2003
  • 2004
  • Final Report