Arsenic and Maternal and Infant Immune Function

EPA Grant Number: R834599
Center: Children's Environmental Health and Disease Prevention Center - Dartmouth College
Center Director: Karagas, Margaret Rita
Title: Arsenic and Maternal and Infant Immune Function
Investigators: Karagas, Margaret Rita , Cottingham, Kathryn L. , Folt, Carol L. , Gui, Jiang , Korrick, Susan A. , Moeschler, John B. , Onega, Tracy L. , Punshon, Tracy , Rees, Judy , Robbins, David J , Shi, Xun
Current Investigators: Karagas, Margaret Rita , Cottingham, Kathryn L. , Enelow, Richard I. , Folt, Carol L. , Gui, Jiang , Korrick, Susan A. , Madan, Juliette , Miller, Stephanie , Moeschler, John B. , Onega, Tracy L. , Punshon, Tracy , Purvis, Lisa A. , Rees, Judy , Robbins, David J , Shi, Xun
Institution: Dartmouth Medical School , Dartmouth College , Dartmouth Hitchcock Medical Center , Harvard Medical School , University of Miami
EPA Project Officer: Callan, Richard
Project Period: February 15, 2010 through February 14, 2013 (Extended to February 14, 2014)
Project Amount: $1,079,663
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

Dartmouth College has established a Formative Center for Children’s Environmental Health and Disease Prevention Research located in rural New England. Our overall goals are to fill critical gaps in our understanding of the impact of drinking water and food borne sources of environmental contaminants on children’s health, and to strengthen our ties with communities to reduce the risk of environmental threats to children’s health.

Approach:

This Formative Center will: 1) provide the means for uniting multidisciplinary research teams to identify and address new and emerging issues; and 2) mentor promising new investigators in the investigation of problems related to children’s environmental health and disease prevention. Capitalizing upon expertise and research presently underway at Dartmouth, the Center will comprise an administrative core and four tightly interlinked and interdisciplinary projects.

Expected Results:

Research Project 1 builds on an ongoing cohort study of pregnant women who use a private well in a region of New Hampshire (NH) with elevated arsenic levels. Pregnant women and their offspring will be evaluated for the occurrence of infections along with infant’s vaccine response in the 1st year of life. Pilot Project 2 will enhance data collected on mothers and infants of the NH cohort to investigate the contribution of diet to infant exposure to arsenic early in life. Pilot Project 3 will take advantage of a Birth Conditions Program in NH, and data on well water arsenic concentrations from public and private water systems to perform a Geographic Information Systems (GIS) analysis of arsenic and birth defects. This will be followed by a pilot case-control study in which cases of children born with birth defects are compared with typically developing children (the controls). Pilot Project 4 will explore the impact of arsenic on hedgehog signaling, a key pathway in human development, and investigate a mechanistic basis and potential biomarker for arsenic’s effects on the occurrence of congenital anomalies. We designed the formative phase of our center to promote the mission of the NIEHS and EPA by maximizing our success in garnering informative results, developing a strong interdisciplinary team, and supporting an environment that will prepare the groundwork for establishing a highly effective comprehensive Center in the next 3 years. This integrated center will address emerging areas of public health and environmental concern, including the potential for significant exposure to arsenic in infant food and water. Based on available evidence, these exposures could impact susceptibility to infection and vaccine response and disrupt major pathways involved in human development resulting in birth defects. The research projects to be conducted by the Center are among the first to examine exposure to multiple sources (i.e., food and water) of arsenic and possible health effects in susceptible populations in the US. The results of our work will further our understanding of these exposures and help characterize potential risks to pregnant women and children.


Journal Articles: 29 Displayed | Download in RIS Format

Other center views: All 76 publications 29 publications in selected types All 29 journal articles
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Journal Article Carey AM, Norton GJ, Deacon C, Scheckel KG, Lombi E, Punshon T, Guerinot ML, Lanzirotti A, Newville M, Choi Y, Price AH, Meharg AA. Phloem transport of arsenic species from flag leaf to grain during grain filling. New Phytologist 2011;192(1):87-98. R834599 (2012)
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  • Journal Article Carey A-M, Lombi E, Donner E, de Jonge MD, Punshon T, Jackson BP, Guerinot ML, Price AH, Meharg AA. A review of recent developments in the speciation and location of arsenic and selenium in rice grain. Analytical and Bioanalytical Chemistry 2012;402(10):3275-3286. R834599 (2012)
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  • Journal Article Cottingham KL, Karimi R, Gruber JF, Zens MS, Sayarath V, Folt CL, Punshon T, Morris JS, Karagas MR. Diet and toenail arsenic concentrations in a New Hampshire population with arsenic-containing water. Nutrition Journal 2013;12:149. R834599 (2011)
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  • Journal Article Davis MA, Mackenzie TA, Cottingham KL, Gilbert-Diamond D, Punshon T, Karagas MR. Rice consumption and urinary arsenic concentrations in U.S. children. Environmental Health Perspectives 2012;120(10):1418-1424. R834599 (2012)
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  • Journal Article Farzan SF, Karagas MR, Chen Y. In utero and early life arsenic exposure in relation to long-term health and disease. Toxicology and Applied Pharmacology 2013;272(2):384-390. R834599 (Final)
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  • Journal Article Farzan SF, Korrick S, Li Z, Enelow R, Gandolfi AJ, Madan J, Nadeau K, Karagas MR. In utero arsenic exposure and infant infection in a United States cohort: a prospective study. Environmental Research 2013;126:24-30. R834599 (Final)
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  • Journal Article Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ. Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Research 2012;72(17):4449-4458. R834599 (2012)
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  • Journal Article Fei DL, Koestler DC, Li Z, Giambelli C, Sanchez-Mejias A, Gosse JA, Marsit CJ, Karagas MR, Robbins DJ. Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study. Environmental Health 2013;12:58 (8 pp.). R834599 (Final)
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  • Journal Article Gilbert-Diamond D, Cottingham KL, Gruber JF, Punshon T, Sayarath V, Gandolfi AJ, Baker ER, Jackson BP, Folt CL, Karagas MR. Rice consumption contributes to arsenic exposure in US women. Proceedings of the National Academy of Sciences of the United States of America 2011;108(51):20656-20660. R834599 (2011)
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  • Journal Article Gruber JF, Karagas MR, Gilbert-Diamond D, Bagley PJ, Zens MS, Sayarath V, Punshon T, Morris JS, Cottingham KL. Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. Nutrition Journal 2012;11:45 (10 pp.). R834599 (2011)
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  • Journal Article Jackson BP, Taylor VF, Punshon T, Cottingham KL. Arsenic concentration and speciation in infant formulas and first foods. Pure and Applied Chemistry 2012;84(2):215-223. R834599 (2012)
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  • Journal Article Jackson BP, Taylor VF, Karagas MR, Punshon T, Cottingham KL. Arsenic, organic foods, and brown rice syrup. Environmental Health Perspectives 2012;120(5):623-626. R834599 (2011)
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  • Journal Article Karagas MR. Arsenic-related mortality in Bangladesh. The Lancet 2010;376(9737):213-214. R834599 (Final)
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  • Journal Article Karagas MR, Wasson JH. A World Wide Web-based survey of non-medical tattooing in the United States. Journal of the American Academy of Dermatology 2012;66(1):e13-e14. R834599 (2011)
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  • Journal Article Karagas MR, Choi AL, Oken E, Horvat M, Schoney R, Kamai E, Cowell W, Grandjean P, Korrick S. Evidence on the human health effects of low-level methylmercury exposure. Environmental Health Perspectives 2012;120(6):799-806. R834599 (2011)
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  • Journal Article Karagas MR, Andrew AS, Nelson HH, Li Z, Punshon T, Schned A, Marsit CJ, Morris JS, Moore JH, Tyler AL, Gilbert-Diamond D, Guerinot ML, Kelsey KT. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Human Genetics 2012;131(3):453-461. R834599 (2011)
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  • Journal Article Koestler DC, Christensen B, Karagas MR, Marsit CJ, Langevin SM, Kelsey KT, Wiencke JK, Houseman EA. Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis. Epigenetics 2013;8(8):816-826. R834599 (Final)
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  • Journal Article Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environmental Health Perspectives 2013;121(8):971-977. R834599 (2011)
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  • Journal Article Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicology Letters 2012;210(1):100-106. R834599 (2011)
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  • Journal Article Madan JC, Farzan SF, Hibberd PL, Karagas MR. Normal neonatal microbiome variation in relation to environmental factors, infection and allergy. Current Opinion in Pediatrics 2012;24(6):753-759. R834599 (2012)
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  • Journal Article Madan JC, Koestler DC, Stanton BA, Davidson L, Moulton LA, Housman ML, Moore JH, Guill MF, Morrison HG, Sogin ML, Hampton TH, Karagas MR, Palumbo PE, Foster JA, Hibberd PL, O'Toole GA. Serial analysis of the gut and respiratory microbiome in cystic fibrosis in infancy: interaction between intestinal and respiratory tracts and impact of nutritional exposures. mBio 2012;3(4):e00251-12 (10 pp.). R834599 (2012)
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  • Journal Article Nadeau KC, Li Z, Farzan S, Koestler D, Robbins D, Fei DL, Malipatlolla M, Maecker H, Enelow R, Korrick S, Karagas MR. In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort. Clinical Immunology 2014;155(2):188-197. R834599 (2011)
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  • Journal Article Oken E, Choi AL, Karagas MR, Marien K, Rheinberger CM, Schoeny R, Sunderland E, Korrick S. Which fish should I eat? Perspectives influencing fish consumption choices. Environmental Health Perspectives 2012;120(6):790-798. R834599 (2011)
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  • Journal Article Punshon T, Tappero R, Ricachenevsky FK, Hirschi K, Nakata PA. Contrasting calcium localization and speciation in leaves of the Medicago truncatula mutant cod5 analyzed via synchrotron X-ray techniques. The Plant Journal 2013;76(4):627-633. R834599 (Final)
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  • Journal Article Punshon T, Ricachenevsky FK, Hindt MN, Socha AL, Zuber H. Methodological approaches for using synchrotron X-ray fluorescence (SXRF) imaging as a tool in ionomics: examples from Arabidopsis thaliana. Metallomics 2013;5(9):1133-1145. R834599 (Final)
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  • Journal Article Shi X, Miller S, Mwenda K, Onda A, Rees J, Onega T, Gui J, Karagas M, Demidenko E, Moeschler J. Mapping disease at an approximated individual level using aggregate data: a case study of mapping New Hampshire birth defects. International Journal of Environmental Research and Public Health 2013;10(9):4161-4174. R834599 (Final)
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  • Journal Article Sunderland EM, Amirbahman A, Burgess NM, Dalziel J, Harding G, Jones SH, Kamai E, Karagas MR, Shi X, Chen CY. Mercury sources and fate in the Gulf of Maine. Environmental Research 2012;119:27-41. R834599 (2011)
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  • Journal Article Wilhelm-Benartzi CS, Koestler DC, Karagas MR, Flanagan JM, Christensen BC, Kelsey KT, Marsit CJ, Houseman EA, Brown R. Review of processing and analysis methods for DNA methylation array data. British Journal of Cancer 2013;109(6):1394-1402. R834599 (Final)
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  • Journal Article Yang J, Punshon T, Guerinot ML, Hirschi KD. Plant calcium content: ready to remodel. Nutrients 2012;4(8):1120-1136. R834599 (2012)
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  • Supplemental Keywords:

    Water, drinking water, ground water, exposure, risk, health effects, human health, vulnerability, sensitive populations, population, infants, children, susceptibility, metals, heavy metals, public policy, decision making, community-based, public good, environmental chemistry, biology, geography, human health, environmental management, international cooperation, Scientific Discipline, Health, Risk Assessment, Biology, Children's Health, Biochemistry, Environmental Policy, Environmental Chemistry, Exposure, Environmental Monitoring, exposure assessment, arsenic exposure, birth defects, developmental disorders, perinatal exposure, prenatal exposure, drinking water, dietary exposure, biological markers, growth & development, children's vulnerability, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Environmental Chemistry, Exposure, Biochemistry, Environmental Monitoring, Children's Health, Environmental Policy, Biology, Risk Assessment, birth defects, prenatal exposure, drinking water, perinatal exposure, children's vulnerablity, biological markers, arsenic exposure, dietary exposure, growth & development, developmental disorders

    Progress and Final Reports:

    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834599C001 Arsenic and Maternal and Infant Immune Function
    R834599C002 Food Borne Exposure to Arsenic During the First Year of Life
    R834599C003 An Integrated Geospatial and Epidemiological Study of Associations Between Birth Defects and Arsenic Exposure in New England
    R834599C004 Determining How Arsenic (As) Modulates Sonic Hedgehog (Shh) Signaling During Development