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Community-Based Participatory ResearchEPA Grant Number: R834514C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R834514
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Washington Center for Child Environmental Health Risks Research (2010)
Center Director: Faustman, Elaine
Title: Community-Based Participatory Research
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Callan, Richard
Project Period: October 1, 2010 through September 24, 2016
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Health
During the past 10 years, the Community-Based Participatory Research Project (CBPR) of our Center has worked with community groups and individuals to examine the take-home pathway of pesticide exposure among children of farm workers in Yakima Valley. The CBPR study provided evidence that demonstrated children's exposure through a para-occupational pathway and in the previous 5 years of this Center grant, the CBPR Research Project conducted a community based intervention project (CIP) that identified and successfully implemented an intervention reducing the occupational take home pesticide exposure pathway for families and their children. These findings led to a number of additional questions on the part of our community partners; specifically, are there other pathways of pesticide exposure and are non-farm workers exposed to pesticides. This proposed renewal project is designed to find answers to these questions. In this project, the CPBR investigators will characterize the seasonal variability of organophosphate (OP) exposure across our cohort by sampling at times of peak OP usage and by evaluating OP metabolite profiles across time during these seasons; assess the influence of gene environment interactions on OP exposure and response profiles; and calculate the contributions from gene, environment and season to within-person and between-person variability of the urinary OP metabolites in farm workers to identify quantitatively differences between persons and across seasons. Secondarily, CBPR investigators will build from the recent observations by our colleagues in the Pesticide Exposure Pathways Research project that measure parent and oxon concentration for 3 OPs during times of peak agricultural usages.
The current studies revealed that measurable CP and CPO levels that were obtained were different than current air models would predict; further, they appear to contribute a proximity factor to our cohort exposure studies. Thus we will coordinate our cohort and household sampling with agricultural practices and field air monitoring.
Supplemental Keywords:RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Biochemistry, Children's Health, Environmental Policy, Biology, Risk Assessment, pesticide exposure, community-based intervention, age-related differences, pesticides, children's vulnerablity, biological markers, agricultural community
Progress and Final Reports:2011 Progress Report
Main Center Abstract and Reports:R834514 University of Washington Center for Child Environmental Health Risks Research (2010)
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834514C001 Community-Based Participatory Research
R834514C002 Pesticide Exposure Pathways
R834514C003 Molecular Mechanisms
R834514C004 Genetic Susceptibility