2015 Progress Report: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters

EPA Grant Number: R834799C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834799
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Investigators: Sarnat, Jeremy , Bergin, Michael , Diaz-Sanchez, David , Fitzpatrick, Anne , Flanders, Dana , Greenwald, Roby , Winquist, Andrea
Current Investigators: Sarnat, Jeremy , Bergin, Michael , Diaz-Sanchez, David , Flanders, Dana , Greenwald, Roby , Winquist, Andrea
Institution: Emory University , Duke University , University of North Carolina at Chapel Hill
Current Institution: Emory University , Duke University , Georgia Institute of Technology , University of North Carolina at Chapel Hill
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
Project Period Covered by this Report: August 1, 2014 through July 31,2015
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The primary aim of Atlanta Commuters Exposure Study Project 2 (ACE-2) is to examine the effects of exposure to particulate mixtures occurring during automobile commuting and within indoor, non-commuting microenvironments (μEs) and corresponding measures of oxidative stress-mediated response.

Progress Summary:

  1. Completed data processing for all continuously and integrated measured pollutant parameters for main Project 2 commuter study (ACE-2), including PM2.5 mass concentration, particle number concentration, particle bound PAHs, black carbon concentration, noise, PM2.5 mass concentration, particulate trace elements, elemental and organic carbon, water soluble organic carbon, and DTT (integrated).
  2. During the previous reporting period we also completed data analysis and processing for the following ACE-2 health endpoints: inflammation biomarkers in DBS and plasma.
  3. Completed metabolomic analyses of all ACE-2 plasma samples using HR-MS under the supervision of Project 2 co-investigator, D. Jones. Feature extraction and initial analyses will begin in Fall 2015.
  4. Published manuscript on effect measure modification of ACE-1 results by asthma control status (Mirabelli, et al., Epidemiology, 2015). Results indicate that poorly-controlled asthmatics may be more susceptible to acute changes in lung function and pulmonary inflammation from exposures to specific in-vehicle pollutant.
  5. Completed initial draft of manuscript comparing cytokine quantitation in Dried Blood Spots (DBS using ELISA) to plasma (using electrochemiluminescence).
  6. Completed initial draft of epidemiologic analyses for Project 2 (ACE-2). Findings show that highway commuting in the ACE-2 study was associated with significantly reduced lung function following a scripted 2h highway commute compared to clinic exposure scenarios. Figure 1 shows measured mean Forced Vital Capacity (FVC) in ACE-2 subjects at periods prior to participating in the study protocol and at several post-exposure time-points. In-vehicle PAHs and BC levels were most predictive of corresponding lung function decrement (results not shown).

Future Activities:

During the next 6 months, we expect to complete analyses of all pollutant and health endpoints, including feature extractions and analyses of plasma samples using HR-MS analyses involving the characterization of metabolomic profiles before and after ACE-2 exposures. Primary attention will continue to focus on completing and submitting the draft manuscripts that currently are in preparation.


Journal Articles on this Report : 6 Displayed | Download in RIS Format

Other subproject views: All 32 publications 7 publications in selected types All 7 journal articles
Other center views: All 334 publications 136 publications in selected types All 132 journal articles
Type Citation Sub Project Document Sources
Journal Article Bergin MH, Tripathi SN, Jai Devi J, Gupta T, Mckenzie M, Rana KS, Shafer MM, Villalobos AM, Schauer JJ. The discoloration of the Taj Mahal due to particulate carbon and dust deposition. Environmental Science & Technology 2015;49(2):808-812. R834799 (2015)
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  • Abstract from PubMed
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  • Journal Article Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044 ( pp.). R834799 (2012)
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  • Journal Article Greenwald R, Bergin MH, Yip F, Boehmer T, Kewada P, Shafer MM, Schauer JJ, Sarnat JA. On-roadway in-cabin exposure to particulate matter: measurement results using both continuous and time-integrated sampling approaches. Aerosol Science and Technology 2014;48(6):664-675. R834799 (2014)
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  • Journal Article Mirabelli MC, Golan R, Greenwald R, Raysoni AU, Holguin F, Kewada P, Winquist A, Flanders WD, Sarnat JA. Modification of traffic-related respiratory response by asthma control in a population of car commuters. Epidemiology 2015;26(4):546-555. R834799 (2015)
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  • Journal Article Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. R834799 (2013)
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    R834799C004 (Final)
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  • Journal Article Sarnat JA, Golan R, Greenwald R, Raysoni AU, Kewada P, Winquist A, Sarnat SE, Flanders WD, Mirabelli MC, Zora JE, Bergin MH, Yip F. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environmental Research 2014;133:66-76. R834799 (2014)
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  • Supplemental Keywords:

    health effects, oxidative stress, inflammation, human health, susceptibility, vulnerability, PAHs, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, Environmental Monitoring, children's health, particulate matter, ambient air monitoring, climate change, automobile exhaust, air pollution, traffic density, airshed modeling, ambient particle health effects, human health risk

    Relevant Websites:

    Southeastern Center for Air Pollution & Epidemiology - Emory/Georgia Tech EPA Clean Air Research Center Exit

    Progress and Final Reports:

    Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2014 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R834799    The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
    R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
    R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
    R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity