University of Washington Center for Clean Air Research (UW CCAR)

EPA Grant Number: R834796
Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: University of Washington Center for Clean Air Research (UW CCAR)
Investigators: Vedal, Sverre
Current Investigators: Vedal, Sverre , Campen, Matthew J. , Jobson, Thomas , Kaufman, Joel D. , Larson, Timothy V. , McDonald, Jacob D. , Rosenfeld, Michael , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Simpson, Christopher , Szpiro, Adam , VanReken, Timothy M. , Yost, Michael
Institution: University of Washington , Lovelace Respiratory Research Institute , University of New Mexico , Washington State University
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
Project Amount: $8,000,000
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The UW CCAR is focused on the cardiovascular health effects of near-roadway pollution, a complex mixture of particle, vapor and gas phase components that vary by vehicle emission source, road surface, extent of physical aging and the type and degree of atmospheric processing and photochemical reactions. This exposure scenario is not only known to be of considerable health importance, it also serves as a prototypical case for developing research approaches to dealing with multi-pollutant exposure-effect relationships. Our aim is to integrate exposure, epidemiological, toxicological, clinical, and statistical sciences to study cardiovascular hazards of fresh and aged roadway emissions and significantly advance our understanding of the components and reaction products that cause these effects.

Approach:

Investigators from four institutions are joining in a multi-disciplinary effort to study health effects of near-roadway pollution in line with current efforts to move from a single-pollutant to a multi-pollutant perspective. The Center consists of five highly-integrated research projects and two facility cores (including a Biostatistics Core) that together have the following six tasks: (1) to characterize real-world near-roadway pollutant concentrations, particle size distributions and chemical composition; (2) to simulate realistic contrasting near-roadway multi-pollutant exposure atmospheres for laboratory animal and human studies; (3) to identify cardiovascular and immunologic effects and the pathogenic mechanisms of near-roadway exposures using animal models; (4) to identify cardiovascular and immunologic effects of near-roadway exposures in human clinical studies; (5) to identify effects of long-term exposure to traffic-derived particles and gases on sub-clinical measures of cardiovascular disease and DNA methylation in a multi-ethnic population; and (6) to develop a statistical and methodological framework for studying health effects of multi-pollutant mixtures.

Expected Results:

The Center program of research addresses at least three of the research questions posed in the RFA: (1) pollutant health effects in a multi-pollutant context; (2) biological mechanisms underlying health effects; and (3) exposure-response relationships. Identifying the most hazardous components of near-roadway exposures will allow more focused, coordinated and effective air pollution health policy based on sound science to reduce health impacts of this multi-pollutant exposure.


Journal Articles: 75 Displayed | Download in RIS Format

Other center views: All 172 publications 76 publications in selected types All 75 journal articles
Type Citation Sub Project Document Sources
Journal Article Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV. Markers of inflammation and coagulation after long-term exposure to coarse particulate matter: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis. Environmental Health Perspectives 2015;123(6):541-548. R834796 (2014)
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  • Journal Article Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ. Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology 2016;16(2):163-171. R834796 (2015)
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  • Journal Article Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environmental Health Perspectives 2013;121(9):1017-1025. R834796 (2013)
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  • Journal Article Bergen S, Szpiro AA. Mitigating the impact of measurement error when using penalized regression to model exposure in two-stage air pollution epidemiology studies. Environmental and Ecological Statistics 2015;22(3):601-631. R834796 (2014)
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  • Journal Article Campen MJ, Lund A, Rosenfeld M. Mechanisms linking traffic-related air pollution and atherosclerosis. Current Opinion in Pulmonary Medicine 2012;18(2):155-160. R834796 (2012)
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  • Journal Article Campen M, Robertson S, Lund A, Lucero J, McDonald J. Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology 2014;26(6):353-360. R834796 (2014)
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  • Journal Article Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. Long-term air pollution exposure and blood pressure in the Sister Study. Environmental Health Perspectives 2015;123(10):951-958. R834796 (2015)
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  • Journal Article Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health 2016;15(1):119 (12 pp.). R834796 (2016)
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  • Journal Article Cosselman KE, Navas-Acien A, Kaufman JD. Environmental factors in cardiovascular disease. Nature Reviews Cardiology 2015;12(11):627-642. R834796 (2015)
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  • Journal Article Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Technology Discussions 2013;6:6005-6046. R834796 (2013)
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  • Journal Article Erickson MH, Gueneron M, Jobson BT. Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques 2014;7(1):225-239. R834796 (2014)
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  • Journal Article Fox JR, Cox DP, Drury BE, Gould TR, Kavanagh TJ, Paulsen MH, Sheppard L, Simpson CD, Stewart JA, Larson TV, Kaufman JD. Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions. Air Quality, Atmosphere & Health 2015;8(5):507-519. R834796 (2014)
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  • Journal Article Galaviz VE, Yost MG, Simpson CD, Camp JE, Paulsen MH, Elder JP, Hoffman L, Flores D, Quintana PJE. Traffic pollutant exposures experienced by pedestrians waiting to enter the U.S. at a major U.S.-Mexico border crossing. Atmospheric Environment 2014;88:362-369. R834796 (2014)
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  • Journal Article Gueneron M, Erickson MH, VanderSchelden GS, Jobson BT. PTR-MS fragmentation patterns of gasoline hydrocarbons. International Journal of Mass Spectrometry 2015;379:97-109. R834796 (2014)
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  • Journal Article Herring CL, Faiola CL, Massoli P, Sueper D, Erickson MH, McDonald JD, Simpson CD, Yost MG, Jobson BT, VanReken TM. New methodology for quantifying polycyclic aromatic hydrocarbons (PAHs) using high-resolution aerosol mass spectrometry. Aerosol Science and Technology 2015;49(11):1131-1148. R834796 (2015)
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  • Journal Article Hudda N, Gould T, Hartin K, Larson TV, Fruin SA. Emissions from an international airport increase particle number concentrations 4-fold at 10 km downwind. Environmental Science & Technology 2014;48(12):6628-6635. R834796 (2014)
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  • Journal Article Keller JP, Olives C, Kim S-Y, Sheppard L, Sampson PD, Szpiro AA, Oron AP, Lindstrom J, Vedal S, Kaufman JD. A unified spatiotemporal modeling approach for predicting concentrations of multiple air pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Environmental Health Perspectives 2015;123(4):301-309. R834796 (2014)
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  • Journal Article Keller JP, Chang HH, Strickland MJ, Szpiro AA. Measurement error correction for predicted spatiotemporal air pollution exposures. Epidemiology 2017;28(3):338-345. R834796 (2016)
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  • Journal Article Kim S-Y, Dutton SJ, Sheppard L, Hannigan MP, Miller SL, Milford JB, Peel JL, Vedal S. The short-term association of selected components of fine particulate matter and mortality in the Denver Aerosol Sources and Health (DASH) study. Environmental Health 2015;14:49. R834796 (2014)
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  • Journal Article Kim S-Y, Sheppard L, Bergen S, Szpiro AA, Sampson PD, Kaufman JD, Vedal S. Prediction of fine particulate matter chemical components with a spatio-temporal model for the Multi-Ethnic Study of Atherosclerosis cohort. Journal of Exposure Science & Environmental Epidemiology 2016;26(5):520-528. R834796 (2016)
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  • Journal Article Kim S-Y, Olives C, Sheppard L, Sampson PD, Larson TV, Kaufman JD. Historical prediction modeling approach for estimating long-term concentrations of PM2.5 in cohort studies before 1999 implementation of widespread monitoring. Environmental Health Perspectives 2017;125(1):38-46. R834796 (2016)
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  • Journal Article Kim S-Y, Sheppard L, Kaufman JD, Bergen S, Szpiro AA, Larson TV, Adar SD, Diez Roux AV, Polak JF, Vedal S. Individual-level concentrations of fine particulate matter chemical components and subclinical atherosclerosis: a cross-sectional analysis based on 2 advanced exposure prediction models in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2014;180(7):718-728. R834796 (2014)
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  • Journal Article Kim S-Y, Sheppard L, Larson TV, Kaufman JD, Vedal S. Combining PM2.5 component data from multiple sources: data consistency and characteristics relevant to epidemiological analyses of predicted long-term exposures. Environmental Health Perspectives 2015;123(7):651-658. R834796 (2014)
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  • Journal Article Kioumourtzoglou MA, Spiegelman D, Szpiro AA, Sheppard L, Kaufman JD, Yanosky JD, Williams R, Laden F, Hong B, Suh H. Exposure measurement error in PM2.5 health effects studies: a pooled analysis of eight personal exposure validation studies. Environmental Health 2014;13(1):2. R834796 (2014)
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  • Journal Article Larson T, Gould T, Riley EA, Austin E, Fintzi J, Sheppard L, Yost M, Simpson C. Ambient air quality measurements from a continuously moving mobile platform: estimation of area-wide, fuel-based, mobile source emission factors using absolute principal component scores. Atmospheric Environment 2017;152:201-211. R834796 (2016)
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  • Journal Article Lee A, Szpiro A, Kim SY, Sheppard L. Impact of preferential sampling on exposure prediction and health effect inference in the context of air pollution epidemiology. Environmetrics 2015;26(4):255-267. R834796 (2015)
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  • Journal Article Lindstrom J, Szpiro AA, Sampson PD, Oron AP, Richards M, Larson TV, Sheppard L. A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics 2014;21(3):411-433. R834796 (2013)
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  • Journal Article Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhalation Toxicology 2013;25(6):309-324. R834796 (2013)
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  • Journal Article Mauderly JL, Kracko D, Brower J, Doyle-Eisele M, McDonald JD, Lund AK, Seilkop SK. The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases. Inhalation Toxicology 2014;26(11):691-696. R834796 (2014)
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  • Journal Article McDonald JD, Chow JC, Peccia J, Liu Y, Chand R, Hidy GM, Mauderly JL. Influence of collection region and site type on the composition of paved road dust. Air Quality, Atmosphere & Health 2013;6(3):615-628. R834796 (2013)
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  • Journal Article Olives C, Sheppard L, Lindstrom J, Sampson PD, Kaufman JD, Szpiro AA. Reduced-rank spatio-temporal modeling of air pollution concentrations in the Multi-Ethnic Study of Atherosclerosis and Air Pollution. Annals of Applied Statistics 2014;8(4):2509-2537. R834796 (2014)
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  • Journal Article Oppenheim HA, Lucero J, Guyot A-C, Herbert LM, McDonald JD, Mabondzo A, Lund AK. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Particle and Fibre Toxicology 2013;10:62. R834796 (2014)
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  • Journal Article Paffett ML, Zychowski KE, Sheppard L, Robertson S, Weaver JM, Lucas SN, Campen MJ. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences 2015;146(2):244-253. R834796 (2014)
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  • Journal Article Riley EA, Banks L, Fintzi J, Gould TR, Hartin K, Schaal L, Davey M, Sheppard L, Larson T, Yost MG, Simpson CD. Multi-pollutant mobile platform measurements of air pollutants adjacent to a major roadway. Atmospheric Environment 2014;98:492-499. R834796 (2014)
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  • Journal Article Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicological Sciences 2013;134(2):304-311. R834796 (2013)
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  • Journal Article Sampson PD, Richards M, Szpiro AA, Bergen S, Sheppard L, Larson TV, Kaufman JD. A regionalized national universal kriging model using Partial Least Squares regression for estimating annual PM2.5 concentrations in epidemiology. Atmospheric Environment 2013;75:383-392. R834796 (2013)
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  • Journal Article Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhalation Toxicology 2015;27(5):272-280. R834796 (2015)
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  • Journal Article Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope III CA, Brunekreef B. Confounding and exposure measurement error in air pollution epidemiology. Air Quality, Atmosphere & Health 2012;5(2):203-216. R834796 (2012)
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  • Journal Article Spalt EW, Curl CL, Allen RW, Cohen M, Williams K, Hirsh JA, Adar SD, Kaufman JD. Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science & Environmental Epidemiology 2016;26(4):341-348. R834796 (2014)
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  • Journal Article Spalt EW, Curl CL, Allen RW, Cohen M, Adar SD, Stukovsky KH, Avol E, Castro-Diehl C, Nunn C, Mancera-Cuevas K, Kaufman JD. Time-location patterns of a diverse population of older adults:the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science & Environmental Epidemiology 2016;26(4):349-355. R834796 (2014)
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  • Journal Article Sun M, Kaufman JD, Kim S-Y, Larson TV, Gould TR, Polak JF, Budoff MJ, Diez Roux AV, Vedal S. Particulate matter components and subclinical atherosclerosis:common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environmental Health 2013;12:39. R834796 (2013)
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  • Journal Article Szpiro AA, Sheppard L, Lumley T. Efficient measurement error correction with spatially misaligned data. Biostatistics 2011;12(4):610-623. R834796 (2012)
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  • Journal Article Szpiro AA, Paciorek CJ, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 2011;22(5):680-685. R834796 (2012)
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  • Journal Article Szpiro AA, Paciorek CJ. Measurement error in two-stage analyses, with application to air pollution epidemiology. Environmetrics 2013;24(8):501-517. R834796 (2013)
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  • Journal Article Szpiro AA, Sheppard L, Adar SD, Kaufman JD. Estimating acute air pollution health effects from cohort study data. Biometrics 2014;70(1):164-174. R834796 (2013)
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  • Journal Article Vedal S, Kaufman JD. What does multi-pollutant air pollution research mean? American Journal of Respiratory and Critical Care Medicine 2011;183(1):4-6. R834796 (2012)
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  • Journal Article Wang M, Keller JP, Adar SD, Kim S-Y, Larson TV, Olives C, Sampson PD, Sheppard L, Szpiro AA, Vedal S, Kaufman JD. Development of long-term spatiotemporal models for ambient ozone in six metropolitan regions of the United States: the MESA Air Study. Atmospheric Environment 2015;123(Part A):79-87. R834796 (2016)
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  • Journal Article Wang M, Brunekreef B, Gehring U, Szpiro A, Hoek G, Beelen R. A new technique for evaluating land-use regression models and their impact on health effect estimates. Epidemiology 2016;27(1):51-56. R834796 (2015)
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  • Journal Article Weuve J, Kaufman JD, Szpiro AA, Curl C, Puett RC, Beck T, Evans DA, Mendes de Leon CF. Exposure to traffic-related air pollution in relation to progression in physical disability among older adults. Environmental Health Perspectives 2016;124(7):1000-1008. R834796C005 (2016)
    R831697 (Final)
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  • Full-text: EHP-Full-Text PDF
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  • Journal Article Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33(6):1153-1161. R834796 (2013)
    R834796 (2014)
    R834796 (2015)
    R834796C003 (2013)
    R834796C003 (2016)
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  • Journal Article Young MT, Sandler DP, DeRoo LA, Vedal S, Kaufman JD, London SJ. Ambient air pollution exposure and incident adult asthma in a nationwide cohort of U.S. women. American Journal of Respiratory and Critical Care Medicine 2014;190(8):914-921. R834796 (2015)
    R834796C005 (2015)
    R834796C005 (2016)
    R831697 (Final)
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  • Journal Article Brower JB, Doyle-Eisele M, Moeller B, Stirdivant S, McDonald JD, Campen MJ. Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions. Inhalation Toxicology 2016;28(5):241-250. R834796 (2016)
    R834796C003 (2016)
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  • Journal Article Zychowski KE, Lucas SN, Sanchez B, Herbert G, Campen MJ. Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure. Toxicology and Applied Pharmacology 2016;305:40-45. R834796 (2016)
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  • Journal Article Riley EA, Gould T, Hartin K, Fruin SA, Simpson CD, Yost MG, Larson T. Ultrafine particle size as a tracer for aircraft turbine emissions. Atmospheric Environment 2016;139:20-29. R834796 (2016)
    R834796C001 (2016)
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  • Journal Article Tyler CR, Zychowski KE, Sanchez BN, Rivero V, Lucas S, Herbert G, Liu J, Irshad H, McDonald JD, Bleske BE, Campen MJ. Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes. Particle and Fibre Toxicology 2016;13(1):64 (18 pp.). R834796 (2016)
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  • Journal Article Xu W, Riley EA, Austin E, Sasakura M, Schaal L, Gould TR, Hartin K, Simpson CD, Sampson PD, Yost MG, Larson TV, Xiu G, Vedal S. Use of mobile and passive badge air monitoring data for NOx and ozone air pollution spatial exposure prediction models. Journal of Exposure Science and Environmental Epidemiology March 23, 2016; doi:10.1038/jes.2016.9 [epub ahead of print]. R834796C001 (2015)
    R834796C001 (2016)
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  • Journal Article Chi GC, Hajat A, Bird CE, Cullen MR, Griffin BA, Miller KA, Shih RA, Stefanick ML, Vedal S, Whitsel EA, Kaufman JD. Individual and neighborhood socioeconomic status and the association between air pollution and cardiovascular disease. Environmental Health Perspectives 2016; doi:10.1289/EHP199 (Epub ahead of print]. R834796C005 (2015)
    R834796C005 (2016)
  • Full-text: EHP-Full Text PDF (advance publication)
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  • Journal Article Wang M, Sampson PD, Hu J, Kleeman M, Keller JP, Olives C, Szpiro AA, Vedal S, Kaufman JD. Combining land-use regression and chemical transport modeling in a spatio-temporal geostatistical model for ozone and PM2.5. Environmental Science & Technology 2016;50(10):5111-5118. R834796 (2016)
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  • Journal Article Riley EA, Schaal L, Sasakura M, Crampton R, Gould TR, Hartin K, Sheppard L, Larson T, Simpson CD, Yost MG. Correlations between short-term mobile monitoring and long-term passive sampler measurements of traffic-related air pollution. Atmospheric Environment 2016;132:229-239. R834796 (2016)
    R834796C001 (2016)
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  • Journal Article Hazlehurst MF, Spalt EW, Curl CL, Davey ME, Vedal S, Burke GL, Kaufman JD. Integrating data from multiple time-location measurement methods for use in exposure assessment: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Journal of Exposure Science and Environmental Epidemiology January 25, 2017 [Epub ahead of print]. R834796 (2016)
    R834796C005 (2016)
    R831697 (Final)
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  • Journal Article Fann N, Kim S-Y, Olives C, Sheppard L. Estimated changes in life expectancy and adult mortality resulting from declining PM2.5 exposures in the contiguous United States:1980-2010. Environmental Health Perspectives 2017;125(9):097003 (8 pp.). R834796 (2016)
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  • Journal Article Herring CL, Faiola CL, Massoli P, Sueper D, Erickson MH, McDonald JD, Simpson CD, Yost MG, Jobson BT, VanReken TM:New Methodology for Quantifying Polycyclic Aromatic Hydrocarbons (PAHs) Using High-Resolution Aerosol Mass Spectrometry. Aerosol Science and Technology. 2015, 49(11):1131-1148. R834796C001 (2016)
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    Journal Article Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 2013, 33(6):1153-61. R834796C003 (2016)
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    Journal Article Galaviz V, Yost M, Simpson C, Camp J, Paulsen M, Elder J, Hoffman L, Flores D, Quintana P:Traffic pollutant exposures experienced by pedestrians waiting to enter the US at a major US–Mexico border crossing. Atmospheric Environment. 2014, 88:362-369. R834796C001 (2016)
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    Journal Article Erickson M, Gueneron M, Jobson B:Measuring long chain alkanes in diesel engine exhaust by thermal desorption PTR-MS. Atmospheric Measurement Techniques. 2014, 7(1):225-239. R834796C001 (2016)
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    Journal Article Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ:Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures. Cardiovascular toxicology. 2016, 16(2):163-171. R834796C003 (2016)
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    Journal Article Campen MJ, Lund A, Rosenfeld M:Mechanisms linking traffic-related air pollution and atherosclerosis. Current opinion in pulmonary medicine. 2012, 18(2):155. R834796C003 (2016)
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    Journal Article Yin F, Driscoll WS, Sulaiman D, Ricks R, Ramanathan G, Stewart JA, Mehrabian M, Beaven SW, Lusis AL, Rosenfeld ME, Araujo JA. Diesel Exhaust Alters Lipid Metabolism and Induces Hyperlipidemia in Association with Down-Regulation of PPAR alpha and Changes in Gut Microbiota. Atherosclerosis, Thrombosis and Vascular Biology (ATVB). 2016. Submitted. R834796C003 (2016)
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    Journal Article Hudda N, Gould T, Hartin K, Larson TV, Fruin SA:Emissions from an international airport increase particle number concentrations 4-fold at 10 km downwind. Environmental science & technology. 2014, 48(12):6628-6635. R834796C001 (2016)
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    Journal Article Campen M, Robertson S, Lund A, Lucero J, McDonald J:Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation toxicology. 2014, 26(6):353-360. R834796C003 (2016)
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    Journal Article Gueneron M, Erickson MH, VanderSchelden GS, Jobson BT:PTR-MS fragmentation patterns of gasoline hydrocarbons. International Journal of Mass Spectrometry. 2015, 379:97-109. R834796C001 (2016)
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    Journal Article Paffett ML, Sheppard L, Robertson S, Weaver J, Lucas SN, Campen MJ. Ozone inhalation enhances coronary artery constriction and impairs dilation via superoxide-dependent mechanisms. Toxicol Appl Pharmacol. 2015, In press. R834796C003 (2016)
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    Journal Article Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The Effects of α-Pinene-vs. Toluene-Derived Secondary Organic Aerosol Exposure on the Expression of Markers Associated with Vascular Disease. Inhalation Toxicology. 2013, 25(6):309-324. R834796C002 (2016)
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    Journal Article Schisler J, Campen MJ, Madden M, and Willis MS. Transcriptional Endothelial Biosensor Response to Diesel-Induced Plasma Compositional Changes. Inhalation Toxicology. 2015, 27(5):272–280. R834796C003 (2016)
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    Journal Article Galaviz VE, Quintana PJE, Yost MG, Sheppard L, Paulsen MH, Camp JE, Simpson CD. Urinary metabolites of 1-nitropyrene in US-Mexico border residents who frequently cross the San Ysidro Port of Entry. Journal of Exposure Science and Environmental Epidemiology. 2017 Jan 1;27(1):84-9. R834796 (2016)
    R834796C001 (2016)
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    Supplemental Keywords:

    atherosclerosis, epidemiology, toxicology, transportation,, Health, Scientific Discipline, Health Risk Assessment, Risk Assessments, Biochemistry, Environmental Monitoring, Atmospheric Sciences, particulate matter, airway disease, bioavailability, air pollution, particle exposure, ambient particle health effects, vascular dysfunction, cardiotoxicity

    Progress and Final Reports:

    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    2014 Progress Report
    2015 Progress Report
    2016 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
    R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
    R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
    R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
    R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort