Grantee Research Project Results
2016 Progress Report: Center for Children's Health, the Environment, Microbiome, and Metabolomics
EPA Grant Number: R836153Center: Center for Children’s Health, the Environment, Microbiome, and Metabolomics’ Center
Center Director: McCauley, Linda
Title: Center for Children's Health, the Environment, Microbiome, and Metabolomics
Investigators: McCauley, Linda
Current Investigators: McCauley, Linda , Ryan, P. Barry
Institution: Emory University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2015 through August 31, 2019 (Extended to August 31, 2020)
Project Period Covered by this Report: September 1, 2015 through August 31,2016
Project Amount: $1,797,870
RFA: Children's Environmental Health and Disease Prevention Research Centers (2014) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The overarching goal of Emory University’s “Center for Children’s Health, the Environment, Microbiome, and Metabolomics (C-CHEM2) is to investigate the interrelationships of components of the prenatal and postnatal environment of the fetus and child (i.e., environmental toxicants, maternal prenatal microbiome, and metabolome) and their impacts upon birth outcome, the infant microbiome and neurodevelopment. The Center seeks to produce new knowledge on the underlying mechanisms of and complex interactions between environmental exposures, microbiome and metabolic factors, and effects on neurodevelopment, to provide opportunities for new cross-disciplinary collaborations, and to disseminate this knowledge to both the scientific and lay community. With regard to the latter, we propose a strong focus on community engagement and the translation of our research findings into meaningful and culturally appropriate messages to communities. Built around our scientific theme of environmental exposures, the microbiome, metabolomics and neurodevelopment, the Center will develop and sustain centralized research resources and infrastructure, promote interdisciplinary research activities, train future generations of environmental health scientists, and conduct significant outreach to clinicians and communities at risk for health effects from environmental exposures. We plan to accomplish these ends through an Administrative Core, support of three thematic research studies, implementation of a pilot project program, and a Community Outreach and Translation Core (COTC) that will inform the work of the Center and assure that communities benefit from discoveries about environmental exposures and the association with the health of children.
The strategic objectives of the Center are to:
- Lead and manage a center that provides infrastructure and resources to support the development and conduct of research to quantify environmental exposures of African American women and infants and their impact upon the child microbiome, metabolome, and neurodevelopment.
- Intensify and develop interdisciplinary research collaborations and expand trainee opportunities to promote, sustain, and expand the scientific study of environmental exposures and their association with the child microbiome, metabolome, neurodevelopment and health outcomes.
- Translate Center discoveries into effective and sustainable strategies to reduce or counter environmental exposures that negatively impact the child microbiome, metabolome, neurodevelopment and health via engagement of African American families in metropolitan Atlanta to inform the Center on environmental concerns and culturally-relevant, family-centered interventions.
Progress Summary:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the progress made toward meeting the overall goals of the Center.
Future Activities:
Please refer to the detailed descriptions provided in each report for Center projects for a description of the activities planned in order to meet the overall goals of the Center.
Journal Articles: 29 Displayed | Download in RIS Format
| Other center views: | All 77 publications | 31 publications in selected types | All 29 journal articles |
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Chang C, Barr D, Zhang Q, Dunlop A, Smarr M, Kannan K, Panuwet P, Tangpricha V, Shi L, Liang D, Corwin E, Ryan P. Associations of single and multiple per-and polyfluoroalkyl substance PFAS exposure with vitamin D biomarkers in African American women during pregnancy. ENVIRONMENTAL RESEARCH 2021;202(111713). |
R836153 (Final) |
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Chang C, Ryan P, Smarr M, Kannan K, Panuwet P, Dunlop A, Corwin E, Barr D. Serum per-and polyfluoroalkyl substance PFAS concentrations and predictors of exposure among pregnant African American women in the Atlanta area, Georgia. ENVIRONMENTAL RESEARCH 2021;198(110445). |
R836153 (Final) |
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Corwin EJ, Hogue CJ, Pearce B, Hill CC, Read TD, Mulle J, Dunlop AL. Protocol for the Emory University African American Vaginal, Oral, and Gut Microbiome in Pregnancy Cohort Study. BMC Pregnancy and Childbirth 2017;17(1):161 (8 pp.). |
R836153 (2018) |
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Eatman J, Dunlop A, Barr D, Corwin E, Hill C, Brennan P, Ryan P, Panuwet P, Taibl K, Tan Y, Liang D, Eik S. Exposure to phthalate metabolites, bisphenol A, and psychosocial stress mixtures and pregnancy outcomes in the Atlanta African American maternal-child cohort. ENVIRONMENTAL RESEARCH 2023;233(116464) |
R836153 (Final) |
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Edwards SM, Cunningham SA, Dunlop AL, Corwin EJ. The maternal gut microbiome during pregnancy. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):310-317. |
R836153 (2018) R836153 (2019) |
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Eick S, Tan Y, Taibl K, Ryan P, Barr D, Huls A, Eatman J, Panuwet P, D'Souza P, Yakimavets V, Lee G, Brennan P, Corwin E, Dunlop A, Liang D. Prenatal exposure to persistent and non-persistent chemical mixtures and associations with adverse birth outcomes in the Atlanta African American Maternal-Child Cohort. JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMMIOLOGY 2023;Early Access |
R836153 (Final) |
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Eick S, Barr D, Brennan P, Taibl K, Tan Y, Robinson M, Kannan K, Panuwet P, Yakimavets V, Ryan P, Liang D, Dunlop A. Per-and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2023;857(2):159450. |
R836153 (Final) |
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Frediani JK, Naioti EA, Vos MB, Figueroa J, Marsit CJ, Welsh JA. Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environmental Health 2018;17(1):6 (8 pp.). |
R836153 (2018) R835442 (2018) |
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Gardinassi LG, Xia J, Safo SE, Li S. Bioinformatics tools for the interpretation of metabolomics data. Current Pharmacology Reports 2017;3(6):374-383. |
R836153 (2018) |
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Gardinassi LG, Cordy RJ, Lacerda MVG, Salinas JL, Monteiro WM, Melo GC, Siqueira AM, Val FF, Tran V, Jones DP, Galinski MR, Li S. Metabolome-wide association study of peripheral parasitemia in Plasmodium vivax malaria. International Journal of Medical Microbiology 2017;307(8):533-541. |
R836153 (2018) |
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Kartavenka K, Panuwet P, Yakimavets V, Jaikang C, Thipubon K, D'Souza P, Barr D, Ryan P. LC-MS Quantification of Malondialdehyde-Dansylhydrazine Derivatives in Urine and Serum Samples. JOURNAL OF ANALYTICAL TOXICOLOGY 2020;44(5):470-481. |
R836153 (Final) |
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Li S, Dunlop AL, Jones DP, Corwin EJ. High-resolution metabolomics: review of the field and implications for nursing science and the study of preterm birth. Biological Research for Nursing 2016;18(1):12-22. |
R836153C001 (2016) R836153C003 (2016) R836153C003 (2017) |
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Mutic AD, Baker BJ, McCauley LA. Deleterious effects from occupational exposure to ethylene thiourea in pregnant women. Workplace Health and Safety 2017;65(12):595-602. |
R836153 (2018) |
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Mutic AD, Jordan S, Edwards SM, Ferranti EP, Thul TA, Yang I. The postpartum maternal and newborn microbiomes. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):326-331. |
R836153 (2018) |
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Rodriguez J, Huntington-Moskos L, Johnson A, Williams S, Gulledge E, Feeley C, Rice M. Collecting biological measures for research with children and adolescents. Journal of Pediatric Health Care 2016;30(3):279-283. |
R836153C002 (2016) |
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Rodriguez J, Jordan S, Mutic A, Thul T. The neonatal microbiome: implications for neonatal intensive care unit nurses. MCN: The American Journal of Maternal/Child Nursing 2017;42(6):332-337. |
R836153 (2018) |
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Runkle J, Flocks J, Economos J, Dunlop AL. A systematic review of Mancozeb as a reproductive and developmental hazard. Environment International 2017; 99:29-42. |
R836153 (2018) R836153 (2019) |
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Swales DA, Winiarski DA, Smith AK, Stowe ZN, Newport DJ, Brennan PA. Maternal depression and cortisol in pregnancy predict offspring emotional reactivity in the preschool period. Developmental Psychobiology 2018;60(5):557-566. |
R836153 (2018) |
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Talibl K, Dunlop A, Barr D, Ryan P, Panuwet P, Corwin E, Eatman J, Tan Y, Liang D, Eick S. Phthalate exposure increases interferon-γ during pregnancy: The Atlanta African American Maternal-Child Cohort. SCIENCE OF THE TOTAL ENVIRONMENT 2024;916(170344) |
R836153 (Final) |
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Tan Y, Eick S, Dunlop A, Barr D, Taibl K, Steenland K, Kannan K, Robinson M, Chang C, Panuwet P, Yahimavets V, Marsit C, Ryan P, Liang D. A Prospective Analysis of Per-and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort. ENVIRONMENTAL HEALH PERSPECTIVES 2024;132(11). |
R836153 (Final) |
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Tchen R, Tan Y, Barr D, Ryan P, Tran V, Li Z, Hu Y, Smith A, Jones D, Dunlop A. Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American women. ENVIRONMENTAL INTERNATIONAL 2022;169(107530). |
R836153 (Final) |
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Yakimavets V, Qiu T, Panuwet P, D'Souza P, Brennan P, Dunlop A, Ryan P, Barr D. Simultaneous quantification of urinary tobacco and marijuana metabolites using solid-supported liquid-liquid extraction coupled with liquid chromatography tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2022;1208(123378). |
R836153 (Final) |
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Zhang Z, Barr D, Dunlop A, Panuwet P, Sarnat J, Lee G, Tan Y, Corwin E, Jones D, Ryan P, Liang D. Assessment of metabolic perturbations associated with exposure to phthalates among pregnant African American women. SCIENCE OF THE TOTAL ENVIRONMENT 2022;818(151689). |
R836153 (Final) |
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Dunlop AL, Knight AK, Satten GA, Cutler AJ, Wright ML, Mitchell RM, Read TD, Mulle J, Hertzberg VS, Hill CC, Smith AK. Stability of the vaginal, oral, and gut microbiota across pregnancy among African American women:the effect of socioeconomic status and antibiotic exposure. PeerJ 2019;7:e8004. |
R836153 (2019) |
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Dunlop AL, Jordan SL, Ferranti EP, Hill CC, Patel S, Hao L, Corwin EJ, Tangpricha V. Total and Free 25-Hydroxy-Vitamin D and Bacterial Vaginosis in Pregnant African American Women. Infectious diseases in obstetrics and gynecology. 2019;2019. |
R836153 (2019) |
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Jordan, S., Baker, B., Dunn, A., Edwards, S., Ferranti, E. Mutic, A., Yang, I., & Rodriguez, J. (2017). Maternal‐child microbiome:Collection, storage, and implications for research and practice. Nursing Research, 66(2), 175‐183. |
R836153 (2017) R836153C002 (2017) |
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Rodriguez, J., Huntington-Moskos, L., Johnson, A., Williams, S., Gulledge, E., Feeley, C., & Rice, M. (2016). Collecting biological measures for research with children and adolescents. Journal of Pediatric Health Care, Doi 10.1016/j.pedhc.2015.12.007. |
R836153C002 (2017) |
not available |
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Rodriguez, J., Jordan, S., Mutic, A., & Thul, T. The neonatal microbiome:Implications for the NICU nurse. MCN:The American Journal of Maternal/Child Nursing. (in press). |
R836153 (2017) |
not available |
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Mutic, A., Jordan, S., Ferranti, E., Thul, T., Edwards, S., Yang, I. (2017). The Postpartum and Newborn Microbiomes. MCN; The American Journal of Maternal/Child Nursing. (in press). |
R836153 (2017) R836153C002 (2017) |
not available |
Relevant Websites:
Nell Hodgson Woodruff School of Nursing | Emory Exit
Center for Children’s Health, the Environment, the Microbiome, and Metabolomics (C-CHEM2) Exit
Progress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R836153C001 Characterizing Exposures and Outcomes in an Urban Birth Cohort (CHERUB)
R836153C002 Microbiome, Environment, and Neurodevelopmental Delay (MEND)
R836153C003 Metabolic, Microbiome and Toxicant-Related Interactions (MATRIX)
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.