Grantee Research Project Results
Integrating And Informing Actionable Agricultural Community Tools (II-ACT): Using Risk-Based Approaches For Evaluating Cumulative Early Life Environmental Stressors
EPA Grant Number: R840631Title: Integrating And Informing Actionable Agricultural Community Tools (II-ACT): Using Risk-Based Approaches For Evaluating Cumulative Early Life Environmental Stressors
Investigators: Faustman, Elaine , Marsillach, Judit , Seto, Edmund , Min, Esther , Griffith, William C. , Wallace, James C , Karr, Catherine , Sherris, Allison R
Current Investigators: Faustman, Elaine , Griffith, William C. , Seto, Edmund , Karr, Catherine , Marsillach, Judit , Min, Esther , Wallace, James C , Sherris, Allison R
Institution: University of Washington
EPA Project Officer: Brooks, Donald
Project Period: December 1, 2023 through May 2, 2025
Project Amount: $1,896,439
RFA: Center for Early Lifestage Vulnerabilities to Environmental Stressors - Cumulative Health Impacts for Children in Underserved Rural Agricultural Communities in the United States Request for Applications (RFA) (2023) RFA Text | Recipients Lists
Research Category: Biomarkers to Environmental Health and Risk Assessment , Children's Health , Endocrine Disruptors , Environment
Objective:
The objectives of this center are to (1) develop a life-stage exposomic approach characterizing both chemical and non-chemical stressors from child health cohort data to identify early and preventable health impacts in children in rural agricultural communities; (2) evaluate emerging cumulative impact assessment maps to inform decisions to improve children’s environmental health in rural agricultural communities in the United States; and (3) foster partnerships between academic researchers and communities so that information is accessible and translated into studies for communities and researchers, using community-based participatory approaches.
Approach:
The experimental approach includes adoption of a common exposome-based framing for its research and translation activities. We will use integrative biomarkers to test how they support our exposure and response evaluations to improve our ability to evaluate cumulative impacts in agricultural children’s cohorts. We will also compare spatial data and cumulative impact scores from both nationwide and state-specific mapping tools that are utilized in environmental justice analyses and decision-making processes. Further, the center activities are connected to improving children’s health in rural, agricultural communities, in particular Yakima Valley communities through bidirectional communication, environmental health literacy advancement, community engaged research practice, and meaningful dissemination.
Expected Results:
The expected outputs of the project are (1) integrative biomarker assays and publicly available models to define the exposome for agricultural cohorts; (2) detailed mapping tools and recommendations for improved methods and data for future cumulative mapping frameworks ; and (3) research products for dissemination (i.e. journal articles, news briefs, low-literacy and bilingual materials).
Supplemental Keywords:
risk assessment, children’s susceptibility, mechanismsProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.