Research Grants/Fellowships/SBIR

Great Lakes Air Center for Integrative Environmental Research (GLACIER)

EPA Grant Number: R834797
Center: Great Lakes Air Center for Integrative Environmental Research
Center Director: Harkema, Jack
Title: Great Lakes Air Center for Integrative Environmental Research (GLACIER)
Investigators: Harkema, Jack
Institution: Michigan State University , The Ohio State University - Main Campus , University of California - Los Angeles , University of Michigan - Ann Arbor
EPA Project Officer: Ilacqua, Vito
Project Period: January 1, 2011 through December 31, 2016
Project Amount: $7,999,875
RFA: Clean Air Research Centers (2009) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

GLACIER is a multidisciplinary center with the objective to explore one of the most prevalent and important global health-environment interfaces: the interrelationships between facets of the cardiometabolic syndrome (CMS) and air pollution. CMS is among the leading causes of death and threats to worldwide health. In tandem, exposure to air pollution, most notably fine particle matter (PM2.5), remains highly prevalent and ranks among the leading causes of global mortality. Inter-relationships and health impacts of this burgeoning confluence between these two epidemics are of tremendous importance to elucidate. Our previous research has elucidated that PM2.5 exposure plays a critical, yet under-appreciated, role in eliciting or exacerbating several key facets of the CMS-including elevating blood pressure, impairing vascular function, and even worsening metabolic insulin sensitivity and adiposity over a chronic duration. We have also found that the location of exposure, multipollutant context, and constituents within PM2.5 affect the responses. The full extent and importance of inter-relationships between CMS and air pollution, individual susceptibility, specific pollution components, multipollutant atmospheres, PM2.5 - ozone (O3) coexposures, and underlying mechanisms of toxicity are all key issues remaining to be clarified. Our center’s overall hypothesis is that PM2.5 and O3 are 1) capable of eliciting multiple important adverse cardiometabolic health effects that are dependent on 2) the local multipollutant milieu, 3) an individual’s pre-existing cardiovascular (CV) and metabolic condition (susceptibility), and 4) the interactive toxicity of PM2.5 and O3 coexposure.

Approach:

In conjunction with core facilities, GLACIER consists of 3 controlled exposure projects that each addresses specific aspects of the CMS-air pollution interface. The projects are scientifically integrated and interactive which will foster synergistic insights and cohesive synthesis of conclusions. The Exposure Characterization Core (ECC) is an integral part of all three Projects of the Great Lakes Air Center for Integrative Environmental Research (GLACIER). In coordination with and support of the GLACIER Research Projects, the ECC will provide measurements of multi-pollutant exposures for both human subject (Project 1) and animal toxicology (Projects 2 and 3) studies. The overall objectives of the ECC are to 1) determine the mass, size, and chemical composition of pollutants for each exposure period, 2) determine the atmospheric emission sources responsible for the observed exposure concentrations, and 3) provide a detailed assessment of the differences in air pollution composition, sources, and chemistry between each of the exposure sites across each of the Projects. The objectives of the GLACIER BDMC are to provide guidance for the statistical design and analysis of studies and data management services that allow for the integration of the data into a single platform that facilitates timely analysis for GLACIER investigators and projects. Specific aims for this Core are (1) to assist GLACIER investigators with statistical and data aspects of their research by providing expertise in the design, conduct and analysis of studies in Projects 1-3; (2) to establish a database for each project on a secure computerized system; and (3) to implement a website to allow data import and export in a secured, controlled environment with a user-friendly interface.

Project 1 aims to elucidate in humans the mechanisms of adverse CMS responses and the concentration-response relationships of acute exposures to differing PM2.5 mixtures.

Project 2 aims to determine the short-term CV, autonomic and airway toxicity in rats exposed to differing PM2.5 mixtures.

Project 3 expands upon the main theme by determining the CMS toxicity of differing longer-term exposures in mice. Each project will also investigate the role of pre-existing susceptibility and the comparative effects of PM2.5 mixtures derived from 2-3 dissimilar multipollutant milieus of regional importance (near-roadway, industrial, transported). Toxic effects of PM2.5, O3, each alone and in combination, will be evaluated at each location.

Expected Results:

We will address 1) temporal-response relationships to pollutant exposure and the development of CMS, 2) CMS effects of ozone and fine particle mixtures from 3 differing locations and their interactive toxicity, 3) the role of obesity and pre-existing cardiometabolic abnormalities in individual susceptibility, 4) concentration-response relationships for particles and O3; and 5) mechanisms whereby air pollutants elicit CV and metabolic health effects. Our results will provide critical insights into the health effects of PM2.5, O3, and their coexposures in a multipollutant context.


Journal Articles: 46 Displayed | Download in RIS Format

Other center views: All 114 publications 46 publications in selected types All 46 journal articles
Type Citation Sub Project Document Sources
Journal Article Balasubramanian P, Sirivelu MP, Weiss KA, Wagner JG, Harkema JR, Morishita M, Mohankumar PS, Mohankumar SM. Differential effects of inhalation exposure to PM 2.5 on hypothalamic monoamines and corticotrophin releasing hormone in lean and obese rats. NeuroToxicology 2013;36:106-111. R834797 (2013)
R834797 (2014)
R834797 (2015)
R834797C002 (2012)
R834797C002 (2013)
R834797C002 (2014)
R834797C002 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Blazek A, Rutsky J, Osei K, Maiseyeu A, Rajagopalan S. Exercise-mediated changes in high-density lipoprotein: impact on form and function. American Heart Journal 2013;166(3):392-400. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C003 (2013)
    R834797C003 (2014)
    R834797C003 (2015)
  • Abstract from PubMed
  • Full-text: Pfizer-Full Text PDF
    Exit
  • Abstract: American Heart Journal-Abstract
    Exit
  • Other: ScienceDirect-Abstract
    Exit
  • Journal Article Brandenberger C, Li N, Jackson-Humbles DN, Rockwell CE, Wagner JG, Harkema JR. Enhanced allergic airway disease in old mice is associated with a Th17 response. Clinical & Experimental Allergy 2014;44(10):1282-1292. R834797 (2014)
    R834797 (2015)
    R834797C002 (2015)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Brook RD, Rajagopalan S. Can what you breathe trigger a stroke within hours? Comment on "ambient air pollution and the risk of acute ischemic stroke". Archives of Internal Medicine 2012;172(3):235-236. R834797 (2014)
    R834797 (2015)
    R834797C003 (2012)
  • Abstract from PubMed
  • Abstract: Archives of Internal Medicine-Abstract & Preview
    Exit
  • Journal Article Brook RD, Bard RL, Kaplan MJ, Yalavarthi S, Morishita M, Dvonch JT, Wang L, Yang H-Y, Spino C, Mukherjee B, Oral EA, Sun Q, Brook JR, Harkema J, Rajagopalan S. The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study. Inhalation Toxicology 2013;25(10):587-592. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C001 (2013)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2013)
    R833740 (2012)
    R833740 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Taylor and Francis-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Brook RD, Xu X, Bard RL, Dvonch JT, Morishita M, Kaciroti N, Sun Q, Harkema J, Rajagopalan S. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. The Science of the Total Environment 2013;448:66-71. R834797 (2012)
    R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C001 (2012)
    R834797C001 (2013)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2012)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang H-Y, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S. Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location. Environmental Health Perspectives 2014;122(6):624-630. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C001 (2013)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
    R833740 (2012)
    R833740 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Carey SA, Ballinger CA, Plopper CG, McDonald RJ, Bartolucci AA, Postlethwait EM, Harkema JR. Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. American Journal of Physiology: Lung Cellular and Molecular Physiology 2011;300(2):L242-L254. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: APS Journals-Full Text HTML
    Exit
  • Abstract: APS Journals-Abstract
    Exit
  • Other: APS Journals-Full Text PDF
    Exit
  • Journal Article Deiuliis JA, Kampfrath T, Zhong J, Oghumu S, Maiseyeu A, Chen LC, Sun Q, Satoskar AR, Rajagopalan S. Pulmonary T cell activation in response to chronic particulate air pollution. American Journal of Physiology: Lung Cellular and Molecular Physiology 2012;302(4):L399-L409. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: APS Journals-Full Text HTML
    Exit
  • Abstract: APS Journals-Abstract
    Exit
  • Other: APS Journals-Full Text PDF
    Exit
  • Journal Article Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, Nelson RJ. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Molecular Psychiatry 2011;16(10):987-995. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Molecular Psychiatry-Full Text HTML
    Exit
  • Abstract: Molecular Psychiatry-Abstract
    Exit
  • Other: Molecular Psychiatry-Full Text PDF
    Exit
  • Journal Article Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Higher fine particulate matter and temperature levels impair exercise capacity in cardiac patients. Heart 2015;101(16):1293-1301. R834797 (2014)
    R834797 (2015)
    R834797C001 (2015)
  • Abstract from PubMed
  • Abstract: BMJ-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Giorgini P, Rubenfire M, Das R, Gracik T, Wang L, Morishita M, Bard RL, Jackson EA, Fitzner CA, Ferri C, Brook RD. Particulate matter air pollution and ambient temperature: opposing effects on blood pressure in high-risk cardiac patients. Journal of Hypertension 2015;33(10):2032-2038. R834797 (2014)
    R834797 (2015)
    R834797C001 (2015)
  • Abstract from PubMed
  • Abstract: Wolters Kluwer-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Hubbs AF, Mercer RR, Benkovic SA, Harkema J, Sriram K, Schwegler-Berry D, Goravanahally MP, Nurkiewicz TR, Castranova V, Sargent LM. Nanotoxicology--a pathologist's perspective. Toxicologic Pathology 2011;39(2):301-324. R834797 (2014)
    R834797 (2015)
  • Abstract from PubMed
  • Full-text: Sage Publications-Full Text HTML
    Exit
  • Abstract: Sage Publications-Abstract
    Exit
  • Other: Sage Publications-Full Text PDF
    Exit
  • Journal Article Kamal AS, Rohr AC, Mukherjee B, Morishita M, Keeler GJ, Harkema JR, Wagner JG. PM2.5-induced changes in cardiac function of hypertensive rats depend on wind direction and specific sources in Steubenville, Ohio. Inhalation Toxicology 2011;23(7):417-430. R834797 (2014)
    R834797 (2015)
  • Abstract from PubMed
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and experimental links between air pollution and type 2 diabetes. Toxicologic Pathology 2013;41(2):361-373. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C002 (2012)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2013)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Sage Journals-Full Text HTML
    Exit
  • Abstract: Sage Journals-Abstract
    Exit
  • Other: Sage Journals-Full Text PDF
    Exit
  • Journal Article Liu C, Xu X, Bai Y, Wang T-Y, Rao X, Wang A, Sun L, Ying Z, Gushchina L, Maiseyeu A, Morishita M, Sun Q, Harkema JR, Rajagopalan S. Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environmental Health Perspectives 2014;122(1):17-26. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Liu C, Bai Y, Xu X, Sun L, Wang A, Wang TY, Maurya SK, Periasamy M, Morishita M, Harkema J, Ying Z, Sun Q, Rajagopalan S. Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Particle and Fibre Toxicology 2014;11:27. R834797 (2014)
    R834797 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Liu C, Fonken LK, Wang A, Maiseyeu A, Bai Y, Wang T-Y, Maurya S, Ko Y-A, Periasamy M, Dvonch T, Morishita M, Brook RD, Harkema J, Ying Z, Mukherjee B, Sun Q, Nelson RJ, Rajagopalan S. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Particle and Fibre Toxicology 2014;11:53. R834797 (2014)
    R834797 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Maiseyeu A, Yang H-Y, Ramanathan G, Yin F, Bard RL, Morishita M, Dvonch JT, Wang L, Spino C, Mukherjee B, Badgeley MA, Barajas-Espinosa A, Sun Q, Harkema J, Rajagopalan S, Araujo JA, Brook RD. No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function. Inhalation Toxicology 2014;26(1):23-29. R834797 (2014)
    R834797 (2015)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
    R833740 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. American Journal of Physiology: Lung Cellular and Molecular Physiology 2011;300(3):L462-L471. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: APS-Full Text HTML
    Exit
  • Abstract: APS-Abstract
    Exit
  • Other: APS-Full Text PDF
    Exit
  • Journal Article Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. American Journal of Translational Research 2013;5(2):224-234. R834797C003 (2014)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: AJTR-Full Text-PDF
    Exit
  • Abstract: AJTR-Abstract
    Exit
  • Other: ResearchGate-Abstract & Full Text-PDF
    Exit
  • Journal Article Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Source identification of ambient PM2.5 for inhalation exposure studies in Steubenville, Ohio using highly time-resolved measurements. Atmospheric Environment 2011;45(40):7688-7697. R834797 (2014)
    R834797 (2015)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Morishita M, Keeler GJ, Kamal AS, Wagner JG, Harkema JR, Rohr AC. Identification of ambient PM2.5 sources and analysis of pollution episodes in Detroit, Michigan using highly time-resolved measurements. Atmospheric Environment 2011;45(8):1627-1637. R834797 (2014)
    R834797 (2015)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Morishita M, Bard RL, Kaciroti N, Fitzner CA, Dvonch T, Harkema JR, Rajagopalan S, Brook RD. Exploration of the composition and sources of urban fine particulate matter associated with same-day cardiovascular health effects in Dearborn, Michigan. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):145-152. R834797 (2014)
    R834797 (2015)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate-Abstract & Full Text PDF
    Exit
  • Abstract: Nature.com-Abstract
    Exit
  • Journal Article Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q, Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal of Exposure Science & Environmental Epidemiology 2015;25(2):153-159. R834797 (2014)
    R834797 (2015)
    R834797C001 (2014)
    R834797C001 (2015)
    R834797C002 (2015)
    R834797C003 (2015)
    R833740 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Nature.Com-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, Forastiere F, Franchini M, Franco OH, Graham I, Hoek G, Hoffmann B, Hoylaerts MF, Kunzli N, Mills N, Pekkanen J, Peters A, Piepoli MF, Rajagopalan S, Storey RF, ESC Working Group on Thrombosis, European Association for Cardiovascular Prevention and Rehabilitation, ESC Heart Failure Association. Expert position paper on air pollution and cardiovascular disease. European Heart Journal 2015;36(2):83-93b. R834797 (2014)
    R834797 (2015)
    R834797C003 (2015)
  • Abstract from PubMed
  • Full-text: Oxford Journals-Full Text HTML
    Exit
  • Abstract: Oxford Journals-Abstract
    Exit
  • Other: Oxford Journals-Full Text PDF
    Exit
  • Journal Article Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-induced type 2 immunity in nasal airways. Development and lymphoid cell dependence in mice. American Journal of Respiratory Cell and Molecular Biology 2016;54(3):331-340. R834797 (2014)
    R834797 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
  • Abstract from PubMed
  • Full-text: ResearchGate-Abstract & Full Text PDF
    Exit
  • Abstract: ATS Journals-Abstract
    Exit
  • Journal Article Pancras JP, Landis MS, Norris GA, Vedantham R, Dvonch JT. Source apportionment of ambient fine particulate matter in Dearborn, Michigan, using hourly resolved PM chemical composition data. The Science of the Total Environment 2013;448:2-13. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
  • Abstract from PubMed
  • Full-text: Science Direct-Full Text HTML
    Exit
  • Abstract: Science Direct-Abstract
    Exit
  • Other: Science Direct-Full Text PDF
    Exit
  • Journal Article Rajagopalan S, Brook RD. Personalizing your airspace and your health. Journal of the American College of Cardiology 2015;65(21):2288-2290. R834797 (2014)
    R834797 (2015)
    R834797C003 (2015)
  • Abstract from PubMed
  • Full-text: Science Direct-Full Text HTML
    Exit
  • Abstract: Science Direct-Abstract
    Exit
  • Other: Science Direct-Full Text PDF
    Exit
  • Journal Article Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR, Sun Q, Rajagopalan S. CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circulation Research 2014;115(9):770-780. R834797 (2014)
    R834797 (2015)
    R834797C002 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Circulation Research-Full Text HTML
    Exit
  • Abstract: Circulation Research-Abstract
    Exit
  • Other: Circulation Research-Full Text PDF
    Exit
  • Journal Article Rao X, Patel P, Puett R, Rajagopalan S. Air pollution as a risk factor for type 2 diabetes. Toxicological Sciences 2015;143(2):231-241. R834797 (2014)
    R834797 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Oxford Journals-Full Text HTML
    Exit
  • Abstract: Oxford Journals-Abstract
    Exit
  • Other: Oxford Journals-Full Text PDF
    Exit
  • Journal Article Rao X, Montresor-Lopez J, Puett R, Rajagopalan S, Brook RD. Ambient air pollution: an emerging risk factor for diabetes mellitus. Current Diabetes Reports 2015;15(6):603. R834797 (2014)
    R834797 (2015)
    R834797C003 (2015)
  • Abstract from PubMed
  • Abstract: SpringerLink-Abstract
    Exit
  • Other: ResearchGate-Abstract
    Exit
  • Journal Article Rohr AC, Kamal A, Morishita M, Mukherjee B, Keeler GJ, Harkema JR, Wagner JG. Altered heart rate variability in spontaneously hypertensive rats is associated with specific particulate matter components in Detroit, Michigan. Environmental Health Perspectives 2011;119(4):474-480. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Sun L, Liu C, Xu X, Ying Z, Maiseyeu A, Wang A, Allen K, Lewandowski RP, Bramble LA, Morishita M, Wagner JG, Dvonch JT, Sun Z, Yan X, Brook RD, Rajagopalan S, Harkema JR, Sun Q, Fan Z. Ambient fine particulate matter and ozone exposures induce inflammation in epicardial and perirenal adipose tissues in rats fed a high fructose diet. Particle and Fibre Toxicology 2013;10:43. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C001 (2013)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2013)
    R834797C003 (2014)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Particle and Fibre Toxicology-Full Text HTML
    Exit
  • Abstract: Particle and Fibre Toxicology-Abstract
    Exit
  • Other: Particle and Fibre Toxicology-Full Text PDF
    Exit
  • Journal Article Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C. Alterations of the murine gut microbiome with age and allergic airway disease. Journal of Immunology Research 2015;2015:892568 (8 pp.). R834797 (2015)
    R834797C002 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Hindawi Publishing-Full Text HTML
    Exit
  • Abstract: Hindawi Publishing-Abstract
    Exit
  • Other: Hindawi Publishing-Full Text PDF
    Exit
  • Journal Article Wagner JG, Morishita M, Keeler GJ, Harkema JR. Divergent effects of urban particulate air pollution on allergic airway responses in experimental asthma: a comparison of field exposure studies. Environmental Health 2012;11:45 (13 pp.). R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Environmental Health-Full Text HTML
    Exit
  • Abstract: Environmental Health-Abstract
    Exit
  • Other: Environmental Health-Full Text PDF
    Exit
  • Journal Article Wagner JG, Allen K, Yang HY, Nan B, Morishita M, Mukherjee B, Dvonch JT, Spino C, Fink GD, Rajagopalan S, Sun Q, Brook RD, Harkema JR. Cardiovascular depression in rats exposed to inhaled particulate matter and ozone: effects of diet-induced metabolic syndrome. Environmental Health Perspectives 2014;122(1):27-33. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C001 (2013)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2013)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Other: ResearchGate-Abstract & Full Text PDF
    Exit
  • Journal Article Wagner JG, Kamal AS, Morishita M, Dvonch JT, Harkema JR, Rohr AC. PM2.5-induced cardiovascular dysregulation in rats is associated with elemental carbon and temperature-resolved carbon subfractions. Particle and Fibre Toxicology 2014;11:25 (10 pp.). R834797 (2014)
    R834797 (2015)
    R834797C002 (2014)
    R834797C002 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Wold LE, Ying Z, Hutchinson KR, Velten M, Gorr MW, Velten C, Youtz DJ, Wang A, Lucchesi PA, Sun Q, Rajagopalan S. Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution. Circulation: Heart Failure 2012;5(4):452-461. R834797 (2014)
    R834797 (2015)
    R834797C003 (2012)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: American Heart Association-Full Text HTML
    Exit
  • Abstract: American Heart Association-Abstract
    Exit
  • Other: American Heart Association-Full Text PDF
    Exit
  • Journal Article Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S, Sun Q. Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicological Sciences 2011;124(1):88-98. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Oxford Journals-Full Text HTML
    Exit
  • Abstract: Oxford Journals-Abstract
    Exit
  • Other: Oxford Journals-Full Text PDF
    Exit
  • Journal Article Xu X, Liu C, Xu Z, Tzan K, Wang A, Rajagopalan S, Sun Q. Altered adipocyte progenitor population and adipose-related gene profile in adipose tissue by long-term high-fat diet in mice. Life Sciences 2012;90(25-26):1001-1009. R834797 (2014)
    R834797 (2015)
    R834797C003 (2012)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen L-C, Sun Q. Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues. Particle and Fibre Toxicology 2011;8:20 (14 pp.). R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: BioMed Central-Full Text HTML
    Exit
  • Abstract: BioMed Central-Abstract
    Exit
  • Other: BioMed Central-Full Text PDF
    Exit
  • Journal Article Ying Z, Xu X, Chen M, Liu D, Zhong M, Chen L-C, Sun Q, Rajagopalan S. A synergistic vascular effect of airborne particulate matter and nickel in a mouse model. Toxicological Sciences 2013;135(1):72-80. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Toxicological Sciences-Full Text HTML
    Exit
  • Abstract: Toxicological Sciences-Abstract
    Exit
  • Other: Toxicological Sciences-Full Text PDF
    Exit
  • Journal Article Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S. Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation. Environmental Health Perspectives 2014;122(1):79-86. R834797 (2013)
    R834797 (2014)
    R834797 (2015)
    R834797C002 (2013)
    R834797C002 (2014)
    R834797C002 (2015)
    R834797C003 (2013)
    R834797C003 (2014)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Ying Z, Xie X, Bai Y, Chen M, Wang X, Zhang X, Morishita M, Sun Q, Rajagopalan S. Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats. Particle and Fibre Toxicology 2015;12:15 (10 pp.). R834797 (2014)
    R834797 (2015)
    R834797C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Particle and Fibre Toxicology-Full Text HTML
    Exit
  • Abstract: Particle and Fibre Toxicology-Abstract
    Exit
  • Other: Particle and Fibre Toxicology-Full Text PDF
    Exit
  • Journal Article Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Huttemann M, Grossman LI, Chen LC, Rajagopalan S, Sun Q, Zhang K. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. Journal of Hepatology 2013;58(1):148-154. R834797 (2014)
    R834797 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate-Abstract & Full Text PDF
    Exit
  • Abstract: Journal of Hepatology-Abstract
    Exit
  • Other: ScienceDirect-Abstract
    Exit
  • Supplemental Keywords:

    Multipollutant, PM2.5, O3, cardiometabolic syndrome, Great Lakes,, Scientific Discipline, Air, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, air toxics, Health Risk Assessment, Exposure, Biochemistry, Biology, Risk Assessment, ambient air quality, particulate matter, aerosol particles, susceptible populations, human exposure, physiology, acute cardiovascualr effects, cardiopulmonary, cardiotoxicity, acute exposure

    Progress and Final Reports:

    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    2014 Progress Report
    2015 Progress Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834797C001 Cardiometabolic Effects of Exposure to Differing Mixtures and Concentrations of PM2.5 in Obese and Lean Adults
    R834797C002 Cardiometabolic, Autonomic, and Airway Toxicity of Acute Exposures to PM2.5 from Multipollutant Atmospheres in the Great Lakes Region
    R834797C003 Long Term Metabolic Consequences of Exposures to Multipollutant Atmospheres in the Great Lakes Region