Air Pollution Mixtures: Health Effects Across Life Stages

EPA Grant Number: R834798
Center: Air Pollution Mixtures: Health Effects across Life Stages
Center Director: Koutrakis, Petros
Title: Air Pollution Mixtures: Health Effects Across Life Stages
Investigators: Koutrakis, Petros , Godleski, John J.
Current Investigators: Koutrakis, Petros , Coull, Brent , Dominici, Francesca , Godleski, John J. , Gold, Diane R. , Mittleman, Murray , Schwartz, Joel
Institution: Harvard University
EPA Project Officer: Ilacqua, Vito
Project Period: January 1, 2011 through December 31, 2015 (Extended to December 31, 2016)
Project Amount: $7,997,561
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The main objectives of the proposed Center are: 1) to investigate the acute and chronic health effects across life stages of six exposure metrics (short- and long- term exposures to individual pollutants, pollution sources and multi-pollutant mixtures) on: cognitive/neuropsychological function, cardiovascular/endothelial function, inflammation, birth weight/growth, and CVD-related hospitalization/mortality; and 2) to identify susceptibility and vulnerability factors that modify these effects.

Approach:

Project 1 will investigate the toxicity of air pollutant mixtures in Boston, focusing on the identification of pollutant characteristics that are responsible for the most toxic effects, including: individual components, combinations of components (mixtures), formation processes, and source types. Exposures will be generated using a novel integration of our ambient particle concentrator and photochemical chamber technologies. Sprague-Dawley rats will be exposed and toxicity will be assessed by changes in: in vivo oxidant response, blood pressure, inflammation, and vascular reactivity. Projects 2-5 will examine the health effects of the six exposure metrics on multiple integrated specific health outcomes. Project 2 will examine effects of these exposure metrics on cognitive and neuropsychological function; cardiovascular and endothelial function; inflammation; and oxidative stress among elderly individuals living in New England enrolled in the Normative Aging Study. Project 3 will investigate effects of the six metrics on cognitive impairment and interference, as well as vascular and endothelial function, among middle-aged and older adults living in New England enrolled in the Framingham Offspring and Third Generation Study. Project 4 will investigate effects of the metrics on somatic growth, blood pressure, cardiovascular fitness, and cognition, in the Viva ongoing prebirth study of over 1,300 children from Eastern Massachusetts. Project 5 will estimate mortality and hospitalization risks in hundreds of Counties across the US. It will also study two cohorts in New England to: 1) estimate risks of adverse birth outcomes using approximately 700,000 live births; and 2) assess mortality and morbidity risks using 2.3 million Medicare enrollees. Finally, these Projects (2-5) will study the modifying effect of measures of susceptibility (clinical/biologic) and vulnerability (social milieu) and will link outcomes to the same pollution mixtures across all life stages.

Expected Results:

Our Center will address four of the six research priorities of the EPA solicitation to establish Clean Air Centers. It will: I) investigate the effects of pollutants and mixtures through animal and human studies; 2) identify sub-populations that are at increased risk through the investigation of the modifying effects of gender, diabetes, obesity, socioeconomic disparities, stress, depression, violence, smoking, and omega-3 fatty acid intake in children, adults, and elderly; 3) explain regional and temporal differences in air pollution risks; and 4) examine the shapes of exposure-response relationships for associations resulting from the use of multiple exposure metrics, outcomes and populations.


Journal Articles: 305 Displayed | Download in RIS Format

Other center views: All 359 publications 297 publications in selected types All 297 journal articles
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Journal Article Alexeeff SE, Schwartz J, Kloog I, Chudnovsky A, Koutrakis P, Coull BA. Consequences of kriging and land use regression for PM2.5 predictions in epidemiologic analyses:insights into spatial variability using high-resolution satellite data. Journal of Exposure Science and Environmental Epidemiology 2015;25(2):138-144. R834798 (2014)
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  • Journal Article Anderson GB, Bell ML. Lights out: impact of the August 2003 power outage on mortality in New York, NY. Epidemiology 2012;23(2):189-193. R834798 (2013)
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  • Journal Article Anderson GB, Krall JR, Peng RD, Bell ML. Is the relationship between ozone and mortality confounded by chemical components of particulate matter? Analysis of 7 components in 57 US communities. American Journal of Epidemiology 2012;176(8):726-732. R834798 (2013)
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  • Journal Article Anderson GB, Dominici F, Wang Y, McCormack MC, Bell ML, Peng RD. Heat-related emergency hospitalizations for respiratory diseases in the Medicare population. American Journal of Respiratory & Critical Care Medicine 2013;187(10):1098-1103. R834798 (2013)
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  • Journal Article Anderson GB, Bell ML, Peng RD. Methods to calculate the heat index as an exposure metric in environmental health research. Environmental Health Perspectives 2013;121(10):1111-1119. R834798 (2013)
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  • Journal Article Austin E, Coull B, Thomas D, Koutrakis P. A framework for identifying distinct multipollutant profiles in air pollution data. Environment International 2012;45:112-121. R834798 (2013)
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  • Journal Article Austin E, Coull BA, Zanobetti A, Koutrakis P. A framework to spatially cluster air pollution monitoring sites in US based on the PM2.5 composition. Environment International 2013;59:244-254. R834798 (2013)
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  • Journal Article Austin E, Zanobetti A, Coull B, Schwartz J, Gold D, Koutrakis P. Ozone trends and their relationship to characteristic weather patterns. Journal of Exposure Science and Environmental Epidemiology 2015;25(5):532-542. R834798 (Final)
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  • Journal Article Baccarelli A, Barretta F, Dou C, Zhang X, McCracken JP, Diaz A, Bertazzi PA, Schwartz J, Wang S, Hou L. Effects of particulate air pollution on blood pressure in a highly exposed population in Beijing, China: a repeated-measure study. Environmental Health 2011;10:108. R834798 (2013)
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  • Journal Article Baja ES, Schwartz JD, Coull BA, Wellenius GA, Vokonas PS, Suh HH. Structural equation modeling of the inflammatory response to traffic air pollution. Journal of Exposure Science and Environmental Epidemiology 2013;23(3):268-274. R834798 (2013)
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  • Journal Article Barr CD, Diez DM, Wang Y, Dominici F, Samet JM. Comprehensive smoking bans and acute myocardial infarction among Medicare enrollees in 387 US counties: 1999–2008. American Journal of Epidemiology 2012;176(7):642-648. R834798 (2013)
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  • Journal Article Behbod B, Urch B, Speck M, Scott JA, Liu L, Poon R, Coull B, Schwartz J, Koutrakis P, Silverman F, Gold DR. Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures. Occupational and Environmental Medicine 2013;70(11):761-767. R834798 (2013)
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  • Journal Article Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012;117:83-89. R834798 (2013)
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  • Journal Article Bell ML, Ebisu K. Environmental inequality in exposures to airborne particulate matter components in the United States. Environmental Health Perspectives 2012;120(12):1699-1704. R834798 (2013)
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  • Journal Article Bell ML, Zanobetti A, Dominici F. Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter: a systematic review and meta-analysis. American Journal of Epidemiology 2013;178(6):865-876. R834798 (2013)
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  • Journal Article Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. Associations of PM2.5 constituents and sources with hospital admissions:analysis of four counties in Connecticut and Massachusetts (USA) for persons ≥ 65 years of age. Environmental Health Perspectives 2014;122(2):138-144. R834798 (2013)
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  • Journal Article Bell ML, Zanobetti A, Dominici F. Who is more affected by ozone pollution? A systematic review and meta-analysis. American Journal of Epidemiology 2014;180(1):15-28. R834798 (Final)
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  • Journal Article Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, Silverman F, Gold D, Baccarelli AA. DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments. Journal of the American Heart Association 2013;2(3):e000212. R834798 (2013)
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  • Journal Article Bind M-A, Zanobetti A, Gasparrini A, Peters A, Coull B, Baccarelli A, Tarantini L, Koutrakis P, Vokonas P, Schwartz J. Effects of temperature and relative humidity on DNA methylation. Epidemiology 2014;25(4):561-569. R834798 (2014)
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  • Journal Article Bind M-A, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. Epidemiology 2012;23(2):332-340. R834798 (2012)
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  • Journal Article Bind M-A, Coull B, Suh H, Wright R, Baccarelli A, Vokonas P, Schwartz J. A novel genetic score approach using instruments to investigate interactions between pathways and environment: application to air pollution. Plos One 2014;9(4):e96000. R834798 (2014)
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  • Journal Article Bind M-A, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A, Coull BA, Tarantini L, Vokonas PS, Koutrakis P, Schwartz J. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics 2014;9(3):448-458. R834798 (2014)
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  • Journal Article Bind M-AC, Coull BA, Peters A, Baccarelli AA, Tarantini L, Cantone L, Vokonas PS, Koutrakis P, Schwartz JD. Beyond the mean: quantile regression to explore the association of air pollution with gene-specific methylation in the Normative Aging Study. Environmental Health Perspectives 2015;123(8):759-765. R834798 (2015)
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  • Journal Article Bobb JF, Dominici F, Peng RD. Reduced hierarchical models with application to estimating health effects of simultaneous exposure to multiple pollutants. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2013;62(3):451-472. R834798 (2012)
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  • Journal Article Bobb JF, Peng RD, Bell ML, Dominici F. Heat-related mortality and adaptation to heat in the United States. Environmental Health Perspectives 2014;122(8):811-816. R834798 (2014)
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  • Journal Article Bottino CJ, Rifas-Shiman SL, Kleinman KP, Oken E, Redline S, Gold D, Schwartz J, Melly SJ, Koutrakis P, Gillman MW, Taveras EM. The association of urbanicity with infant sleep duration. Health & Place 2012;18(5):1000-1005. R834798 (2013)
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  • Journal Article Bravo MA, Fuentes M, Zhang Y, Burr MJ, Bell ML. Comparison of exposure estimation methods for air pollutants: ambient monitoring data and regional air quality simulation. Environmental Research 2012;116:1-10. R834798 (2013)
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  • Journal Article Breysse PN, Delfino RJ, Dominici F, Elder ACP, Frampton MW, Froines JR, Geyh AS, Godleski JJ, Gold DR, Hopke PK, Koutrakis P, Li N, Oberdorster G, Pinkerton KE, Samet JM, Utell MJ, Wexler AS. US EPA particulate matter research centers: summary of research results for 2005–2011. Air Quality, Atmosphere & Health 2013;6(2):333-355. R834798 (2013)
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  • Journal Article Carreras H, Zanobetti A, Koutrakis P. Effect of daily temperature range on respiratory health in Argentina and its modification by impaired socio-economic conditions and PM10 exposures. Environmental Pollution 2015;206:175-182. R834798 (2015)
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  • Journal Article Cefalu M, Dominici F. Does exposure prediction bias health-effect estimation?: The relationship between confounding adjustment and exposure prediction. Epidemiology 2014;25(4):583-590. R834798 (Final)
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  • Journal Article Chiu Y-HM, Coull BA, Sternthal MJ, Kloog I, Schwartz J, Cohen S, Wright RJ. Effects of prenatal community violence and ambient air pollution on childhood wheeze in an urban population.Journal of Allergy and Clinical Immunology 2014;133(3):713-722.e4 R834798 (Final)
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  • Journal Article Chudnovsky AA, Lee HJ, Kostinski A, Kotlov T, Koutrakis P. Prediction of daily fine particulate matter concentrations using aerosol optical depth retrievals from the Geostationary Operational Environmental Satellite (GOES). Journal of the Air & Waste Management Association 2012;62(9):1022-1031. R834798 (2013)
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  • Journal Article Chudnovsky AA, Koutrakis P, Kloog I, Melly S, Nordio F, Lyapustin A, Wang Y, Schwartz J. Fine particulate matter predictions using high resolution Aerosol Optical Depth (AOD) retrievals. Atmospheric Environment 2014;89:189-198. R834798 (2014)
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  • Journal Article Chudnovsky AA, Kostinski A, Lyapustin A, Koutrakis P. Spatial scales of pollution from variable resolution satellite imaging. Environmental Pollution 2013;172:131-138. R834798 (2013)
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  • Journal Article Chudnovsky A, Tang C, Lyapustin A, Wang Y, Schwartz J, Koutrakis P. A critical assessment of high-resolution aerosol optical depth retrievals for fine particulate matter predictions. Atmospheric Chemistry and Physics 2013;13(21):10907-10917. R834798 (2013)
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  • Journal Article Chudnovsky A, Lyapustin A, Wang Y, Tang C, Schwartz J, Koutrakis P. High resolution aerosol data from MODIS satellite for urban air quality studies. Central European Journal of Geosciences 2014:6(1):17-26. R834798 (2014)
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  • Journal Article Chung M, Wang DD, Rizzo AM, Gachette D, Delnord M, Parambi R, Kang C-M, Brugge D. Association of PNC, BC, and PM2.5 measured at a central monitoring site with blood pressure in a predominantly near highway population. International Journal of Environmental Research and Public Health 2015;12(3):2765-2780. R834798 (2015)
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  • Journal Article Chung Y, Dominici F, Wang Y, Coull BA, Bell ML. Associations between long-term exposure to chemical constituents of fine particulate matter (PM2.5) and mortality in Medicare enrollees in the eastern United States. Environmental Health Perspectives 2015;123(5):467-474. R834798 (2014)
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  • Journal Article Correia AW, Pope III CA, Dockery DW, Wang Y, Ezzati M, Dominici F. Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period 2000 to 2007. Epidemiology 2013;24(1):23-31. R834798 (2012)
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  • Journal Article Dai L, Zanobetti A, Koutrakis P, Schwartz JD. Associations of fine particulate matter species with mortality in the United States: a multicity time-series analysis. Environmental Health Perspectives 2014;122(8):837-842. R834798 (2014)
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  • Journal Article Dai L, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. Use of the adaptive LASSO method to identify PM2.5 components associated with blood pressure in elderly men: the Veterans Affairs Normative Aging Study. Environmental Health Perspectives 2016;124(1):120-125. R834798 (2015)
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  • Journal Article Diaz EA, Lemos M, Coull B, Long MS, Rohr AC, Ruiz P, Gupta T, Kang C-M, Godleski JJ. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)--power plant studies: assessment of breathing pattern. Inhalation Toxicology 2011;23(Suppl 2):42-59. R834798 (2013)
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  • Journal Article Diaz EA, Chung Y, Papapostolou V, Lawrence J, Long MS, Hatakeyama V, Gomes B, Calil Y, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged vehicular exhaust emissions on breathing pattern and cellular responses - pilot single vehicle study. Inhalation Toxicology 2012;24(5):288-295. R834798 (2012)
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  • Journal Article Diaz EA, Chung Y, Lamoureux DP, Papapostolou V, Lawrence J, Long MS, Mazzaro V, Buonfiglio H, Sato R, Koutrakis P, Godleski JJ. Effects of fresh and aged traffic-related particles on breathing pattern, cellular responses, and oxidative stress. Air Quality, Atmosphere & Health 2013;6(2):431-444. R834798 (2012)
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  • Journal Article Diez DM, Dominici F, Zarubiak D, Levi JI. Statistical approaches for identifying air pollutant mixtures associated with aircraft departures at Los Angeles International Airport. Environmental Science & Technology 2012;46(15):8229-8235. R834798 (2013)
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  • Journal Article Dominici F, Mittleman MA. China’s air quality dilemma:reconciling economic growth with environmental protection. Journal of the American Medical Association 2012;307(19):2100-2102 (editorial). R834798 (2012)
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  • Journal Article Dominici F, Greenstone M, Sunstein CR. Particulate matter matters. Science 2014;344(6181):257-259. R834798 (Final)
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  • Journal Article Ebisu K, Bell ML. Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States. Environmental Health Perspectives 2012;120(12):1746-1752. R834798 (2013)
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  • Journal Article Fang SC, Mehta AJ, Alexeeff SE, Gryparis A, Coull B, Vokonas P, Christiani DC, Schwartz J. Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging study. Environmental Health Perspectives 2012;120(5):674-680. R834798 (2013)
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  • Journal Article Fang SC, Schwartz J, Yang M, Yaggi HK, Bliwise DL, Araujo AB. Traffic‐related air pollution and sleep in the Boston Area Community Health Survey. Journal of Exposure Science & Environmental Epidemiology 2015;25(5):451-456. R834798 (Final)
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  • Journal Article Fleisch AF, Gold DR, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, Coull BA, Zanobetti A, Gillman MW, Oken E. Air pollution exposure and abnormal glucose tolerance during pregnancy:the Project Viva cohort. Environmental Health Perspectives 2014:122(4):378-383. R834798 (2014)
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  • Journal Article Fossati S, Baccarelli A, Zanobetti A, Hoxha M, Vokonas PS, Wright RO, Schwartz J. Ambient particulate air pollution and MicroRNAs in elderly men. Epidemiology 2014;25(1):68-78. R834798 (2014)
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  • Journal Article Fuller CH, Brugge D, Williams PL, Mittleman MA, Durant JL, Spengler JD. Estimation of ultrafine particle concentrations at near-highway residences using data from local and central monitors. Atmospheric Environment 2012;57:257-265. R834798 (2013)
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  • Journal Article Godleski JJ, Diaz EA, Lemos M, Long M, Ruiz P, Gupta T, Kang C-M, Coull B. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA)-power plant studies: assessment of cellular responses. Inhalation Toxicology 2011;23(Suppl 2):60-74. R834798 (2013)
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  • Journal Article Godleski JJ, Rohr AC, Kang CM, Diaz EA, Ruiz PA, Koutrakis P. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA): introduction and overview. Inhalation Toxicology 2011;23(Suppl 2):1-10. R834798 (2013)
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  • Journal Article Godleski JJ, Rohr AC, Coull BA, Kang CM, Diaz EA, Koutrakis P. Toxicological Evaluation of Realistic Emission Source Aerosols (TERESA): summary and conclusions. Inhalation Toxicology 2011;23(Suppl 2):95-103. R834798 (2013)
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  • Journal Article Gold DR, Mittleman MA. New insights into pollution and the cardiovascular system: 2010 to 2012. Circulation 2013;127(18):1903-1913. R834798 (2013)
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  • Journal Article Greven S, Dominici F, Zeger S. An approach to the estimation of chronic air pollution effects using spatio-temporal information. Journal of the American Statistical Association 2011;106(494):396-406. R834798 (2013)
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  • Journal Article Habre R, Coull B, Koutrakis P. Impact of source collinearity in simulated PM2.5 data on the PMF receptor model solution. Atmospheric Environment 2011;45(38):6938-6946. R834798 (2013)
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  • Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. Prenatal and childhood traffic-related pollution exposure and childhood cognition in the Project Viva Cohort (Massachusetts, USA). Environmental Health Perspectives 2015;123(10):1072-1078. R834798 (2015)
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  • Journal Article Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR. Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environmental Health Perspectives 2012;120(2):241-246. R834798 (2012)
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  • Journal Article Hou L, Wang S, Dou C, Zhang X, Yu Y, Zheng Y, Avula U, Hoxha M, Díaz A, McCracken J, Barretta F, Marinelli B, Bertazzi PA, Schwartz J, Baccarelli AA. Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study. Environment International 2012;48:71-77. R834798 (2013)
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  • Journal Article Hou L, Zhang X, Dioni L, Barretta F, Dou C, Zheng Y, Hoxha M, Bertazzi PA, Schwartz J, Wu S, Wang S, Baccarelli AA. Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study. Particle and Fibre Toxicology 2013;10:17. R834798 (2013)
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  • Journal Article Hou L, Zhang X, Zheng Y, Wang S, Dou C, Guo L, Byun H-M, Motta V, McCracken J, Díaz A, Kang C-M, Koutrakis P, Bertazzi PA, Li J, Schwartz J, Baccarelli AA. Altered methylation in tandem repeat element and elemental component levels in inhalable air particles. Environmental and Molecular Mutagenesis 2014;55(3):256-265. R834798 (2014)
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  • Journal Article Hsu H-HL, Chiu Y-HM, Coull BA, Kloog I, Schwartz J, Lee A, Wright RO, Wright RJ. Prenatal particulate air pollution and asthma onset in urban children. Identifying sensitive windows and sex differences. American Journal of Respiratory and Critical Care Medicine 2015;192(9):1052-1059. R834798 (2015)
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  • Journal Article Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, Vonk JM, Williams PV, Shapiro GG, McKone EF, Hallstrand TS, Koenig JQ, Schildcrout JS, Lumley T, Fuhlbrigge AN, Koutrakis P, Schwartz J, Weiss ST, Gold DR. Ambient air pollution, lung function, and airway responsiveness in asthmatic children. Journal of Allergy and Clinical Immunology 2016;137(2):390-399. R834798 (2015)
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  • Journal Article Jhun I, Oyola P, Moreno F, Castillo MA, Koutrakis P. PM2.5 mass and species trends in Santiago, Chile, 1998 to 2010:the impact of fuel-related interventions and fuel sales. Journal of the Air & Waste Management Association 2013;63(2):161-169. R834798 (2013)
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  • Journal Article Jhun I, Coull BA, Zanobetti A, Koutrakis P. The impact of nitrogen oxides concentration decreases on ozone trends in the USA. Air Quality, Atmosphere & Health 2015;8(3):283-292. R834798 (2014)
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  • Journal Article Kang C-M, Gupta T, Ruiz PA, Wolfson JM, Ferguson ST, Lawrence JE, Rohr AC, Godleski J, Koutrakis P. Aged particles derived from emissions of coal-fired power plants: the TERESA field results. Inhalation Toxicology 2011;23(Suppl 2):11-30. R834798 (2013)
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  • Journal Article Kioumourtzoglou MA, Coull BA, Dominici F, Koutrakis P, Schwartz J, Suh H. The impact of source contribution uncertainty on the effects of source-specific PM2.5 on hospital admissions: a case study in Boston, MA. Journal of Exposure Science and Environmental Epidemiology 2014;24(4):365-371. R834798 (2014)
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  • Journal Article Kioumourtzoglou M-A, Zanobetti A, Schwartz JD, Coull BA, Dominici F, Suh HH. The effect of primary organic particles on emergency hospital admissions among the elderly in 3 US cities. Environmental Health 2013;12(1):68 (10 pp.). R834798 (2013)
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  • Journal Article Kioumourtzoglou M-A, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F, Zanobetti A. Long-term PM2.5 exposure and neurological hospital admissions in the Northeastern United States. Environmental Health Perspectives 2015, doi:10.1289/ehp.1408973 [epub ahead of print]. R834798 (Final)
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  • Journal Article Kioumourtzoglou M-A, Austin E, Koutrakis P, Dominici F, Schwartz J, Zanobetti A. PM2.5 and survival among older adults: effect modification by particulate composition. Epidemiology 2015;26(3):321-327. R834798 (2015)
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  • Journal Article Kioumourtzoglou M-A, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F, Zanobetti A. Long-term PM2.5 exposure and neurological hospital admissions in the northeastern United States. Environmental Health Perspectives 2016:124(1):23-29. R834798 (2015)
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  • Journal Article Kloog I, Koutrakis P, Coull BA, Lee HJ, Schwartz J. Assessing temporally and spatially resolved PM2.5 exposures for epidemiological studies using satellite aerosol optical depth measurements. Atmospheric Environment 2011;45(35):6267-6275. R834798 (2012)
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  • Journal Article Kloog I, Coull BA, Zanobetti A, Koutrakis P, Schwartz JD. Acute and chronic effects of particles on hospital admissions in New-England. PLoS ONE 2012;7(4):e34664. R834798 (2012)
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  • Journal Article Kloog I, Chudnovsky A, Koutrakis P, Schwartz J. Temporal and spatial assessments of minimum air temperature using satellite surface temperature measurements in Massachusetts, USA. Science of The Total Environment 2012;432:85-92. R834798 (2013)
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  • Journal Article Kloog I, Melly SJ, Ridgway WL, Coull BA, Schwartz J. Using new satellite based exposure methods to study the association between pregnancy PM2.5 exposure, premature birth and birth weight in Massachusetts. Environmental Health 2012;11:40 (8 pp.). R834798 (2012)
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  • Journal Article Kloog I, Nordio F, Coull BA, Schwartz J. Incorporating local land use regression and satellite aerosol optical depth in a hybrid model of spatiotemporal PM2.5 exposures in the Mid-Atlantic states. Environmental Science & Technology 2012;46(21):11913-11921. R834798 (2013)
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  • Journal Article Kloog I, Ridgway B, Koutrakis P, Coull BA, Schwartz JD. Long-and short-term exposure to PM2.5 and mortality: using novel exposure models. Epidemiology 2013;24(4):555-561. R834798 (2013)
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  • Journal Article Kloog I, Nordio F, Zanobetti A, Coull BA, Koutrakis P, Schwartz JD. Short term effects of particle exposure on hospital admissions in the Mid-Atlantic states: a population estimate. PLoS ONE 2014;9(2):e88578. R834798 (2014)
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  • Journal Article Kloog I, Nordio F, Coull BA, Schwartz J. Predicting spatiotemporal mean air temperature using MODIS satellite surface temperature measurements across the Northeastern USA. Remote Sensing of Environment 2014;150:132-139. R834798 (2014)
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  • Journal Article Kloog I, Zanobetti A, Nordio F, Coull BA, Baccarelli AA, Schwartz J. Effects of airborne fine particles (PM2.5) on deep vein thrombosis admissions in the northeastern United States. Journal of Thrombosis and Haemostasis 2015;13(5):768-774. R834798 (2015)
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  • Journal Article Kloog I, Melly SJ, Coull BA, Nordio F, Schwartz JD. Using satellite-based spatiotemporal resolved air temperature exposure to study the association between ambient air temperature and birth outcomes in Massachusetts. Environmental Health Perspectives 2015:123(10):1053-1058 doi:10.1289/ehp.1308075. R834798 (2015)
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  • Journal Article Krall JR, Anderson GB, Dominici F, Bell ML, Peng RD. Short-term exposure to particulate matter constituents and mortality in a national study of U.S. urban communities. Environmental Health Perspectives 2013;121(10):1148-1153. R834798 (2013)
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  • Journal Article Lamoureux DP, Diaz EA, Chung Y, Coull BA, Papapostolou V, Lawrence J, Sato R, Godleski JJ. Effects of fresh and aged vehicular particulate emissions on blood pressure in normal adult male rats. Air Quality, Atmosphere & Health 2013;6(2):407-418. R834798 (2012)
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  • Journal Article Lee HJ, Coull BA, Bell ML, Koutrakis P. Use of satellite-based aerosol optical depth and spatial clustering to predict ambient PM2.5 concentrations. Environmental Research 2012;118:8-15. R834798 (2013)
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  • Journal Article Lee HJ, Kang C-M, Coull BA, Bell ML, Koutrakis P. Assessment of primary and secondary ambient particle trends using satellite aerosol optical depth and ground speciation data in the New England region, United States. Environmental Research 2014;133:103-110. R834798 (2014)
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  • Journal Article Lee HJ, Koutrakis P. Daily ambient NO2 concentration predictions using satellite ozone monitoring instrument NO2 data and land use regression. Environmental Science & Technology 2014;48(4):2305-2311. R834798 (2014)
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  • Journal Article Lee M, Kloog I, Chudnovsky A, Lyapustin A, Wang Y, Melly S, Coull B, Koutrakis P, Schwartz J. Spatiotemporal prediction of fine particulate matter using high-resolution satellite images in the Southeastern US 2003-2011. Journal of Exposure Science & Environmental Epidemiology 2016(June);26(4):377-384 doi:10.1038/jes.2015.41 [Epub ahead of print]. R834798 (2015)
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  • Journal Article Lemos M, Diaz EA, Gupta T, Kang CM, Ruiz P, Coull BA, Godleski JJ, Gonzalez-Flecha B. Cardiac and pulmonary oxidative stress in rats exposed to realistic emissions of source aerosols. Inhalation Toxicology 2011;23(Suppl 2):75-83. R834798 (2013)
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  • Journal Article Lepeule J, Laden F, Dockery D, Schwartz J. Chronic exposure to fine particles and mortality: an extended follow-up of the Harvard Six Cities study from 1974 to 2009. Environmental Health Perspectives 2012;120(7):965-970. R834798 (2012)
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  • Journal Article Lepeule J, Baccarelli A, Motta V, Cantone L, Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study. Epigenetics 2012;7(3):261-269. R834798 (2012)
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  • Journal Article Lepeule J, Bind M-AC, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, Sparrow D, Vokonas P, Schwartz JD. Epigenetic influences on associations between air pollutants and lung function in elderly men: the Normative Aging Study. Environmental Health Perspectives 2014;122(6):566-572. R834798 (2014)
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  • Journal Article Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. R834798 (2012)
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  • Journal Article Link MS, Luttmann-Gibson H, Schwartz J, Mittleman MA, Wessler B, Gold DR, Dockery DW, Laden F. Acute exposure to air pollution triggers atrial fibrillation. Journal of the American College of Cardiology 2013;62(9):816-825. R834798 (2013)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Mittleman MA, Hamburg NM. Short-term exposure to air pollution and digital vascular function. American Journal of Epidemiology 2014;180(5):482-489. R834798 (Final)
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  • Journal Article Lue S-H, Wellenius GA, Wilker EH, Mostofsky E, Mittleman MA. Residential proximity to major roadways and renal function. Journal of Epidemiology & Community Health 2013;67(8):629-634. R834798 (2013)
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  • Journal Article Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro III A, Vokonas PS, Cantone L, Kubzansky L, Schwartz J. Air pollution and DNA methylation: interaction by psychological factors in the VA Normative Aging Study. American Journal of Epidemiology 2012;176(3):224-232. R834798 (2013)
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  • Journal Article Madrigano J, Kloog I, Goldberg R, Coull BA, Mittleman MA, Schwartz J. Long-term exposure to PM2.5 and incidence of acute myocardial infarction. Environmental Health Perspectives 2013;121(2):192-196. R834798 (2013)
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  • Journal Article Masri S, Kang C-M, Koutrakis P. Composition and sources of fine and coarse particles collected during 2002–2010 in Boston, MA. Journal of the Air & Waste Management Association 2015;65(3):287-297. R834798 (2015)
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  • Journal Article McDevitt JJ, Koutrakis P, Ferguson ST, Wolfson JM, Fabian MP, Martins M, Pantelic J, Milton DK. Development and performance evaluation of an exhaled-breath bioaerosol collector for influenza virus. Aerosol Science and Technology 2013;47(4):444-451. R834798 (2013)
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  • Journal Article Mehta AJ, Zanobetti A, Koutrakis P, Mittleman MA, Sparrow D, Vokonas P, Schwartz J. Associations between short-term changes in air pollution and correlates of arterial stiffness: the Veterans Affairs Normative Aging Study, 2007-2011. American Journal of Epidemiology 2014;179(2):192-199. R834798 (2014)
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  • Journal Article Mehta AJ, Kubzansky LD, Coull BA, Kloog I, Koutrakis P, Sparrow D, Spiro III A, Vokonas P, Schwartz J. Associations between air pollution and perceived stress: the Veterans Administration Normative Aging Study. Environmental Health 2015;14:10, 10 pp. R834798 (2015)
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  • Journal Article Mittleman MA, Mostofsky E. Exchangeability in the case-crossover design. International Journal of Epidemiology 2014;43(5):1645-1655. R834798 (2014)
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  • Journal Article Mordukhovich I, Lepeule J, Coull BA, Sparrow D, Vokonas P, Schwartz J. The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men. Thorax 2015;70(2):133-137. R834798 (2015)
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  • Journal Article Mostofsky E, Schwartz J, Coull BA, Koutrakis P, Wellenius GA, Suh HH, Gold DR, Mittleman MA. Modeling the association between particle constituents of air pollution and health outcomes. American Journal of Epidemiology 2012;176(4):317-326. R834798 (2013)
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  • Journal Article Mostofsky E, Wilker EH, Schwartz J, Zanobetti A, Gold DR, Wellenius GA, Mittleman MA. Short-term changes in ambient temperature and risk of ischemic stroke. Cerebrovascular Diseases Extra 2014;4(1):9-18. R834798 (2014)
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  • Journal Article Nguyen JL, Laden F, Link MS, Schwartz J, Luttmann-Gibson H, Dockery DW. Weather and triggering of ventricular arrhythmias in patients with implantable cardioverter-defibrillators. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):175-181. R834798 (2015)
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  • Journal Article Nguyen JL, Link MS, Luttmann-Gibson H, Laden F, Schwartz J, Wessler BS, Mittleman MA, Gold DR, Dockery DW. Drier air, lower temperatures, and triggering of paroxysmal atrial fibrillation. Epidemiology 2015;26(3):374-380. R834798 (2015)
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  • Journal Article Nordio F, Kloog I, Coull BA, Chudnovsky A, Grillo P, Bertazzi PA, Baccarelli AA, Schwartz J. Estimating spatio-temporal resolved PM10 aerosol mass concentrations using MODIS satellite data and land use regression over Lombardy, Italy. Atmospheric Environment 2013;74:227-236. R834798 (2013)
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  • Journal Article Oken E, Baccarelli AA, Gold DR, Kleinman KP, Litonjua AA, De Meo D, Rich-Edwards JW, Rifas-Shiman SL, Sagiv S, Taveras EM, Weiss ST, Belfort MB, Burris HH, Camargo Jr. CA, Huh SY, Mantzoros C, Parker MG, Gillman MW. Cohort profile: Project Viva. International Journal of Epidemiology 2015;44(1):37-48. R834798 (Final)
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  • Journal Article Papapostolou V, Lawrence JE, Diaz EA, Wolfson JM, Ferguson ST, Long MS, Godleski JJ, Koutrakis P. Laboratory evaluation of a prototype photochemical chamber designed to investigate the health effects of fresh and aged vehicular exhaust emissions. Inhalation Toxicology 2011;23(8):495-505. R834798 (2010)
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  • Journal Article Papapostolou V, Lawrence JE, Ferguson ST, Wolfson JM, Diaz EA, Godleski JJ, Koutrakis P. Development and characterization of an exposure generation system to investigate the health effects of particles from fresh and aged traffic emissions. Air Quality, Atmosphere & Health 2013;6(2):419-429. R834798 (2012)
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  • Journal Article Patton AP, Collins C, Naumova EN, Zamore W, Brugge D, Durant JL. An hourly regression model for ultrafine particles in a near-highway urban area. Environmental Science & Technology 2014;48(6):3272-3280. R834798 (2014)
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  • Journal Article Pereira G, Bell ML, Lee HJ, Koutrakis P, Belanger K. Sources of fine particulate matter and risk of preterm birth in Connecticut, 2000–2006: a longitudinal study. Environmental Health Perspectives 2014;122(10):1117-1122. R834798 (2015)
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  • Journal Article Peters JL, Kubzansky LD, Ikeda A, Spiro III A, Wright RO, Weisskopf MG, Kim D, Sparrow D, Nie LH, Hu H, Schwartz J. Childhood and adult socioeconomic position, cumulative lead levels, and pessimism in later life: the VA Normative Aging Study. American Journal of Epidemiology 2011;174(12):1345-1353. R834798 (2010)
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  • Journal Article Power, MC, Weisskopf MG, Alexeef SE, Coull BA, Spiro III A , Schwartz J. Traffic-related air pollution and cognitive function in a cohort of older men. Environmental Health Perspectives 2011;119(5):682-687. R834798 (2010)
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  • Journal Article Power MC, Weisskopf MG, Alexeeff SE, Wright RO, Coull BA, Spiro A, Schwartz J. Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study. Environmental Health 2013;12:16. R834798 (2014)
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  • Journal Article Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR, O'Connor GT, Mittleman MA. Short-term exposure to air pollution and lung function in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 2013;188(11):1351-1357. R834798 (Final)
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  • Journal Article Rice MB, Thurston GD, Balmes JR, Pinkerton KE. Climate change. A global threat to cardiopulmonary health. American Journal of Respiratory and Critical Care Medicine 2014;189(5):512-519. R834798 (Final)
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  • Journal Article Rice MB, Rifas-Shiman SL, Oken E, Gillman MW, Ljungman PL, Litonjua AA, Schwartz J, Coull BA, Zanobetti A, Koutrakis P, Melly SJ, Mittleman MA, Gold DR. Exposure to traffic and early life respiratory infection: a cohort study. Pediatric Pulmonology 2015;50(3):252-259. R834798 (2014)
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  • Journal Article Rice MB, Rifas-Shiman SL, Litonjua AA, Oken E, Gillman MW, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull B, Schwartz J, Koutrakis P, Mittleman MA, Gold DR. Lifetime exposure to ambient pollution and lung function in children. American Journal of Respiratory and Critical Care Medicine 2016;193(8):861-888. R834798 (2015)
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  • Journal Article Rosenbloom JI, Wilker EH, Mukamal KJ, Schwartz J, Mittleman MA. Residential proximity to major roadway and 10-year all-cause mortality after myocardial infarction. Circulation 2012;125(18):2197-2203. R834798 (2012)
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  • Journal Article Schwartz J, Alexeeff SE, Mordukhovich I, Gryparis A, Vokonas P, Suh H, Coull BA. Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study. Occupational and Environmental Medicine 2012;69(6):422-427. R834798 (2012)
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  • Journal Article Schwartz J, Austin E, Bind M-A, Zanobetti A, Koutrakis P. Estimating causal associations of fine particles with daily deaths in Boston. American Journal of Epidemiology 2015;182(7):644-650. R834798 (2015)
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  • Journal Article Shi L, Kloog I, Zanobetti A, Liu P, Schwartz JD. Impacts of temperature and its variability on mortality in New England. Nature Climate Change 2015;5:988-991. R834798 (2015)
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  • Journal Article Shi L, Zanobetti A, Kloog I, Coull BA, Koutrakis P, Melly SJ, Schwartz JD. Low-concentration PM2.5 and mortality: estimating acute and chronic effects in a population-based study. Environmental Health Perspectives 2016;124(1):46-52. R834798 (2015)
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  • Journal Article Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, Gold DR, Lukic KZ, Speck M, Kusha M, Farid T, Poku K, Shi E, Floras J, Nanthakumar K. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. Journal of the American College of Cardiology 2011;57(2):198-206. R834798 (2012)
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  • Journal Article Sofer T, Maity A, Coull B, Baccarelli A, Schwartz J, Lin X. Multivariate gene selection and testing in studying the exposure effects on a gene set. Statistics in Bioscience 2012;4(2):319-338. R834798 (2013)
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  • Journal Article Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz J. Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway. Epigenomics 2013;5(2):147-154. R834798 (2013)
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  • Journal Article Son J-Y, Lee J-T, Park YH, Bell ML. Short-term effects of air pollution on hospital admissions in Korea. Epidemiology 2013;24(4):545-554. R834798 (2013)
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  • Journal Article Son J-Y, Lee J-T, Kim K-H, Jung K, Bell ML. Characterization of fine particulate matter and associations between particulate chemical constituents and mortality in Seoul, Korea. Environmental Health Perspectives 2012;120(6):872-878. R834798 (2013)
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  • Journal Article Valdes A, Zanobetti A, Halonen JI, Cifuentes L, Morata D, Schwartz J. Elemental concentrations of ambient particles and cause specific mortality in Santiago, Chile: a time series study. Environmental Health 2012;11:82. R834798 (2014)
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  • Journal Article van Rossem L, Rifas-Shiman SL, Melly SJ, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz JD, Mittleman MA, Oken E, Gillman MW, Koutrakis P, Gold DR. Prenatal air pollution exposure and newborn blood pressure. Environmental Health Perspectives 2015;123(4):353-359. R834798 (2015)
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  • Journal Article Wang Y, Eliot MN, Koutrakis P, Gryparis A, Schwartz JD, Coull BA, Mittleman MA, Milberg WP, Lipsitz LA, Wellenius GA. Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston Study. Environmental Health Perspectives 2014;122(6):553-558. R834798 (Final)
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  • Journal Article Wellenius GA, Burger MR, Coull BA, Schwartz J, Suh HH, Koutrakis P, Schlaug G, Gold DR, Mittleman MA. Ambient air pollution and the risk of acute ischemic stroke. Archives of Internal Medicine 2012;172(3):229-234. R834798 (2012)
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  • Journal Article Wellenius GA, Wilhelm-Benartzi CS, Wilker EH, Coull BA, Suh HH, Koutrakis P, Lipsitz LA. Ambient particulate matter and the response to orthostatic challenge in the elderly: the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study. Hypertension 2012;59(3):558-563. R834798 (2013)
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  • Journal Article Wellenius GA, Boyle LD, Coull BA, Milberg WP, Gryparis A, Schwartz J, Mittleman MA, Lipsitz LA. Residential proximity to nearest major roadway and cognitive function in community-dwelling seniors: results from the MOBILIZE Boston Study. Journal of the American Geriatric Society 2012;60(11):2075-2080. R834798 (2012)
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  • Journal Article Wellenius GA, Boyle LD, Wilker EH, Sorond FA, Coull BA, Koutrakis P, Mittleman MA, Lipsitz LA. Ambient fine particulate matter alters cerebral hemodynamics in the elderly. Stroke 2013;44(6):1532-1536. R834798 (2013)
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  • Journal Article Weuve J, Puett RC, Schwartz J, Yanosky JD, Laden F, Grodstein F. Exposure to particulate air pollution and cognitive decline in older women. Archives of Internal Medicine 2012;172(3):219-227. R834798 (2013)
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  • Journal Article Wilker EH, Yeh G, Wellenius GA, Davis RB, Phillips RS, Mittleman MA. Ambient temperature and biomarkers of heart failure: a repeated measures analysis. Environmental Health Perspectives 2012;120(8):1083-1087. R834798 (2012)
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  • Journal Article Wilker EH, Mittleman MA, Coull BA, Gryparis A, Bots ML, Schwartz J, Sparrow D. Long-term exposure to black carbon and carotid intima-media thickness: the Normative Aging Study. Environmental Health Perspectives 2013;121(9):1061-1067. R834798 (2013)
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  • Journal Article Wilker EH, Ljungman PL, Rice MB, Kloog I, Schwartz J, Gold DR, Koutrakis P, Vita JA, Mitchell GF, Vasan RS, Benjamin EJ, Hamburg NM, Mittleman MA. Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia. American Journal of Cardiology 2014;113(12):2057-2063. R834798 (2014)
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  • Journal Article Wilker EH, Preis SR, Beiser AS, Wolf PA, Au R, Kloog I, Li W, Schwartz J, Koutrakis P, DeCarli C, Seshadri S, Mittleman MA. Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke 2015;46(5):1161-1166. R834798 (2015)
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  • Journal Article Yeh RW, Normand S-LT, Wang Y, Barr CD, Dominici F. Geographic disparities in the incidence and outcomes of hospitalized myocardial infarction:does a rising tide lift all boats? Circulation: Cardiovascular Quality and Outcomes 2012;5(2):197-204. R834798 (2012)
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  • Journal Article Zanobetti A, Schwartz J. Ozone and survival in four cohorts with potentially predisposing diseases. American Journal of Respiratory and Critical Care Medicine 2011;184(7):836-841. R834798 (2010)
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  • Journal Article Zanobetti A, O'Neill MS, Gronlund CJ, Schwartz JD. Summer temperature variability and long-term survival among elderly people with chronic disease. Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6608-6613. R834798 (2012)
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  • Journal Article Zanobetti A, Coull BA, Gryparis A, Kloog I, Sparrow D, Vokonas PS, Wright RO, Gold DR, Schwartz J. Associations between arrhythmia episodes and temporally and spatially resolved black carbon and particulate matter in elderly patients. Occupational and Environmental Medicine 2014;71(3):201-207. R834798 (2014)
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  • Journal Article Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR. Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: a repeated-measures study. Environmental Health Perspectives 2014;122(3):242-248. R834798 (2013)
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  • Journal Article Zanobetti A, Dominici F, Wang Y, Schwartz JD. A national case-crossover analysis of the short-term effect of PM2.5 on hospitalizations and mortality in subjects with diabetes and neurological disorders. Environmental Health 2014;13(1):38 (11 pp.). R834798 (Final)
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  • Journal Article Zanobetti A, Peters A. Disentangling interactions between atmospheric pollution and weather. Journal of the Epidemiology and Community Health 2015;69(7):613-615. R834798 (2015)
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  • Journal Article Zhong J, Colicino E, Lin X, Mehta A, Kloog I, Zanobetti A, Byun H-M, Bind M-A, Cantone L, Prada D, Tarantini L, Trevisi L, Sparrow D, Vokonas P, Schwartz J, Baccarelli AA. Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of Toll‐like receptor 2 and dietary flavonoid intake. Journal of the American Heart Association 2015;4(1):e001423, 21 pp. R834798 (2015)
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  • Journal Article Zigler CM, Dominici F, Wang Y. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 2012;13(2):289-302. R834798 (2012)
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  • Journal Article Zigler CM, Watts K, Yeh RW, Wang Y, Coull BA, Dominici F. Model feedback in Bayesian propensity score estimation. Biometrics 2013;69(1):263-273. R834798 (2013)
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  • Journal Article Zigler CM, Dominici F. Point: clarifying policy evidence with potential-outcomes thinking--beyond exposure-response estimation in air pollution epidemiology. American Journal of Epidemiology 2014;180(12):1133-1140. R834798 (Final)
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  • Journal Article Zigler CM, Dominici F. Uncertainty in propensity score estimation: Bayesian methods for variable selection and model averaged causal effects. Journal of the American Statistical Association 2014;109(505):95-107. R834798 (2014)
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  • Journal Article Wang Y, Kloog I, Coull B, Kosheleva A, Zanobetti A, Schwartz J. Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey. Environmental Health Perspectives 2016:1-38. R834798 (2016)
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  • Journal Article Rodosthenous S, Coull BA, Lu Q, Vokonas PS, Schwartz JD, Baccarelli AA. Ambient Particulate Matter and MicroRNAs in Extracellular Vesicles:a Pilot Study of Older Individuals. Particle and Fibre Toxicology 2016; 13:1-13. R834798 (2016)
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  • Journal Article Colicino E, Giuliano G, Power MC, Lepeule J, Wilker EH, Vokonas P, Brennan KJM, Fossati S, Hoxha M, Spiro A, Weisskopf MG, Schwartz J, Baccarelli AA. Long-term Exposure to Black Carbon, Cognition and Single Nucleotide Polymorphisms in MicroRNA Processing Genes in Older Men. Environment International 2016; 88:86-93. R834798 (2016)
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  • Journal Article Ljungman PL, Wilker EH, Rice MB, et al. Short-term exposure to air pollution and digital vascular function. Am J Epidemiol. 2014a;180:482-489. R834798C003 (Final)
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  • Journal Article Sagiv SK, Oken E. Prenatal and childhood traffic-related air pollution exposure and childhood executive function and behavior. Neurotoxicol Teratol. 2016 Sep-Oct;57:60-70. doi:10.1016/j.ntt.2016.06.008. PMID:27350569. R834798 (Final)
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  • Journal Article Schwartz, J., Austin, E., Bind, M.A., Zanobetti, A., and Koutrakis, P. (2015). Estimating Causal Associations of Low PM2.5 on Daily Deaths in Boston. American Journal of Epidemiology 182, 644-650. R834798C002 (Final)
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    Journal Article Pereira, G., Bell, M.L., Lee, H.J., Koutrakis, P., and Belanger, K. (2014). Sources of Fine Particulate Matter and Risk of Preterm Birth in Connecticut, 2000–2006:A Longitudinal Study. Environmental Health Perspectives 122, 1117-1122. R834798C005 (Final)
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    Journal Article Peng, C., Bind, M.-A., Colicino, E., Kloog, I., Byun, H.-M., Cantione, L., Trevisi, L.Z., J., Brennan, K., Dereix, A.E., Vokonas, P., Coull, B.A., Schwartz, J., and Baccarelli, A.A. (2016). Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals:Associations and E[pigenetic Mediation in the Normative Aging Study, 2000-2011. Environmental Health Perspectives http://dx.doi.org/10.1289/EHP183, 1-34. R834798 (Final)
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    Journal Article Dai, L., Bind, M.-A., Koutrakis, P., Coull, B.A., Sparrow, D., Vokonas, P.S., and Schwartz, J.D. (2016). Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction:Analysis on particulate species and sources. J Expos Sci Environ Epidemiol. R834798 (Final)
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    Journal Article Peng, C., Bind, M.-A., Colicino, E., Kloog, I., Byun, H.-M., Cantione, L., Trevisi, L.Z., J., Brennan, K., Dereix, A.E., Vokonas, P., Coull, B.A., Schwartz, J., and Baccarelli, A.A. (2016). Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals:Associations and E[pigenetic Mediation in the Normative Aging Study, 2000-2011. Environmental Health Perspectives http://dx.doi.org/10.1289/EHP183, 1-34. R834798 (Final)
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    Journal Article Peng C, Bind M-A, Colicino E, Kloog I, Byun H-M, Cantione L, Trevisi LZ, J., Brennan K, Dereix AE, Vokonas P, Coull BA, Schwartz J, Baccarelli AA. Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals:Associations and E[pigenetic Mediation in the Normative Aging Study, 2000-2011. Environmental Health Perspectives 2016; http://dx.doi.org/10.1289/EHP183:1-34. R834798 (2016)
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    Journal Article Zhong, J., Cayir, A., Trevis, L., Sanchez-Guerra, M., Peng, L.X., Bind, M.A., Prada, D., Laue, H., Brennan, K.J.D., A., Sparrow, D., Vokonas, P., Schwartz, J., and. R834798C002 (Final)
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    Journal Article Antonelli, J., Cefalu, M., and Bornn, L. (2016). The Positive Effects of Population-based Preferential Sampling in Environmental Epidemiology. Biostatistics 17, 764-778. R834798 (Final)
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    Journal Article Zhong, J., Colicino, E., Lin, X., Mehta, A., Kloog, I., Zanobetti, A., Byun, H.M., Bind, M.A., Cantone, L., Prada, D., Tarantini, L., Trevisi, L., Sparrow, D., Vokonas, P.,. R834798C002 (Final)
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    Journal Article Rodosthenous, S., Coull, B.A., Lu, Q., Vokonas, P.S., Schwartz, J.D., and Baccarelli, A.A. (2016). Ambient Particulate Matter and MicroRNAs in Extracellular Vesicles:a Pilot Study of Older Individuals. Particle and Fibre Toxicology 13, 1-13. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Zanobetti, A., Coull, B., Kloog, I., Sparrow, D., Vokonas, P., Gold, D.R., and Schwartz, J. (2017). Fine-Scale Spatial and Temporal Variaton in Temperature and Arrhythmia Episodes in the VA Normative Aging Study. Journal of the Air and Waste Management Association 67, 96-104. R834798 (Final)
    R834798C002 (Final)
    R834798C004 (Final)
    R834798C005 (Final)
    R835872 (2016)
    not available
    Journal Article Mordukhovich, I., Coull, B.A., Kloog, I., Koutrakis, P., Vokonas, P., and Schwartz, J. (2015). Exposure to Sub-Chronic and Long-t4erm Particulate Air Pollution and Heart Rate Variability in an Elderly Cohort:the Normative Aging Study. Environmental Health 14, 1-10. R834798C002 (Final)
    R834798C005 (Final)
    not available
    Journal Article Rodosthenous, S., Coull, B.A., Lu, Q., Vokonas, P.S., Schwartz, J.D., and Baccarelli, A.A. (2016). Ambient Particulate Matter and MicroRNAs in Extracellular Vesicles:a Pilot Study of Older Individuals. Particle and Fibre Toxicology 13, 1-13. R834798 (Final)
    R834798C002 (Final)
    not available
    Journal Article Li, W., Dorans, K.S., Wilker, E.H., Rice, M.B., Long, M.T., Schwartz, J., Coull, B.A., Koutrakis, P., Gold, D.G., Fox, C.S., and Mittleman, M.A. (2017). Residential Proximity to Major Roadways, Fine Particulate Matter, and Hepatic Steatosis:The Framingham Heart Study. American Journal of Epidemiology DOI:10.1093/aje/kwx127 1-28. R834798 (Final)
    R834798C004 (Final)
    not available
    Journal Article Li, W., Dorans, K.S., Wilker, E.H., Rice, M.B., Schwartz, J., Coull, B.A., Koutrakis, P., Gold, D.R., Fox, C.S., and Mittleman, M.A. (2016). Residential Proximity to Major Roadways, Fine Particulate Matter, and Adiposity:The Framingham Heart Study. Obesity 24, 2593-2599. R834798 (Final)
    not available
    Journal Article Li, W., Dorans, K.S., Wilker, E.H., Rice, M.B., Long, M.T., Schwartz, J., Coull, B.A., Koutrakis, P., Gold, D.G., Fox, C.S., and Mittleman, M.A. (2017). Residential Proximity to Major Roadways, Fine Particulate Matter, and Hepatic Steatosis:The Framingham Heart Study. American Journal of Epidemiology DOI:10.1093/aje/kwx127 1-28. R834798 (Final)
    R834798C004 (Final)
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    Journal Article MacNaughton, P., Eitland, E., Kloog, I., Schwartz, J., and Allen, J. (2017). Impact of Particulate Matter Exposure and Surrounding “Greenness” on Chronic Absenteeism in Massachusetts Public Schools. International Journal of Environmental Research and Public Health 14, 207. R834798 (Final)
    R835872 (2016)
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    Journal Article Wang, Y., Eliot, M.N., Koutrakis, P., Gryparis, A., Schwartz, J.D., Coull, B.A., Mittleman, M.A., Milberg, W.P., Lipsitz, L.A., and Wellenius, G.A. (2014). Ambient Air Pollution and Depressive Symptoms in Older Adults:Results from the MOBILIZE Boston Study. Environmental Health Perspectives 122, 553 – 558. R834798C003 (Final)
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    Journal Article Wang, Y., Eliot, M.N., Kuchel, G.A., Schwartz, J., Coull, B.A., Mittleman, M.A., Lipsitz, L.A., and Wellenius, G.A. (2014). Long-Term Exposure to Ambient Air Pollution and. R834798C003 (Final)
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    Journal Article Masri, S., Gariepy, J., Coull, B., and Koutrakis, P. (2016). A Novel Calibration Approach Using Satellite and Visibility Observations to Estimate PM2.5 Exposures in Southwest Asia and Afghanistan. Journal of the Air and Waste Management Association 67, 86-95. R834798 (Final)
    R835872 (2016)
    not available
    Journal Article Masri, S., Garshick, E., Hart, J., Bouhamra, W., and Koutrakis, P. (2017). Use of Visual Range Measurements to Predict PM2.5 Exposures in Southwest Asia and Afghanistan. Journal of the Air and Waste Management Association 67, 75-85. R834798 (Final)
    R835872 (2016)
    not available
    Journal Article Colicino, E., Giuliano, G., Power, M.C., Lepeule, J., Wilker, E.H., Vokonas, P., Brennan, K.J.M., Fossati, S., Hoxha, M., Spiro, A., Weisskopf, M.G., Schwartz, J., and Baccarelli, A.A. (2016). Long-term Exposure to Black Carbon, Cognition and Single Nucleotide Polymorphisms in MicroRNA Processing Genes in Older Men. Environment International 88, 86-93. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Wang, Y., H. Montas P.T. Leisnham, K. Brubaker, A. Shirmohammadi, V. Chanse, A. Rockler. 2017. A diagnostic decision support system for BMP selection in a small urban watershed. Water Resources Management 31(5):1649-1664. R834798C005 (Final)
    R835284 (Final)
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    Journal Article Zhong, J., Karlsson, O., Wang, G., Li, J., Guo, Y., Lin, X., Zemplenyi, M., Sanchez-Guerra, M., Trevisi, L., Urch, B., Speck, M., Liang, L., Coull, B.A., Koutrakis, P., Silverman, F., Gold, D.R., Wu, T., and Baccarelli, A.A. (2017). B Vitamins Attenuate the Epigenetic Effects of Ambient Fine Particles in a Pilot Human Intervention Trial. Proceedings of the National Academy of Sciences 114, 3503-3508. R834798 (Final)
    R834798C004 (Final)
    not available
    Journal Article Mordukhovich, I., Kloog, I., Coull, B., Koutrakis, P., Vokonas, P., and Schwartz, J. (2016). Association Between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort. Epidemiology 27, 284-290. R834798 (Final)
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    Journal Article Shi, L., Kloog, I., Zanobetti, A., Liu, P., and Schwartz, J. (2015). Impacts of Temperature and its Variability on Mortality in New England. Nature Climate Change 5, 1-6. R834798C002 (Final)
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    Journal Article Dai, L., Kloog, I., Coull, B.A., Sparrow, D., Spiro, A.I., Vokonas, P.S., and Schwartz, J.D. (2016). Cognitive Function and Short-term Exposure to Residential Air Temperature:A repeated Measure Study Based on Spatiotemporal Estimates of Temperature. Environmental Research 150, 446-451. R834798 (Final)
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    Journal Article Lee, M., Kloog, I., Chudnovsky, A., Lyapustin, A., Wang, Y., Melly, S., Coull, B., Koutrakis, P., and Schwartz, J. (2015). Spatiotemporal Prediction of Fine Particulate Matter using High-resolution Satellite Images in the Southeastern US 2003-2011. J Expos Sci Environ Epidemiol, 1-8. R834798C002 (Final)
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    Journal Article Wang, Y., Kloog, I., Coull, B., Kosheleva, A., Zanobetti, A., and Schwartz, J. (2016). Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey. Environmental Health Perspectives, 1-38. R834798C005 (Final)
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    Journal Article Wang, Y., Kloog, I., Coull, B., Kosheleva, A., Zanobetti, A., and Schwartz, J. (2016). Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey. Environmental Health Perspectives, 1-38. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Phipatanakul, W., Kourakis, P., Coull, B., Kang, C.-M., Wolfson, J.M., Ferguson, S., Petty, C.R., Samnaliev, M., Cunningham, A., Sheehan, W.J., Gaffin, J.M., Baxi, S.N., Lai, P.S., Permaul, P., Liang, L., Thorne, P.S., Adamkiewicz, G., Brennan, K.J., Baccarelli, A., and Gold, D.R. (2017). The School Inner-City Asthma Intervention Study:Design, Rationale, Methods, and Lessons Learned. Contemporary Clinical Trials 60, 14-23. R834798 (Final)
    R835872 (2016)
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    Journal Article Chudnovsky, A., Kourakis, P., Kostinski, A., Proctor, S., and Garshick, E. (2017). Spatial and Temporal Variability in Desert Dust and Anthropogenic Pollution in Iraq 1997-2010. Journal of the Air and Waste Management Association 1, 17-26. R834798 (Final)
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    Journal Article Schwartz JB, M-A., Koutrakis P. Estimating Causal Effects of Local Air Pollution on Daily Deaths:Effect of Low Levels. Environmental Health Perspectives 2016; http://dx.doi.org/10.1289/EHP232:1-30. R834798 (2016)
    R834798 (Final)
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    Journal Article Di, Q., Koutrakis, P., Lyapustin, A., Wang, Y., and Schwartz, J. (2016). Assessing PM2.5 Exposures with High Spatio-Temporal Resolution across the Continental United States. Environmental Science & Technology DOI:10.1021/acs.est.5b06121, 1-35. R834798C002 (Final)
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    Journal Article Dai, L., Koutrakis, P., Coull, B.A., Sparrow, D., Vokonas, P.S., and Schwartz, J. (2015). Use of the Adaptive LASSO method to Identify PM2.5 components Associated with Blood Pressure in Elderly Men:Veterans Affairs Normative Aging Study. Environmental Health Perspectives 121, 120-125. R834798C002 (Final)
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    Journal Article Mehta, A., Kubzansky, L., Coull, B., Kloog, I., Koutrakis, P., Sparrow, D., Spiro, A., Vokonas, P., and Schwartz, J. (2015). Associations Between Air Pollution and Perceived Stress:the Veterans Administration Normative Aging Study. Environmental Health 14, 10. R834798C002 (Final)
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    Journal Article Conti, S., Lafranconi, A., Zanobetti, A., Fornari, C., Madotto, F., Schwartz, J., and Cesana, G. (2015). Cardiorespiratory Treatments as Modifiers of the Relationship between Particulate Matter and Health:A Case-Only Analysis on Hospitalized Patients in Italy. Environmental Research 136, 491-499. R834798C005 (Final)
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    Journal Article Mordukhovich, I., Lepeule, J., Coull, B.A., Sparrow, D., Vokonas, P., and Schwartz, J. (2015). The Effect of Oxidative Stress Polymorphisms on the Association between Long-term Black Carbon Exposure and Lung Function among Elderly Men. Thorax 70, 133-137. R834798C002 (Final)
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    Journal Article Lepeule, J., Litonjua, A.A., Coull, B., Koutrakis, P., Sparrow, D., Vokonas, P.S., and Schwartz, J. (2014). Long-Term Effects of Traffic Particles on Lung Function Decline in the Elderly. American Journal of Respiratory and Critical Care Medicine 190, 542-548. R834798C002 (Final)
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    Journal Article Shi, L., Liu, P., Wang, Y., Zanobetti, A., Kosheleva, A., Koutrakis, P., and Schwartz, J. (2016). Chronic Effects of Temperature on Mortality in the Southeastern USA Using Satellite-based Exposure Metrics. Scientific Reports 6, 30161. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Shi, L., Liu, P., Kloog, I., Lee, M., Kosheleva, A., and Schwartz, J. (2016). Estimating Daily Air Temperature Across the Southeastern United States Using High-Resolution Satellite Data:A Statistical Modeling Study. Environmental Research 146, 51-58. R834798 (Final)
    R834798C002 (Final)
    R834798C005 (Final)
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    Journal Article Shi, L., Liu, P., Wang, Y., Zanobetti, A., Kosheleva, A., Koutrakis, P., and Schwartz, J. (2016). Chronic Effects of Temperature on Mortality in the Southeastern USA Using Satellite-based Exposure Metrics. Scientific Reports 6, 30161. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Peng, C., Luttmann-Gibson, H., Zanobetti, A., Cohen, A., De Souza, C., Coull, B.A., Horton, E.S., Schwartz, J., Koutrakis, P., and Gold, D.R. (2016). Air pollution Influences on Exhaled Nitric Oxide among People with Type II Diabetes. Air Quality, Atmosphere & Health 9, 265-273. R834798 (Final)
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    Journal Article Fleisch, A., Luttmann-Gibson, H., Perng, W., Rifas-Shiman, S., Coull, B.A., Kloog, I., Koutrakis, P., Schwartz, J., Zanobetti, A., Mantzoros, C., Gillman, M., Gold, D.R., and Oken, E. (2017). Prenatal and Early Life Exposure to Traffic Pollution and Cardiometabolic Health in Childhood. Pediatric Obesity 12, 48-57. R834798 (Final)
    R834798C004 (Final)
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    Journal Article Panni, T., Mehta, A.J., Schwartz, J.D., Baccarelli, A.A., Just, A.C., Wolf, K.r., Wahl, S., Cyrys, J., Kunze, s.S., K. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Madrigano, J., Mittleman, M., Baccarelli, A., Goldberg, R., Melly, S.J., Von Klot, S., and Schwartz, J. (2013). Temperature, Myocardial Infarction, and Mortality Effect Modification by Individual-and Area-level Characteristics. Epidemiology 24, 439-446. R834798C002 (Final)
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    Journal Article Waldenberger, M., Peters A. A Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations:KORA F3, KORA F4, and the Normative Aging Study. Environmental Health Perspectives 2016; http://dx.doi.org/10.1289/3hp.1509966:1-32. R834798 (2016)
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    Journal Article Mostofsky, E., Schwartz, J., Coull, B., Koutrakis, P., Wellenius, G.A., Suh, H.H., Gold, D.R., and Mittleman, M.A. (2012). Modeling the Association between Particle Constituents of Air Pollution and Health Outcomes. American Journal of Epidemiology 176, 317 – 326. R834798C002 (Final)
    R834798C003 (Final)
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    Journal Article Wang, Y., Shi, L., Zanobetti, A., and Schwartz, J.D. (2016). Estimating and Projecting the Effect of Cold Waves on Mortality in 209 US Cities. Environment International 94, 141-149. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Zhong J, Cayir A, Trevis L, Sanchez-Guerra M, Peng LX, Bind MA, Prada D, Laue H, Brennan KJD, A., Sparrow D, Vokonas P, Schwartz J, Baccarelli AA. Traffic Related Air Pollution, Blood Pressure, and Adaptive Response of Mitochondrial Abundance. Circulation 2015; CIRCULATIONAHA.115.018802. R834798 (2016)
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    Journal Article Mannshardt, E., Sucic, K., Jiao, W., Dominici, F., Frey, C.H., Reich, B., and Fuentes, M. (2013). Comparing Exposure Metrics for the Effects of Fine Particulate Matter on Emergency Hospital Admissions. Journal of Exposure Science and Environmental Epidemiology 23, 627–636. R834798C005 (Final)
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    Journal Article Zhong, J., Trevisi, L., Urch, B., Lin, X., Speck, M., Coull, B.A., Liss, G., Thompson, A., Wu, S., Wilson, A., Koutrakis, P., Silverman, F., Gold, D.G., and Baccarelli, A. (2017). B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation:A Pilot Human Intervention Trial. Scientific Reports DOI:10.1038/srep45322, 1-9. R834798 (Final)
    R834798C004 (Final)
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    Journal Article Chung, M., Wang, D.D., Rizzo, A.M., Gachette, D., Delnord, M., Parambi, R., Kang, C.-M., and Brugge, D. (2015). Association of PNC, BC, and PM2.5 Measured at a Central Monitoring Site with Blood Pressure in a Predominantly Near Highway Population. International Journal of Environmental Research and Public Health 12, 2765-2780. R834798C005 (Final)
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    Journal Article Dominici, F., Wang, Y., Correia, A.W., Ezzati, M., Pope, C.A.I., and Dockery, D.W. (2015). Chemical Composition of Fine Particulate Matter and Life Expectancy in 95 US Counties Between 2002 and 2007. Epidemiology 26, 556-564. R834798 (Final)
    R834798C005 (Final)
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    Journal Article Di, Q., Wang, Y., Zanobetti, A., Wang, Y., Kourakis, P., Choirat, C., Dominici, F., and Schwartz, J.D. (2017). Air Pollution and Mortality in the Medicare Population. New England Journal of Medicine 376, 2513-2522. R834798C002 (Final)
    R835872 (2016)
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    Journal Article Dominici, F., Wang, Y., Correia, A.W., Ezzati, M., Pope, C.A.I., and Dockery, D.W. (2015). Chemical Composition of Fine Particulate Matter and Life Expectancy in 95 US Counties Between 2002 and 2007. Epidemiology 26, 556-564. R834798 (Final)
    R834798C005 (Final)
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    Journal Article Li, W., Wilker, E.H., Dorans, K., Rice, M.B., Schwartz, J., Coull, B., Koutrakis, P., Gold, D.R., Keaney, J.F.J., Lin, H., Vasan, R., Benjamin, E.J., and Mittleman, M.A. (2016). Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress:The Framingham Heart Study. JournAL Of the American Heart Association DOI:10.1161/JAHA.115.002742, 1-8. R834798 (Final)
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    Journal Article Colicino, E., Wilson, A., Frisardi, M.C., Prada, D., Power, M.C., Hoxha, M., Doni, L., Spiro, A.I., Vokonas, P.S., Weisskopf, M.G., Schwartz, J., and Baccarelli, A. (2017). Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men:The VA Normative Aging Study. Environmental Health Perspectives 125, 76-81. R834798 (Final)
    R835872 (2016)
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    Journal Article Ierodiakonou, D., Zanobetti, A., Coull, B., Melly, S., Postma, D.S., Boezen, H.M., Vonk, J.M., Williams, P.V., Shapiro, G.G., McKone, E.F., Hallstrand, T.S., Koenig, J.Q., Schildcrout, J.S., Lumley, T., Fuhlbrigge, A.N., Koutrakis, P., Schwartz, J., Weiss, S.T., and Gold, D.R. (2016). Ambient Air Pollution, Lung Function, and Airway Responsiveness in Asthmatic Children. Journal of Allergy and Clinical Immunology 137, 390-399. R834798C005 (Final)
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    Journal Article Kloog, I., Zanobetti, A., Nordio, F., Coull, B., Baccarelli, A., and Schwartz, J. (2015). Effects of Airborne Fine Particles (PM2.5) on Deep Vein Thrombosis Admissions in the Northeastern United States. Journal of Thrombosis and AHaemostasis 13, 768-774. R834798C002 (Final)
    R834798C005 (Final)
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    Journal Article Shi, L., Zanobetti, A., Kloog, I., Coull, B.A., Koutrakis, P., Melly, S.J., and Schwartz, J. (2015). Low-Concentration PM2.5 and Mortality:Estimating Acute and Chronic Effects in a Population-Based Study. Environmental Health Perspectives 124, 46-52. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Schwartz, J., and Baccarelli, A.A. (2015). Cardiac Autonomic Dysfunction:Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake. Journal of the American Heart Association 4. R834798C002 (Final)
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    Journal Article Dominici, F., and Mittleman, M. (2012). China's Dilemma:Reconciling Economic Growth with Environmental Protection. Journal of the American Medical Association 307, 2100-2012. R834798C005 (Final)
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    Journal Article Waldenberger, M., and Peters, A. (2016). A Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations:KORA F3, KORA F4, and the Normative Aging Study. Environmental Health Perspectives http://dx.doi.org/10.1289/3hp.1509966, 1-32. R834798 (Final)
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    Journal Article Bind, M.-A., Peters, A., Koutrakis, P., Coull, B., Vokonas, P., and Schwartz, J. (2016). Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives http://doi.org/10.1289/ehp.1510044, 1-34. R834798 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Schwartz, J., James, P., Dominici, F., and Zanobetti, A. (2016). PM2.5 and Mortality in 207 US Cities:Modification by Temperature and City Characteristics. Epidemiology 27, 221-227. R834798 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Austin, E., Koutrakis, P., Dominici, F.S., J. D., and Zanobetti, A. (2015). PM2.5 and Survival Among Older Adults Effect Modification by Particulate Composition. Epidemiology 26, 321-327. R834798C005 (Final)
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    Journal Article Kioumourtzoglou, M.-A., Schwartz, J., Weisskopf, M.G., Melly, S., Wang, Y., Dominici, F., and Zanobetti, A. (2015). Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States. Environmental Health Perspectives 124, 23-29. R834798C005 (Final)
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    Journal Article Bind, M.-A., Peters, A., Koutrakis, P., Coull, B., Vokonas, P., and Schwartz, J. (2016). Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives http://doi.org/10.1289/ehp.1510044, 1-34. R834798 (Final)
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    R834798C005 (Final)
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    Journal Article Lee, W.-C., Shen, L., Catalano, P.J., Mickley, L.J., and Koutrakis, P. (2017). Effects of Future Temperature Change on PM2.5 Infiltration in the Greater Boston Area. Atmospheric Environment 150, 98-105. R834798 (Final)
    R835437 (2016)
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    Journal Article Lee, M.-S., LeBouf, R.F., Son, Y.-S., Koutrakis, P., and Christiani, D.C. (2017). Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco-and menthol-flavored e-cigarettes. Environmental Health 16, 42. R834798 (Final)
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    Journal Article Panni T, Mehta AJ, Schwartz JD, Baccarelli AA, Just AC, Wolf Kr, Wahl S, Cyrys J, Kunze sS, K. R834798 (2016)
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    Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Belfort MB, Webster TF,. R834798C004 (Final)
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    Journal Article Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men:the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241; Erratum:http://dx.doi.org/10.1289/EHP1813. R834798C002 (Final)
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    Journal Article Réquia Júnior WJ, Roig HL, Koutrakis P. A novel land use approach for assessment of human health:The relationship between urban structure types and cardiorespiratory disease risk. Environment International 2015; 85:334-342. R834798 (2016)
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    Journal Article Baccarelli, A.A. (2015). Traffic Related Air Pollution, Blood Pressure, and Adaptive Response of Mitochondrial Abundance. Circulation CIRCULATIONAHA.115.018802. R834798C002 (Final)
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    Journal Article Wellenius, G.A., Boyle, L.D., Coull, B.A., Milberg, W.P., Gryparis, A., Schwartz, J., Mittleman, M.A., and Lipsitz, L.A. (2012a). Residential Proximity to Nearest Major Roadway and Cognitive Function in Community-Dwelling Seniors:Results from the MOBILIZE Boston Study. Journal of the American Geriatric Society 60, 2075–2080. R834798C003 (Final)
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    Journal Article Wellenius, G.A., Wilhelm-Benartzi, C.S., Wilker, E.H., Coull, B.A., Suh, H.H., Koutrakis, P., and Lipsitz, L.A. (2012c). Ambient Particulate Matter and the Response to Orthostatic Challenge in the Elderly:The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston Study. Hypertension 59, 558-563. R834798C003 (Final)
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    Journal Article Baccarelli, A.A. (2016). Long-term Exposure to Black Carbon, Cognition and Single Nucleotide Polymorphisms in MicroRNA Processing Genes in Older Men. Environment International 88, 86-93. R834798C002 (Final)
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    Journal Article Fleisch AF, Kloog I, Luttmann-Gibson H, Gold DR, Oken E, Schwartz JD. Air Pollution Exposure and Gestational Diabetes Mellitus Among Pregnant Women in Massachusetts:a Cohort Study. Environmental Health 2016; 15:1-9. R834798 (2016)
    R834798C004 (Final)
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    Journal Article Peng C, Luttmann-Gibson H, Zanobetti A, Cohen A, De Souza C, Coull BA, Horton ES, Schwartz J, Koutrakis P, Gold DR. Air pollution influences on exhaled nitric oxide among people with type 2 diabetes. Air Quality, Atmosphere and Health. http://link.springer.com/article/10.1007%2Fs11869-015-0336-5Mar 26, 2015. R834798C004 (Final)
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    Journal Article Ljungman PL, Mittleman MA. Ambient air pollution and stroke. Stroke. 2014b;45:3734-3741. R834798C003 (Final)
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    Journal Article Mordukhovich I, Coull BA, Kloog I, Koutrakis P, Vokonas P, Schwartz J. Association between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort. Epidemiol, 2016 Mar;27(2):284-90. doi:10.1097/EDE.0000000000000424. R834798C002 (Final)
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    Journal Article McGuinn LA, Ward-Caviness CK, Neas LM, Schneider A, Diaz-Sanchez D, Cascio WE, Kraus WE, Hauser E, Dowdy E, Haynes C, Chudnovsky A, Koutrakis P, Devlin RB. Association between Satellite-based Estimates of Long-term PM2.5 Exposure and Coronary Artery Disease. Environmental Research 2016; 145:9-17. R834798 (2016)
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    Journal Article Rice, M.B., Li, W., Wilker, E.H., Gold, D.R., Schwartz, J., Kourakis, P., Washko, G., O'Connor, G.T., and Mittleman, M.A. (2017). Extreme Temperatures and Lung Function in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 195. R834798 (Final)
    R834798C004 (Final)
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    Journal Article Schwartz, J.B., M-A., and Koutrakis, P. (2016). Estimating Causal Effects of Local Air Pollution on Daily Deaths:Effect of Low Levels. Environmental Health Perspectives http://dx.doi.org/10.1289/EHP232, 1-30. R834798 (Final)
    R834798C002 (Final)
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    Journal Article Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. R834798C003 (Final)
    R834514C004 (Final)
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    Journal Article Rice, M.B., Li, W., Wilker, E.H., Gold, D.R., Schwartz, J., Kourakis, P., Washko, G., O'Connor, G.T., and Mittleman, M.A. (2017). Extreme Temperatures and Lung Function in the Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 195. R834798 (Final)
    R834798C004 (Final)
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    Journal Article Dai L, Kloog I, Coull BA, Sparrow D, Spiro A, Vokonas PS, Schwartz JD. Cognitive function and short-term exposure to residential air temperature:A repeated measures study based on spatiotemporal estimates of temperature. Environmental Research 2016:150, 446-451. R834798C002 (Final)
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    Journal Article Zhong J, Urch B, Speck M, Coull BA, Koutrakis P, Thorne PS, Scott J, Liu L, Brook Rd, Behbod B, Gibson H, Silverman F, Mittlemanm MA, Baccarelli AA. Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures Hypertension 2015; 66:509-516. R834798 (2016)
    R834798C004 (Final)
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    Journal Article Shi L, Liu P, Kloog I, Lee M, Kosheleva A, Schwartz J. Estimating Daily Air Temperature Across the Southeastern United States Using High-Resolution Satellite Data:A Statistical Modeling Study. Environmental Research 2016; 146:51-58. R834798 (2016)
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    Journal Article Wang Y, Shi L, Zanobetti A, Schwartz JD. Estimating and Projecting the Effect of Cold Waves on Mortality in 209 US Cities. Environment International 2016; 94:141-149. R834798 (2016)
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    Journal Article Fleisch, A.F., Kloog, I., Luttmann-Gibson, H., Gold, D.R., Oken, E., and Schwartz, J.D. (2016). Air Pollution Exposure and Gestational Diabetes Mellitus Among Pregnant Women in Massachusetts:a Cohort Study. Environmental Health 15, 1-9. R834798 (Final)
    R834798C005 (Final)
    R835437 (2016)
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    Journal Article Dai L, Bind M-A, Koutrakis P, Coull BA, Sparrow D, Vokonas PS, Schwartz JD. Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction:Analysis on particulate species and sources. J Expos Sci Environ Epidemiol 2016. R834798 (2016)
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    Journal Article Wilker EH, Martinez-Ramirez S, Kloog I, et al. Fine particulate matter, residential proximity to major roads, and markers of small vessel disease in a memory study population. J Alzheimers Dis. 2016;53:1315-1323. R834798C003 (Final)
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    Journal Article Lee, M.H., Koutrakis, P., Coull, B.A., Kloog, I., and Schwartz, J. (2015). Acute Effects of Fine Particulate Matter on Mortality in Three Southeastern States from 2007-2011. Journal of Exposure Science and Environmental Epidemiology, 1-7. R834798C002 (Final)
    R834798C005 (Final)
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    Journal Article Tang, C.H., Kourakis, P., Schwartz, J., Coull, B.A., and Di, Q. (2017). Trends and Spatial Patterns of Fine Resolution AOD-Derived PM2.5 Emissions in Northeast United States from 2002 to 2013. Journal of the Air and Waste Management Association http://dx.doi.org/10.1080/10962247.2016.1218393, 64-74. R834798 (Final)
    R835872 (2016)
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    Journal Article Tang, C.H., Coull, B.A., Schwartz, J., Lyapustin, A., Di, Q., and Koutrakis, P. (2017). Developing Particle Emission Inventories Using Remote Sensing (PEIRS). Journal of the Air and Waste Management Association http://dx.doi.org/10.1080/10962247.2016.1214630, 53-63. R834798 (Final)
    R835872 (2016)
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    Journal Article Wilker, E.H., Martinez-Ramirez, S., Kloog, I., Schwartz, J., Mostofsky, E., Kourakis, P., Mittleman, M.A., and Viswanathan, A. (2016). Fine Particulate Matter, Residential Proximity to Major Roads, and Markers of Small Vessel Disease in a Memory Study Population. Journal of Alzheimer's Disease 53, 1315-1323. R834798 (Final)
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    Journal Article Wilker, E.H., Yeh, G., Wellenius, G.A., Davis, R.B., Phillips, R.S., and Mittleman, M.A. (2012). Ambient Temperature and Biomarkers of Heart Failure:A Repeated Measures Analysis. Environmental Health Perspectives 120, 1083 – 1087. R834798C003 (Final)
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    Journal Article Wilker, E.H., Preis, S.R., Beiser, A.S., Wolf, P.A., Au, R., Kloog, I., Li, W., Schwartz, J., Koutrakis, P., DeCarli, C., Seshadri, S., and Mittleman, M.A. (2015). Long-Term Exposure to Fine Particulate Matter, Residential Proximity to Major Roads and Measures of Brain Structure. Stroke 46, 1161-1166. R834798C002 (Final)
    not available
    Journal Article Lee, M.H., Koutrakis, P., Coull, B.A., Kloog, I., and Schwartz, J. (2015). Acute Effects of Fine Particulate Matter on Mortality in Three Southeastern States from 2007-2011. Journal of Exposure Science and Environmental Epidemiology, 1-7. R834798C002 (Final)
    R834798C005 (Final)
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    Journal Article Raimundo RD, Godleski JJ. Heart rate variability in metabolic syndrome. Journal of Human Growth and Development. 2015; 25(1):7-10. R834798C001 (Final)
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    Journal Article Carll AP, Crespo SM, Silva MF, Zati DH, Coull BA, Raimundo R, Jaeger T, Ricci-Vitor AL, Papapostolou V, Lawrence JM, Garner DM, Diaz EA, Perry B, Harkema JA, Godleski JJ. Inhaled Ambient-Level Traffic-Derived Particulates Decrease Cardiac Vagal Regulation and Baroreflexes and Increase Arrhythmia in a Rat Model of Metabolic Syndrome. Particle and Fiber Toxicology, 2017 14:16 DOI 10.1186/s12989-017-0196-. R834798 (2016)
    R834798C001 (Final)
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    Journal Article Requia, W.J., Roig, H.L., Koutrakis, P., and Adams, M.D. (2017). Modeling Spatial Patterns of Traffic Emissions across 5570 Municipal Districts in Brazil. Journal of Cleaner Production 148, 845-853. R834798 (Final)
    R835872 (2016)
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    Journal Article Mehta, A.J., Zanobetti, A., Bind, M.A., Kloog, I., Kourakis, P.S., D., Vokonas, P., and Schwartz, J. (2016). Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men:The Veterans Administration Normative Aging Study. Environmental Health Perspectives 124, 1353-1360. R834798 (Final)
    R834798C002 (Final)
    R834514C004 (Final)
    not available
    Journal Article Requia, W.J., Adams, M.D., and Koutrakis, P. (2017). Association of PM2.5 with Diabetes, Asthma, and High Blood Pressure Incidence in Canada:A Spatiotemporal Analysis of the Impacts of the Energy Generation and Fuel Sales. Science of The Total Environment 584–585, 1077-1083. R834798 (Final)
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    Journal Article Réquia, W.J., Koutrakis, P., Roig, H.L., and Adams, M.D. (2016). Spatiotemporal Analysis of Traffic Emissions in over 5000 Municipal Districts in Brazil. Journal of the Air & Waste Management Association 66, 1284-1293. R834798 (Final)
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    Journal Article Requia, W.J., Roig, H.L., Adams, M.D., Zanobetti, A., and Kourakis, P. (2016). Mapping Distance-Decay of Cardiorespiratory Disease Risk Related to Neighborhood Environments. Environmental Research 151, 203-215. R834798 (Final)
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    Journal Article Requia, W.J., Adams, M.D., Afrain, A., Koutrakis, P., and Ferguson, M. (2017). Carbon Dioxide Emissions of Plug-in Hybrid Electric Vehicles:A Life-cycle Analysis in Eight Canadian Cities. Renewable and Sustainable Energy Reviews 78, 1390-1396. R834798 (Final)
    R835872 (2016)
    R835872C005 (2016)
    not available
    Journal Article Requia, W.J., Koutrakis, P., Roig, H.L., Adams, M.D., and Santos, C.M. (2016). Association Between Vehicular Emissions and Cardiorespiratory Disease Rsk in Brazil and its Variation by Spatial Clustering of Socio-economic Factors. Environmental Research 150, 452-460. R834798 (Final)
    not available
    Journal Article Requia, W.J., Dalumpines, R., Adams, M.D., Arain, A., Ferguson, M., and Koutrakis, P. (2017). Modeling Spatial Patterns of Link-based PM2.5 Emissions and Subsequent Human Exposure in a Large Canadian Metropolitan Area. Atmospheric Environment 158, 172-180. R834798 (Final)
    R835872 (2016)
    not available
    Journal Article Requia, W.J., Roig, H.L., Koutrakis, P., and S., R.M. (2016). Mapping Alternatives for Public Policy Decision Making Related to Human Exposures from Air Pollution Sources in the Federal District. Land Use Policy 59, 375-385. R834798 (Final)
    not available
    Journal Article Serum Leptin in Older Adults:Results from the MOBILIZE Boston Study. Journal of Occupational and Environmental Medicine 56, e73-e77. R834798C003 (Final)
    not available
    Journal Article Bell, M.L., Son, J.-Y., Peng, R.D., Wang, Y., and Dominici, F. (2015). Ambient PM2.5 and Risk of Hospital Admissions Do Risks Differ for Men and Women? Epidemiology 26, 575-579. R834798 (Final)
    R834798C005 (Final)
    not available
    Journal Article Rice MB, Ljungman PL, Wilker EH, et al. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham Heart Study. Am J Respir Crit Care Med. 2015;191:656-664. R834798C003 (Final)
    R834798C004 (Final)
    not available
    Journal Article 192. McGuinn, L.A., Ward-Caviness, C.K., Neas, L.M., Schneider, A., Diaz-Sanchez, D., Cascio, W.E., Kraus, W.E., Hauser, E., Dowdy, E., Haynes, C., Chudnovsky, A., Koutrakis, P., and Devlin, R.B. (2016). Association between Satellite-based Estimates of Long-term PM2.5 Exposure and Coronary Artery Disease. Environmental Research 145, 9-17. R834798 (Final)
    not available
    Journal Article Carll, A.P., Crespo, S.M., Filho, M.S., Zati, D.H., Coull, B.A., Diaz, E.A., Raimundo, R.D., Jaeger, T.N.G., Ricci-Vitor, A.L., Papapostolou, V., Lawrence, J.E., Garner, D.M., Perry, B.S., Harkema, J.R., and Godleski, J.J. (2017). Inhaled Ambient-level Traffic-derived Particulates Decrease Cardiac Vagal Influence and Baroreflexes and Increase Arrhythmia in a Rat Model of Metabolic Syndrome. Particle and Fibre Toxicology 14, 16. R834798 (Final)
    R834797C002 (Final)
    not available
    Journal Article Kioumourtzoglou M-A, Schwartz J, James P, Dominici F, Zanobetti A. PM2.5 and Mortality in 207 US Cities:Modification by Temperature and City Characteristics. Epidemiology 2016; 27:221-227. R834798 (2016)
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    Journal Article Fleisch A, Luttmann-Gibson H, Perng W, Rifas-Shiman S, Coull BA, Kloog I, Koutrakis P, Schwartz J, Zanobetti A, Mantzoros C, Gillman M, Gold DR, Oken E. Prenatal and Early Life Exposure to Traffic Pollution and Cardiometabolic Health in Childhood. Pediatric Obesity 2016; doi:10.1111/ijpo.12106:1-10. R834798 (2016)
    R834798C004 (Final)
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    Journal Article Harris MH, Gold DR, Rifas-Shiman SL, Melly SJ, Zanobetti A, Coull BA, Schwartz JD, Gryparis A, Kloog I, Koutrakis P, Bellinger DC, White RF, Sagiv SK, Oken E. Prenatal and childhood exposure to traffic-related pollution and childhood cognition. Environ Health Perspect. 2015. Apr 3. [Epub ahead of print]. PMID:25839914. R834798C004 (Final)
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    Journal Article van Rossem L, Melly S, Rifas-Shiman SL, Melly S, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull B, Schwartz J, Mittleman M, Oken E, Gillman M, Koutrakis P, Gold DR. Prenatal exposure to air pollution and newborn blood pressure. Environ Health Perspect. 2015. Apr;123(4):353-9. doi:10.1289/ehp.1307419. Epub 2015 Jan 27.PMID:25625652. R834798C004 (Final)
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    Journal Article Fleisch AF, Rifas-Shiman SL, Koutrakis P, Schwartz J , Kloog I, Melly S, Coull B, Zanobetti A, Gillman M, Gold DR, Oken E. Prenatal exposure to traffic pollution:associations with reduced fetal growth and rapid infant weight gain. Epidemiology. 2015 Jan;26(1):43-50. doi:10.1097/EDE.0000000000000203.PMID:25437317. R834798C004 (Final)
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    Journal Article Bind M-A, Peters A, Koutrakis P, Coull B, Vokonas P, Schwartz J. Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men:The Normative Aging Study. Environmental Health Perspectives 2016; http://doi.org/10.1289/ehp.1510044:1-34. R834798 (2016)
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    Journal Article Dorans KS, Wilker EH, Li W, et al. Residential proximity to major roads, exposure to fine particulate matter and aortic calcium:The Framingham Heart Study, a cohort study. BMJ open. 2017;7:e013455. R834798C003 (Final)
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    Journal Article Dorans KS, Wilker EH, Li W, et al. Residential proximity to major roads, exposure to fine particulate matter, and coronary artery calcium:The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2016. R834798C003 (Final)
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    Journal Article Li W, Dorans KS, Wilker EH, et al. Residential proximity to major roadways, fine particulate matter, and adiposity:The Framingham Heart Study. Obesity. 2016a;24:2593-2599. R834798C003 (Final)
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    Journal Article Li W, Dorans KS, Wilker EH, et al. Residential proximity to major roadways, fine particulate matter, and hepatic steatosis:The Framingham Heart Study. Am J Epidemiol. 2017. R834798C003 (Final)
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    Journal Article Dorans, K.S., Wilker, E.H., Li, W., Rice, M.B., Ljungman, P.L., Schwartz, J., Coull, B.A., Kloog, I., Koutrakis, P., D'Agostino, R.B., Massaro, J.M., Hoffmann, U., O'Donnell, J., and Mittleman, M.A. (2016). Residential Proximity to Major Roads, Exposure to Fine Particulate Matter and Aortic Calcium:the Framingham Heart Study, a Cohort Study. British Journal of Medicine 7. R834798 (Final)
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    Journal Article Schildcrout, J.S., Lumley, T., Fuhlbrigge, A.N., Koutrakis, P., Schwartz, J., Weiss, S.T., and Gold, D.R. (2016). Ambient Air Pollution, Lung Function, and Airway Responsiveness in Asthmatic Children. Journal of Allergy and Clinical Immunology 137, 390-399. R834798C005 (Final)
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    Journal Article Dorans, K.S., Wilker, E.H., Li, W., Rice, M.B., Ljungman, P.L., Schwartz, J., Coull, B.A., Kloog, I., Koutrakis, P., D'Agostino, R.B., Massari, J.M., Hoffmann, U., O'Donnell, J., and Mittleman, M.A. (2016). Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium. The Framingham Study. Arterioscler Thromb Vasc Biol DOI:10.1161/ATVBAHA.116.307141, 1679-1685. R834798 (Final)
    R835872 (2016)
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    Journal Article Li W, Wilker EH, Dorans K, Rice MB, Schwartz J, Coull B, Koutrakis P, Gold DR, Keaney JFJ, Lin H, Vasan R, Benjamin EJ, Mittleman MA. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress:The Framingham Heart Study. JournAL Of the American Heart Association 2016; DOI:10.1161/JAHA.115.002742:1-8. R834798 (2016)
    R834798C003 (Final)
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    Journal Article Ljungman PL, Wilker EH, Rice MB, Austin E, Schwartz J, Gold DR, Koutrakis P, Benjamin EJ, Vita JA, Mitchell GF, Vasan RS, Hamburg NM, Mittleman MA. The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function. Epidemiology 2016; 27:194-201. R834798 (2016)
    R834798C003 (Final)
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    Journal Article Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. R834798C005 (Final)
    R834514C004 (Final)
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    Supplemental Keywords:

    particles, air pollution mixtures, cognitive health, cardiovascular health, inflammation, air pollution, children, elderly,, Scientific Discipline, Air, air toxics, Environmental Chemistry, Health Risk Assessment, Air Pollution Effects, Biochemistry, Environmental Monitoring, Biology, ambient air quality, children's health, complex mixtures, health effects, particulates, sensitive populations, aerosol particles, air pollutants, biological sensitivities, exposure and effects, lung epithelial cells, susceptible populations, chemical composition, neurotoxicity, human exposure, toxicity, coronary artery disease, cardiopulmonary, cardiotoxicity, environmental effects, human health, mortality

    Progress and Final Reports:

    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    2014 Progress Report
    2015 Progress Report
    2016 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834798C001 Relative Toxicity of Air Pollution Mixtures
    R834798C002 Cognitive Decline, Cardiovascular Changes, and Biological Aging in Response to Air Pollution
    R834798C003 Identifying the Cognitive and Vascular Effects of Air Pollution Sources and Mixtures in the Framingharn Offspring and Third Generation Cohorts
    R834798C004 Longitudinal Effects of Multiple Pollutants on Child Growth, Blood Pressure and Cognition
    R834798C005 A National Study to Assess Susceptibility, Vulnerability, and Effect Modification of Air Pollution Health Risks