Final Report: Health Effects Institute (2010-2015)EPA Grant Number: R834677
Center: Health Effects Institute (2005 — 2010)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2010-2015)
Investigators: Greenbaum, Daniel S.
Institution: Health Effects Institute (HEI)
EPA Project Officer: Chung, Serena
Project Period: April 1, 2010 through March 31, 2015
Project Amount: $25,000,000
RFA: Health Effects Institute (2010) RFA Text | Recipients Lists
Research Category: Health Effects , Air Quality and Air Toxics , Air
This project involved targeted strategic research in four key areas:
- Multipollutant Exposure, Epidemiology, and Toxicology Research
- Emerging Technologies and Fuels
- Health Outcomes of Air Quality Improvements (Accountability)
- An International Perspective
HEI also proposed to infuse several cross-cutting issues throughout its efforts from 2010 – 2015, including sensitive populations, enhanced statistical techniques, use of new methods in toxicity testing, and enhanced public access to data.
ACCOMPLISHMENTS OVER THE PAST FIVE YEARS (2010-2015)
HEI published 37 full Research Reports and 6 Special Reports, Perspectives, and Communications on these priority topics. The key findings are summarized below.
Multipollutant Exposure, Epidemiology, and Toxicology Research
- A study of coal bans in Ireland found clear decreases in black smoke concentrations, particularly during the heating season, after each ban. Respiratory mortality decreased significantly in the aftermath of the bans (confirming an earlier study). However, unlike the earlier study, the current study did not find a reduction in total or cardiovascular mortality after the bans. The study demonstrates the importance—and challenges—of disentangling the effects of an intervention from those of other social and economic factors that also might influence long-term trends in health.
- A study in Beijing provided important supporting evidence that air quality improvements such as those found during the Beijing Olympic Games can improve health biomarkers, with the potential for beneficial health effects in the affected population.
- A study in London represented a creative effort to explore a subtle change in air quality associated with a complex intervention to reduce traffic congestion. Although the investigators were unable to demonstrate a clear effect of the Congestion Charging Scheme either on individual air pollutant levels or on oxidative potential of particulate matter, this study offers many lessons for future studies of interventions that are expected to influence air quality.
Journal Articles: 5 Displayed | Download in RIS Format
|Other center views:||All 69 publications||62 publications in selected types||All 5 journal articles|
||Greenbaum D, Shaikh R. First steps toward multipollutant science for air quality decisions. Epidemiology 2010;21(2):195-197.||
||Meng Q, Hackfeld LC, Hodge RP, Walker VE. Comparison of mutagenicity of stereochemical forms of 1,2,3,4-diepoxybutane at HPRT and TK loci in human cells. Environmental and Molecular Mutagenesis 2003;41(36 Supplement):77.||
||Meng Q, Redetzke DL, Hackfeld LC, Hodge RP, Walker DM, Walker VE. Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphoblastoid cells. Chemico-Biological Interactions 2007;166(1-3):207-218.||
||van Erp AM, Kelly FJ, Demerjian KL, Pope III CA, Cohen AJ. Progress in research to assess the effectiveness of air quality interventions towards improving public health. Air Quality, Atmosphere & Health 2012;5(2):217-230.||
||van Erp AM, Cohen AJ, Shaikh R, O’Keefe R. Recent progress and challenges in assessing the effectiveness of air quality interventions toward improving public health: the HEI experience. EM Magazine 2012;10:22-28.||
Supplemental Keywords:air pollution, health effects, particulate matter, ozone, air toxics, diesel, fuels, fuel technologies, accountability, traffic
Progress and Final Reports:Original Abstract
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834677C149 Development and Application of a Sensitive Method to Determine Concentrations of Acrolein and Other Carbonyls in Ambient Air
R834677C150 Mutagenicity of Stereochemical Configurations of 1,3-Butadiene Epoxy Metabolites in Human Cells
R834677C151 Biologic Effects of Inhaled Diesel Exhaust in Young and Old Mice: A Pilot Project
R834677C152 Evaluating Heterogeneity in Indoor and Outdoor Air Pollution Using Land-Use Regression and Constrained Factor Analysis
R834677C153 Improved Source Apportionment and Speciation of Low-Volume Particulate Matter Samples
R834677C155 The Impact of the Congestion Charging Scheme on Air Quality in London
R834677C156 Concentrations of Air Toxics in Motor Vehicle-Dominated Environments
R834677C158 Air Toxics Exposure from Vehicle Emissions at a U.S. Border Crossing: Buffalo Peace Bridge Study
R834677C159 Role of Neprilysin in Airway Inflammation Induced by Diesel Exhaust Emissions
R834677C160 Personal and Ambient Exposures to Air Toxics in Camden, New Jersey
R834677C162 Assessing the Impact of a Wood Stove Replacement Program on Air Quality and Children’s Health
R834677C163 The London Low Emission Zone Baseline Study
R834677C165 Effects of Controlled Exposure to Diesel Exhaust in Allergic Asthmatic Individuals
R834677C168 Evaluating the Effects of Title IV of the 1990 Clean Air Act Amendments on Air Quality
R834677C172 Potential Air Toxics Hot Spots in Truck Terminals and Cabs
R834677C173 Detection and Characterization of Nanoparticles from Motor Vehicles
R834677C174 Cardiorespiratory Biomarker Responses in Healthy Young Adults to Drastic Air Quality Changes Surrounding the 2008 Beijing Olympics