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Assessing the Effects of BPA Exposure on Early Human DevelopmentEPA Grant Number: R834678C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834678
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Children's Environmental Health and Disease Prevention Research Center: Formative Center - University of California, San Francisco
Center Director: Woodruff, Tracey J.
Title: Assessing the Effects of BPA Exposure on Early Human Development
Investigators: McMaster, Michael
Institution: University of California - San Francisco
EPA Project Officer: Louie, Nica
Project Period: May 1, 2010 through April 30, 2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Health
In animal studies, Bisphenol A (BPA) adversely impacts development through multiple pathways; yet little is known about mechanisms in humans. We propose to address this gap in our knowledge by using an in vitro cell model system for studying the effects of BPA on human embryonic development. Using a microarray approach, we will measure changes in global gene expression induced by environmentally-relevant BPA doses in a cell colony observed over multiple time points. We will conduct a parallel experiment with physiologically-relevant doses of 17beta-estradiol (E2) to understand to what degree effects are estrogen-dependent.
By identifying and then validating the specific molecular targets altered by BPA exposure at the protein level and in partially-differentiated embryoid bodies, we will gain important information about the mechanisms that underlie BPA induced interference with the earliest events in human development. This information could be used in a tutorial targeted to community groups, clinicians and patients intended to educate and raise awareness on the prevention of harmful chemical exposures during pregnancy.
Supplemental Keywords:risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods;, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, Biochemistry, Children's Health, Environmental Policy, Biology, prenatal exposure, developmental toxicity, biological response, chemical mixtures, children's vulnerablity, assessment of exposure, children's environmental health
Main Center Abstract and Reports:R834678 Children's Environmental Health and Disease Prevention Research Center: Formative Center - University of California, San Francisco
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy