2013 Progress Report: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters

EPA Grant Number: R834799C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834799
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures
Center Director: Tolbert, Paige
Title: Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
Investigators: Sarnat, Jeremy , Bergin, Michael , Brown, Lou Ann , Darrow, Lyndsey , Fitzpatrick, Anne , Flanders, Dana , Greenwald, Roby , Guensler, Randy , Wongtrakool, Cherry
Current Investigators: Sarnat, Jeremy , Bergin, Michael , Diaz-Sanchez, David , Flanders, Dana , Greenwald, Roby , Winquist, Andrea
Institution: Emory University , Georgia Institute of Technology
Current Institution: Emory University , Duke University , Georgia Institute of Technology , University of North Carolina at Chapel Hill
EPA Project Officer: Chung, Serena
Project Period: January 1, 2011 through December 31, 2016
Project Period Covered by this Report: August 1, 2012 through July 31,2013
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The primary aim of Atlanta Commuters Exposure Study Project 2 (ACE-2) is to examine the effects of exposure to particulate mixtures occurring during automobile commuting and within indoor, non-commuting microenvironments (μE’s) and corresponding measures of oxidative stress-mediated response.

Progress Summary:

The following is a summary of specific Project 2 tasks completed during the previous reporting period:
  1. Data collection. As of July 5, 2013, 100 (of 120 total) sampling sessions have been completed for Project 2. We anticipate completion of the data collection portion of this study by fall 2013. To date, every subject has successfully completed the entire two-day study protocol. Of the 100 sampling sessions, 50 have been highway commutes, 23 surface street commutes, and 27 clinics; with each subject completing a highway commute and randomly assigned either a clinic or surface street E. Review of the health and pollutant measurements indicate satisfactory data capture and completeness. For all the measured parameters, data have been collected above the designated 90% data capture objective.
  2. Manuscript preparation of results from Pilot Study. Several manuscripts from the pilot Atlanta Commuters Exposure Study (ACE-1) are currently in preparation. By September 2013, we expect the first three manuscripts to be submitted for peer review. The first of these papers (Ladva et al.) examines correlations between in-vehicle pollutant concentrations and corresponding noise levels with the goal of examining the potential of noise to serve as a confounder of traffic pollution health effects. A second paper (Greenwald et al.) summarizes our method for characterizing commuter exposures and presents results on speciated particulate matter concentrations. This paper also presents a novel method for identifying pollutant exposure events during commuting. Finally, a third paper (Sarnat et al.) presents initial epidemiologic results from ACE-1. Among the key findings from this analysis, we observed significant (p < 0.0001) increases in exhaled nitric oxide (eNO) (Figure 1a) and decreases in SDNN, a measure of heart rate variability, at three post-commute time periods (Figure 1b). Presentations on the results from each of these papers will be given at the Joint Annual Conference of the International Society for Environmental Epidemiology and Exposure Science and Indoor Air Quality in August.

Future Activities:

During the upcoming year, Project 2 staff will work on completing manuscripts from ACE-1. We expect seven ACE-1 manuscripts to be submitted during the upcoming reporting period. Field data collection will continue through fall 2013 for ACE-2, with a target end date for sampling of September 30, 2013. Many of the data parameters have been processed and will be ready for data analysis shortly after sampling ends. Chemical analyses of PM organic and elemental species, blood biomarker analyses and heart rate variability data processing will likely continue through December 2013. Finalizing epidemiologic model specification and initial exposure and health effects modeling will commence in 2014.


Journal Articles on this Report : 2 Displayed | Download in RIS Format

Other subproject views: All 32 publications 7 publications in selected types All 7 journal articles
Other center views: All 334 publications 136 publications in selected types All 132 journal articles
Type Citation Sub Project Document Sources
Journal Article Brown MS, Sarnat SE, DeMuth KA, Brown LAS, Whitlock DR, Brown SW, Tolbert PE, Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012;7(5):e37044 ( pp.). R834799 (2012)
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R834799 (2014)
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R834799 (Final)
R834799C002 (2013)
R834799C002 (2014)
R834799C002 (2015)
R834799C002 (Final)
R834799C004 (2012)
R834799C004 (2013)
R834799C004 (2014)
R834799C004 (2015)
R834799C004 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: PLoS ONE-Full Text-PDF
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  • Abstract: PLoS ONE-Abstract & Full Text-HTML
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  • Journal Article Sarnat JA, Sarnat SE, Flanders WD, Chang HH, Mulholland J, Baxter L, Isakov V, Ozkaynak H. Spatiotemporally resolved air exchange rate as a modifier of acute air pollution-related morbidity in Atlanta. Journal of Exposure Science & Environmental Epidemiology 2013;23(6):606-615. R834799 (2013)
    R834799 (2014)
    R834799 (2015)
    R834799 (2016)
    R834799 (Final)
    R834799C002 (2013)
    R834799C002 (2014)
    R834799C002 (2015)
    R834799C002 (Final)
    R834799C004 (2013)
    R834799C004 (2014)
    R834799C004 (2015)
    R834799C004 (Final)
  • Abstract from PubMed
  • Full-text: ResearchGate-Full Text PDF
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  • Abstract: JESEE-Abstract
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  • Supplemental Keywords:

    health effects, oxidative stress, inflammation, human health, susceptibility, vulnerability, PAHs, PM2.5, organics, elemental carbon, metals, ozone, oxidants, PAH, sulfates, source characterization, mobile sources, Georgia, GA, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, Environmental Monitoring, children's health, particulate matter, ambient air monitoring, climate change, automobile exhaust, air pollution, traffic density, airshed modeling, ambient particle health effects, human health risk

    Relevant Websites:

    Southeastern Center for Air Pollution & Epidemiology - Emory/Georgia Tech EPA Clean Air Research Center Exit

    Progress and Final Reports:

    Original Abstract
  • 2011 Progress Report
  • 2012 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R834799    The Southeastern Center for Air Pollution and Epidemiology: Multiscale Measurements and Modeling of Mixtures

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834799C001 Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS
    R834799C002 Examining In-Vehicle Pollution and Oxidative Stress in a Cohort of Daily Commuters
    R834799C003 Novel Estimates of Pollutant Mixtures and Pediatric Health in Two Birth Cohorts
    R834799C004 A Multi-City Time-Series Study of Pollutant Mixtures and Acute Morbidity