Health Effects of long-Term Exposure to Particles and Other Air Pollutants in Elderly Nonsmoking California ResidentsEPA Grant Number: R827998
Title: Health Effects of long-Term Exposure to Particles and Other Air Pollutants in Elderly Nonsmoking California Residents
Investigators: Knutsen, Synnove F. , Abbey, David E. , Beeson, Larry
Institution: Loma Linda University
EPA Project Officer: Chung, Serena
Project Period: March 1, 2000 through February 28, 2003 (Extended to February 28, 2005)
Project Amount: $763,910
RFA: Airborne Particulate Matter Health Effects (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air , Health Effects
- To extend mortality and cancer incidence ascertainment from 1992 through 1999 on a cohort of 6,338 nonsmoking California Seventh-day Adventists which have been followed prospectively since 1977.
- To update estimates through 1999 of ambient particles - 2.5 microns in diameter (PM2.5), which are currently available 1966-1986.
- To update estimates of particles -10 microns in diameter (PM10), suspended sulfates (SO4), sulfur dioxide (SO2), ozone (O3), and nitrogen dioxide (NO2), currently available through 1992.
- To determine associations between long-term and updated concentrations of PM2.5 and all natural cause and non-malignant respiratory mortality, lung cancer and CVD mortality and incidence.
- To study the health effects of Mixed Pollutants using same outcomes as in # 4.
- To evaluate associations between updated air pollutants and the outcomes in #4 in sensitive subgroups.
- Using the updated data, to confirm associations between elevated long-term concentrations of PM10 with outcomes mentioned in #4.
- Conduct single and multi-pollutant analyses for other air pollutants and the outcomes mentioned in #4.
- Update residence and work location histories, and exposures to occupational air pollutants and environmental tobacco smoke for the cohort.
- Interpolate monthly indices of air pollutants to zip code centroids according to updated work and residence histories of individual study participants.
- Estimate PM2.5 indirectly using site/seasonal specific regression equations based on visibility for 57% of subjects living in the vicinity of nine airports scattered throughout California.
- Update cancer incidence data using the Statewide California Tumor Registry.
- Update total mortality and fatal cancers and CVD using the state and national death indices.
- Multivariate Cox proportional hazards regression models will be used to study associations between risk of disease or death adjusting for other air pollutants, lifestyle and other covariates.