Children's Environmental Health and Disease Prevention Research Centers: Formative Centers

EPA Grant Number: R834678
Center: Children's Environmental Health and Disease Prevention Research Center: Formative Center - University of California, San Francisco
Center Director: Woodruff, Tracey J.
Title: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers
Investigators: Woodruff, Tracey J. , Fisher, Susan J. , McMaster, Michael , Steinauer, Jody , Stotland, Naomi
Current Investigators: Woodruff, Tracey J. , Fisher, Susan J. , Gerona, Roy , McMaster, Michael , Stotland, Naomi , Sutton, Patrice
Institution: University of California - San Francisco
EPA Project Officer: Louie, Nica
Project Period: May 5, 2010 through May 4, 2014
Project Amount: $762,983
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

Our overall theme is to advance our understanding of how exposure to environmental chemicals affects early development using a new multidisciplinary approach that: 1) integrates epidemiologic and biomonitoring research on sources and exposures to environmental chemicals during pregnancy with basic biological research on how chemical exposures may disrupt early development; and 2) translates these scientific findings to community groups and healthcare providers in order to improve clinical care and prevent prenatal exposures to harmful chemicals. The Center will focus on Bisphenol A (BPA) as a model chemical for enhancing our general understanding of sources and exposures during the prenatal period and subsequent potential adverse health effects. Our objectives are to:

Assess the body burden of BPA in a geographically and socioeconomically diverse group of pregnant women and understand the role of intrauterine metabolism, developmental stage and placenta in influencing intrauterine exposures;

Investigate the relationship between exposure to BPA and early human development through development of an experimental in vitro cell model system ;

Identify sources of exposure to BPA in a geographically and socioeconomically diverse population of pregnant women; and

Mentor new researchers in the field of prenatal environmental health by partnering with community groups and health care providers to increase their capacity to prevent preconception and prenatal exposures to environmental hazards and to promote prevention‐oriented health policies.

Expected Results:

We expect, at the end of this project, to be able to 1) characterize sources of maternal exposure to BPA, the relationship between maternal and intrauterine levels of BPA and 2) gain an in‐depth understanding of BPA affects early development. We anticipate this will improve our ability to integrate the knowledge of enhanced exposures and susceptibilities we gain through this research into improved environmental health decision‐making.


Journal Articles: 16 Displayed | Download in RIS Format

Other center views: All 79 publications 20 publications in selected types All 16 journal articles
Type Citation Sub Project Document Sources
Journal Article Gerona RR, Woodruff TJ, Dickenson CA, Pan J, Schwartz JM, Sen S, Friesen MW, Fujimoto VY, Hunt PA. Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in midgestation umbilical cord serum in a northern and central California population. Environmental Science & Technology 2013;47(21):12477-12485. R834678 (Final)
R834678C001 (Final)
R834678C003 (Final)
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  • Journal Article Johnson PI, Sutton P, Atchley DS, Koustas E, Lam J, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of human evidence for PFOA effects on fetal growth. Environmental Health Perspectives 2014;122(10):1028-1039. R834678 (Final)
    R835433 (2014)
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  • Journal Article Koustas E, Lam J, Sutton P, Johnson PI, Atchley DS, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—evidence-based medicine meets environmental health: systematic review of nonhuman evidence for PFOA effects on fetal growth. Environmental Health Perspectives 2014;122(10):1015-1027. R834678 (Final)
    R835433 (2014)
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  • Journal Article Stotland NE, Sutton P, Trowbridge J, Atchley DS, Conry J, Trasande L, Gerbert B, Charlesworth A, Woodruff TJ. Counseling patients on preventing prenatal environmental exposures--a mixed-methods study of obstetricians. PLoS ONE 2014;9(6):e98771 (7 pp.). R834678 (Final)
    R835433 (2014)
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  • Journal Article Sutton P, Conry J, Rodriguez P, Woodruff T. The Navigation Guide: an evidence-based tool to bridge the gap between clinical practice and environmental health science. San Francisco Medicine: Journal of the San Francisco Medical Society 2010;83(3):25-26. R834678 (Final)
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  • Journal Article Sutton P, Giudice LC, Woodruff TJ. Reproductive environmental health. Current Opinion in Obstetrics and Gynecology 2010;22(6):517-524. R834678 (2012)
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  • Journal Article Sutton P, Woodruff TJ, Vogel S, Bero LA. Conrad and Becker's "10 Criteria" fall short of addressing conflicts of interest in chemical safety studies. Environmental Health Perspectives 2011;119(12):A506-507. R834678 (2010)
    R834678 (2011)
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  • Journal Article Sutton P, Wallinga D, Perron J, Gottlieb M, Sayre L, Woodruff T. Reproductive health and the industrialized food system: a point of intervention for health policy. Health Affairs 2011;30(5):888-897. R834678 (2010)
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  • Journal Article Sutton P, Woodruff TJ, Conry J, Giudice LC. Toxic matters and fertility: what can a doctor do? San Francisco Medicine: Journal of the San Francisco Medical Society 2012;85(5)20-22. R834678 (2012)
    R834678 (Final)
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  • Journal Article Sutton P, Woodruff TJ, Perron J, Stotland N, Conry JA, Miller MD, Giudice LC. Toxic environmental chemicals: the role of reproductive health professionals in preventing harmful exposures. American Journal of Obstetrics and Gynecology 2012;207(3)164-173. R834678 (2010)
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  • Journal Article Sutton P, Woodruff TJ. Risk communication and decision tools for children's health protection. Birth Defects Research Part C: Embryo Today: Reviews 2013;99(1):45-49. R834678 (2012)
    R834678 (Final)
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  • Journal Article Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, vom Saal FS, Woodruff TJ. A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environmental Health 2014;13(1):25 (20 pp.). R834678 (Final)
    R834678C001 (Final)
    R835436 (2014)
    R835436 (2015)
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  • Journal Article Woodruff TJ, Sutton P. Pulling back the curtain: improving reviews in environmental health. Environmental Health Perspectives 2010;118(8):a326-a327. R834678 (Final)
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  • Journal Article Woodruff TJ, Sutton P, Navigation Guide Work Group. An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. Health Affairs 2011;30(5):931-937. R834678 (2010)
    R834678 (2011)
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  • Journal Article Woodruff TJ, Burke TA, Zeise L. The need for better public health decisions on chemicals released into our environment. Health Affairs 2011;30(5):957-967. R834678 (2011)
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  • Journal Article Woodruff TJ, Sutton P. The Navigation Guide systematic review methodology: a rigorous and transparent method for translating environmental health science into better health outcomes. Environmental Health Perspectives 2014;122(10):1007-1014. R834678 (Final)
    R835433 (2014)
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  • Supplemental Keywords:

    risk assessment, metabolism, bioavailability, ethnic groups, endocrine disruptors, sensitive populations, decision making, measurement methods; Scientific Discipline, Health, RFA, Biology, Health Risk Assessment, Children's Health, Biochemistry, children's environmental health, assessment of exposure, prenatal exposure, biological response, RFA, Health, Scientific Discipline, Health Risk Assessment, Biochemistry, Children's Health, Biology, prenatal exposure, biological response, assessment of exposure

    Progress and Final Reports:

    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834678C001 Assessing Maternal and Fetal Exposure to Chemicals
    R834678C002 Assessing the Effects of BPA Exposure on Early Human Development
    R834678C003 (Pilot Study): Predictors of Maternal Exposure to BPA During Pregnancy