Health Effects Institute (2010-2015)

EPA Grant Number: R834677
Center: Health Effects Institute (2005 — 2010)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2010-2015)
Investigators: Greenbaum, Daniel S.
Institution: Health Effects Institute (HEI)
EPA Project Officer: Chung, Serena
Project Period: April 1, 2010 through March 31, 2015
Project Amount: $25,000,000
RFA: Health Effects Institute (2010) RFA Text |  Recipients Lists
Research Category: Health Effects , Air Quality and Air Toxics , Air


The Health Effects Institute's (HEI) Board of Directors, chaired by Richard Celeste, consists of public figures in science and policy who are committed to the public-private partnership that is central to the HEI approach. The Institute's scientific work is overseen by two independent scientific committees. The Health Research Committee works with the Institute's scientific staff to develop and manage HEI's research program. The Health Review Committee which has no role in selecting or overseeing studies, works with the Institute's scientific staff to evaluate and interpret the results of HEI studies and related research. HEI's priorities for research and special reviews are guided by the five-year HEI Strategic Plan , which is reviewed and updated annually after consultations with HEI sponsors and other interested parties.


HEI is also asked periodically to produce special reports reviewing an entire area of scientific literature on topics such as the health effects of exposure to traffic and air toxics.

To accomplish its mission, HEI:

  • Identifies the highest priority areas for health effects research;
  • Funds and oversees the conduct of high-quality research in these priority areas;
  • Provides intensive, independent review of HEI-supported and related research;
  • Integrates HEI’s research results with those of other institutions into coherent, broader evaluations of health effects; and
  • Communicates the results of HEI research and analyses to public and private decision makers.

The HEI research program has addressed questions about the health effects associated with exposure to both regulated pollutants such as carbon monoxide, ozone, and nitrogen dioxide, and unregulated pollutants such as diesel exhaust, aldehydes, and methanol. HEI has also funded studies to understand the mechanisms of diseases, to develop better methods to assess health effects and determine dose response relationships. The program includes theoretical, in vitro, animal, controlled human exposure, and epidemiological studies.


HEI is an independent, nonprofit corporation chartered in 1980 to provide high-quality, impartial, and relevant science on the health effects air pollution. Supported jointly by the U.S. Environmental Protection Agency (EPA) and industry, HEI has funded more than 280 research projects, the results of which have informed decisions regarding carbon monoxide, air toxics, nitrogen oxides, diesel exhaust, ozone, particulate matter, and other pollutants. These results have appeared in the peer-reviewed literature and in more than 200 comprehensive reports published by HEI.

Expected Results:

The center is conducting research in a number of priority areas, including: new approaches to understanding exposure to and health effect of multiple pollutants )including particulate matter, gases, and air toxics; measuring health outcomes and benefits resulting from air quality actions; and assessing potential health consequences of new fuels and technology. Throughout its research HEI seeks to incorporate effects on sensitive subpopulations, development and validation of new scientific techniques, and providing public access to the data underlying its studies.

Journal Articles: 5 Displayed | Download in RIS Format

Other center views: All 69 publications 62 publications in selected types All 5 journal articles
Type Citation Sub Project Document Sources
Journal Article Greenbaum D, Shaikh R. First steps toward multipollutant science for air quality decisions. Epidemiology 2010;21(2):195-197. R834677 (Final)
  • Abstract from PubMed
  • Full-text: LWW-Full Text HTML
  • Other: LWW-Full Text PDF
  • Journal Article Meng Q, Hackfeld LC, Hodge RP, Walker VE. Comparison of mutagenicity of stereochemical forms of 1,2,3,4-diepoxybutane at HPRT and TK loci in human cells. Environmental and Molecular Mutagenesis 2003;41(36 Supplement):77. R834677C150 (Final)
    not available
    Journal Article Meng Q, Redetzke DL, Hackfeld LC, Hodge RP, Walker DM, Walker VE. Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphoblastoid cells. Chemico-Biological Interactions 2007;166(1-3):207-218. R834677C150 (Final)
  • Abstract from PubMed
  • Abstract: ScienceDirect-Abstract
  • Journal Article van Erp AM, Kelly FJ, Demerjian KL, Pope III CA, Cohen AJ. Progress in research to assess the effectiveness of air quality interventions towards improving public health. Air Quality, Atmosphere & Health 2012;5(2):217-230. R834677 (Final)
  • Abstract: Springer-Abstract
  • Journal Article van Erp AM, Cohen AJ, Shaikh R, O’Keefe R. Recent progress and challenges in assessing the effectiveness of air quality interventions toward improving public health: the HEI experience. EM Magazine 2012;10:22-28. R834677 (Final)
  • Full-text: EM Magazine-Full Text PDF
  • Supplemental Keywords:

    Emmissions, Air Quality, Diesel, Health Effects, Carbon Monoxide, Ozone, Nitrogen Dioxide, Particulate Matter;

    Relevant Websites:

    Health Effects Institute: April 1, 2000 through March 31, 2005
    Health Effects Institute: April 1, 2005 through March 31, 2010
    Research Centers - Health Effects Institute Exit

    Progress and Final Reports:

  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834677C149 Development and Application of a Sensitive Method to Determine Concentrations of Acrolein and Other Carbonyls in Ambient Air
    R834677C150 Mutagenicity of Stereochemical Configurations of 1,3-Butadiene Epoxy Metabolites in Human Cells
    R834677C151 Biologic Effects of Inhaled Diesel Exhaust in Young and Old Mice: A Pilot Project
    R834677C152 Evaluating Heterogeneity in Indoor and Outdoor Air Pollution Using Land-Use Regression and Constrained Factor Analysis
    R834677C153 Improved Source Apportionment and Speciation of Low-Volume Particulate Matter Samples
    R834677C155 The Impact of the Congestion Charging Scheme on Air Quality in London
    R834677C156 Concentrations of Air Toxics in Motor Vehicle-Dominated Environments
    R834677C158 Air Toxics Exposure from Vehicle Emissions at a U.S. Border Crossing: Buffalo Peace Bridge Study
    R834677C159 Role of Neprilysin in Airway Inflammation Induced by Diesel Exhaust Emissions
    R834677C160 Personal and Ambient Exposures to Air Toxics in Camden, New Jersey
    R834677C162 Assessing the Impact of a Wood Stove Replacement Program on Air Quality and Children’s Health
    R834677C163 The London Low Emission Zone Baseline Study
    R834677C165 Effects of Controlled Exposure to Diesel Exhaust in Allergic Asthmatic Individuals
    R834677C168 Evaluating the Effects of Title IV of the 1990 Clean Air Act Amendments on Air Quality
    R834677C172 Potential Air Toxics Hot Spots in Truck Terminals and Cabs
    R834677C173 Detection and Characterization of Nanoparticles from Motor Vehicles
    R834677C174 Cardiorespiratory Biomarker Responses in Healthy Young Adults to Drastic Air Quality Changes Surrounding the 2008 Beijing Olympics