2011 Progress Report: Associations of Short-Term Pollution Exposures with Childhood Autoimmune DiseaseEPA Grant Number: R834992
Title: Associations of Short-Term Pollution Exposures with Childhood Autoimmune Disease
Investigators: Zeft, Andrew S. , Pope, Clive Arden
Institution: Brigham Young University
Current Institution: Cleveland Clinic Foundation , Brigham Young University
EPA Project Officer: Ilacqua, Vito
Project Period: June 1, 2011 through May 31, 2014 (Extended to May 31, 2015)
Project Period Covered by this Report: June 1, 2011 through May 31,2012
Project Amount: $298,857
RFA: Exploring New Air Pollution Health Effects Links in Existing Datasets (2010) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Health Effects , Air
We are further testing the hypothesis that clinical autoimmune disease presentation and exacerbation are associated with exposures to short-term pollution, including PM2.5, constituents of PM2.5, and O3. In Objective 1, we will further establish associations between short-term PM2.5 exposure and the clinical onset of Systemic Onset Juvenile Idiopathic Arthritics, a subtype of JIA. In Objective 2, we will establish associations between short-term ambient PM2.5 and O3 and the clinical onset of Kawasaki Disease. In Objective 3, we will establish associations between short-term PM2.5 and O3 exposures and clinical disease activity of Henoch Schonlein Purpura. Cases come from various geographic metropolitan regions of the US and Canada (Toronto).
We have assembled PM2.5 exposure measurements from monitors and have carefully imputed PM2.5 to provide day-to-day temporal variability and resolution for reliable time series indexes of pollution exposures for each metropolitan area (Philadelphia, Boston, Toronto, Chicago, Atlanta, Cincinnati, San Diego, Salt Lake City).
We continue the process of collecting case datasets from collaborating institutions involving the necessary university and hospital institutional review board processes and the generation of data transfer agreements between institutions.
In the coming year, we will perform the following:
- Complete the process of subject data transfer from all collaborating centers
- Finish assembling measured and imputed exposure data from Denver and Cleveland, metropolitan centers added to the study
- Perform the case-crossover analysis and interpretation of results
- Submit initial results in form of scientific abstracts to national meetings
- Begin manuscript preparation for future submission for peer reviewed publication