2013 Progress Report: Air Pollution Mixtures: Health Effects Across Life Stages

EPA Grant Number: R834798
Center: Air Pollution Mixtures: Health Effects across Life Stages
Center Director: Koutrakis, Petros
Title: Air Pollution Mixtures: Health Effects Across Life Stages
Investigators: Koutrakis, Petros , Bell, Michelle L. , Diaz, Edgar , Dominici, Francesca , Gillman, Matthew , Godleski, John J. , Gold, Diane R. , Lawrence, Joy , Mittleman, Murray , Oken, Emily , Schwartz, Joel , Wolfson, Michael , Zanobetti, Antonella
Current Investigators: Koutrakis, Petros , Coull, Brent , Dominici, Francesca , Godleski, John J. , Gold, Diane R. , Mittleman, Murray , Schwartz, Joel
Institution: Harvard University , Harvard T.H. Chan School of Public Health , Yale University
Current Institution: Harvard University
EPA Project Officer: Ilacqua, Vito
Project Period: January 1, 2011 through December 31, 2015 (Extended to December 31, 2016)
Project Period Covered by this Report: August 1, 2012 through July 31,2013
Project Amount: $7,997,561
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

This report presents an overview and summary of the progress and achievements of the third year of funding for the Harvard University Clean Air Research Center. The primary objective of the Center is to estimate health effects of air pollution mixtures, sources, and individual pollutants across life stages (prenatal to senescence). The Harvard CLARC addresses four of the six research priorities of the EPA solicitation to establish Clean Air Centers. The Center: (1) investigates the effects of pollutants and mixtures through animal and human studies;( 2) identifies sub-populations that are at increased risk through the investigation of the modifying effects of gender, diabetes, obesity, socioeconomic disparities, stress, depression, violence, smoking, and omega-3 fatty acid intake in children, adults, and elderly; (3) explains regional and temporal differences in air pollution risks; and (4) examines the shapes of exposure-response relationships for associations resulting from the use of multiple exposure metrics, outcomes and populations.
 
The Harvard CLARC has assembled a multidisciplinary team with expertise in a wide range of fields, including epidemiology, biostatistics, air pollution, exposure assessment, cell biology, pathology, and toxicology. To meet our main objective, we have developed five research Projects that will be supported by three technical Cores. We have developed a common set of hypotheses that will be tested in the different Projects using a synergistic and integrative approach. Importantly, as part of the proposed Center, we will examine the consistency of findings across different health outcomes and across populations at different stages of life by: (1) relying on a common set of exposure metrics; (2) exploring the same set of susceptibility and vulnerability factors; and (3) integrating results from laboratory animal experiments with cohort and population based studies. Specifically, we plan to: (1) investigate the acute and chronic effects of short- and long-term exposures to individual pollutants, pollution sources and multi-pollutant mixtures on: cognitive/neuropsychological function, cardiovascular/endothelial function, inflammation, birth weight/growth, and CVD-related hospitalization/mortality across life stages; and (2) identify susceptibility and vulnerability factors that modify these effects.
 
In the sections that follow, each project is discussed separately. For each project, we summarize the objectives, progress and achievements, publications and presentations, changes to key personnel, and future activities. This report concludes with sections discussing our center collaborations quality assurance, and a list of center publications to date. A financial report is submitted separately.
 
 
Project 1 (R834798C001): Relative Toxicity of Air Pollution Mixtures. PI: John J. Godleski, HSPH.

This is an inhalation toxicological animal exposure study which investigates the relative toxicity of air pollution mixtures. These mixtures include both particles and gases that are emitted directly from sources (primary species) or are formed in the atmosphere through a series of reactions that are predominantly photochemical (secondary species). The project uses source-specific emissions and our photochemical chamber technologies to generate realistic mixtures. We are testing the biological responses of exposure to fresh, aged primary, and secondary pollutants (both gas and particle phase) formed from the photochemical oxidation of traffic emissions or Boston ambient air. Toxicity is assessed in Sprague-Dawley rats by changes in: (1) in vivo chemiluminescence (IVCL) as a measure of oxidant response; (2) blood pressure (BP);( 3) measures of pulmonary and systemic inflammation; and (4) vascular blood flow/resistance. Comparisons among exposures groups will determine which mixtures have toxicity for specific outcomes.
 
Project 2 (R834798C002): Cognitive Decline, Cardiovascular Changes, and Biological Aging in Response to Air Pollution. PI: Joel Schwartz, HSPH.
 
In this Project, we investigate the acute and chronic effects of air pollution on cognitive and neurological impairments, systemic inflammation, and vascular dysfunction. We examine how these effects differ depending on the composition of multi-pollutant mixtures and the source contributions to PM composition. Also, we ascertain the level of increased effects in susceptible and vulnerable subpopulations by examining modifying factors of obesity, diabetes, diet, socioeconomic position, and psychosocial stress.
 
Project 3 (R834798C003): Identifying the cognitive and vascular effects of air pollution sources and mixtures in the Framingham Offspring and Third Generation Cohorts. PI: Murray Mittleman
 
Long- and short-term exposures to ambient air pollution are associated with adverse acute and chronic cardiovascular and perhaps cognitive function, but these effects are poorly understood. Using data from the Framingham Offspring and Third Generation Cohorts, well-characterized populations that have not been previously investigated in association with ambient environmental exposures, we will: (1) determine whether long-term exposures to ambient pollutants and mixtures are associated with cognitive impairment and cognitive interference; (2) test whether short- and long-term exposures to pollutants, mixtures and sources are associated  with acute and chronic vascular and endothelial function; and (3) consider whether markers of biological susceptibility and vulnerability differentially influence  these associations, allowing us to identify subpopulations at increased risk for harmful effects of air pollution.
 
Project 4 (R834798C004): Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition. PI: Diane Gold
 
The main aim of this project is to determine the health effects of prenatal and postnatal exposures to individual pollutants, sources, and pollutant mixtures on somatic growth, cardiovascular risk (blood pressure, exercise tolerance) and cognition in children. The strength of chronic and acute effects of individual pollutants will vary by source and mixture, as well as the timing of prenatal and postnatal exposures. Increased vulnerability or susceptibility to pollution effects on these adverse health outcomes will also result from socioeconomic disparities, stress and violence, environmental tobacco smoke, and reduced maternal and child omega-3 fatty acid intake measured in the prenatal as well as postnatal periods. Our Advisory Committee recommended including asthma as an outcome, and evaluating genetic variants as sources for susceptibility.
 
Project 5 (R834798C005): A National Study to Assess Susceptibility, Vulnerability, and Effect Modification of Air Pollution Health Risks. PI: Francesca Dominici
 
This National study is aimed at identifying factors that explain the heterogeneity of health risks associated with air pollution exposure. We hypothesize that such factors include medical and social conditions, conditions that modify exposure, and differences in pollution composition that modify exposure toxicity. Moreover, we hypothesize that the relevant factors vary among different health outcomes. We will conduct national studies of short- and long-term exposures to individual pollutants, sources, and mixtures. We will establish a cohort of 2.3 million Medicare enrollees residing in Massachusetts and surrounding states and follow its members prospectively for cause-specific hospital admissions and mortality for the period 2000-2014, and also study all live births in Eastern MA, geo-coded to exact address and followed for adverse birth outcomes.
 
 

Progress Summary:

Project 1 (R834798C001)

During the reporting period, we published three papers in one issue of the Journal Air Quality, Atmosphere, and Health, which discuss our present work on the toxicity of primary and secondary pollutants related to traffic. Specifically, these papers described the reaction chamber and exposure system used to study emissions from a northeastern traffic tunnel. Three types of exposures were generated: primary (P), secondary organic aerosols (SOA), and primary plus secondary (PA+SOA). All exposures were generated at a target dose of 50 µg/m3. Exposure to primary or secondary particles initially increases blood pressure. However, only primary particles have a sustained response while secondary particles increase then subsequently decrease blood pressure. Combined primary and secondary exposures increased blood pressure over the first two weeks, but during the third week the increase was not sustained. Respiratory responses differed among the three exposures types. Although all produced decreases in tidal/minute volumes and inspirato­ry/expiratory flows, there were differences in inflammatory changes in BAL. Specifically, we observed an increase in neutrophils for SOA and P+SOA and an increase in lymphocytes for P and P+SOA.
 
Mechanisms responsible for the association PM2.5 exposures and increases in blood pressure have yet to be elucidated. We measured effects of primary and secondary components of traffic-derived PM2.5 on baroreceptor reflex sensitivity (BRS) and gene expression of 84 blood pressure related genes using Quigen® Rat Hypertension RNA expression microarrays, and RT-PCR of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) primary mediators of blood pressure on heart and lung tissues. Rats were exposed to P, SOA, P+SOA, or filtered air (FA) for 5 hours/day, 4 days/week for 3 consecutive weeks. Gene expression was measured through real-time PCR of heart and lung tissue mRNA after 2 and 4 days of exposure. BRS was assessed in the P+SOA and FA groups after injection of phenylephrine (10 µg/kg).
 
In all mechanistic studies PM2.5 exposures were targeted to be about 50 µg/m3. Mass measurements for all exposures averaged 49.1±2.9 µg/m3. A two-fold decrease in eNOS was seen in heart tissue for P and P+SOA exposures after two days. A 3.5-fold decrease in ET-1 was seen in lung for P exposures after 4 days. For P+SOA, a three-fold increase in ET-1 was seen in heart tissue after two days with a 12-fold increase after 4 days. In the microarray studies, SOA exposure had the greatest response with both increasing and decreasing blood pressure response and control systems. P and P+SOA exposures activated or inactivated fewer genes, but the findings are consistent with increases in blood pressure with some evidence of changes showing control mechanisms.
 
Suggestive trends showed both traffic related particle exposed rats and sham exposed rats responded with a normal BRS gain after exposure indicating a compensatory response. Exposed animals showed a diminished response, or possible resetting, in week one which returned to normal by weeks two and three. The trends in BRS and gene expression of eNOS and ET-1 explain the initial increase in BP (↓ eNOS, ↑ ET-1 and no change in BRS). The subsequent lack of increase in BP in some exposure groups with continued exposure correlated with the changes in gene expression of numerous blood pressure control mechanisms to limit increases in blood pressure.
 
A major goal of this project was to measure changes in vascular flow and resistance in all vital organs after exposure to traffic-related aerosols or filtered air. These experiments are challenging because they require preparation of rats with implanted hardware for repeated injections of fluorescent microspheres. Specifically, this procedure includes catheterizing the left ventricle for perfusion and the thoracic aorta for sampling, and connecting these catheters to access ports implanted subcutaneously in the posterior intra-scapular area. In this year, we implanted the cardiac hardware via an abdominal approach with less morbidity. Preliminary studies showed that exposures to traffic-related particles at an exposure dose in the range of only 30 µg/m3 decrease blood flow to the heart and the brain. These studies should provide useful information in determining the mechanisms of both cardiovascular and central nervous system health effects.
 
Project 2 (R834798C002)
 
We have made good progress with our NAS cohort as well as satellite based exposure models which we present below:
 
Results using Central Site Monitoring: In Madrigano et al (2012) we reported that exposure to Black Carbon (BC) particles and PM2.5 in the Normative Aging Study were associated with decreased methylation of iNOS, but not of the glucocorticoid receptor, and that subjects with low optimism and high anxiety had effects that were 3-4 times larger.
 
In Bind (2012), we found effects of particle number, BC, nitrogen dioxide (NO2), and carbon monoxide (CO) on fibrinogen concentrations. Ozone (O3) was a predictor of C-reactive protein (CRP) and ICAM-1 in the NAS. Particle number, BC, NO2, CO, PM2.5, and sulfates were associated with ICAM-1 and VCAM-1. When we examined effect modification by DNA methylation status and we found stronger effects in subjects with lower LINE-1 or higher Alu methylation. Lower methylation at one position in the promoter of factor III (F3) was associated with a stronger effect of air pollution on fibrinogen levels, while lower methylation of TLR-2 was associated with stronger effects on CRP concentrations. This establishes that gene specific methylation state can be a modifier of the health effects of air pollution.
 
In Sofer (2012), we introduced a method of gene selection for genome-wide methylation studies. The method is based on the continuous nature of methylation data, as opposed to genetic polymorphism data, and uses supervised canonical correlation analyses. In Schwartz (2013), we used genome-wide methylation from the Nimblegen array to demonstrate that exposure to BC and sulfate particles was associated with changes in DNA methylation along the asthma pathway, based on KEGG. This provides an important clue to why epidemiologic studies have reported associations of traffic pollution with asthma.
 
In Valdez, we expanded a method we previously used to examine interactions between monthly species specific mass ratios to PM2.5 mass and PM2.5 as modifiers of the particle effects on mortality in a daily time series.
 
In Von Klot et al., we showed that control for influenza epidemics explained the irregular part of seasonal variability in cardiovascular mortality, allowing seasonal control to be established with half the degrees of freedom, but a better fit, than with traditional models with e.g., 6 df per year of seasonal control using splines. This offers a possibility of better separation of environmental exposures from seasonal patterns.
 
Results using spatiotemporal exposure models: In Nordio (2013) we showed out spatiotemporal AOD-LUR models work well for predicting PM10 as well as PM2.5, and work in very different topography than New England. This model is now being used to analyze health data in Italy.
 
In Kloog (2013), we combined our Spatiotemporal AID-LUR PM2.5 model with individual mortality data in Massachusetts geocoded to home address, and showed associations with both long- and short-term exposure. Unlike most cohort studies, which have samples highly unrepresentative of the general population, these results are for the entire population of Massachusetts. For short-term exposure, we found that for every 10-μg/m3 increase in PM2.5 exposure there was a 2.8% increase in PM-related mortality (95% confidence interval (CI) = 2.0–3.5). For the long-term exposure at the grid cell level, we found a Rate Ratio (RR) for every 10-μg/m3 increase of 1.6 (CI = 1.5–1.8) for particle-related diseases. Local PM2.5 had an RR of 1.4 (CI = 1.3–1.5), which was independent of and additive to the grid cell effect.
 
In Power (2013), we used our spatiotemporal BC exposure model to show that the association of BC with cognitive function in the Normative Aging Study was modified by polymorphisms in the hemochromatosis gene, which regulates metal uptake into cells. This suggests the involvement of metals associated with traffic particles in the cognitive association.
 
In Wilker (2013), we showed that long-term BC exposure was associated with coronary artery Intima Media Thickness, indicating that traffic particles play a key role in atherosclerosis.
 
In Kloog (2012), we demonstrated how AOD can be used reliably to predict daily PM2.5 mass concentrations in the Mid-Atlantic area, validating our previous model in New England. We have also shown how our model improves further by adding methodological improvements, allowing us to address some of the shortcoming of the first iteration of the model. These included inverse probability weighting to address nonrandom missingness, sub regions, and a shrinkage approach to covariates. For all days without AOD values, model performance was excellent (mean “out-of-sample” R2=0.81, year-to-year variation 0.79−0.84). Upon removal of outliers in the PM2.5 monitoring data, the results of the cross- validation procedure was even better (overall mean ”out of sample” R2 of 0.85). Further, cross validation results revealed no bias in the predicted concentrations (Slope of observed versus predicted = 0.97−1.01). We are now applying this exposure to administrative data.
 
Project 3 (R834798C003)
 
Over the past year, we have continued to make progress on our specific aims. As projected on last year’s progress report, we have integrated all relevant exposure data, including spatially resolved model-based PM2.5 data into the Framingham master dataset for Offspring Cycles 6, 7, 8 and Generation 3 Cycles 1 and 2. We continued to work on analyses of both short- and long-term exposures to air pollutants, sources and mixtures on vascular and neurocognitive function including flow-mediated vasodilatation (FMD), flow velocity and peripheral arterial tonometry (PAT). We conducted preliminary analyses of the association between long-term exposures to air pollution sources and mixtures and cognitive outcomes beyond the Mini-Mental Status Examination. We extended our aims to include a detailed evaluation of lung structure and function including pulmonary function tests (FEV1, FVC), diffusing capacity (DLCO), and full chest computed tomography (CT) data to investigate subclinical chronic obstructive lung disease and airway thickening.
 
We evaluated the impact of residential proximity to a major roadway (primary or secondary highway) and spatially resolved average PM2.5 on brachial artery flow mediated dilation and reactive hyperemia in the Framingham Offspring and Third Generation cohorts (n=5,146). We found that compared to living 400 m away from a major road, living 50 m from a major roadway was associated with 0.14% lower FMD (95%CI: -0.26%, -0.02%) and an interquartile range (IQR) increase in PM2.5 (1.99 µg/m3) was associated with -0.16% (-0.27,-0.06%) lower FMD%. Living near a major road was not significantly associated with hyperemic flow velocity, but an IQR increase in PM2.5 was associated with -0.70 cm/s lower hyperemic flow (95%CI: -1.36, -0.05 cm/s). Neither residential proximity to a major roadway nor exposure to PM2.5 was associated with baseline brachial diameter nor baseline mean flow velocity. This work will be presented at the International Society of Environmental Epidemiology (ISEE) meeting in Basel, Switzerland, August 2013.
 
We have conducted analyses investigating associations between short-term exposures to ambient air pollution and micro-vascular function measured with peripheral arterial tonometry in 1940 participants of the Offspring and Third Generation cohorts of the Framingham Heart Study. When analyzing one pollutant at a time without taking into account the context of its mixture and we found depressed micro-vascular function associated only with higher particle number levels for baseline pulse amplitude, but no associations for PM2.5. Using cluster analyses to separate days into 5 distinct clusters or mixtures of air pollution we found strong associations between higher 1-day moving average of PM2.5 and baseline pulse amplitude on days with mixtures characterized by pollution from combustion sources of traffic, heating oil and wood containing higher number of particles (25.0% per 5 µg/m3 of PM2.5 CI 95% 4.6; 49.2). These results will be presented at the 2013 ISEE meeting in Basel, Switzerland in August.
 
We evaluated associations between short-term exposure to air pollutants and lung function in the Framingham Offspring and Third Generation Cohorts. We found negative associations between 1- and 2-day moving averages of NO2 and O3 and both FEV1 and FVC. A 10 ppb increase in NO2 concentration 1 day prior to testing was associated with a -11.1 mL lower FEV1 (95% CI: -20.2, -2.0) and a 10 ppb increase in O3 1 day prior to testing was associated with a -14.7 mL lower FEV1 (95% CI: -27.2, -2.1).  This work will be presented at the ISEE meeting in August 2013. Dr. Mary Rice submitted an NRSA proposal on her work evaluating subclinical COPD and air pollution exposure in Framingham, which was scored in the 8th percentile. 
 
In addition to our work on the Framingham Study, we have completed related work which builds on the aims of our project.  In collaboration with Greg Wellenius at Brown University, we have 2 papers examining cognitive function and cerebral hemodynamics in the MOBILIZE (Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly) cohort. In the first, published in the Journal of the American Geriatric Society (2012), we found that residential proximity to a major roadway was associated with poorer performance on cognitive tests of verbal learning and memory, psychomotor speed, language, and executive function, with those residing within 100 m of a major roadway having the worst performance in general. In the second published in Stroke (2013), we used transcranial Doppler ultrasound to measure beat-to-beat flow velocity in the middle cerebral artery at rest and in response to changes in end-tidal CO2 and arterial blood pressure. In this cohort, exposure to PM2.5 during the previous 28 days was associated with higher resting cerebrovascular resistance and lower cerebral blood flow velocity. These results were published in Stroke.
 
We examined the association between residential proximity to high traffic roads and post-stroke mortality among 1,683 patients ≥21 years of age admitted to the Beth Israel Deaconess Medical Center (BIDMC) from January 1999 to October 2008 with neurologist-confirmed ischemic stroke residing in the Boston metropolitan region. Deaths were identified through June 2012. We found that patients living ≤100 m from high traffic roadways at the time of stroke onset had a 20% (95% CI: 1%, 43%) higher rate of post-stroke mortality than patients living > 400m away (p-trend = 0.02). These results were presented at the International Stroke Conference (ISC) in Honolulu, Hawaii in February, 2013, and are now published in the Journal of Stroke and Cerebrovascular Diseases.
 
We also evaluated the impact of long-term near-roadway exposure on renal dysfunction in a population of 1,103 consecutive Boston-area patients hospitalized with confirmed ischemic stroke. In this study, we found that patients living closer to a major roadway had lower estimated glomerular filtration rate (eGFR) than patients living farther away. Comparing patients living 50 m versus 1,000 m from a major roadway was associated with a 3.9 mL/min/1.73 m2 lower eGFR (95% CI 1.0 to 6.7; p = 0.007): a difference comparable in magnitude to the reduction in eGFR observed for a 4-year increase in age in population-based studies. This work has been published in the Journal of Epidemiology and Community Health (2013).

We used the time-stratified case-crossover design to examine the association between apparent temperature and humidity and the risk of ischemic stroke among 1,705 Boston area patients hospitalized with neurologist-confirmed ischemic stroke. The incidence rate ratio of ischemic stroke was 1.09 (95% confidence interval 1.01-1.18) following a 5ºC decrement in average apparent temperature over the 2 days preceding symptom onset. The higher risk associated with cooler temperatures peaked in the first 14 to 34 hours. The association between ischemic stroke and temperature was stronger on days with higher levels of relative humidity. The preliminary results were presented at the ISC meeting in February 2013 and a manuscript describing this work is currently under review.

Project 4 (R834798C004)
 
We have geocoded the entire longitudinal address history and have used this to link to longitudinal GIS and census data. With these data we have created a longitudinal data set with: (1) estimated spatially and temporally resolved BC and PM2.5; and (2) neighborhood-level SES variables. We are designing approaches to estimate longer term exposure estimates for the significant proportion of families who move between health assessment visits. We have analyzed associations of temporally- and spatiotemporally-resolved short- and long-term averages of individual pollutants with maternal outcomes (glucose tolerance, hypertension in pregnancy); somatic growth, blood pressure, cognition and sleep duration. Maria Harris, a doctoral candidate is using Project Viva data to assess pollution on behavioral as well as cognitive outcomes.
 
In response to advisory committee requests to include respiratory outcomes, Dr. Rice has completed analyses on prenatal proximity to roadway and respiratory illness incidence, and has begun longitudinal evaluation of associations of pre- and post-natal pollution and weather exposures with acute respiratory illness, asthma onset and asthma morbidity. Also in response to Advisory Committee requests to expand our focus on pollution and asthma morbidity, Dr. Ierodiakonou, a University of Groningen doctoral candidate, has used data from the Childhood Asthma Management Program (CAMP) trial to evaluate pollution associations with repeated measures of lung function and effect modification by treatment group. In addition, she used hypothesis-free and pathway specific genome-wide level analyses to investigate whether genetic variants modify the long-term effects of carbon monoxide and NO2 on FEV1 in children with asthma.
 
In Project Viva, we are assessing the relation of measures of socioeconomic status to green space, distance to roadway, sources of air pollution, and levels of air pollution. We apply this work to consideration of individual, family, and neighborhood markers for socioeconomic status and urbanicity as potential confounders or effect modifiers of associations of pollution with Project Viva outcomes. We have begun to use longitudinal exposure and health outcome data to evaluate individual pollutant associations with outcomes up through age 7 in Project Viva. In collaboration with investigators from all projects we have collaborated on definition of pollutant, pollutant component, and weather clusters. We have begun to look at effects of pollution sources and mixtures on Project Viva outcomes.
 
Our published papers and abstracts present our most outstanding findings. Elevated PM2.5 in the second trimester, cumulative traffic density and closer residential distance to roadway in pregnancy were associated with abnormal glucose tolerance during pregnancy. Closer distance to roadway was associated with increased sleep deprivation. Increased BC exposure and urbanicity predicted lower fetal growth; increased traffic density predicted development of adiposity by 6 months of age. Increased residence-level BC levels or closer distance to roadway in pregnancy predicted reduced cognition by age 7, but associations were confounded by SES. Increased temporally- and spatiotemporally-resolved BC and PM2.5 in the last 2 to 90 days of pregnancy predicted higher neonatal blood pressure. Associations were also found between long-term averages of gases (NOX, CO, and O3) and blood pressure, and we are evaluating the extent to which season and trend can account for these associations.
 
Project 5 (R834798C005)

Epidemiological studies: We are making progress toward all the aims by conducting epidemiological studies and also by developing statistical methods. In Bell et al, we have reviewed recent literature to summarize the state of scientific evidence on effect modification and identify consistencies across studies. We focused on time series and case-crossover studies of the effects of short-term exposure to PM or O3 on mortality and morbidity. In Correia et al we have conducted a nationwide epidemiological study on changes in PM2.5 in recent years and increase in life expectancy for 545 U.S. counties. In Kloog et al, we have further improved models to predict PM2.5 exposures at a finer spatial scale and at daily level for all the United StatesS. In Kloog et al., we have conducted epidemiological studies to estimate acute and chronic effects of air pollution in both elderly, adults, and for pregnancy outcomes. In Bell et al we have conducted an epidemiological study focused on an in-depth investigation of the effect of PM2.5 components and sources on the risk of hospital admissions in four counties in Connecticut. Finally, in Zanobetti et al., we have submitted for publication a paper that uses the Medicare data to estimate the short term effects of PM2.5 on mortality separately for Medicare enrollees that have had a previous hospitalization for diabetes or a neurological disorder.
 
Development of innovative statistical methods: In addition to conducting many epidemiological studies on particulate matter, its chemical composition and sources, the team has been very productive in developing new statistical methods. In Wang et al, we have developed a new approach that accounts for the uncertainty associated with the confounding adjustment in epidemiological studies of air pollution and health. This paper was favorably received by Dr. Thomas a member of the advisory board and we are now extending this work to nonlinear outcomes and to the case where we deal with multiple exposure variables. In Zigler et al, we have developed a new statistical approach aimed at assessing (using causal inference arguments), the effect of attainment versus not attainment status to the NAAQS for PM10, both on the levels of pollution (PM10 and O3) but also on the outcome (mortality). The statistical approach allows us to assess separately indirect and direct effects of air quality regulations on health outcomes. Finally in Bobb et al., we have developed a new class of Bayesian hierarchical models to estimating the joint effect associated with simultaneous exposure to more than one pollutant. We have applied this newly developed method to a multi-site time series study to estimate the joint effect of PM10 and ozone on mortality.

 

Future Activities:

Project 1 (R834798C001)
 
We will continue with our investigations as described above. Exposures to fresh and photochemically aged traffic particles with and without ozone and other secondary gases will be conducted. Toxicity of exposures will be assessed in rats using a variety of outcome described above (including changes in vivo chemiluminescence, blood pressure, inflammation, and vascular flow/resistance) to determine the contribution of different components of the exposure mixture to observed biological effects.
 
Project 2 (R834798C002)
 
We will continue our work on exploring multi-pollutant mixtures by examining the effect of metals, EC, and OC in a national study of cities with speciation data. This will also include meta-analyses to examine effect modification by temperature and other city characteristics. We will apply our cluster analyses, and our daily XRF data, and look at health effects of clusters and metals in the NAS, and we will expand our examination of pollution effects on DNA methylation, using the Illumina 450k array. We will further refine our PM2.5 model using 1km MAIAC data and apply it to the NAS and other cohorts.
 
Project 3 (R834798C003)
 
Future work will include continuing to integrate additional exposure-measures, including particle constituents and additional model-based data into the Framingham master dataset for Offspring Cycles 6, 7, 8 and Generation 3 Cycles 1 and 2. We will complete analyses and publish manuscripts on acute and chronic effects of air pollution measures, including mixtures and sources on vascular outcomes including FMD, flow rates, blood pressure, peripheral arterial tonometry, pulse wave morphology and velocity and biomarkers of inflammation, oxidative stress and hemostasis. In addition, we will complete manuscripts on short- and long-term exposures on pulmonary function and extend this work to include chest CT data to evaluate subclinical pulmonary disease. We will also continue to develop analyses of neurocognitive outcomes.
 
Project 4 (R834798C004)
 
In Project Viva, we will complete and submit additional papers on prenatal individual pollutant exposures and early life outcomes. We will use longitudinal exposure and health outcome data to evaluate individual pollutant associations with repeated measures outcomes up through age 7. In collaboration with investigators from all projects we have collaborated on definition of pollutant, pollutant component, and weather clusters. We will expand investigation of effects of pollution sources and mixtures on Project Viva outcomes. We will continue to assess sources of vulnerability and susceptibility to individual pollutants, pollution sources and mixtures.
 
Project 5 (R834798C005)
 
There is a great amount of synergy and productivity among the members of the team. Below are summarized some examples. Matt Cefalu, a recently appointed postdoctoral fellow, and Itai Kloog, Schwartz and Dominici are conducting a study to better understand the role of confounders when some of these confounders are also used to predict exposure to air pollution. Kloog, Schwartz and Nordio are continuing to improve and refine exposure prediction models for fine particulate matter. Dominici is extending her previous work on PM2.5 and life expectance, by looking specifically at which components of PM2.5 are the main drivers of documented improvement in life expectancy. Zanobetti, Dominici, Bell and Bobb are all heavily involved in studies of climate change and health outcomes.
 
We will continue analysis of national short- and long-term exposures to individual pollutants, sources, and mixtures at a national scale. We will also continue development and analysis of a cohort of Medicare enrollees in Massachusetts and surrounding states for cause-specific hospital admissions and mortality; studying all live births in Eastern MA, geo-coded to exact address and followed for adverse birth outcomes.
 
Center Collaborations:
 
Collaboration 1: Toxicity of Traffic-Based Air Pollution in Rats with Diet-Induced Cardiometabolic Syndrome
 
Lead Harvard Investigator: John Godleski
Collaborative Centers: GLACIER, University of Washington CLARCs, and EPA

The Harvard CLARC interacts with many other CLARCs. In particular, in collaboration with our Project 1 and the GLACIER and University of Washington CLARCs as well as EPA in-house scientist, we planned a study of animals with diet-induced cardiovascular disease using the exposure system in use at each Center. In our case, our exposure system differentiating primary and secondary particles from traffic-related ambient urban pollution (TRAUP) was used. Protocols for these studies were developed through a series of emails following the 2011 Center Director’s meeting and finalized at the 2012 meeting. Project 1 scientists played a leadership role in organizing this study and coordinating among the various CLARCs participating in this collaboration.
 
Using an established high fructose-diet-fed rat model of Cardio-Metabolic Syndrome (CMS), this collaborative study is designed: (1) to determine whether this dysfunctional cardio-metabolic condition predisposes to the toxic effects of traffic-related air pollution; and (2) to identify underlying toxicological modes of action by which this may occur. We hope to discern if CMS renders the laboratory animal more susceptible to the CV, autonomic and airway toxicity of a multi-pollutant mixture of primary particles and secondary organic aerosols derived from traffic emissions in the Boston Tunnel. CMS is defined as three or more of the following abnormalities: abdominal obesity; increased blood pressure; elevated blood glucose; and hyperlipidemia. Common coexisting pathologically linked abnormalities include impaired vascular endothelial function, autonomic nervous system imbalance, systemic inflammation, and oxidative stress. Though it represents an emergent phenotype due to interactions among multiple physiological systems, pre-existing genetic propensity, and environmental factors (e.g., obesity, diet, lifestyle), defects in insulin sensitivity among organs/tissues is a fundamental underlying cause. The animal model is established in Sprague-Dawley rats. These species and strain that have been used at our CLARC thus we have considerable data for comparison between this model of susceptibility and normal animals. At the same time, the GLACIER CLARC has found that exposure to concentrated ambient particles plus O3 produces a reduction in heart rate and blood pressure in this model, the opposite of what we have found with our traffic exposures in normal animals. This model will also be exposed at the University of Washington CLARC and EPA laboratories. The GLACIER CLARC will provide the diet and protocol to each collaborating laboratory, as well as it will provide data for comparisons among groups.
 
Our plan is to compare filtered air versus TRUAP exposures in rats on a high fructose diet which produces hypertension and other facets of the metabolic syndrome (e.g., insulin resistance, hyperglycemia, dyslipidemia). From the telemetered animals we assess the following outcomes: Blood pressure, heart rate, heart rate variability, and body temperature all derived from the telemetry system; Respiratory rate, times of inspiration, expiration, inspiratory pause, expiratory pause and relaxation, peak air flows during inspiration and expiration, average air flow during expiration, tidal and minute volumes, inspiratory duty cycle, and minute ventilation. In a group of non-telemetered animals, we will assess bronchoalveolar lavage parameters after 4 days of exposure including cells and cell types as well as total protein and ß-N-Acetyl-Glucuronidase determinations in the lavage fluid using 6 animals/TRUAP or filtered air group. From the animals on which BAL is done, we will also collect heart blood for complete blood count and differential analysis and for platelet counts measurements. Also blood chemistry (Chem 17) will be performed including blood glucose, electrolytes, insulin, triglycerides, and hepatic function assessment. A third group of 6 non-telemetered animals (TRUAP and Filtered air groups) will be exposed for a length of time to be determined for specific outcomes to be assessed by collaborating CLARC investigators at one laboratory using serum from these animals to assess in vitro effects on vascular endothelial cells.
 
During the past year, exposures were completed at our facility for these studies. Blood chemistry studies confirmed the development of metabolic syndrome. Exposure dose was in the range of 30 µg/m3 which is similar to that in to our micro-bead studies. BAL studies failed to reveal a difference between traffic pollution and filtered air. All other analyses are still in progress.
 
In summary, this collaborative project will assess the various traffic-related exposures in use in different CLARCs on one susceptible model for which extensive data exists on the normal counterpart of this model. This collaborative project will use similar outcomes in all CLARCs and will use serum samples from a subset of animals for an in vitro study using endothelial cells.
 
Collaboration 2: Characterization of primary and secondary traffic related particles
 
Lead Harvard Investigator: Petros Koutrakis
Collaborating Center: SCAPE
 
The objective of this collaborative project was to characterize the composition of tunnel primary, secondary, and aged primary plus secondary aerosols generated for exposures in our toxicology study (Project 1). Dr. Sally Ng from Georgia Institute of Technology (GIT) and her doctoral student Matt Kollman collaborated with us on this effort, using an Aerosol Chemical Speciation Monitor (ACSM) provided by Aerodyne Inc.  The ACSM provides quantitative measurement of non-refractory submicron aerosol composition, including mass spectra, with a time resolution on the order of 15 to 30 min. The ACSM measures organics, nitrate, sulfate, ammonium, and chloride. The extent of oxidation of chamber aerosols can also be determined semi-continuously from the mass fraction m/z 44 (CO2+), allowing measurement of the evolution of O/C over the course of each experiment.
 
For exposures conducted during the collaboration, the ACSM was operated continuously. The goal was to provide complementary chemical data including near real-time determination of the contribution of primary and secondary aerosols, as well as the extent of oxidation over the course of each experiment. An additional goal of the collaboration was to provide information about the atmosphere inside the photochemical chamber and how the secondary products relate to those found in the atmosphere. To do this, the ACSM was operated through the normal startup procedures of the photochemical chamber during the primary plus secondary organic aerosol (P+SOA) and SOA only atmospheres, as well as with the primary tunnel particles (P), to evaluate the changes observed in aerosol evolution as the photochemical chamber output stabilized prior to exposures. During this portion of the study, we conducted additional measurements collocated with the ACSM, including integrated particle mass, EC/OC, and trace elemental concentrations, as well as continuous particle size distribution using a Scanning Mobility Particle Sizer (SMPS).
 
During animal exposures, we conducted our routine measurements made at the point of exposure, including integrated particle mass, EC/OC, and trace elemental concentrations, as well as continuous particle size distribution using a Scanning Mobility Particle Sizer (SMPS). During the hours where animals were not being exposed, we operated a collocated SMPS along with the ACSM, but the remaining chamber output was utilized for collecting samples for Georgia Tech to analyze for reactive oxygen species.
 
We are in the process of integrating our data with Georgia Tech’s measurements made during this study, and analysis is in the early stages. In general, it was found that the ACSM and SMPS (and integrated measurements) had reasonable agreement for the SOA and P+SOA atmospheres, though better for the SOA. Both continuous instruments showed the same trends over time, appearing to track together, and we expect that they will be found to be reasonably well correlated. Measurement of P (primary tunnel particles), however, does not seem to agree between the methods. The ACSM measurements are much lower than the other measurements, including the SMPS, integrated PM collected on Teflon filters, and integrated EC/OC collected on quartz fiber filters over the same period. Understanding of this finding is still evolving. We are continuing to work on this with Dr. Ng, and are looking forward to completing this interesting collaborative analysis.
 
Collaboration 3: Obesity and Diet as Sources of Susceptibility to Systemic and Specific Airway Responses to PM2.5, O3, and Multipollutant\Mixtures
 
Lead Harvard Investigator: Diane Gold
Collaborating Centers: GLACIER, EPA
 
We plan a collaborative project amongst our Project 4, GLACIER, and EPA in-house scientists: to evaluate obesity and diet (high fructose, high caloric, or high fat) as sources of susceptibility to systemic and specific airway inflammatory/oxidative stress responses to PM2.5, O3, and multi-pollutant mixtures. We have recruited approximately 155 children since December 2012, assessing diet (including detailed information on use of high sugar beverages), anthropometric measurements, FeNO (pulmonary inflammation), and collecting nasal swabs for DNA/RNA and urine. This will make it possible to evaluate obesity and high sugar intake as a modifier of pollution effects on pulmonary and upper respiratory inflammatory outcomes, and compare and results with those of the Michigan group, both in controlled human exposures studies and in their rodent model.
 
Collaboration 4: Inter-comparison of Ambient PM2.5 Estimation Models in NC
Lead Harvard Investigator: Petros Koutrakis
Collaborating Centers: SCAPE, CCAR
 
Satellites offer a new resource for air quality management, providing regular observations of air pollutants with wide spatial coverage. Among various satellite retrieved parameters, aerosol optical depth (AOD) has been used extensively in estimating ground level PM2.5 concentrations. This collaboration will evaluate the performance of various satellite-driven PM2.5 exposure models as well as CMAQ PM2.5 in North Carolina.
 
We have processed the 10 x 10 km MODIS AOD data and have predicted PM2.5 concentrations for North Carolina. These data were sent to Dr. Devlin at EPA. Our understanding is that Dr. Liu is expecting the 3x3 km AOD product to be released by NASA so he can estimate PM2.5 concentrations.
 

 

References:

Project 2 (R834798C002)
 
Nordio F, Kloog I, Coull BA, Chudnovsky A, Grillo P, Bertazzi PA, Baccarelli AA, Schwartz J. 2013. Estimating Spatio-temporal Resolved PM10 Aerosol Mass Concentrations Using MODIS Satellite Data and Land Use Regression Over Lombardy, Italy. Atmospheric Environment 74: 227-36
 
Kloog I, Zanobetti A, Schwartz J. Using Novel Exposure Models to Investigate the Association between Mortality and Long and Short Term Exposure to PM2.5 in Massachusetts. Epidemiology, 2013, in press.

Schwartz J, Sofer T, Baccarelli A, Cantone L, Coull BA, Maity A,  Lin X. Exposure to airborne particles is associated with methylation pattern in the asthma pathway. Epigenomics, 2013, Apr;5(2):147-54.
Power MC, Weisskopf MG, Alexeeff SE, Wright RO, Coull BA, Spiro A and Schwartz J. Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a prospective cohort study. Environ Health, 2013 Feb 15;12:16. DOI: 10.1186.
Madrigano J, Kloog I, Goldberg R, Coull BA, Mittleman MA, Schwartz J. Long term exposure to PM2.5 and incidence of acute myocardial infarction. Environ Health Perspect, 2013 Feb;121(2):192-6.
 
Valdés A, Zanobetti A, Halonen JI, Cifuentes L, Morata D, Schwartz J. Elemental concentrations of ambient particles and cause specific mortality in Santiago, Chile: a time series study. Environmental Health 2012, 11:82. 

Sofar T, Maity A, Baccarelli AA, Schwartz J, Lin X. Multivariate gene selection and testing in studying the exposure effects on a gene set. Statistics in Bioscience, 2012, DOI: 10.1007/s12561-012-9072-7.
Von Klot S, Zanobetti A, Schwartz J. Influenza epidemics, seasonality, and the effects of cold weather on cardiac mortality. Environmental Health, 2012, 11:74 DOI: 10.1186/1476-069X-11-74.
 
Wilker EH, Mittleman MA, Coull BA, Gryparis A, Bots ML, Schwartz J, Sparrow D. Long-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Study. Environ Health Perspect. 2013 Jul 2. [Epub ahead of print]
 
Kloog I, Nordio F, Coull B, and Schwartz J. “Incorporating Local Land Use Regression and Satellite Aerosol Optical Depth in a Hybrid Model of Spatiotemporal PM2.5 Exposures in the Mid-Atlantic States.” Environmental Science & Technology 46, no. 21 (2012): 11913–11921.

 


Journal Articles: 297 Displayed | Download in RIS Format

Other center views: All 358 publications 295 publications in selected types All 295 journal articles
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Journal Article Alexeeff SE, Schwartz J, Kloog I, Chudnovsky A, Koutrakis P, Coull BA. Consequences of kriging and land use regression for PM2.5 predictions in epidemiologic analyses:insights into spatial variability using high-resolution satellite data. Journal of Exposure Science and Environmental Epidemiology 2015;25(2):138-144. R834798 (2014)
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  • Journal Article Anderson GB, Bell ML. Lights out: impact of the August 2003 power outage on mortality in New York, NY. Epidemiology 2012;23(2):189-193. R834798 (2013)
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  • Journal Article Anderson GB, Krall JR, Peng RD, Bell ML. Is the relationship between ozone and mortality confounded by chemical components of particulate matter? Analysis of 7 components in 57 US communities. American Journal of Epidemiology 2012;176(8):726-732. R834798 (2013)
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  • Journal Article Anderson GB, Dominici F, Wang Y, McCormack MC, Bell ML, Peng RD. Heat-related emergency hospitalizations for respiratory diseases in the Medicare population. American Journal of Respiratory & Critical Care Medicine 2013;187(10):1098-1103. R834798 (2013)
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  • Journal Article Anderson GB, Bell ML, Peng RD. Methods to calculate the heat index as an exposure metric in environmental health research. Environmental Health Perspectives 2013;121(10):1111-1119. R834798 (2013)
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  • Journal Article Antonelli J, Cefalu M, Bornn L. The positive effects of population-based preferential sampling in environmental epidemiology. Biostatistics 2016;17(4):764-778. R834798 (Final)
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  • Journal Article Austin E, Coull B, Thomas D, Koutrakis P. A framework for identifying distinct multipollutant profiles in air pollution data. Environment International 2012;45:112-121. R834798 (2013)
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  • Journal Article Austin E, Coull BA, Zanobetti A, Koutrakis P. A framework to spatially cluster air pollution monitoring sites in US based on the PM2.5 composition. Environment International 2013;59:244-254. R834798 (2013)
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  • Journal Article Austin E, Zanobetti A, Coull B, Schwartz J, Gold D, Koutrakis P. Ozone trends and their relationship to characteristic weather patterns. Journal of Exposure Science and Environmental Epidemiology 2015;25(5):532-542. R834798 (Final)
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  • Journal Article Baccarelli A, Barretta F, Dou C, Zhang X, McCracken JP, Diaz A, Bertazzi PA, Schwartz J, Wang S, Hou L. Effects of particulate air pollution on blood pressure in a highly exposed population in Beijing, China: a repeated-measure study. Environmental Health 2011;10:108. R834798 (2013)
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  • Journal Article Baja ES, Schwartz JD, Coull BA, Wellenius GA, Vokonas PS, Suh HH. Structural equation modeling of the inflammatory response to traffic air pollution. Journal of Exposure Science and Environmental Epidemiology 2013;23(3):268-274. R834798 (2013)
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  • Journal Article Barr CD, Diez DM, Wang Y, Dominici F, Samet JM. Comprehensive smoking bans and acute myocardial infarction among Medicare enrollees in 387 US counties:1999–2008. American Journal of Epidemiology 2012;176(7):642-648. R834798 (2013)
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  • Journal Article Behbod B, Urch B, Speck M, Scott JA, Liu L, Poon R, Coull B, Schwartz J, Koutrakis P, Silverman F, Gold DR. Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures. Occupational and Environmental Medicine 2013;70(11):761-767. R834798 (2013)
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  • Journal Article Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012;117:83-89. R834798 (2013)
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  • Journal Article Bell ML, Ebisu K. Environmental inequality in exposures to airborne particulate matter components in the United States. Environmental Health Perspectives 2012;120(12):1699-1704. R834798 (2013)
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  • Journal Article Bell ML, Zanobetti A, Dominici F. Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter:a systematic review and meta-analysis. American Journal of Epidemiology 2013;178(6):865-876. R834798 (2013)
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  • Journal Article Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. Associations of PM2.5 constituents and sources with hospital admissions:analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age. Environmental Health Perspectives 2014;122(2):138-144. R834798 (2013)
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  • Journal Article Bell ML, Zanobetti A, Dominici F. Who is more affected by ozone pollution? A systematic review and meta-analysis. American Journal of Epidemiology 2014;180(1):15-28. R834798 (Final)
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  • Journal Article Bell ML, Son JY, Peng RD, Wang Y, Dominici F. Ambient PM2.5 and risk of hospital admissions:do risks differ for men and women? Epidemiology 2015;26(4):575-579. R834798 (Final)
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  • Journal Article Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure:findings from controlled human exposure experiments. Journal of the American Heart Association 2013;2(3):e000212 (11 pp.). R834798 (2013)
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  • Journal Article Bind M-A, Zanobetti A, Gasparrini A, Peters A, Coull B, Baccarelli A, Tarantini L, Koutrakis P, Vokonas P, Schwartz J. Effects of temperature and relative humidity on DNA methylation. Epidemiology 2014;25(4):561-569. R834798 (2014)
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  • Journal Article Bind M-A, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. Air pollution and markers of coagulation, inflammation, and endothelial function:associations and epigene-environment interactions in an elderly cohort. Epidemiology 2012;23(2):332-340. R834798 (2012)
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  • Journal Article Bind M-A, Coull B, Suh H, Wright R, Baccarelli A, Vokonas P, Schwartz J. A novel genetic score approach using instruments to investigate interactions between pathways and environment: application to air pollution. PLoS One 2014;9(4):e96000 (8 pp.). R834798 (2014)
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  • Journal Article Bind M-A, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A, Coull BA, Tarantini L, Vokonas PS, Koutrakis P, Schwartz J. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics 2014;9(3):448-458. R834798 (2014)
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  • Journal Article Bind M-AC, Coull BA, Peters A, Baccarelli AA, Tarantini L, Cantone L, Vokonas PS, Koutrakis P, Schwartz JD. Beyond the mean: quantile regression to explore the association of air pollution with gene-specific methylation in the Normative Aging Study. Environmental Health Perspectives 2015;123(8):759-765. R834798 (2015)
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  • Journal Article Bobb JF, Dominici F, Peng RD. Reduced hierarchical models with application to estimating health effects of simultaneous exposure to multiple pollutants. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2013;62(3):451-472. R834798 (2012)
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  • Journal Article Bobb JF, Peng RD, Bell ML, Dominici F. Heat-related mortality and adaptation to heat in the United States. Environmental Health Perspectives 2014;122(8):811-816. R834798 (2014)
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  • Journal Article Bottino CJ, Rifas-Shiman SL, Kleinman KP, Oken E, Redline S, Gold D, Schwartz J, Melly SJ, Koutrakis P, Gillman MW, Taveras EM. The association of urbanicity with infant sleep duration. Health & Place 2012;18(5):1000-1005. R834798 (2013)
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  • Journal Article Bravo MA, Fuentes M, Zhang Y, Burr MJ, Bell ML. Comparison of exposure estimation methods for air pollutants:ambient monitoring data and regional air quality simulation. Environmental Research 2012;116:1-10. R834798 (2013)
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  • Journal Article Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. R834798 (2013)
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  • Journal Article Carll AP, Crespo SM, Mauricio Filho S, Zati DH, Coull BA, Diaz EA, Raimundo RD, Jaeger TN, Ricci-Vitor AL, Papapostolou V, Lawrence JE, Garner DM, Perry BS, Harkema JR, Godleski JJ. Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Particle and Fibre Toxicology 2017;14(1):16. R834798 (2016)
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  • Journal Article Carreras H, Zanobetti A, Koutrakis P. Effect of daily temperature range on respiratory health in Argentina and its modification by impaired socio-economic conditions and PM10 exposures. Environmental Pollution 2015;206:175-182. R834798 (2015)
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  • Journal Article Cefalu M, Dominici F. Does exposure prediction bias health-effect estimation?: The relationship between confounding adjustment and exposure prediction. Epidemiology 2014;25(4):583-590. R834798 (Final)
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  • Journal Article Chiu Y-HM, Coull BA, Sternthal MJ, Kloog I, Schwartz J, Cohen S, Wright RJ. Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population.Journal of Allergy and Clinical Immunology 2014;133(3):713-722.e4. R834798 (Final)
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  • Journal Article Chudnovsky AA, Lee HJ, Kostinski A, Kotlov T, Koutrakis P. Prediction of daily fine particulate matter concentrations using aerosol optical depth retrievals from the Geostationary Operational Environmental Satellite (GOES). Journal of the Air & Waste Management Association 2012;62(9):1022-1031. R834798 (2013)
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  • Journal Article Chudnovsky AA, Tang C, Lyapustin A, Wang Y, Schwartz J, Koutrakis P. A critical assessment of high-resolution aerosol optical depth retrievals for fine particulate matter predictions. Atmospheric Chemistry and Physics 2013;13(21):10907-10917. R834798 (2013)
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  • Journal Article Chudnovsky AA, Koutrakis P, Kloog I, Melly S, Nordio F, Lyapustin A, Wang Y, Schwartz J. Fine particulate matter predictions using high resolution Aerosol Optical Depth (AOD) retrievals. Atmospheric Environment 2014;89:189-198. R834798 (2014)
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  • Journal Article Chudnovsky AA, Lyapustin A, Wang Y, Tang C, Schwartz J, Koutrakis P. High resolution aerosol data from MODIS satellite for urban air quality studies. Central European Journal of Geosciences 2014:6(1):17-26. R834798 (2014)
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  • Journal Article Chudnovsky AA, Koutrakis P, Kostinski A, Proctor SP, Garshick E. Spatial and temporal variability in desert dust and anthropogenic pollution in Iraq, 1997–2010.Journal of the Air & Waste Management Association 2017;67(1):17-26. R834798 (Final)
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  • Journal Article Chudnovsky AA, Kostinski A, Lyapustin A, Koutrakis P. Spatial scales of pollution from variable resolution satellite imaging. Environmental Pollution 2013;172:131-138. R834798 (2013)
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  • Journal Article Chung M, Wang DD, Rizzo AM, Gachette D, Delnord M, Parambi R, Kang C-M, Brugge D. Association of PNC, BC, and PM2.5 measured at a central monitoring site with blood pressure in a predominantly near highway population. International Journal of Environmental Research and Public Health 2015;12(3):2765-2780. R834798 (2015)
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  • Journal Article Chung Y, Dominici F, Wang Y, Coull BA, Bell ML. Associations between long-term exposure to chemical constituents of fine particulate matter (PM2.5) and mortality in Medicare enrollees in the eastern United States. Environmental Health Perspectives 2015;123(5):467-474. R834798 (2014)
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  • Journal Article Colicino E, Power MC, Cox DG, Weisskopf MG, Hou L, Alexeeff SE, Sanchez-Guerra M, Vokonas P, Spiro III A, Schwartz J, Baccarelli AA. Mitochondrial haplogroups modify the effect of black carbon on age‐related cognitive impairment. Environmental Health 2014;13(1):42. R834798 (Final)
    R834798C002 (2014)
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  • Journal Article Colicino E, Giuliano G, Power MC, Lepeule J, Wilker EH, Vokonas P, Brennan KJ, Fossati S, Hoxha M, Spiro III A, Weisskopf MG Schwartz J, Baccarelli AA. Long-term exposure to black carbon, cognition and single nucleotide polymorphisms in microRNA processing genes in older men. Environment International 2016;88:86-93. R834798 (Final)
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  • Journal Article Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro III A, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environmental Health Perspectives 2017;125(1):76. R834798 (Final)
    R835872 (2016)
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  • Journal Article Correia AW, Pope III CA, Dockery DW, Wang Y, Ezzati M, Dominici F. Effect of air pollution control on life expectancy in the United States:an analysis of 545 U.S. counties for the period 2000 to 2007. Epidemiology 2013;24(1):23-31. R834798 (2012)
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  • Journal Article Dai L, Zanobetti A, Koutrakis P, Schwartz JD. Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis. Environmental Health Perspectives 2014;122(8):837-842. R834798 (2014)
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  • Journal Article Dai L, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. Use of the adaptive LASSO method to identify PM2.5 components associated with blood pressure in elderly men: the Veterans Affairs Normative Aging Study. Environmental Health Perspectives 2016;124(1):120-125. R834798 (2015)
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  • Journal Article Dai L, Bind MA, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction: analysis on particulate species and sources. Journal of Exposure Science and Environmental Epidemiology 2016;26(4):415-421. R834798 (Final)
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  • Journal Article Dai L, Kloog I, Coull BA, Sparrow D, Spiro III A, Vokonas PS, Schwartz JD. Cognitive function and short-term exposure to residential air temperature:A repeated measures study based on spatiotemporal estimates of temperature. Environmental Research 2016;150:446-451. R834798 (Final)
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  • Journal Article Diaz EA, Lemos M, Coull B, Long MS, Rohr AC, Ruiz P, Gupta T, Kang C-M, Godleski JJ. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)--power plant studies: assessment of breathing pattern. Inhalation Toxicology 2011;23(Suppl 2):42-59. R834798 (2013)
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  • Journal Article Diaz EA, Chung Y, Papapostolou V, Lawrence J, Long MS, Hatakeyama V, Gomes B, Calil Y, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses – pilot single vehicle study. Inhalation Toxicology 2012;24(5):288-295. R834798 (2012)
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  • Journal Article Diaz EA, Chung Y, Lamoureux DP, Papapostolou V, Lawrence J, Long MS, Mazzaro V, Buonfiglio H, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses, and oxidative stress. Air Quality, Atmosphere & Health 2013;6(2):431-444. R834798 (2012)
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  • Journal Article Diez DM, Dominici F, Zarubiak D, Levi JI. Statistical approaches for identifying air pollutant mixtures associated with aircraft departures at Los Angeles International Airport. Environmental Science & Technology 2012;46(15):8229-8235. R834798 (2013)
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  • Journal Article Dominici F, Mittleman MA. China’s air quality dilemma: reconciling economic growth with environmental protection. Journal of the American Medical Association 2012;307(19):2100-2102 (editorial). R834798 (2012)
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  • Journal Article Dominici F, Greenstone M, Sunstein CR. Particulate matter matters. Science 2014;344(6181):257-259. R834798 (Final)
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  • Journal Article Dominici F, Wang Y, Correia AW, Ezzati M, Pope IIII CA, Dockery DW. Chemical composition of fine particulate matter and life expectancy: in 95 US counties between 2002 and 2007. Epidemiology 2015;26(4):556-564. R834798 (Final)
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  • Journal Article Dorans KS, Wilker EH, Li W, Rice MB, Ljungman PL, Schwartz J, Coull BA, Kloog I, Koutrakis P, D’Agostino RB, Massaro JM, Hoffmann U, O'Donnell J, Mittleman MA. Residential proximity to major roads, exposure to fine particulate matter, and coronary artery calcium:the Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology 2016:36(8):1679-1685. R834798 (Final)
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  • Journal Article Dorans KS, Wilker EH, Li W, Rice MB, Ljungman PL, Schwartz J, Coull BA, Kloog I, Koutrakis P, D’Agostino RB, Massaro JM, Hoffmann U, O'Donnell J, Mittleman MA. Residential proximity to major roads, exposure to fine particulate matter and aortic calcium: the Framingham Heart Study, a cohort study. BMJ Open. 2017;7(3):e013455. R834798 (Final)
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  • Journal Article Ebisu K, Bell ML. Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States. Environmental Health Perspectives 2012;120(12):1746-1752. R834798 (2013)
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  • Journal Article Fang SC, Mehta AJ, Alexeeff SE, Gryparis A, Coull B, Vokonas P, Christiani DC, Schwartz J. Residential black carbon exposure and circulating markers of systemic inflammation in elderly males:the normative aging study. Environmental Health Perspectives 2012;120(5):674-680. R834798 (2013)
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  • Journal Article Fang SC, Schwartz J, Yang M, Yaggi HK, Bliwise DL, Araujo AB. Traffic‐related air pollution and sleep in the Boston Area Community Health Survey. Journal of Exposure Science & Environmental Epidemiology 2015;25(5):451-456. R834798 (Final)
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  • Journal Article Fleisch AF, Gold DR, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, Coull BA, Zanobetti A, Gillman MW, Oken E. Air pollution exposure and abnormal glucose tolerance during pregnancy:the Project Viva cohort. Environmental Health Perspectives 2014:122(4):378-383. R834798 (2014)
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  • Journal Article Fleisch AF, Luttmann‐Gibson H, Perng W, Rifas‐Shiman SL, Coull BA, Kloog I, Koutrakis P, Schwartz JD, Zanobetti A, Mantzoros CS, Gillman MW, Gold DR, Oken E. Prenatal and early life exposure to traffic pollution and cardiometabolic health in childhood. Pediatric Obesity 2017;12(1):48-57. R834798 (Final)
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  • Journal Article Fossati S, Baccarelli A, Zanobetti A, Hoxha M, Vokonas PS, Wright RO, Schwartz J. Ambient particulate air pollution and MicroRNAs in elderly men. Epidemiology 2014;25(1):68-78. R834798 (2014)
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  • Journal Article Fuller CH, Brugge D, Williams PL, Mittleman MA, Durant JL, Spengler JD. Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors. Atmospheric Environment 2012;57:257-265. R834798 (2013)
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  • Journal Article Godleski JJ, Diaz EA, Lemos M, Long M, Ruiz P, Gupta T, Kang C-M, Coull B. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)-power plant studies: assessment of cellular responses. Inhalation Toxicology 2011;23(Suppl 2):60-74. R834798 (2013)
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  • Journal Article Godleski JJ, Rohr AC, Kang CM, Diaz EA, Ruiz PA, Koutrakis P. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA):introduction and overview. Inhalation Toxicology 2011;23(Suppl 2):1-10. R834798 (2013)
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  • Journal Article Godleski JJ, Rohr AC, Coull BA, Kang CM, Diaz EA, Koutrakis P. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA): summary and conclusions. Inhalation Toxicology 2011;23(Suppl 2):95-103. R834798 (2013)
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  • Journal Article Gold DR, Mittleman MA. New insights into pollution and the cardiovascular system: 2010 to 2012. Circulation 2013;127(18):1903-1913. R834798 (2013)
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  • Journal Article Greven S, Dominici F, Zeger S. An approach to the estimation of chronic air pollution effects using spatio-temporal information. Journal of the American Statistical Association 2011;106(494):396-406. R834798 (2013)
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  • Journal Article Habre R, Coull B, Koutrakis P. Impact of source collinearity in simulated PM2.5 data on the PMF receptor model solution. Atmospheric Environment 2011;45(38):6938-6946. R834798 (2013)
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  • Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. Prenatal and childhood traffic-related pollution exposure and childhood cognition in the Project Viva Cohort (Massachusetts, USA). Environmental Health Perspectives 2015;123(10):1072-1078. R834798 (2015)
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  • Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, Belfort MB, Webster TF, White RF, Sagiv SK, Oken E. Prenatal and childhood traffic-related air pollution exposure and childhood executive function and behavior. Neurotoxicology and Teratology 2016;57(Sep-Oct):60-70. R834798 (Final)
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  • Journal Article Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. R834798 (2012)
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  • Journal Article Hou L, Wang S, Dou C, Zhang X, Yu Y, Zheng Y, Avula U, Hoxha M, Díaz A, McCracken J, Barretta F, Marinelli B, Bertazzi PA, Schwartz J, Baccarelli AA. Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study. Environment International 2012;48:71-77. R834798 (2013)
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  • Journal Article Hou L, Zhang X, Dioni L, Barretta F, Dou C, Zheng Y, Hoxha M, Bertazzi PA, Schwartz J, Wu S, Wang S, Baccarelli AA. Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study. Particle and Fibre Toxicology 2013;10:17. R834798 (2013)
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  • Journal Article Hou L, Zhang X, Zheng Y, Wang S, Dou C, Guo L, Byun H-M, Motta V, McCracken J, Díaz A, Kang C-M, Koutrakis P, Bertazzi PA, Li J, Schwartz J, Baccarelli AA. Altered methylation in tandem repeat element and elemental component levels in inhalable air particles. Environmental and Molecular Mutagenesis 2014;55(3):256-265. R834798 (2014)
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  • Journal Article Hsu H-HL, Chiu Y-HM, Coull BA, Kloog I, Schwartz J, Lee A, Wright RO, Wright RJ. Prenatal particulate air pollution and asthma onset in urban children. Identifying sensitive windows and sex differences. American Journal of Respiratory and Critical Care Medicine 2015;192(9):1052-1059. R834798 (2015)
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  • Journal Article Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, Vonk JM, Williams PV, Shapiro GG, McKone EF, Hallstrand TS, Koenig JQ, Schildcrout JS, Lumley T, Fuhlbrigge AN, Koutrakis P, Schwartz J, Weiss ST, Gold DR. Ambient air pollution, lung function, and airway responsiveness in asthmatic children. Journal of Allergy and Clinical Immunology 2016;137(2):390-399. R834798 (2015)
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  • Journal Article Jhun I, Oyola P, Moreno F, Castillo MA, Koutrakis P. PM2.5 mass and species trends in Santiago, Chile, 1998 to 2010:the impact of fuel-related interventions and fuel sales. Journal of the Air & Waste Management Association 2013;63(2):161-169. R834798 (2013)
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  • Journal Article Jhun I, Coull BA, Zanobetti A, Koutrakis P. The impact of nitrogen oxides concentration decreases on ozone trends in the USA. Air Quality, Atmosphere & Health 2015;8(3):283-292. R834798 (2014)
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  • Journal Article Kang C-M, Gupta T, Ruiz PA, Wolfson JM, Ferguson ST, Lawrence JE, Rohr AC, Godleski J, Koutrakis P. Aged particles derived from emissions of coal-fired power plants: the TERESA field results. Inhalation Toxicology 2011;23(Suppl 2):11-30. R834798 (2013)
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  • Journal Article Kioumourtzoglou MA, Coull BA, Dominici F, Koutrakis P, Schwartz J, Suh H. The impact of source contribution uncertainty on the effects of source-specific PM2.5 on hospital admissions:a case study in Boston, MA. Journal of Exposure Science and Environmental Epidemiology 2014;24(4):365-371. R834798 (2014)
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  • Journal Article Kioumourtzoglou M-A, Zanobetti A, Schwartz JD, Coull BA, Dominici F, Suh HH. The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities. Environmental Health 2013;12(1):68 (10 pp.). R834798 (2013)
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  • Journal Article Kioumourtzoglou M-A, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F, Zanobetti A. Long-term PM2.5 exposure and neurological hospital admissions in the Northeastern United States. Environmental Health Perspectives 2016;124(1):23-29. R834798 (Final)
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  • Journal Article Kioumourtzoglou M-A, Schwartz J, James P, Dominici F, Zanobetti A. PM2.5 and mortality in 207 US cities: modification by temperature and city characteristics. Epidemiology 2016;27(2):221-227. R834798 (Final)
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  • Journal Article Kioumourtzoglou M-A, Austin E, Koutrakis P, Dominici F, Schwartz J, Zanobetti A. PM2.5 and survival among older adults: effect modification by particulate composition. Epidemiology 2015;26(3):321-327. R834798 (2015)
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  • Journal Article Kioumourtzoglou M-A, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F, Zanobetti A. Long-term PM2.5 exposure and neurological hospital admissions in the northeastern United States. Environmental Health Perspectives 2016:124(1):23-29. R834798 (2015)
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  • Journal Article Kloog I, Koutrakis P, Coull BA, Lee HJ, Schwartz J. Assessing temporally and spatially resolved PM2.5 exposures for epidemiological studies using satellite aerosol optical depth measurements. Atmospheric Environment 2011;45(35):6267-6275. R834798 (2012)
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  • Journal Article Kloog I, Coull BA, Zanobetti A, Koutrakis P, Schwartz JD. Acute and chronic effects of particles on hospital admissions in New-England. PLoS ONE 2012;7(4):e34664. R834798 (2012)
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  • Journal Article Kloog I, Chudnovsky A, Koutrakis P, Schwartz J. Temporal and spatial assessments of minimum air temperature using satellite surface temperature measurements in Massachusetts, USA. Science of The Total Environment 2012;432:85-92. R834798 (2013)
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  • Journal Article Kloog I, Melly SJ, Ridgway WL, Coull BA, Schwartz J. Using new satellite based exposure methods to study the association between pregnancy PM2.5 exposure, premature birth and birth weight in Massachusetts. Environmental Health 2012;11:40 (8 pp.). R834798 (2012)
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  • Journal Article Kloog I, Nordio F, Coull BA, Schwartz J. Incorporating local land use regression and satellite aerosol optical depth in a hybrid model of spatiotemporal PM2.5 exposures in the Mid-Atlantic states. Environmental Science & Technology 2012;46(21):11913-11921. R834798 (2013)
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  • Journal Article Kloog I, Ridgway B, Koutrakis P, Coull BA, Schwartz JD. Long- and short-term exposure to PM2.5 and mortality: using novel exposure models. Epidemiology 2013;24(4):555-561. R834798 (2013)
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  • Journal Article Kloog I, Nordio F, Zanobetti A, Coull BA, Koutrakis P, Schwartz JD. Short term effects of particle exposure on hospital admissions in the Mid-Atlantic states:a population estimate. PLoS ONE 2014;9(2):e88578 (7 pp.). R834798 (2014)
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  • Journal Article Kloog I, Nordio F, Coull BA, Schwartz J. Predicting spatiotemporal mean air temperature using MODIS satellite surface temperature measurements across the Northeastern USA. Remote Sensing of Environment 2014;150:132-139. R834798 (2014)
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  • Journal Article Kloog I, Zanobetti A, Nordio F, Coull BA, Baccarelli AA, Schwartz J. Effects of airborne fine particles (PM2.5) on deep vein thrombosis admissions in the northeastern United States. Journal of Thrombosis and Haemostasis 2015;13(5):768-774. R834798 (2015)
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  • Journal Article Kloog I, Melly SJ, Coull BA, Nordio F, Schwartz JD. Using satellite-based spatiotemporal resolved air temperature exposure to study the association between ambient air temperature and birth outcomes in Massachusetts. Environmental Health Perspectives 2015;123(10):1053-1058. R834798 (2015)
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  • Journal Article Krall JR, Anderson GB, Dominici F, Bell ML, Peng RD. Short-term exposure to particulate matter constituents and mortality in a national study of U.S. urban communities. Environmental Health Perspectives 2013;121(10):1148-1153. R834798 (2013)
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  • Journal Article Lamoureux DP, Diaz EA, Chung Y, Coull BA, Papapostolou V, Lawrence J, Sato R, Godleski JJ. Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. Air Quality, Atmosphere & Health 2013;6(2):407-418. R834798 (2012)
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  • Journal Article Lee HJ, Coull BA, Bell ML, Koutrakis P. Use of satellite-based aerosol optical depth and spatial clustering to predict ambient PM2.5 concentrations. Environmental Research 2012;118:8-15. R834798 (2013)
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  • Journal Article Lee HJ, Kang C-M, Coull BA, Bell ML, Koutrakis P. Assessment of primary and secondary ambient particle trends using satellite aerosol optical depth and ground speciation data in the New England region, United States. Environmental Research 2014;133:103-110. R834798 (2014)
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  • Journal Article Lee HJ, Koutrakis P. Daily ambient NO2 concentration predictions using satellite ozone monitoring instrument NO2 data and land use regression. Environmental Science & Technology 2014;48(4):2305-2311. R834798 (2014)
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  • Journal Article Lee MS, LeBouf RF, Son YS, Koutrakis P, Christiani DC. Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco-and menthol-flavored e-cigarettes. Environmental Health 2017;16(1):42 (10 pp.). R834798 (Final)
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  • Journal Article Lee M, Kloog I, Chudnovsky A, Lyapustin A, Wang Y, Melly S, Coull B, Koutrakis P, Schwartz J. Spatiotemporal prediction of fine particulate matter using high-resolution satellite images in the Southeastern US 2003-2011. Journal of Exposure Science & Environmental Epidemiology 2016;26(4):377-384. R834798 (2015)
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  • Journal Article Lee W-C, Shen L, Catalano PJ, Mickley LJ, Koutrakis P. Effects of future temperature change on PM2.5 infiltration in the Greater Boston area. Atmospheric Environment 2017;50:98-105. R834798 (Final)
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  • Journal Article Lemos M, Diaz EA, Gupta T, Kang C-M, Ruiz P, Coull BA, Godleski JJ, Gonzalez-Flecha B. Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols. Inhalation Toxicology 2011;23(Suppl 2):75-83. R834798 (2013)
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  • Journal Article Lepeule J, Laden F, Dockery D, Schwartz J. Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009. Environmental Health Perspectives 2012;120(7):965-970. R834798 (2012)
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  • Journal Article Lepeule J, Baccarelli A, Tarantini L, Motta V, Cantone L, Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. Gene promoter methylation is associated with lung function in the elderly:the Normative Aging Study. Epigenetics 2012;7(3):261-269. R834798 (2012)
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  • Journal Article Lepeule J, Bind M-AC, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the Normative Aging Study. Environmental Health Perspectives 2014;122(6):566-572. R834798 (2014)
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  • Journal Article Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. R834798 (2012)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential proximity to major roadways, fine particulate matter, and adiposity: the Framingham Heart Study. Obesity 2016;24(12):2593-2599. R834798 (Final)
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  • Journal Article Li W, Wilker EH, Dorans KS, Rice MB, Schwartz J, Coull BA, Koutrakis P, Gold DR, Keaney JF, Lin H, Vasan RS, Benjamin EJ, Mittleman MA. Short‐term exposure to air pollution and biomarkers of oxidative stress: the Framingham Heart Study. Journal of the American Heart Association 2016;5(5):e002742 (9 pp.). R834798 (Final)
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  • Journal Article Li W, Dorans KS, Wilker EH, Rice MB, Long MT, Schwartz J, Coull BA, Koutrakis P, Gold DR, Fox CS, Mittleman MA. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis: the Framingham Heart Study. American Journal of Epidemiology. 2017;186(7):857-865. R834798 (Final)
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  • Journal Article Li Wenyuan, KS Dorans, EH Wilker, MB Rice, I Kloog, JD Schwartz P Koutrakis, BA Coull, DR Gold, JB Meigs, CS Fox, MA Mittleman. Ambient air pollution, adipokines, and glucose homeostasis: the Framingham Heart Study. Environmental International 2018;111:14-22. R834798 (Final)
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  • Journal Article Link MS, Luttmann-Gibson H, Schwartz J, Mittleman MA, Wessler B, Gold DR, Dockery DW, Laden F. Acute exposure to air pollution triggers atrial fibrillation. Journal of the American College of Cardiology 2013;62(9):816-825. R834798 (2013)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Mittleman MA, Hamburg NM. Short-term exposure to air pollution and digital vascular function. American Journal of Epidemiology 2014;180(5):482-489. R834798 (Final)
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  • Journal Article Lue S-H, Wellenius GA, Wilker EH, Mostofsky E, Mittleman MA. Residential proximity to major roadways and renal function. Journal of Epidemiology & Community Health 2013;67(8):629-634. R834798 (2013)
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  • Journal Article MacNaughton P, Eitland E, Kloog I, Schwartz J, Allen J. Impact of particular matter exposure and surrounding “greenness” on chronic absenteeism in Massachusetts public schools. International Journal of Environmental Research and Public Health 2017;14(2):207. R834798 (Final)
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  • Journal Article Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro III A, Vokonas PS, Cantone L, Kubzansky L, Schwartz J. Air pollution and DNA methylation: interaction by psychological factors in the VA Normative Aging Study. American Journal of Epidemiology 2012;176(3):224-232. R834798 (2013)
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  • Journal Article Madrigano J, Kloog I, Goldberg R, Coull BA, Mittleman MA, Schwartz J. Long-term exposure to PM2.5 and incidence of acute myocardial infarction. Environmental Health Perspectives 2013;121(2):192-196. R834798 (2013)
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  • Journal Article Masri S, Garshick E, Hart J, Bouhamra W, Koutrakis P. Use of visual range measurements to predict fine particulate matter exposures in Southwest Asia and Afghanistan. Journal of the Air & Waste Management Association 2017;67(1):75-85. R834798 (Final)
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  • Journal Article Masri S, Garshick E, Coull B, Koutrakis P. A novel calibration approach using satellite and visibility observations to estimate PM2. 5 exposures in Southwest Asia and Afghanistan. Journal of the Air & Waste Management Association 2016;67(1):86-95. R834798 (Final)
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  • Journal Article McDevitt JJ, Koutrakis P, Ferguson ST, Wolfson JM, Fabian MP, Martins M, Pantelic J, Milton DK. Development and performance evaluation of an exhaled-breath bioaerosol collector for influenza virus. Aerosol Science and Technology 2013;47(4):444-451. R834798 (2013)
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  • Journal Article Mehta AJ, Zanobetti A, Koutrakis P, Mittleman MA, Sparrow D, Vokonas P, Schwartz J. Associations between short-term changes in air pollution and correlates of arterial stiffness: the Veterans Affairs Normative Aging Study, 2007-2011. American Journal of Epidemiology 2014;179(2):192-199. R834798 (2014)
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  • Journal Article Mehta AJ, Kubzansky LD, Coull BA, Kloog I, Koutrakis P, Sparrow D, Spiro III A, Vokonas P, Schwartz J. Associations between air pollution and perceived stress: the Veterans Administration Normative Aging Study. Environmental Health 2015;14:10 (10 pp.). R834798 (2015)
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  • Journal Article Mehta AJ, Zanobetti A, Bind MA, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. Long-term exposure to ambient fine particulate matter and renal function in older men: the Veterans Administration Normative Aging Study. Environmental Health Perspectives 2016;124(9):1353-1360. R834798 (Final)
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  • Journal Article Mittleman MA, Mostofsky E. Exchangeability in the case-crossover design. International Journal of Epidemiology 2014;43(5):1645-1655. R834798 (2014)
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  • Journal Article Mordukhovich I, Lepeule J, Coull BA, Sparrow D, Vokonas P, Schwartz J. The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men. Thorax 2015;70(2):133-137. R834798 (2015)
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  • Journal Article Mordukhovich I, Kloog I, Coull B, Koutrakis P, Vokonas P, Schwartz J. Association between particulate air pollution and QT interval duration in an elderly cohort. Epidemiology 2016;27(2):284-290. R834798 (Final)
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  • Journal Article Mostofsky E, Schwartz J, Coull BA, Koutrakis P, Wellenius GA, Suh HH, Gold DR, Mittleman MA. Modeling the association between particle constituents of air pollution and health outcomes. American Journal of Epidemiology 2012;176(4):317-326. R834798 (2013)
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  • Journal Article Mostofsky E, Wilker EH, Schwartz J, Zanobetti A, Gold DR, Wellenius GA, Mittleman MA. Short-term changes in ambient temperature and risk of ischemic stroke. Cerebrovascular Diseases Extra 2014;4(1):9-18. R834798 (2014)
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  • Journal Article Nguyen JL, Laden F, Link MS, Schwartz J, Luttmann-Gibson H, Dockery DW. Weather and triggering of ventricular arrhythmias in patients with implantable cardioverter-defibrillators. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):175-181. R834798 (2015)
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  • Journal Article Nguyen JL, Link MS, Luttmann-Gibson H, Laden F, Schwartz J, Wessler BS, Mittleman MA, Gold DR, Dockery DW. Drier air, lower temperatures, and triggering of paroxysmal atrial fibrillation. Epidemiology 2015;26(3):374-380. R834798 (2015)
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  • Journal Article Nordio F, Kloog I, Coull BA, Chudnovsky A, Grillo P, Bertazzi PA, Baccarelli AA, Schwartz J. Estimating spatio-temporal resolved PM10 aerosol mass concentrations using MODIS satellite data and land use regression over Lombardy, Italy. Atmospheric Environment 2013;74:227-236. R834798 (2013)
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  • Journal Article Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo Jr. CA, Huh SY, Mantzoros C, Parker MG, Gillman MW. Cohort profile: Project Viva. International Journal of Epidemiology 2015;44(1):37-48. R834798 (Final)
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  • Journal Article Panni T, Mehta AJ, Schwartz JD, Baccarelli AA, Just AC, Wolf K, Wahl S, Cyrys J, Kunze S, Strauch K, Waldenberger M. Genome-wide analysis of DNA methylation and fine particulate matter air pollution in three study populations:KORA F3, KORA F4, and the Normative Aging Study. Environmental Health Perspectives 2016;124(7):983-990. R834798 (Final)
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  • Journal Article Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS, Godleski JJ, Koutrakis P. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhalation Toxicology 2011;23(8):495-505. R834798 (2010)
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  • Journal Article Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski JJ, Koutrakis P. Development and characterization of an exposure generation system to investigate the health effects of particles from fresh and aged traffic emissions. Air Quality, Atmosphere & Health 2013;6(2):419-429. R834798 (2012)
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  • Journal Article Patton AP, Collins C, Naumova EN, Zamore W, Brugge D, Durant JL. An hourly regression model for ultrafine particles in a near-highway urban area. Environmental Science & Technology 2014;48(6):3272-3280. R834798 (2014)
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  • Journal Article Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR. Air pollution influences on exhaled nitric oxide among people with type II diabetes. Air Quality, Atmosphere & Health 2016;9(3):265-273. R834798 (Final)
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  • Journal Article Peng C, Bind MA, Colicino E, Kloog I, Byun HM, Cantone L, Trevisi L, Zhong J, Brennan K, Dereix AE, Vokonas PS, Coull BA, Schwartz JD, Baccarelli AA. Particulate air pollution and fasting blood glucose in nondiabetic individuals:associations and epigenetic mediation in the normative aging study, 2000–2011. Environmental Health Perspectives 2016;124(11):1715-1721. R834798 (Final)
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  • Journal Article Pereira G, Bell ML, Lee HJ, Koutrakis P, Belanger K. Sources of fine particulate matter and risk of preterm birth in Connecticut, 2000–2006: a longitudinal study. Environmental Health Perspectives 2014;122(10):1117-1122. R834798 (2015)
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  • Journal Article Peters JL, Kubzansky LD, Ikeda A, Spiro III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. American Journal of Epidemiology 2011;174(12):1345-1353. R834798 (2010)
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  • Journal Article Phipatanakul W, Koutrakis P, Coull BA, Kang CM, Wolfson JM, Ferguson ST, Petty CR, Samnaliev M, Cunningham A, Sheehan WJ, Gaffin JM, Baxi SN, Lai PS, Permaul P, Liang L, Thorne PS, Adamkiewicz G, Brennan KJ, Baccarelli AA, Gold DR. The school inner-city asthma intervention study:design, rationale, methods, and lessons learned. Contemporary Clinical Trials 2017;60:14-23. R834798 (Final)
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  • Journal Article Power, MC, Weisskopf MG, Alexeef SE, Coull BA, Spiro III A , Schwartz J. Traffic-related air pollution and cognitive function in a cohort of older men. Environmental Health Perspectives 2011;119(5):682-687. R834798 (2010)
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  • Journal Article Power MC, Weisskopf MG, Alexeeff SE, Wright RO, Coull BA, Spiro A, Schwartz J. Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men:a cohort study. Environmental Health 2013;12:16 (8 pp.). R834798 (2014)
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  • Journal Article Requia WJ, Roig HL, Koutrakis P, Rossi MS. Mapping alternatives for public policy decision making related to human exposures from air pollution sources in the Federal District, Brazil. Land Use Policy 2016;59:375-385. R834798 (Final)
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  • Journal Article Requia WJ, Koutrakis P, Roig H, Adams MD. Spatiotemporal analysis of traffic emissions in over 5000 municipal districts in Brazil. Journal of the Air & Waste Management Association 2016;66(12):1284-1293. R834798 (Final)
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  • Journal Article Requia WJ, Roig HL, Adams MD, Zanobetti A, Koutrakis P. Mapping distance-decay of cardiorespiratory disease risk related to neighborhood environments. Environmental Research 2016;151:203-215. R834798 (Final)
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  • Journal Article Requia WJ, Koutrakis P, Roig HL, Adams MD, Santos CM. Association between vehicular emissions and cardiorespiratory disease risk in Brazil and its variation by spatial clustering of socio-economic factors. Environmental Research 2016;150:452-460. R834798 (Final)
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  • Journal Article Requia WJ, Adams MD, Koutrakis P. Association of PM2. 5 with diabetes, asthma, and high blood pressure incidence in Canada: a spatiotemporal analysis of the impacts of the energy generation and fuel sales. Science of the Total Environment 2017;584-585:1077-1083. R834798 (Final)
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  • Journal Article Requia WJ, Roig HL, Koutrakis P, Adams MD. Modeling spatial patterns of traffic emissions across 5570 municipal districts in Brazil. Journal of Cleaner Production 2017;148:845-853. R834798 (Final)
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  • Journal Article Requia WJ, Dalumpines R, Adams MD, Arain A, Ferguson M, Koutrakis P. Modeling spatial patterns of link-based PM2. 5 emissions and subsequent human exposure in a large Canadian metropolitan area. Atmospheric Environment 2017;158:172-180. R834798 (Final)
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  • Journal Article Requia WJ, Adams MD, Arain A, Koutrakis P, Ferguson M. Carbon dioxide emissions of plug-in hybrid electric vehicles:a life-cycle analysis in eight Canadian cities. Renewable and Sustainable Energy Reviews 2017;78:1390-1396. R834798 (Final)
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  • Journal Article Requia WJ, Higgins CD, Adams MD, Mohamed M, Koutrakis P. The health impacts of weekday traffic: a health risk assessment of PM2.5 emissions during congested periods. Environment International 2018;111:164-176. R834798 (Final)
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  • Journal Article Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR, O'Connor GT, Mittleman MA. Short-term exposure to air pollution and lung function in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 2013;188(11):1351-1357. R834798 (Final)
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  • Journal Article Rice MB, Thurston GD, Balmes JR, Pinkerton KE. Climate change. A global threat to cardiopulmonary health. American Journal of Respiratory and Critical Care Medicine 2014;189(5):512-519. R834798 (Final)
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  • Journal Article Rice MB, Rifas-Shiman SL, Oken E, Gillman MW, Ljungman PL, Litonjua AA, Schwartz J, Coull BA, Zanobetti A, Koutrakis P, Melly SJ, Mittleman MA, Gold DR. Exposure to traffic and early life respiratory infection: a cohort study. Pediatric Pulmonology 2015;50(3):252-259. R834798 (2014)
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  • Journal Article Rice MB, Rifas-Shiman SL, Litonjua AA, Oken E, Gillman MW, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull B, Schwartz J, Koutrakis P, Mittleman MA, Gold DR. Lifetime exposure to ambient pollution and lung function in children. American Journal of Respiratory and Critical Care Medicine 2016;193(8):861-888. R834798 (2015)
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  • Journal Article Rodosthenous RS, Coull BA, Lu Q, Vokonas PS, Schwartz JD, Baccarelli AA. Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals. Particle and Fibre Toxicology 2016;13:13 (13 pp.). R834798 (2016)
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  • Journal Article Rosenbloom JI, Wilker EH, Mukamal KJ, Schwartz J, Mittleman MA. Residential proximity to major roadway and 10-year all-cause mortality after myocardial infarction. Circulation 2012;125(18):2197-2203. R834798 (2012)
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  • Journal Article Schwartz J, Alexeeff SE, Mordukhovich I, Gryparis A, Vokonas P, Suh H, Coull BA. Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study. Occupational and Environmental Medicine 2012;69(6):422-427. R834798 (2012)
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  • Journal Article Schwartz J, Austin E, Bind M-A, Zanobetti A, Koutrakis P. Estimating causal associations of fine particles with daily deaths in Boston. American Journal of Epidemiology 2015;182(7):644-650. R834798 (2015)
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  • Journal Article Schwartz J, M-A., Koutrakis P. Estimating causal effects of local air pollution on daily deaths: effect of low levels. Environmental Health Perspectives 2017;125(1):23-29. R834798 (2016)
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  • Journal Article Shi L, Kloog I, Zanobetti A, Liu P, Schwartz JD. Impacts of temperature and its variability on mortality in New England. Nature Climate Change 2015;5:988-991. R834798 (2015)
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  • Journal Article Shi L, Zanobetti A, Kloog I, Coull BA, Koutrakis P, Melly SJ, Schwartz JD. Low-concentration PM2.5 and mortality: estimating acute and chronic effects in a population-based study. Environmental Health Perspectives 2016;124(1):46-52. R834798 (2015)
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  • Journal Article Shi L, Liu P, Wang Y, Zanobetti A, Kosheleva A, Koutrakis P, Schwartz J. Chronic effects of temperature on mortality in the Southeastern USA using satellite-based exposure metrics. Scientific Reports 2016;6:30161 (8 pp.). R834798 (Final)
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  • Journal Article Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E, Floras J, Nanthakumar K. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. Journal of the American College of Cardiology 2011;57(2):198-206. R834798 (2012)
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  • Journal Article Sofer T, Maity A, Coull B, Baccarelli A, Schwartz J, Lin X. Multivariate gene selection and testing in studying the exposure effects on a gene set. Statistics in Bioscience 2012;4(2):319-338. R834798 (2013)
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  • Journal Article Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz J. Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway. Epigenomics 2013;5(2):147-154. R834798 (2013)
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  • Journal Article Son J-Y, Lee J-T, Park YH, Bell ML. Short-term effects of air pollution on hospital admissions in Korea. Epidemiology 2013;24(4):545-554. R834798 (2013)
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  • Journal Article Son J-Y, Lee J-T, Kim K-H, Jung K, Bell ML. Characterization of fine particulate matter and associations between particulate chemical constituents and mortality in Seoul, Korea. Environmental Health Perspectives 2012;120(6):872-878. R834798 (2013)
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  • Journal Article Tang CH, Coull BA, Schwartz J, Lyapustin A, Di Q, Koutrakis P. Developing particle emission inventories using remote sensing (PEIRS). Journal of the Air & Waste Management Association 2017;67(1):53-63. R834798 (Final)
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  • Journal Article van Rossem L, Rifas-Shiman SL, Melly SJ, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz JD, Mittleman MA, Oken E, Gillman MW, Koutrakis P, Gold DR. Prenatal air pollution exposure and newborn blood pressure. Environmental Health Perspectives 2015;123(4):353-359. R834798 (2015)
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  • Journal Article Wang C, Parmigiani G, Dominici F. Bayesian effect estimation accounting for adjustment uncertainty. Biometrics 2012;68(3):661-671. R834798 (2012)
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  • Journal Article Wang Y, Eliot MN, Koutrakis P, Gryparis A, Schwartz JD, Coull BA, Mittleman MA, Milberg WP, Lipsitz LA, Wellenius GA. Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston Study. Environmental Health Perspectives 2014;122(6):553-558. R834798 (Final)
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  • Journal Article Wang Y, Eliot MN, Kuchel GA, Schwartz J, Coull BA, Mittleman MA, Lipsitz LA, Wellenius GA. Long-term exposure to ambient air pollution and serum leptin in older adults: results from the MOBILIZE Boston Study. Journal of Occupational and Environmental Medicine 2014;56(9):e73-e77. R834798 (Final)
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  • Journal Article Wellenius GA, Wilhelm-Benartzi CS, Wilker EH, Coull BA, Suh HH, Koutrakis P, Lipsitz LA. Ambient particulate matter and the response to orthostatic challenge in the elderly: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study. Hypertension 2012;59(3):558-563. R834798 (2013)
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  • Journal Article Wellenius GA, Boyle LD, Coull BA, Milberg WP, Gryparis A, Schwartz J, Mittleman MA, Lipsitz LA. Residential proximity to nearest major roadway and cognitive function in community-dwelling seniors: results from the MOBILIZE Boston Study. Journal of the American Geriatric Society 2012;60(11):2075-2080. R834798 (2012)
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  • Journal Article Wellenius GA, Boyle LD, Wilker EH, Sorond FA, Coull BA, Koutrakis P, Mittleman MA, Lipsitz LA. Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke 2013;44(6):1532-1536. R834798 (2013)
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  • Journal Article Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. Exposure to particulate air pollution and cognitive decline in older women. Archives of Internal Medicine 2012;172(3):219-227. R834798 (2013)
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  • Journal Article Wilker EH, Yeh G, Wellenius GA, Davis RB, Phillips RS, Mittleman MA. Ambient temperature and biomarkers of heart failure: a repeated measures analysis. Environmental Health Perspectives 2012;120(8):1083-1087. R834798 (2012)
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  • Journal Article Wilker EH, Mittleman MA, Coull BA, Gryparis A, Bots ML, Schwartz J, Sparrow D. Long-term exposure to black carbon and carotid intima-media thickness: the Normative Aging Study. Environmental Health Perspectives 2013;121(9):1061-1067. R834798 (2013)
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  • Journal Article Wilker EH, Wu C-D, McNeely E, Mostofsky E, Spengler J, Wellenius GA, Mittleman MA. Green space and mortality following ischemic stroke. Environmental Research 2014;133:42-48. R834798 (2014)
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  • Journal Article Wilker EH, Ljungman PL, Rice MB, Kloog I, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Hamburg NM, Mittleman MA. Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia. American Journal of Cardiology 2014;113(12):2057-2063. R834798 (2014)
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  • Journal Article Wilker EH, Preis SR, Beiser AS, Wolf PA, Au R, Kloog I, Li W, Schwartz J, Koutrakis P, DeCarli C, Seshadri S, Mittleman MA. Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke 2015;46(5):1161-1166. R834798 (2015)
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  • Journal Article Wilker EH, Martinez-Ramirez S, Kloog I, Schwartz J, Mostofsky E, Koutrakis P, Mittleman MA, Viswanathan A. Fine particulate matter, residential proximity to major roads, and markers of small vessel disease in a memory study population. Journal of Alzheimer's Disease 2016;53(4):1315-1323. R834798 (Final)
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  • Journal Article Yeh RW, Normand S-LT, Wang Y, Barr CD, Dominici F. Geographic disparities in the incidence and outcomes of hospitalized myocardial infarction:does a rising tide lift all boats? Circulation: Cardiovascular Quality and Outcomes 2012;5(2):197-204. R834798 (2012)
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  • Journal Article Zanobetti A, Schwartz J. Ozone and survival in four cohorts with potentially predisposing diseases. American Journal of Respiratory and Critical Care Medicine 2011;184(7):836-841. R834798 (2010)
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  • Journal Article Zanobetti A, O'Neill MS, Gronlund CJ, Schwartz JD. Summer temperature variability and long-term survival among elderly people with chronic disease. Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6608-6613. R834798 (2012)
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  • Journal Article Zanobetti A, Coull BA, Gryparis A, Kloog I, Sparrow D, Vokonas PS, Wright RO, Gold DR, Schwartz J. Associations between arrhythmia episodes and temporally and spatially resolved black carbon and particulate matter in elderly patients. Occupational and Environmental Medicine 2014;71(3):201-207. R834798 (2014)
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  • Journal Article Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environmental Health Perspectives 2014;122(3):242-248. R834798 (2013)
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  • Journal Article Zanobetti A, Peters A. Disentangling interactions between atmospheric pollution and weather. Journal of the Epidemiology and Community Health 2015;69(7):613-615. R834798 (2015)
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  • Journal Article Zanobetti A, Coull B, Kloog I, Sparrow D, Vokonas P, Gold DR, Schwartz J. Fine-scale spatial and temporal variaton in temperature and arrhythmia episodes in the VA Normative Aging Study. Journal of the Air & Waste Management Association 2017;67(1):96-104. R834798 (Final)
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  • Journal Article Zhong J, Trevisi L, Urch B, Lin X, Speck M, Coull BA, Liss G, Thompson A, Wu S, Wilson A, Koutrakis P, Silverman F, Gold DG, Baccarelli A. B-vitamin supplementation mitigates effects of fine particles on cardiac autonomic dysfunction and inflammation: a pilot human intervention trial. Scientific Reports 2017;7:45322 (9 pp.) R834798 (Final)
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  • Journal Article Zigler CM, Dominici F, Wang Y. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 2012;13(2):289-302. R834798 (2012)
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  • Journal Article Zigler CM, Watts K, Yeh RW, Wang Y, Coull BA, Dominici F. Model feedback in Bayesian propensity score estimation. Biometrics 2013;69(1):263-273. R834798 (2013)
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  • Journal Article Zigler CM, Dominici F. Point: clarifying policy evidence with potential-outcomes thinking--beyond exposure-response estimation in air pollution epidemiology. American Journal of Epidemiology 2014;180(12):1133-1140. R834798 (Final)
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  • Journal Article Zigler CM, Dominici F. Uncertainty in propensity score estimation: Bayesian methods for variable selection and model averaged causal effects. Journal of the American Statistical Association 2014;109(505):95-107. R834798 (2014)
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  • Journal Article Colicino E, Giuliano G, Power MC, Lepeule J, Wilker EH, Vokonas P, Brennan KJM, Fossati S, Hoxha M, Spiro A, Weisskopf MG, Schwartz J, Baccarelli AA. Long-term Exposure to Black Carbon, Cognition and Single Nucleotide Polymorphisms in MicroRNA Processing Genes in Older Men. Environment International 2016; 88:86-93. R834798 (2016)
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  • Journal Article Kang C-M, Gold D, Koutrakis P. Downwind O3 and PM2.5 speciation during the wildfires in 2002 and 2010. Atmospheric Environment 2014;95:511-519. R834798 (2014)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, et al. Short-term exposure to air pollution and digital vascular function. Am J Epidemiol. 2014a;180:482-489. R834798C003 (Final)
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  • Journal Article Shi L, Liu P, Kloog I, Lee M, Kosheleva A, Schwartz J. Estimating daily air temperature across the Southeastern United States using high-resolution satellite data: a statistical modeling study. Environmental Research 2016; 146:51-58. R834798 (2016)
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  • Journal Article Bind M-A, Peters A, Koutrakis P, Coull B, Vokonas P, Schwartz J. Quantile regression analysis of the distributional effects of air pollution on blood pressure, heart rate variability, blood lipids, and biomarkers of inflammation in elderly american men:the normative aging study. Environmental Health Perspectives 2016;124(8):1189. R834798 (2016)
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  • Journal Article Fleisch AF, Kloog I, Luttmann-Gibson H, Gold DR, Oken E, Schwartz JD. Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a Cohort Study. Environmental Health 2016;15(1):40 (9 pp.). R834798 (2016)
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  • Journal Article McGuinn LA, Ward-Caviness CK, Neas LM, Schneider A, Diaz-Sanchez D, Cascio WE, Kraus WE, Hauser E, Dowdy E, Haynes C, Chudnovsky A, Koutrakis P, Devlin RB. Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease. Environmental Research 2016;145:9-17. R834798 (2016)
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  • Journal Article Wang Y, Shi L, Zanobetti A, Schwartz JD. Estimating and projecting the effect of cold waves on mortality in 209 US cities. Environment International 2016; 94:141-149. R834798 (2016)
    R834798 (Final)
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  • Journal Article Schwartz, J., Austin, E., Bind, M.A., Zanobetti, A., and Koutrakis, P. (2015). Estimating Causal Associations of Low PM2.5 on Daily Deaths in Boston. American Journal of Epidemiology 182, 644-650. R834798C002 (Final)
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    Journal Article Pereira, G., Bell, M.L., Lee, H.J., Koutrakis, P., and Belanger, K. (2014). Sources of Fine Particulate Matter and Risk of Preterm Birth in Connecticut, 2000–2006:A Longitudinal Study. Environmental Health Perspectives 122, 1117-1122. R834798C005 (Final)
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    Journal Article Peng C, Bind M-A, Colicino E, Kloog I, Byun H-M, Cantione L, Trevisi LZ, J., Brennan K, Dereix AE, Vokonas P, Coull BA, Schwartz J, Baccarelli AA. Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals:Associations and E[pigenetic Mediation in the Normative Aging Study, 2000-2011. Environmental Health Perspectives 2016; http://dx.doi.org/10.1289/EHP183:1-34. R834798 (2016)
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    Journal Article Zhong, J., Cayir, A., Trevis, L., Sanchez-Guerra, M., Peng, L.X., Bind, M.A., Prada, D., Laue, H., Brennan, K.J.D., A., Sparrow, D., Vokonas, P., Schwartz, J., and. R834798C002 (Final)
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    Journal Article Zhong, J., Colicino, E., Lin, X., Mehta, A., Kloog, I., Zanobetti, A., Byun, H.M., Bind, M.A., Cantone, L., Prada, D., Tarantini, L., Trevisi, L., Sparrow, D., Vokonas, P.,. R834798C002 (Final)
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    Journal Article Rodosthenous, S., Coull, B.A., Lu, Q., Vokonas, P.S., Schwartz, J.D., and Baccarelli, A.A. (2016). Ambient Particulate Matter and MicroRNAs in Extracellular Vesicles:a Pilot Study of Older Individuals. Particle and Fibre Toxicology 13, 1-13. R834798C002 (Final)
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    Journal Article Mordukhovich, I., Coull, B.A., Kloog, I., Koutrakis, P., Vokonas, P., and Schwartz, J. (2015). Exposure to Sub-Chronic and Long-t4erm Particulate Air Pollution and Heart Rate Variability in an Elderly Cohort:the Normative Aging Study. Environmental Health 14, 1-10. R834798C002 (Final)
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    Journal Article Wang, Y., Eliot, M.N., Koutrakis, P., Gryparis, A., Schwartz, J.D., Coull, B.A., Mittleman, M.A., Milberg, W.P., Lipsitz, L.A., and Wellenius, G.A. (2014). Ambient Air Pollution and Depressive Symptoms in Older Adults:Results from the MOBILIZE Boston Study. Environmental Health Perspectives 122, 553 – 558. R834798C003 (Final)
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    Journal Article Wang, Y., Eliot, M.N., Kuchel, G.A., Schwartz, J., Coull, B.A., Mittleman, M.A., Lipsitz, L.A., and Wellenius, G.A. (2014). Long-Term Exposure to Ambient Air Pollution and. R834798C003 (Final)
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    Journal Article Wang, Y., H. Montas P.T. Leisnham, K. Brubaker, A. Shirmohammadi, V. Chanse, A. Rockler. 2017. A diagnostic decision support system for BMP selection in a small urban watershed. Water Resources Management 31(5):1649-1664. R834798C005 (Final)
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    Journal Article Wang, Y., Kloog, I., Coull, B., Kosheleva, A., Zanobetti, A., and Schwartz, J. (2016). Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey. Environmental Health Perspectives, 1-38. R834798C002 (Final)
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    Journal Article Shi, L., Kloog, I., Zanobetti, A., Liu, P., and Schwartz, J. (2015). Impacts of Temperature and its Variability on Mortality in New England. Nature Climate Change 5, 1-6. R834798C002 (Final)
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    Journal Article Lee, M., Kloog, I., Chudnovsky, A., Lyapustin, A., Wang, Y., Melly, S., Coull, B., Koutrakis, P., and Schwartz, J. (2015). Spatiotemporal Prediction of Fine Particulate Matter using High-resolution Satellite Images in the Southeastern US 2003-2011. J Expos Sci Environ Epidemiol, 1-8. R834798C002 (Final)
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    Journal Article Wang, Y., Kloog, I., Coull, B., Kosheleva, A., Zanobetti, A., and Schwartz, J. (2016). Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey. Environmental Health Perspectives, 1-38. R834798C005 (Final)
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    Journal Article Di, Q., Koutrakis, P., Lyapustin, A., Wang, Y., and Schwartz, J. (2016). Assessing PM2.5 Exposures with High Spatio-Temporal Resolution across the Continental United States. Environmental Science & Technology DOI:10.1021/acs.est.5b06121, 1-35. R834798C002 (Final)
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    Journal Article Dai, L., Koutrakis, P., Coull, B.A., Sparrow, D., Vokonas, P.S., and Schwartz, J. (2015). Use of the Adaptive LASSO method to Identify PM2.5 components Associated with Blood Pressure in Elderly Men:Veterans Affairs Normative Aging Study. Environmental Health Perspectives 121, 120-125. R834798C002 (Final)
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    Journal Article Mehta, A., Kubzansky, L., Coull, B., Kloog, I., Koutrakis, P., Sparrow, D., Spiro, A., Vokonas, P., and Schwartz, J. (2015). Associations Between Air Pollution and Perceived Stress:the Veterans Administration Normative Aging Study. Environmental Health 14, 10. R834798C002 (Final)
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    Journal Article Conti, S., Lafranconi, A., Zanobetti, A., Fornari, C., Madotto, F., Schwartz, J., and Cesana, G. (2015). Cardiorespiratory Treatments as Modifiers of the Relationship between Particulate Matter and Health:A Case-Only Analysis on Hospitalized Patients in Italy. Environmental Research 136, 491-499. R834798C005 (Final)
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    Journal Article Mordukhovich, I., Lepeule, J., Coull, B.A., Sparrow, D., Vokonas, P., and Schwartz, J. (2015). The Effect of Oxidative Stress Polymorphisms on the Association between Long-term Black Carbon Exposure and Lung Function among Elderly Men. Thorax 70, 133-137. R834798C002 (Final)
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    Journal Article Lepeule, J., Litonjua, A.A., Coull, B., Koutrakis, P., Sparrow, D., Vokonas, P.S., and Schwartz, J. (2014). Long-Term Effects of Traffic Particles on Lung Function Decline in the Elderly. American Journal of Respiratory and Critical Care Medicine 190, 542-548. R834798C002 (Final)
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    Journal Article Shi, L., Liu, P., Kloog, I., Lee, M., Kosheleva, A., and Schwartz, J. (2016). Estimating Daily Air Temperature Across the Southeastern United States Using High-Resolution Satellite Data:A Statistical Modeling Study. Environmental Research 146, 51-58. R834798C002 (Final)
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    Journal Article Madrigano, J., Mittleman, M., Baccarelli, A., Goldberg, R., Melly, S.J., Von Klot, S., and Schwartz, J. (2013). Temperature, Myocardial Infarction, and Mortality Effect Modification by Individual-and Area-level Characteristics. Epidemiology 24, 439-446. R834798C002 (Final)
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    Journal Article Waldenberger, M., Peters A. A Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations:KORA F3, KORA F4, and the Normative Aging Study. Environmental Health Perspectives 2016; http://dx.doi.org/10.1289/3hp.1509966:1-32. R834798 (2016)
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    Journal Article Mostofsky, E., Schwartz, J., Coull, B., Koutrakis, P., Wellenius, G.A., Suh, H.H., Gold, D.R., and Mittleman, M.A. (2012). Modeling the Association between Particle Constituents of Air Pollution and Health Outcomes. American Journal of Epidemiology 176, 317 – 326. R834798C002 (Final)
    R834798C003 (Final)
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    Journal Article Wang, Y., Shi, L., Zanobetti, A., and Schwartz, J.D. (2016). Estimating and Projecting the Effect of Cold Waves on Mortality in 209 US Cities. Environment International 94, 141-149. R834798C002 (Final)
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    Journal Article Zhong J, Cayir A, Trevis L, Sanchez-Guerra M, Peng LX, Bind MA, Prada D, Laue H, Brennan KJD, A., Sparrow D, Vokonas P, Schwartz J, Baccarelli AA. Traffic Related Air Pollution, Blood Pressure, and Adaptive Response of Mitochondrial Abundance. Circulation 2015; CIRCULATIONAHA.115.018802. R834798 (2016)
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    Journal Article Mannshardt, E., Sucic, K., Jiao, W., Dominici, F., Frey, C.H., Reich, B., and Fuentes, M. (2013). Comparing Exposure Metrics for the Effects of Fine Particulate Matter on Emergency Hospital Admissions. Journal of Exposure Science and Environmental Epidemiology 23, 627–636. R834798C005 (Final)
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    Journal Article Chung, M., Wang, D.D., Rizzo, A.M., Gachette, D., Delnord, M., Parambi, R., Kang, C.-M., and Brugge, D. (2015). Association of PNC, BC, and PM2.5 Measured at a Central Monitoring Site with Blood Pressure in a Predominantly Near Highway Population. International Journal of Environmental Research and Public Health 12, 2765-2780. R834798C005 (Final)
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    Journal Article Dominici, F., Wang, Y., Correia, A.W., Ezzati, M., Pope, C.A.I., and Dockery, D.W. (2015). Chemical Composition of Fine Particulate Matter and Life Expectancy in 95 US Counties Between 2002 and 2007. Epidemiology 26, 556-564. R834798C005 (Final)
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    Journal Article Di, Q., Wang, Y., Zanobetti, A., Wang, Y., Kourakis, P., Choirat, C., Dominici, F., and Schwartz, J.D. (2017). Air Pollution and Mortality in the Medicare Population. New England Journal of Medicine 376, 2513-2522. R834798C002 (Final)
    R835872 (2016)
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    Journal Article Ierodiakonou, D., Zanobetti, A., Coull, B., Melly, S., Postma, D.S., Boezen, H.M., Vonk, J.M., Williams, P.V., Shapiro, G.G., McKone, E.F., Hallstrand, T.S., Koenig, J.Q., Schildcrout, J.S., Lumley, T., Fuhlbrigge, A.N., Koutrakis, P., Schwartz, J., Weiss, S.T., and Gold, D.R. (2016). Ambient Air Pollution, Lung Function, and Airway Responsiveness in Asthmatic Children. Journal of Allergy and Clinical Immunology 137, 390-399. R834798C005 (Final)
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    Journal Article Kloog, I., Zanobetti, A., Nordio, F., Coull, B., Baccarelli, A., and Schwartz, J. (2015). Effects of Airborne Fine Particles (PM2.5) on Deep Vein Thrombosis Admissions in the Northeastern United States. Journal of Thrombosis and AHaemostasis 13, 768-774. R834798C002 (Final)
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    Journal Article Shi, L., Zanobetti, A., Kloog, I., Coull, B.A., Koutrakis, P., Melly, S.J., and Schwartz, J. (2015). Low-Concentration PM2.5 and Mortality:Estimating Acute and Chronic Effects in a Population-Based Study. Environmental Health Perspectives 124, 46-52. R834798C002 (Final)
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    Journal Article Schwartz, J., and Baccarelli, A.A. (2015). Cardiac Autonomic Dysfunction:Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake. Journal of the American Heart Association 4. R834798C002 (Final)
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    Journal Article Dominici, F., and Mittleman, M. (2012). China's Dilemma:Reconciling Economic Growth with Environmental Protection. Journal of the American Medical Association 307, 2100-2012. R834798C005 (Final)
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    Journal Article Bind, M.-A., Peters, A., Koutrakis, P., Coull, B., Vokonas, P., and Schwartz, J. (2016). Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives http://doi.org/10.1289/ehp.1510044, 1-34. R834798C002 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Schwartz, J., James, P., Dominici, F., and Zanobetti, A. (2016). PM2.5 and Mortality in 207 US Cities:Modification by Temperature and City Characteristics. Epidemiology 27, 221-227. R834798C002 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Austin, E., Koutrakis, P., Dominici, F.S., J. D., and Zanobetti, A. (2015). PM2.5 and Survival Among Older Adults Effect Modification by Particulate Composition. Epidemiology 26, 321-327. R834798C005 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Schwartz, J., Weisskopf, M.G., Melly, S., Wang, Y., Dominici, F., and Zanobetti, A. (2015). Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States. Environmental Health Perspectives 124, 23-29. R834798C005 (Final)
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    Journal Article Bind, M.-A., Peters, A., Koutrakis, P., Coull, B., Vokonas, P., and Schwartz, J. (2016). Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives http://doi.org/10.1289/ehp.1510044, 1-34. R834798C002 (Final)
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    Journal Article Panni T, Mehta AJ, Schwartz JD, Baccarelli AA, Just AC, Wolf Kr, Wahl S, Cyrys J, Kunze sS, K. R834798 (2016)
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    Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Belfort MB, Webster TF,. R834798C004 (Final)
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    Journal Article Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men:the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241; Erratum:http://dx.doi.org/10.1289/EHP1813. R834798C002 (Final)
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    Journal Article Réquia Júnior WJ, Roig HL, Koutrakis P. A novel land use approach for assessment of human health:The relationship between urban structure types and cardiorespiratory disease risk. Environment International 2015; 85:334-342. R834798 (2016)
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    Journal Article Baccarelli, A.A. (2015). Traffic Related Air Pollution, Blood Pressure, and Adaptive Response of Mitochondrial Abundance. Circulation CIRCULATIONAHA.115.018802. R834798C002 (Final)
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    Journal Article Wellenius, G.A., Boyle, L.D., Coull, B.A., Milberg, W.P., Gryparis, A., Schwartz, J., Mittleman, M.A., and Lipsitz, L.A. (2012a). Residential Proximity to Nearest Major Roadway and Cognitive Function in Community-Dwelling Seniors:Results from the MOBILIZE Boston Study. Journal of the American Geriatric Society 60, 2075–2080. R834798C003 (Final)
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    Journal Article Wellenius, G.A., Wilhelm-Benartzi, C.S., Wilker, E.H., Coull, B.A., Suh, H.H., Koutrakis, P., and Lipsitz, L.A. (2012c). Ambient Particulate Matter and the Response to Orthostatic Challenge in the Elderly:The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston Study. Hypertension 59, 558-563. R834798C003 (Final)
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    Journal Article Baccarelli, A.A. (2016). Long-term Exposure to Black Carbon, Cognition and Single Nucleotide Polymorphisms in MicroRNA Processing Genes in Older Men. Environment International 88, 86-93. R834798C002 (Final)
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    Journal Article Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR. Air pollution influences on exhaled nitric oxide among people with type 2 diabetes. Air Quality, Atmosphere and Health. http://link.springer.com/article/10.1007%2Fs11869-015-0336-5Mar 26, 2015. R834798C004 (Final)
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    Journal Article Ljungman PL, Mittleman MA. Ambient air pollution and stroke. Stroke. 2014b;45:3734-3741. R834798C003 (Final)
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    Journal Article Mordukhovich I, Coull BA, Kloog I, Koutrakis P, Vokonas P, Schwartz J. Association between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort. Epidemiol, 2016 Mar;27(2):284-90. doi:10.1097/EDE.0000000000000424. R834798C002 (Final)
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    Journal Article Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. R834798C003 (Final)
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    Journal Article Schwartz, J.B., M-A., and Koutrakis, P. (2016). Estimating Causal Effects of Local Air Pollution on Daily Deaths:Effect of Low Levels. Environmental Health Perspectives http://dx.doi.org/10.1289/EHP232, 1-30. R834798C002 (Final)
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    Journal Article Zhong J, Urch B, Speck M, Coull BA, Koutrakis P, Thorne PS, Scott J, Liu L, Brook Rd, Behbod B, Gibson H, Silverman F, Mittlemanm MA, Baccarelli AA. Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures Hypertension 2015; 66:509-516. R834798 (2016)
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    Journal Article Fleisch, A.F., Kloog, I., Luttmann-Gibson, H., Gold, D.R., Oken, E., and Schwartz, J.D. (2016). Air Pollution Exposure and Gestational Diabetes Mellitus Among Pregnant Women in Massachusetts:a Cohort Study. Environmental Health 15, 1-9. R834798C005 (Final)
    R835437 (2016)
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    Journal Article Dai L, Bind M-A, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction:Analysis on particulate species and sources. J Expos Sci Environ Epidemiol 2016. R834798 (2016)
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    Journal Article Lee, M.H., Koutrakis, P., Coull, B.A., Kloog, I., and Schwartz, J. (2015). Acute Effects of Fine Particulate Matter on Mortality in Three Southeastern States from 2007-2011. Journal of Exposure Science and Environmental Epidemiology, 1-7. R834798C002 (Final)
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    Journal Article Wilker, E.H., Yeh, G., Wellenius, G.A., Davis, R.B., Phillips, R.S., and Mittleman, M.A. (2012). Ambient Temperature and Biomarkers of Heart Failure:A Repeated Measures Analysis. Environmental Health Perspectives 120, 1083 – 1087. R834798C003 (Final)
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    Journal Article Wilker, E.H., Preis, S.R., Beiser, A.S., Wolf, P.A., Au, R., Kloog, I., Li, W., Schwartz, J., Koutrakis, P., DeCarli, C., Seshadri, S., and Mittleman, M.A. (2015). Long-Term Exposure to Fine Particulate Matter, Residential Proximity to Major Roads and Measures of Brain Structure. Stroke 46, 1161-1166. R834798C002 (Final)
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    Journal Article Lee, M.H., Koutrakis, P., Coull, B.A., Kloog, I., and Schwartz, J. (2015). Acute Effects of Fine Particulate Matter on Mortality in Three Southeastern States from 2007-2011. Journal of Exposure Science and Environmental Epidemiology, 1-7. R834798C002 (Final)
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    Journal Article Raimundo RD, Godleski JJ. Heart rate variability in metabolic syndrome. Journal of Human Growth and Development. 2015; 25(1):7-10. R834798C001 (Final)
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    Journal Article Serum Leptin in Older Adults:Results from the MOBILIZE Boston Study. Journal of Occupational and Environmental Medicine 56, e73-e77. R834798C003 (Final)
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    Journal Article Rice MB, Ljungman PL, Wilker EH, et al. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham Heart Study. Am J Respir Crit Care Med. 2015;191:656-664. R834798C003 (Final)
    R834798C004 (Final)
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    Journal Article Kioumourtzoglou M-A, Schwartz J, James P, Dominici F, Zanobetti A. PM2.5 and Mortality in 207 US Cities:Modification by Temperature and City Characteristics. Epidemiology 2016; 27:221-227. R834798 (2016)
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    Journal Article Fleisch A, Luttmann-Gibson H, Perng W, Rifas-Shiman S, Coull BA, Kloog I, Koutrakis P, Schwartz J, Zanobetti A, Mantzoros C, Gillman M, Gold DR, Oken E. Prenatal and Early Life Exposure to Traffic Pollution and Cardiometabolic Health in Childhood. Pediatric Obesity 2016; doi:10.1111/ijpo.12106:1-10. R834798 (2016)
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    Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. Prenatal and childhood exposure to traffic-related pollution and childhood cognition. Environ Health Perspect. 2015. Apr 3. [Epub ahead of print]. PMID:25839914. R834798C004 (Final)
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    Journal Article van Rossem L, Melly S, Rifas-Shiman SL, Melly S, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull B, Schwartz J, Mittleman M, Oken E, Gillman M, Koutrakis P, Gold DR. Prenatal exposure to air pollution and newborn blood pressure. Environ Health Perspect. 2015. Apr;123(4):353-9. doi:10.1289/ehp.1307419. Epub 2015 Jan 27.PMID:25625652. R834798C004 (Final)
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    Journal Article Fleisch AF, Rifas-Shiman SL, Koutrakis P, Schwartz J , Kloog I, Melly S, Coull B, Zanobetti A, Gillman M, Gold DR, Oken E. Prenatal exposure to traffic pollution:associations with reduced fetal growth and rapid infant weight gain. Epidemiology. 2015 Jan;26(1):43-50. doi:10.1097/EDE.0000000000000203.PMID:25437317. R834798C004 (Final)
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    Journal Article Dorans KS, Wilker EH, Li W, et al. Residential proximity to major roads, exposure to fine particulate matter and aortic calcium:The Framingham Heart Study, a cohort study. BMJ open. 2017;7:e013455. R834798C003 (Final)
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    Journal Article Dorans KS, Wilker EH, Li W, et al. Residential proximity to major roads, exposure to fine particulate matter, and coronary artery calcium:The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2016. R834798C003 (Final)
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    Journal Article Li W, Dorans KS, Wilker EH, et al. Residential proximity to major roadways, fine particulate matter, and adiposity:The Framingham Heart Study. Obesity. 2016a;24:2593-2599. R834798C003 (Final)
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    Journal Article Li W, Dorans KS, Wilker EH, et al. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis:The Framingham Heart Study. Am J Epidemiol. 2017. R834798C003 (Final)
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    Journal Article Schildcrout, J.S., Lumley, T., Fuhlbrigge, A.N., Koutrakis, P., Schwartz, J., Weiss, S.T., and Gold, D.R. (2016). Ambient Air Pollution, Lung Function, and Airway Responsiveness in Asthmatic Children. Journal of Allergy and Clinical Immunology 137, 390-399. R834798C005 (Final)
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    Journal Article Li W, Wilker EH, Dorans K, Rice MB, Schwartz J, Coull B, Koutrakis P, Gold DR, Keaney JFJ, Lin H, Vasan R, Benjamin EJ, Mittleman MA. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress:The Framingham Heart Study. JournAL Of the American Heart Association 2016; DOI:10.1161/JAHA.115.002742:1-8. R834798 (2016)
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    Journal Article Ljungman PL, Wilker EH, Rice MB, Austin E, Schwartz J, Gold DR, Koutrakis P, Benjamin EJ, Vita JA, Mitchell GF, Vasan RS, Hamburg NM, Mittleman MA. The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function. Epidemiology 2016; 27:194-201. R834798 (2016)
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    Journal Article Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. R834798C005 (Final)
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    Supplemental Keywords:

    Air, air pollution, air pollutants, health effects, near-roadway exposure, multi-pollutant mixture, Scientific Discipline, Air, air toxics, Environmental Chemistry, Health Risk Assessment, Air Pollution Effects, Biochemistry, Environmental Monitoring, Biology, ambient air quality, complex mixtures, health effects, particulates, sensitive populations, children's health, air pollutants, biological sensitivities, aerosol particles, exposure and effects, lung epithelial cells, susceptible populations, chemical composition, neurotoxicity, human exposure, toxicity, coronary artery disease, cardiopulmonary, cardiotoxicity, environmental effects, mortality, human health

    Progress and Final Reports:

    Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834798C001 Relative Toxicity of Air Pollution Mixtures
    R834798C002 Cognitive Decline, Cardiovascular Changes, and Biological Aging in Response to Air Pollution
    R834798C003 Identifying the Cognitive and Vascular Effects of Air Pollution Sources and Mixtures in the Framingharn Offspring and Third Generation Cohorts
    R834798C004 Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
    R834798C005 A National Study to Assess Susceptibility, Vulnerability, and Effect Modification of Air Pollution Health Risks