Model of Toxicant Response in Engineered Liver

EPA Grant Number: R834998
Title: Model of Toxicant Response in Engineered Liver
Investigators: Rajagopalan, Padmavathy
Current Investigators: Rajagopalan, Padmavathy , Ehrich, Marion , Murali, T. M.
Institution: Virginia Polytechnic Institute and State University
EPA Project Officer: Carleton, James N
Project Period: June 1, 2011 through May 30, 2015
Project Amount: $750,000
RFA: Computational Toxicology: Biologically-Based Multi-Scale Modeling (2010) RFA Text |  Recipients Lists
Research Category: Computational Toxicology , Health , Safer Chemicals


This project proposes to:

  1. engineer a tissue to mimic liver behavior (a so-called 3-Dimensional or 3D liver model);
  2. simulate liver toxicity by exposing the 3D liver model to two known toxicants ( carbon tetrachloride and 1,2 dichloroethylene); and
  3. use gene microarrays and computational modeling to discover and elucidate biological pathways perturbed by each toxicant singly and in combination.
This research will provide the methods and data necessary to understand the effect of toxicants on the liver system. The project can ultimately lead to a better understanding of how chemicals manifest their toxicity across multiple types of liver cells, thus providing the knowledge to protect human health.

Publications and Presentations:

Publications have been submitted on this project: View all 27 publications for this project

Journal Articles:

Journal Articles have been submitted on this project: View all 6 journal articles for this project

Progress and Final Reports:

  • 2011 Progress Report
  • 2012
  • 2013 Progress Report
  • Final