2014 Progress Report: Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition

EPA Grant Number: R834798C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R834798
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Air Pollution Mixtures: Health Effects across Life Stages
Center Director: Koutrakis, Petros
Title: Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
Investigators: Gold, Diane R. , Oken, Emily , Schwartz, Joel
Current Investigators: Gold, Diane R. , Gillman, Matthew , Oken, Emily , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Ilacqua, Vito
Project Period: January 1, 2011 through December 31, 2015 (Extended to December 31, 2016)
Project Period Covered by this Report: January 1, 2014 through December 31,2014
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The main aim of this project is to determine the health effects of prenatal and postnatal exposures to individual pollutants, sources, and pollutant mixtures on somatic growth, cardiovascular risk (blood pressure, exercise tolerance) and cognition in children. The strength of chronic and acute effects of individual pollutants will vary by source and mixture, as well as the timing of prenatal and postnatal exposures. Increased vulnerability or susceptibility to pollution effects on these adverse health outcomes will also result from socioeconomic disparities, stress and violence, environmental tobacco smoke, and reduced maternal and child omega-3 fatty acid intake measured in the prenatal as well as postnatal periods. Our Advisory Committee recommended including asthma as an outcome, and evaluating genetic variants as sources for susceptibility.

Progress Summary:

During the past year we have continued to make excellent progress in each of the specific aims of this project.  Our key accomplishments are summarized briefly below.

Focusing on early life outcomes and outcomes up through mid-childhood, we have analyzed associations of temporally-resolved and spatiotemporally resolved short-term and long term averages of individual pollutants and markers of traffic with a variety of outcomes of interest, including:

  • Maternal and child metabolic and inflammatory outcomes
  • Somatic growth
  • Maternal and child blood pressure
  • Cognition and behavior
  • Respiratory illness in early life, lung function, wheeze and asthma

We began evaluation of longitudinal evaluation associations of fructose and pulmonary outcomes as first step in assessing this and other dietary factors as sources of vulnerability to pollution (collaboration with Michigan group).  Genome-wide measurement of DNA methylation at birth and in early life will offer many opportunities to explore pathways through which pollution influences outcomes.

We are assessing the relation of measures of socioeconomic status to green space, distance to roadway, sources of air pollution, and levels of air pollution. We apply this work to consideration of individual, family, and neighborhood markers for socioeconomic status and urbanicity as potential confounders or effect modifiers of associations of pollution with Project Viva outcomes. In collaboration with investigators from all projects we have collaborated on definition of pollutant, pollutant component, and weather clusters. We have begun to look at effects of pollution sources and mixtures on Project Viva outcomes.

We have estimated spatio-temporally resolved PM2.5 with a 1 km spatial resolution and spatio-temporally resolved temperature with an address-level resolution, to assess their relationships with our childhood outcomes.

Future Activities:

Our plans for the next year in Project Viva are to complete and submit additional papers on prenatal individual pollutant exposures and early life outcomes, and evaluate the effects of pollution sources and mixtures. We will complete the longitudinal exposure and health outcome data to evaluate individual pollutant associations with repeated measures outcomes up through age 7. With investigators from all projects we have collaborated on definition of pollutant, pollutant component, and weather clusters. We will expand investigation of effects of pollution sources and mixtures on Project Viva outcomes. We will continue to assess sources of vulnerability and susceptibility to individual pollutants, pollution sources and mixtures. We will also continue to evaluate effect modification by family and neighborhood socioeconomic status, nutrition, and genes.  Our pathway analyses evaluating the role of epigenetic and biomarker outcomes will continue, and we will complete our GXE work in the CAMP study.


Journal Articles on this Report : 15 Displayed | Download in RIS Format

Other subproject views: All 49 publications 33 publications in selected types All 33 journal articles
Other center views: All 359 publications 297 publications in selected types All 297 journal articles
Type Citation Sub Project Document Sources
Journal Article Austin E, Zanobetti A, Coull B, Schwartz J, Gold D, Koutrakis P. Ozone trends and their relationship to characteristic weather patterns. Journal of Exposure Science and Environmental Epidemiology 2015;25(5):532-542. R834798 (Final)
R834798C004 (2014)
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  • Journal Article Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. Journal of the American Heart Association 2013;2(3):e000212. R834798 (2013)
    R834798 (2014)
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  • Journal Article Bottino CJ, Rifas-Shiman SL, Kleinman KP, Oken E, Redline S, Gold D, Schwartz J, Melly SJ, Koutrakis P, Gillman MW, Taveras EM. The association of urbanicity with infant sleep duration. Health & Place 2012;18(5):1000-1005. R834798 (2013)
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  • Journal Article Fleisch AF, Gold DR, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, Coull BA, Zanobetti A, Gillman MW, Oken E. Air pollution exposure and abnormal glucose tolerance during pregnancy:the Project Viva cohort. Environmental Health Perspectives 2014:122(4):378-383. R834798 (2014)
    R834798 (Final)
    R834798C004 (2014)
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  • Journal Article Gold DR, Mittleman MA. New insights into pollution and the cardiovascular system: 2010 to 2012. Circulation 2013;127(18):1903-1913. R834798 (2013)
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  • Journal Article Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. R834798 (2012)
    R834798 (2013)
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    R834798 (Final)
    R834798C001 (2014)
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    R834798C004 (2012)
    R834798C004 (2014)
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    R832416 (Final)
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  • Journal Article Link MS, Luttmann-Gibson H, Schwartz J, Mittleman MA, Wessler B, Gold DR, Dockery DW, Laden F. Acute exposure to air pollution triggers atrial fibrillation. Journal of the American College of Cardiology 2013;62(9):816-825. R834798 (2013)
    R834798 (2014)
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    R834798C002 (2014)
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    R834798C004 (2013)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Mittleman MA, Hamburg NM. Short-term exposure to air pollution and digital vascular function. American Journal of Epidemiology 2014;180(5):482-489. R834798 (Final)
    R834798C003 (2014)
    R834798C004 (2014)
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  • Journal Article Mostofsky E, Schwartz J, Coull BA, Koutrakis P, Wellenius GA, Suh HH, Gold DR, Mittleman MA. Modeling the association between particle constituents of air pollution and health outcomes. American Journal of Epidemiology 2012;176(4):317-326. R834798 (2013)
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  • Journal Article Mostofsky E, Wilker EH, Schwartz J, Zanobetti A, Gold DR, Wellenius GA, Mittleman MA. Short-term changes in ambient temperature and risk of ischemic stroke. Cerebrovascular Diseases Extra 2014;4(1):9-18. R834798 (2014)
    R834798 (Final)
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  • Journal Article Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo Jr. CA, Huh SY, Mantzoros C, Parker MG, Gillman MW. Cohort profile: Project Viva. International Journal of Epidemiology 2015;44(1):37-48. R834798 (Final)
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  • Journal Article Rice MB, Rifas-Shiman SL, Oken E, Gillman MW, Ljungman PL, Litonjua AA, Schwartz J, Coull BA, Zanobetti A, Koutrakis P, Melly SJ, Mittleman MA, Gold DR. Exposure to traffic and early life respiratory infection: a cohort study. Pediatric Pulmonology 2015;50(3):252-259. R834798 (2014)
    R834798 (Final)
    R834798C004 (2014)
    R834798C004 (Final)
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  • Abstract: Pediatric Pulmonology-Abstract
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  • Journal Article Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E, Floras J, Nanthakumar K. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. Journal of the American College of Cardiology 2011;57(2):198-206. R834798 (2012)
    R834798 (2014)
    R834798 (Final)
    R834798C002 (2014)
    R834798C002 (Final)
    R834798C004 (2012)
    R834798C004 (2014)
    R834798C004 (Final)
    R832416 (Final)
    R832416C002 (2010)
    R832416C002 (Final)
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  • Journal Article Wilker EH, Ljungman PL, Rice MB, Kloog I, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Hamburg NM, Mittleman MA. Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia. American Journal of Cardiology 2014;113(12):2057-2063. R834798 (2014)
    R834798 (Final)
    R834798C003 (2014)
    R834798C003 (Final)
    R834798C004 (2014)
    R834798C004 (Final)
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  • Journal Article Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environmental Health Perspectives 2014;122(3):242-248. R834798 (2013)
    R834798 (2014)
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  • Supplemental Keywords:

    Scientific Discipline, Air, air toxics, Health Risk Assessment, Air Pollution Effects, Biochemistry, Environmental Monitoring, Biology, ambient air quality, complex mixtures, health effects, sensitive populations, children's health, air pollutants, biological sensitivities, exposure and effects, lung epithelial cells, susceptible populations, chemical composition, neurotoxicity, human exposure, toxicity, coronary artery disease, cardiopulmonary, cardiotoxicity, environmental effects, mortality, human health

    Progress and Final Reports:

    Original Abstract
    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    Final Report


    Main Center Abstract and Reports:

    R834798    Air Pollution Mixtures: Health Effects across Life Stages

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834798C001 Relative Toxicity of Air Pollution Mixtures
    R834798C002 Cognitive Decline, Cardiovascular Changes, and Biological Aging in Response to Air Pollution
    R834798C003 Identifying the Cognitive and Vascular Effects of Air Pollution Sources and Mixtures in the Framingharn Offspring and Third Generation Cohorts
    R834798C004 Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
    R834798C005 A National Study to Assess Susceptibility, Vulnerability, and Effect Modification of Air Pollution Health Risks