Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort

EPA Grant Number: R834796C005
Subproject: this is subproject number 005 , established and managed by the Center Director under grant R834796
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
Investigators: Vedal, Sverre , Kaufman, Joel D. , Larson, Timothy V. , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Szpiro, Adam , Yost, Michael
Current Investigators: Kaufman, Joel D. , Larson, Timothy V. , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Szpiro, Adam , Vedal, Sverre , Yost, Michael
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

Exposure to air pollution, especially particulate matter (PM), is consistently linked to cardiovascular disease (CVD) in epidemiological studies. Larger effects of long-term PM exposure are seen with improved exposure estimates. Traffic is a major source of air pollution and an important contributor to CVD; integrating refined traffic exposures into an epidemiologic study of air pollution and CVD would be an important advance. The primary objective of this project is to estimate the effect of individual-level exposure to traffic-derived air pollution on measures of CVD in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) using novel exposure estimation methods and incorporating on-road, in-transit exposure estimates.

Approach:

This project has three tasks. First, a multi-pollutant exposure prediction model for roadway-associated air pollution will be built that incorporates complex spatial information on primary and secondary traffic-derived particles and gases. This model will yield: 1) city-wide exposure surfaces for traffic-derived air pollution components for four study cities, and 2) distributions of traffic-derived air pollutant estimates for various roadway types and traffic conditions in each city. Second, individual-level exposure estimates will be developed for traffic-derived air pollutants, utilizing the models built under the first objective. We will enhance and validate these estimates using a personal, residential, and in-vehicle monitoring campaign, including real-time data logged GPS tracking, in a subset of 144 MESA Air participants. Third, the effect of individual-level exposure to traffic-related air pollution, including on-roadway exposures, on longitudinal vascular outcomes (including left ventricular mass and retinal arteriolar diameter) and DNA methylation will be estimated in a cohort of over 4,000 MESA Air participants.

Expected Results:

This project will transform MESA Air from its current focus on PM2.5 into a multi-pollutant study that can meaningfully investigate the impact of traffic-derived air pollution on cardiovascular health using a source-to-exposure approach. We will integrate data on traffic-derived pollutants from the novel, state-of-the-art mobile monitoring campaign (Project 1) into a multi-pollutant exposure model that incorporates participant-specific time-location information. The relationship between traffic exposure and change in measures of CVD will be assessed in a large and well-characterized cohort, making this project the first application of a multi-pollutant approach to a large-scale air pollution epidemiology study. Results will, in turn, assist policymakers in taking a multi-pollutant approach to controlling adverse health impacts of air pollution exposure.

Publications and Presentations:

Publications have been submitted on this subproject: View all 21 publications for this subprojectView all 172 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 12 journal articles for this subprojectView all 75 journal articles for this center

Supplemental Keywords:

epidemiology, volatile organic compounds, atherosclerosis,, Health, Scientific Discipline, Air, ENVIRONMENTAL MANAGEMENT, Air Quality, air toxics, Health Risk Assessment, Risk Assessments, mobile sources, Risk Assessment, ambient air quality, particulate matter, atmospheric particulate matter, air pollutants, vehicle emissions, aerosol particles, motor vehicle emissions, air quality models, airway disease, bioavailability, motor vehicle exhaust, air pollution, particle exposure, atmospheric aerosols, ambient particle health effects, vascular dysfunction, cardiotoxicity, atmospheric chemistry, cardiovascular disease

Progress and Final Reports:

2011 Progress Report
2012 Progress Report
2013 Progress Report
2015 Progress Report
2016 Progress Report


Main Center Abstract and Reports:

R834796    University of Washington Center for Clean Air Research

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort