Formative Center for the Evaluation of Environmental Impacts on Fetal Development

EPA Grant Number: R834594
Center: Formative Center for the Evaluation of Environmental Impacts on Fetal Development
Center Director: Boekelheide, Kim
Title: Formative Center for the Evaluation of Environmental Impacts on Fetal Development
Investigators: Boekelheide, Kim , Brown, Phil , De Paepe, Monique E , Gruppuso, Phillip , Kostadinov, Stephan , Phipps, Maureen , Thanos, Christopher
Current Investigators: Boekelheide, Kim , Brown, Phil , De Paepe, Monique E , Gruppuso, Phillip , Phipps, Maureen , Thanos, Christopher
Institution: Brown University , Thanos Scientific Consulting Group , Women & Infants Hospital of Rhode Island
Current Institution: Brown University , Women & Infants Hospital of Rhode Island
EPA Project Officer: Louie, Nica
Project Period: February 15, 2010 through February 14, 2014
Project Amount: $1,189,575
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

This Formative Center for the Evaluation of Environmental Impacts on Fetal Development focuses on correlating morphological and molecular biomarkers with exposures to common environmental pollutants and stressors. There are three projects that will examine dysregulation of tissue differentiation and epigenetic programming by environmental agents:

  • Research Project 1 —Liver and the Metabolic Syndrome is guided by the hypothesis that alterations in the intrauterine environment induce epigenetic changes in the developing liver that predispose to metabolic syndrome in the adult human.
  • Research Project 2 —Prostate and Endocrine Disruption is guided by the hypothesis that estrogenic endocrine disrupting chemical exposures produce aberrant differentiation in the prostate due to altered DNA methylation.
  • Research Project 3 —Lung, Arsenic Exposure, and Tissue Remodeling is guided by the hypothesis that arsenic exposure of cells in the developing lung results in disrupted postglandular lung remodeling mediated by molecular and epigenetic alterations.

The Administrative Core, the Community Outreach and Translation Core and the Pediatric Health Specialist will ensure that the Formative Center is responsive to both clinical and societal concerns associated with environmental exposures that impact growth and development. Drawing from many Departments (Community Health, Obstetrics & Gynecology, Pathology & Lab Medicine, Pediatrics, and Sociology) our goal is to use our cross-disciplinary integration to understand and resolve the inherently complex problems generated by intrauterine environmental exposures that can lead to later life disease. We also will translate our discoveries into clinically relevant outcomes, and share with university, hospital, and public audiences both these new insights and more general education on environmental public health.


Journal Articles: 8 Displayed | Download in RIS Format

Other center views: All 13 publications 8 publications in selected types All 8 journal articles
Type Citation Sub Project Document Sources
Journal Article Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM. Predicting later-life outcomes of early-life exposures. Environmental Health Perspectives 2012;120(10):1353-1361. R834594 (Final)
R834594C002 (Final)
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  • Journal Article De Paepe ME, Chu S, Hall S, Heger NE, Thanos C, Mao Q. The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung. Pediatric Pulmonology 2012;47(12):1192-1203. R834594 (2012)
    R834594 (Final)
    R834594C003 (Final)
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  • Journal Article De Paepe ME, Chu S, Heger N, Hall S, Mao Q. Resilience of the human fetal lung following stillbirth: potential relevance for pulmonary regenerative medicine. Experimental Lung Research 2012;38(1):43-54. R834594 (2012)
    R834594 (Final)
    R834594C003 (Final)
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  • Journal Article Heger NE, Hall SJ, Sandrof MA, McDonnell EV, Hensley JB, McDowell EN, Martin KA, Gaido KW, Johnson KJ, Boekelheide K. Human fetal testis xenografts are resistant to phthalate-induced endocrine disruption. Environmental Health Perspectives 2012;120(8):1137-1143. R834594 (Final)
    R834594C002 (Final)
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  • Journal Article Panikkar B, Smith N, Brown P. Reflexive research ethics in fetal tissue xenotransplantation research. Accountability in Research 2012;19(6):344-369. R834594 (2012)
    R834594 (Final)
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  • Journal Article Saffarini CM, McDonnell EV, Amin A, Spade DJ, Huse SM, Kostadinov S, Hall SJ, Boekelheide K. Maturation of the developing human fetal prostate in a rodent xenograft model. The Prostate 2013;73(16):1761-1775. R834594 (2012)
    R834594 (Final)
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  • Journal Article Spade DJ, Hall SJ, Saffarini CM, Huse SM, McDonnell EV, Boekelheide K. Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay. Toxicological Sciences 2014;138(1):148-160. R834594 (Final)
    R834594C002 (Final)
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  • Journal Article Thompson MR, Boekelheide K. Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): body burden and risk factors. Environmental Research 2013;121:23-30. R834594 (Final)
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  • Supplemental Keywords:

    in utero exposure, mammalian, metals, bisphenol A, developmental biology, perinatal programming; environmental management, Scientific Discipline, Health, Risk Assessment, Biology, Risk Assessments, Health Risk Assessment, bioavailability, exposure assessment, biochemical research, intrauterine exposure, developmental effects, perinatal exposure, children's health, biological pathways, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Risk Assessments, Biology, Risk Assessment, biological pathways, children's health, fetal exposure, bioavailability, developmental effects, perinatal exposure, biochemical research

    Progress and Final Reports:

    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834594C001 Liver and the Metabolic Syndrome
    R834594C002 Prostate and Endocrine Disruption
    R834594C003 Lung, Arsenic Exposure, and Tissue Remodeling