2014 Progress Report: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters

EPA Grant Number: R834799C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834799
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Investigators: Sarnat, Jeremy , Bergin, Michael , Brown, Lou Ann , Darrow, Lyndsey , Fitzpatrick, Anne , Flanders, Dana , Greenwald, Roby , Guensler, Randy , Wongtrakool, Cherry
Current Investigators: Sarnat, Jeremy , Bergin, Michael , Diaz-Sanchez, David , Flanders, Dana , Greenwald, Roby , Winquist, Andrea
Institution: Emory University , Georgia Institute of Technology
Current Institution: Emory University , Duke University , Georgia Institute of Technology , University of North Carolina at Chapel Hill
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
Project Period Covered by this Report: October 1, 2013 through September 30,2014
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The primary aim of Atlanta Commuters Exposure Study Project 2 (ACE-2) is to examine the effects of exposure to particulate mixtures occurring during automobile commuting and within indoor, non-commuting microenvironments (µE’s) and corresponding measures of oxidative stress-mediated response.  

Progress Summary:

The following is a summary of specific Project 2 tasks completed during the previous reporting period:

  1. Field data collection. To date, Project 2 efforts have focused primarily on field data sampling. In August 2013, study staff completed the 16-month field data collection component of Project 2, which included 120 exposure sessions for 60 subjects.  Every subject successfully completed the entire two-day study protocol, with no attrition.  Review of the health and pollutant measurements indicate satisfactory data capture and completeness.  Table 1 presents descriptive summary results for the complete ACE-2 panel.

  1. Completed data processing for all continuously measured pollutant parameters for main Project 2 commuter study (ACE-2), including PM2.5 mass concentration; particle number concentration; particle bound PAHs; black carbon concentration; and noise. Completed filter analysis and processing of the following integrated pollutant measurements: PM2.5 mass concentration; particulate trace elements; elemental and organic carbon; water soluble organic carbon.  Analyses pending for particulate organic (integrated) ionic species (integrated); and DTT (integrated).
  2. Completed data processing for the following ACE-2 health endpoints: exhaled nitric oxide; lung function (FEV1, FVC); blood pressure; heart rate; and white blood cell count.  Processing is still pending for the following health endpoints: Inflammation biomarkers in DBS and plasma; EBC malondialdehyde and glutathione, and heart rate variability.
  3. Published initial results from commuter pilot study (ACE-1) on in-vehicle pollutant exposures (Greenwald et al., AS&T, 2014) and acute cardiorespiratory response during highway commuting periods (Sarnat et al., Environ Res, 2014).
  4. Completed manuscript on effect measure modification of ACE-1 results by asthma control status (Mirabelli et al).  Results indicate that poorly-controlled asthmatics may be more susceptible to acute changes in lung function and pulmonary inflammation from exposures to specific in-vehicle pollutant.  Manuscript is currently in CDC clearance, to be submitted to Epidemiology.
  5. Completed preliminary epidemiologic analyses for Project 2 (ACE-2) examining associations between continuously measured pollutants (PM2.5, BC, PAHs, PNC) and corresponding respiratory endpoints.
  6. Completed data processing and analysis of ACE-1 and ACE-2 salivary cortisol samples.  Completed first draft of a manuscript examining relationships between self-perceived stress from commuting and biological measures of response.  
  7. Revised draft manuscript of analysis examining correlations between in-vehicle noise and several particulate pollutants.  Results show strong correlations between noise and indicators of particle number concentration. 
  8. Prepared all available ACE-2 plasma samples for metabolomic analyses to be conducted in summer 2014, by Project 2 co-investigator, D Jones.  

Future Activities:

During the next 6 months, we expect to complete analyses of all pollutant and health endpoints, including plasma samples using novel HR-MS analyses involving the characterization of metabolomic profiles before and after ACE-2 exposures.  As noted, Project 2 activities to date have centered around intensive field data collection and processing.  Moving forward, primary attention will shift to completing and submitting six draft manuscripts that are currently in preparation, as well as conducting new exposure and epidemiologic analyses of ACE-2 data. 


Journal Articles on this Report : 5 Displayed | Download in RIS Format

Other subproject views: All 32 publications 7 publications in selected types All 7 journal articles
Other center views: All 334 publications 136 publications in selected types All 132 journal articles
Type Citation Sub Project Document Sources
Journal Article Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044 ( pp.). R834799 (2012)
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  • Journal Article Chang HH, Reich BJ, Miranda ML. A spatial time-to-event approach for estimating associations between air pollution and preterm birth. Journal of the Royal Statistical Society--Series C (Applied Statistics) 2013;62(2):167-179. R834799 (2014)
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  • Journal Article Greenwald R, Bergin MH, Yip F, Boehmer T, Kewada P, Shafer MM, Schauer JJ, Sarnat JA. On-roadway in-cabin exposure to particulate matter: measurement results using both continuous and time-integrated sampling approaches. Aerosol Science and Technology 2014;48(6):664-675. R834799 (2014)
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  • Journal Article Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. R834799 (2013)
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  • Journal Article Sarnat JA, Golan R, Greenwald R, Raysoni AU, Kewada P, Winquist A, Sarnat SE, Flanders WD, Mirabelli MC, Zora JE, Bergin MH, Yip F. Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters. Environmental Research 2014;133:66-76. R834799 (2014)
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  • Supplemental Keywords:

    health effects, oxidative stress, inflammation, human health, susceptibility, vulnerability, PAHs, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, Environmental Monitoring, children's health, particulate matter, ambient air monitoring, climate change, automobile exhaust, air pollution, traffic density, airshed modeling, ambient particle health effects, human health risk

    Relevant Websites:

    Southeastern Center for Air Pollution & Epidemiology - Emory/Georgia Tech EPA Clean Air Research Center Exit

    Progress and Final Reports:

    Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • 2015 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R834799    The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
    R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
    R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
    R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity