Grantee Research Project Results

A Comprehensive Assessment of Sources of Pesticide Contamination, Concentrations in Pathways, and Exposure-prone Behavior

EPA Grant Number: R826709C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R826709
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: A Comprehensive Assessment of Sources of Pesticide Contamination, Concentrations in Pathways, and Exposure-prone Behavior
Investigators: Eskenazi, Brenda , McKone, Thomas
Institution: University of California - Berkeley
EPA Project Officer: Callan, Richard
Project Period: January 1, 1998 through January 1, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The purpose of this proposal is to better characterize the magnitude and pathways of pesticide exposure to young children. The four specific aims are: (1) to measure prenatal and postnatal organophosphate pesticide exposure to farmworker children and to characterize population-level correlates of exposure; (2) to characterize pesticide concentrations in environmental media along exposure pathways that link children to pesticide use, (3) to describe the exposure-prone behavior of young children; and (4) to develop a multimedia, multipathway pesticide exposure-assessment model. To meet specific aim 1, we will measure the level of organophosphates (OP) metabolites in the urine of 550 mothers during pregnancy and in the urine of their children at 6, 12, 24, and 36 months and compute descriptive statistics for the OP metabolites levels by population characteristics, (e.g season. age. parental occupation, etc). To meet aim 2, we will select from the 550 children 52 each at ages 6 and 14 months. We will administer a detailed exposure questionnaire and make measurements of OP levels in housedust, food/beverage, parents' work clothing, hand-wipes, and maternal urine (for breast-feeding 6-month-olds). To meet specific aim 3, we will select from the 52 children 10 each at ages 6 and 24 months to conduct a videotaped time-activity analysis of dermal contact and hand-to-mouth behaviors. Video-taped activities will be translated into computer text files to develop statistical descriptions of exposure-prone behavior. To meet specific aim 4, we will adapt an existing multimedia-model to the study population and region to simulate exposures for farmworker children. This model will be re-calibrated using actual exposure pathway data (from specific aim 2) and exposure-prone behavior data (from specific aim 3) to increase the reliability with which we can identify important exposure routes, behaviors, and pathways for children's exposures to pesticides. The ultimate goal of this research is to identify the most important exposure pathways for young children so that effective and age-appropriate interventions and policies can be designed.

Publications and Presentations:

Publications have been submitted on this subproject: View all 14 publications for this subproject | View all 140 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 1 journal articles for this subproject | View all 38 journal articles for this center

Supplemental Keywords:

children, health, pesticide, exposure, farmworker., RFA, Scientific Discipline, Health, Toxics, Environmental Chemistry, Health Risk Assessment, pesticides, endocrine disruptors, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Children's Health, genetic susceptability, Biology, Endocrine Disruptors - Human Health, health effects, pesticide exposure, risk assessment, sensitive populations, farmworkers, metabolites, prenatal exposure, endocrine disrupting chemicals, exposure, behavioral assessment, biological response, children, Human Health Risk Assessment, human exposure, pesticide residues, public health, assessment of exposure, pathways, exposure pathways, statistics, environmental health hazard, agricultural community, disease, exposure assessment, organophosphate pesticides, exposure model

Progress and Final Reports:

Main Center Abstract and Reports:

R826709 Center for Integrative Research on Childhood Leukemia and the Environment - 2015

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826709C001 Community Based Intervention to Reduce Pesticide Exposures to Young Children
R826709C002 The Epidemiological Investigation of the Effects of Pesticide Exposure on Neurodevelopmental, Growth, and Respiratory Health of Farmworker Children
R826709C003 A Comprehensive Assessment of Sources of Pesticide Contamination, Concentrations in Pathways, and Exposure-prone Behavior

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.