Water as Solvent for Metal-Mediated Carbon-Carbon Bond Formations

EPA Grant Number: R822668
Title: Water as Solvent for Metal-Mediated Carbon-Carbon Bond Formations
Investigators: Li, Chao-Jun
Institution: Tulane University of Louisiana
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 1997 through July 31, 2000
Project Amount: $200,000
RFA: Technology for a Sustainable Environment (1997) RFA Text |  Recipients Lists
Research Category: Sustainability , Pollution Prevention/Sustainable Development


This award is made to Dr. Chao-Jun Li of the Chemistry Department, Tulane University, for investigation of carbon-carbon bond formation in water. The award is in the Technology for Sustainable Environment component of the EPA/NCER Parnership for Environmental Research, and support is provided by the Organic Synthesis Program and the Office of Multidisciplinary Activities. Carbon-carbon bond forming reactions are typically carried out using metal catalysts in anhydrous organic solvents. In this study, the synthesis of various biologically important compounds and fine chemicals will be carried out in aqueous medium. The new method will be more efficient since the number of synthetic steps will be reduced. Additional research to attempt to make the reaction catalytic is also planned. Metal recovery and recycling from the aqueous stream will be used to ensure that the new process is environmentally beneficial. The specific reactions to be investigated include indium-promoted allylations, propargylation-allenylations, and aldol reactions. Large volumes of organic solvents are used in fine chemical and pharmaceutical industries for both reactions and product isolation. These solvents must be recycled or treated by costly methods rather than being expelled into the environment. By developing alternative synthetic methods using water as a solvent, the disposal problem for organic solvents can be reduced.

Publications and Presentations:

Publications have been submitted on this project: View all 86 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 39 journal articles for this project

Supplemental Keywords:

media, air, ambient air, atmosphere, water, drinking water, watersheds, groundwater pollution, green chemistry, sustainable development, alternatives, clean technologies, innovative technology, renewable, waste reduction, waste minimization, environmentally conscious manufacturing., RFA, Scientific Discipline, Sustainable Industry/Business, Chemical Engineering, Environmental Chemistry, Sustainable Environment, Technology for Sustainable Environment, Economics and Business, cleaner production, waste minimization, waste reduction, aqueous processing, environmentally benign solvents, carbon bond formation, alternative materials, catalysts, anhydrous organic solvents, metal recovery, recycling, pollution prevention, green chemistry

Progress and Final Reports:

  • 1998
  • 1999
  • Final Report