Model of Toxicant Response in Engineered LiverEPA Grant Number: R834998
Title: Model of Toxicant Response in Engineered Liver
Investigators: Rajagopalan, Padmavathy
Current Investigators: Rajagopalan, Padmavathy , Ehrich, Marion , Murali, T. M.
Institution: Virginia Polytechnic Institute and State University
EPA Project Officer: Carleton, James N
Project Period: June 1, 2011 through May 30, 2015
Project Amount: $750,000
RFA: Computational Toxicology: Biologically-Based Multi-Scale Modeling (2010) RFA Text | Recipients Lists
Research Category: Computational Toxicology , Health , Safer Chemicals
This project proposes to:
- engineer a tissue to mimic liver behavior (a so-called 3-Dimensional or 3D liver model);
- simulate liver toxicity by exposing the 3D liver model to two known toxicants ( carbon tetrachloride and 1,2 dichloroethylene); and
- use gene microarrays and computational modeling to discover and elucidate biological pathways perturbed by each toxicant singly and in combination.