2013 Progress Report: Center for Children’s Environmental Health and Disease Prevention Research (P01) (joint EPA and NIEHS) - CHAMACOS

EPA Grant Number: R834513
Center: Center for the Health Assessment of Mothers and Children of Salinas - UC Berkeley School of Public Health: CHAMACOS Office, Berkeley, CA
Center Director: Eskenazi, Brenda
Title: Center for Children’s Environmental Health and Disease Prevention Research (P01) (joint EPA and NIEHS) - CHAMACOS
Investigators: Eskenazi, Brenda , Arora, Manish , Barcellos, Lisa , Barlow, Janice , Blum, Arlene , Bradman, Asa , Crinella, Frank , Eisen, Ellen , Fenster, Laura , Harley, Kim , Harnly, Martha , Holland, Nina T. , Hubbard, Alan , Jerrett, Michael , Johnson, Caroline , Lustig, Robert , McKone, Thomas , Minkler, Meredith , Molitor, John , Rosas, Lisa Goldman , Salvatore, Alicia L. , Sjodin, Andreas , Smith, Donald , Wallerstein, Nina
Institution: University of California - Berkeley
EPA Project Officer: Louie, Nica
Project Period: August 1, 2009 through July 31, 2014 (Extended to July 31, 2017)
Project Period Covered by this Report: June 1, 2012 through May 31,2013
Project Amount: $3,585,543
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

In Project A (R834513C001), we are examining the association of DDT (dichlorodiphenyltrichloroethane), manganese (Mn), and polybrominated diphenyl ethers (PBDEs) with neurodevelopment and onset of puberty in boys in the CHAMACOS cohort. This study directly addresses worldwide concerns that changes in onset of sexual maturation may be related to endocrine disruptors in the environment and fills a large data gap on boys. It also addresses concerns that exposure to DDT/E, PBDEs, and Mn may compromise neurodevelopment.

In Project B (R834513C002), we will examine novel methods of examining prenatal exposure to Mn, PBDE, and DDT/E compounds using shed deciduous teeth and GIS methods.

In Project C (R834513C003), we are investigating the effects of exposure on the epigenome and its relationship with pubertal onset.

The COTC Core (R834513C004) permits Center scientists and community partners to communicate study findings in a culturally appropriate manner, to raise awareness of children’s' environmental health within and beyond the Salinas Valley, and to mobilize groups toward actions that will improve the health of low-income Latino residents in Monterey County.

Progress Summary:

Project A (R834513C001)

1. To maintain and expand the CHAMACOS cohort as children begin the critical transition to puberty, assessing neurodevelopment and pubertal development in 300 boys from 9 to 13 years of age.

We have been successful in maintaining CHAM1 participants (the boys in the CHAMACOS cohort who were followed from birth) and in recruiting CHAM2 participants (new boys enrolled at age 9). We met our goal of enrolling 300 boys, assessing 319 boys at age 9 years and 300 at age 10½. We now have completed CHAMACOS visits at 9, 9¾, and 10½ years of age; visits at 11¼, 12, and 12¾ are still underway. We currently are halfway through the 12-year visits with the CHAMACOS cohort, with 147 boys assessed to date.

2. To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with neurobehavioral functioning at age 9, 10½, and 12 years.

Collection of neurodevelopmental test data at 9 and 10½ years of age now is complete. In preliminary analyses of prenatal Mn exposure measured in teeth, we have found no association with cognition, fine motor coordination, or behavioral outcomes. Similarly, we did not observe any evidence of interaction between prenatal Mn and lead, dialkyl phosphates (DAPs), or PBDEs on neurodevelopment. Analyses of prenatal Mn exposure and neurobehavioral functioning at later ages will be conducted once data entry and cleaning are completed. Analysis of childhood Mn exposure with neurobehavioral outcomes will be conducted once Mn measurements in child hair are finalized.

We recently have published a paper showing associations of prenatal and childhood PBDE exposure with cognitive functioning and behavior (Eskenazi, et al., EHP, 2012). We report that prenatal PBDE concentrations are associated with impaired attention as measured both by maternal report and direct assessment of the child using a continuous performance task. Prenatal PBDE concentrations also are associated with decrements in Verbal and Full-Scale IQ by school age. Additionally, PBDE concentrations in children were significantly or marginally associated with teacher reports of attention problems and decrements in Processing Speed, Perceptual Reasoning, Verbal Comprehension, and Full-Scale IQ.

Prenatal and childhood DDT/E concentrations do not appear to be associated with any parameters of IQ in this population. DDT/E also were not associated with any domains of child behavior, with the exception of prenatal DDE and anxiety. Prenatal DDE concentrations were associated with increased anxiety based on maternal report (OR = 2.3, 95%CI = 1.2, 4.5) but not teacher report. However, we find more convincing evidence of interaction between prenatal DDT/E and PBDEs on child neurodevelopment. Maternal DDT/E appeared to potentiate the association of PBDEs on fine motor coordination (βInter = -1.7; 95%CI = -3.6, 0.3) and teacher report of internalizing problems (βInter = 4.9; 95%CI = 0.8, 9.1; Figure 1), particularly for anxiety (βInter = 4.5; 95%CI = 0.4, 8.7) and somatization (βInter = 6.7; 95%CI = 2.1, 11.3). For instance, maternal PBDE concentrations were associated with a 8.2 point (95%CI: 0.4, 16.1) increase in scores on the BASC somatization problems scale at the 95th percentile of maternal DDT, but no significant association was observed at the 50th percentile of maternal DDT (β = -4.6; 95%CI = -9.2, 0.1). We found no evidence of interaction for postnatal exposure.

3. To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with timing of pubertal development in boys between age 9 and 13 years. At age 9, only 11% of boys had begun genital development and 4% had begun pubic hair development. Data entry and data cleaning of Tanner staging data at 9¾ and 10½ currently is under way but is available for a subset of 101 boys. Based on preliminary data, we expect that more boys will have started puberty by age 10½ (51% for genital development and 12% for pubic hair development). Preliminary analyses of the 10½ year old data suggest that both prenatal DDT/E and PBDE exposure are associated with earlier puberty in boys. Childhood DDE exposure also was associated with earlier puberty in boys and associations with childhood DDT and PBDEs are in the direction of earlier puberty, but are not statistically significant. As presented in Table 1, each 10-fold increase in prenatal DDT and DDE concentrations was associated with more than a two-fold increase in odds of having begun genital development by age 10 (OR = 2.3 for DDT; OR = 2.8 for DDE). Each 10-fold increase in prenatal BDE-153 also was associated with increased odds of genital development (OR = 3.9). Models controlled for mother’s' years of residence in the United States, marital status, household income, child BMI, birth order, child age, child examiner, and cohort (CHAM1 vs. 2). No associations were seen with pubic hair development. Analyses of Mn and timing of puberty are in progress.

4. To determine whether prenatal and childhood exposure to DDT/E, PBDEs, and Mn are associated with hormone levels in boys at age 12.

Blood sample collection at age 12 for analysis of hormones began in March 2012. Thus far, we have collected early morning blood samples from 125 boys (112 CHAM1, 13 CHAM2). We currently are preparing to ship our first batch of age 12 blood samples to the Esoterix laboratory in Calabasas Hills, CA, for measurement of testosterone (T), luteinizing hormone (LH), and follicle stimulating hormone (FSH).

Significance: Animal studies suggest that PBDEs, DDT/E, and Mn may impact both neurodevelopment and pubertal development, but there have been only a limited number of human studies. Boys have been largely overlooked in studies on endocrine disruptors and onset of puberty. This study directly addresses worldwide concerns that changes in onset of sexual maturation may be related to endocrine disruptors in the environment. It also addresses concerns that exposure to DDT/E, PBDEs and Mn may compromise neurodevelopment. This study will fill important data gaps in our knowledge of the health effects of these widespread exposures.

Project B (R834513C002)

Specific Aim 1. To measure Mn, PBDEs, and DDT/E in shed deciduous teeth. (Population: CHAMACOS children participating since birth.) Manganese: We have successfully developed a method for measuring Mn in human teeth by laser ablation ICP-mass spectrometry (LA/ICP/MS), including analysis of 307 teeth collected from the CHAMACOS cohort. Rather than calculate one estimate of cumulative exposure over the entire prenatal period, we have used a method to distinguish Mn exposure experienced in the second trimester from that experienced in the third trimester. We observed a significant association (rspearman = 0.36, p = 0.001, n = 77) between Mn levels in the entire prenatally formed dentine [as 55Mn:43Ca area under the curve (AUC)] with floor dust Mn loading (µg Mn/m2 floor area) and a stronger relationship with Mn levels in dentine formed only in the second trimester (rspearman = 0.40; p = 0.0005; n = 72), likely because dust samples were collected in the second trimester. We also have compared Mn levels in cord blood and mantle dentine. Although there was no significant association of 55Mn:43Ca AUC of all prenatal sampling points with cord blood Mn (rspearman = - 0.01; p = 0.99), 55Mn:43Ca in the sampling point immediately adjacent to the neonatal line in each tooth showed a significant positive correlation with cord blood Mn (rspearman = 0.70; p = 0.003; n = 16). These findings were published in Environmental Science & Technology (Arora, et al., 2012).

PBDEs and DDT/E: Dr. Andreas Sjödin at the CDC in Atlanta attempted to measure PBDEs and DDT in anonymous deciduous teeth collected from patients demographically similar to the CHAMACOS cohort. Using whole tooth digestion, neither PBDEs nor DDT were detected. Additional anonymous deciduous teeth were obtained from a local clinic. Dr. Arora has extracted the dentine from another set of teeth to determine if more sensitive analyses to measure organochlorine (OC) compounds (i.e., DDT) are feasible.

Specific Aim 2. To determine the relationship between Mn, PBDE, and DDT/E levels in teeth with other relevant biological measures (N~50 children participating since birth). Laboratory measurements of Mn have been completed for 330 biological samples, including 202 whole blood samples (maternal blood, cord blood, child'’s blood), and 128 urine samples (maternal at 26 weeks gestation and child at 24 months) by Dr. Smith at the University of California, Santa Cruz (UCSC). Results of our comparison between Mn levels in teeth and other biological samples were presented at the International Society of Exposure Science conference in October 2012 by Dr. Bradman. Consistent with previous studies, we observed significantly higher (p < 0.01) Mn concentrations in maternal blood at delivery than at 26 weeks gestation, higher levels in cord blood than maternal delivery blood, and higher concentrations in cord blood than children’'s blood at 24 months. The Spearman correlation between Mn levels in teeth was strongest between third trimester dentin and cord blood (ρ = 0.31, p < 0.05), again supporting the temporal specificity of Mn measurements in teeth. We did not find any significant differences in Mn urine concentrations over time and did not observe significant correlations between Mn levels in teeth and urine, suggesting that urinary concentrations are not a useful measure of environmental Mn exposure.

Specific Aim 3. To quantify the contribution of agricultural pesticide use to Mn levels in house dust, teeth, hair and child blood. Mn in dust: Measurements of Mn in house dust have been completed by Dr. Smith at UCSC for all 475 household dust samples with 385 unique residences and 90 repeat samples collected approximately 9 months later. We are completing analyses to identify the determinants of Mn in house dust. The strongest correlation between Mn concentrations in house dust and agricultural use of maneb and mancozeb were observed for applications within 1,000 meters of the home during the 30 days prior to dust sample collection. In multivariate models, the number of farmworkers in the home and the amount of agricultural Mn pesticide use were significant determinants of both Mn dust concentrations and floor dust Mn loadings. Mn levels also were higher in homes that were built on Antioch Loam soil versus other soil types, those that were less clean, and in homes with less educated mothers (p < 0.01). For the 90 homes with two measurements of Mn in house dust collected 9 months apart, the intra-class correlation coefficient was 0.6 indicating moderate correlation of Mn concentrations over time. We observed significant (p = 0.03) global spatial autocorrelation of Mn concentrations at 1,000 meters using Moran’s I, but no spatial autocorrelation of Mn dust loading. We currently are evaluating the relationship with precipitation and modified agricultural pesticide use near the home based on wind speed and direction during the month before sample collection. A manuscript is in preparation.

Mn in teeth: We presented our findings on determinants of Mn levels in teeth at the International Society of Exposure Science conference in October 2012 and have submitted a manuscript to Environmental Science & Technology. In multivariate regression models, we found that maternal agricultural work during pregnancy, the number of farmworkers storing their shoes in the home, agricultural applications of Mn-containing fungicides within 3 km of the mother’'s residence during the second and third trimesters of pregnancy, residence built on Antioch Loam soil, and Mn dust loading (µg/g of dust) were significant determinants (p < 0.1) of Mn levels in prenatal dentine. Multivariate regression models explained 22-29% of the variability in Mn levels in prenatal dentine. Future analyses will utilize hierarchical models to evaluate the relationship between predictors of exposure and prenatal and postnatal Mn levels in deciduous teeth.

Mn in hair: In anticipation of using hair Mn levels as an exposure biomarker, and the absence of a validated methodology for the accurate determination of hair Mn without external contamination, we developed and fully validated a methodology for the cleaning and analyses of hair Mn, showing in the process that prior published studies of hair Mn are likely erroneous (Eastmann, et al., 2013). We have collected and shipped hair samples from 455 children (145 boys and 310 girls) to Dr. Smith at UCSC for analysis, which is in progress.

Specific Aim 4. To identify population correlates of PBDEs and DDT/E exposure in 9 year-old boys. CDC analyzed 308 CHAMACOS blood samples for PBDEs and DDT/E and we have started developing models to identify correlates of exposure and to back-extrapolate PBDE levels to the prenatal period. The PBDE and DDT measurements are complete. Dr. Andreas Sjödin will be lead author on an article examining population correlates of PBDE and DDT/E exposures in 9 year-olds.

Additionally, the Exposure Project B is developing estimates of maternal PBDE and DDT/E levels in CHAM 2 motherss for use in statistical analyses evaluating health effects in Project A. These back calculation methods use CHAM1 participant results as a model to identify the best way to estimate the CHAM2 maternal levels during their pregnancies. Preliminary back-extrapolation models completed by Dr. Marc-André Verner for PBDEs have R2 values ranging from 0.46 to 0.80. The higher R2 values are for statistical models (versus PBPK approaches).

Significance: Measurements of Mn in deciduous tooth cross-sections were validated as a new biomarker of Mn exposure in children and agricultural use of Mn fungicides was identified as a source of prenatal exposure, substantially contributing to the field of metal exposure and environmental epidemiology. We will utilize a recently developed methodology for the accurate assessment of hair Mn levels as a biomarker of environmental Mn exposure in a large sample of children. Agricultural use of Mn-containing fungicides is the main source of Mn in California and nationally. Determining whether these pesticides contribute to human exposures and health effects is an important public health issue. Studies of PBDE exposure will inform researchers about the impact of California'’s unique flammability laws.

Project C (R834513C003)

Specific Aims:

1. To analyze global DNA methylation in newborn children by three different assays.

When the research was funded in 2009, 27K Infinium arrays were considered “state-of the art”, and we initially have done analyses of CHAMACOS samples using these BeadChips. However, by the end of 2011, it became apparent that there were significant technical issues with these chips, and we could not reliably use 27K data that were generated already for the majority of the subjects. Fortunately, new 450K arrays that were issued in 2012, appear to be of a much better quality and provide significantly more information (genome-wide, 485,577 CpG sites) to address our Specific Aims. Still, this year we determined that the normalization methodologies provided by Illumina’s Genome Studio software for 450K assay data were inadequate for reducing technical variability, potentially biasing results. To overcome this obstacle, we conducted a comparative assessment of 10 normalization methods including the GenomeStudio(R) Illumina method, the lumi smooth quantile approach, and the newly developed by us All Sample Mean Normalization (ASMN) method. We also examined the performance of normalization methods in combination with correction for the two types of Infinium chemistry utilized on the 450K BeadChip®. The proposed ASMN method performed consistently well both at reducing batch effects and improving replicate comparability. It will be applied to conduct the final analyses of 450K CHAMACOS data. A manuscript describing these results has been submitted to Epigenetics. Currently, we have 450K data generated for a subset of newborns (Discovery dataset, N = 70 and Validation N = 72). However, we may not have sufficient resources remaining on this grant to do all 250 newborn analyses using 450K considering their high cost. We did complete the analyses of global methylation by Alu and LINE-1 assays for all 250 newborns as initially proposed (paper submitted to Environmental and Molecular Mutagenesis). Additional comparisons between DNA methylation using three assays will be completed in Year 5.

We performed differential cell count on blood samples from CHAMACOS 113 newborns (using banked blood smears) to address potential confounding by the variation in DNA methylation in different white blood cell types. No significant relationship between levels of LINE-1 DNA methylation and percentages of white blood cells in newborns has been found (P > 0.05). The lack of effect of differential cell counts on global DNA methylation is an additional confirmation that blood is an appropriate tissue to use for epigenetic analyses in population studies.

2. To determine ontogenetic changes in global DNA methylation in blood of children between birth and 12 years.

We partially completed analyses of samples at 2 years old (N = 45) and 5 years old (N = 43), and we plan to finalize the analyses of ontogenetic changes in DNA methylation in Year 5, including 12-year-old samples from the same children (currently being collected). Increasing the number of newborns and 9-year-old children (n = 250 each time-point) for two assays, we confirmed our preliminary results showing lower global methylation levels in older children. Among those with measures at both time points (n = 134) levels were lower at 9 years of age compared to birth (LINE-1, p = 0.04; Alu, p = 0.07). We found similar results using generalized estimating equation (GEE) to model population differences among all subjects. On average, mean LINE-1 DNA methylation in 9 year-olds was 0.38% 5mC lower than that in newborns (p = 0.001). Although these differences are not large, previous studies have shown that even small differences in methylation can be biologically meaningful. However, for 450K assay the data will be limited to a subset of 25 subjects at all 4 proposed time points due to funding limitations as described above.

3. To investigate the relationship of in utero and 9-year-old blood concentrations of DDT/E and PBDEs with global DNA methylation.

Confirming observations in our preliminary data, we found small but consistent decreases in global methylation measured by both LINE-1 and Alu assays in response to prenatal OC and PBDE exposures in cord blood DNA. We did not observe any effect of prenatal exposures on global methylation in 9-year-old children. Furthermore, because postnatal exposure to PBDEs is generally much higher in our cohort, we also looked at PBDE measurements during childhood. Although we have not completed measurement of 9-year-old DDT/E and PBDE, we did analyze the relationship between 7 year blood concentrations and global methylation at age 9. We did not find a significant relationship between exposure and methylation for those time points. A manuscript describing the relationship of age, sex, and prenatal POPs exposure with global methylation in newborns and 9 year-olds was submitted to Environmental and Molecular Mutagenesis. The power to analyze the relationship between prenatal exposures and 450K data will be limited as explained above. These analyses will be conducted in Year 5 after new ASMN normalization has been implemented.

4. To determine whether global methylation is associated with onset of puberty and hormonal changes.

We analyzed the association of LINE-1 and Alu global methylation at birth and 9 years of age with onset of puberty as determined by Tanner staging. Among girls, we found no evidence of a relationship between global methylation and increased odds of being at a Tanner Stage > 1. However, among boys, we found that increased LINE-1 methylation at birth was associated with lower odds (OR[95%CI]:0.49[0.31-0.79]) of being at a Tanner Stage > 1 at age 9 suggesting that global hypomethylation may be related to later pubertal onset in boys.Furthermore, we observed a similar trend for Alu methylation; however, it was not statistically significant (OR(95%CI): 0.68(0.21-2.19). Next, we plan to analyze the relationship of DNA methylation with hormonal levels as soon as the FSH/LH/T measurements are completed (by Esoterix in 2013).

5. To examine site-specific methylation in relation to age, sex, exposure to DDT/E and PBDEs and puberty onset.

Expanding upon our preliminary analysis of PPARγ site-specific methylation (determined by Illumina 450K) with health outcomes and biomarkers of obesity in our discovery set, we confirmed similar results in our validation set. The same pattern of methylation across the sites was found in both sets at birth and 9-year-old time points. CpG sites located in the north and south shore tended to be highly methylated, while those in the CpG island had lower methylation. Using the discovery set, we found that methylation at birth in sites 1 and 18 was associated with birth weight. Methylation at 9 years in sites 1, 20, and 22 was associated with 9-year BMI. Additionally, at the 9-year time point, methylation in sites 1 and 20 was significantly and positively associated with adiponectin and negatively associated with leptin, biomarkers of obesity. PPARγ site 1 methylation at birth had statistically significant inverse associations with child birth weight (β = -2.5, P = 0.04; β = -3.4, P = 0.03) in both the discovery and validation sets. Site 1 methylation at 9 years was associated with 9-year BMI in the discovery set (β = -4.8, P < 0.001) and borderline significant in the validation set (β = -2.7, P = 0.08). Further, using pooled data from both batches, we found that PPARγ site 1 methylation remained related to child size at birth and 9 years, even after Bonferroni adjustment for multiple testing. Our results suggest that PPARγ methylation may play an important role in obesity development in children, reflecting child birth weight and BMI. Next steps of the analyses will include the relationship with puberty onset, as well as validation of DNA methylation finding for PPARγ and other sites by alternative technologies (deep pyrosequencing and Nanostring).

Significance: We expanded analyses of DNA methylation in CHAMACOS children using three different state-of-the-art assays. We developed an improved approach to analysis of complex Illumina 450K data to decrease technical variability. This is of particular importance in large population studies, where batch variability can bias results. We also found that blood cell heterogeneity, which has been thought to bias methylation results as well, was not associated with differences in global methylation in CHAMACOS newborns. Dr. Holland has contributed to the Special NIH Panel on “Surrogate Tissues for Epigenetic Studies”.

COTC Core (R834513C004)

1. To disseminate Center research findings to study participants, the Salinas Valley community, and other stakeholders.

Over the past year, we have conducted several activities to achieve this aim:

  • Participant Community Forum: Our annual community forum to disseminate new research findings to study participants was held December 1, 2012. Our forum participation exceeded our expectations, with nearly 500 children, parents, and family members in attendance. The forum held three activities simultaneously, one for young children, one for the CHAMACOS participant children, and one for adults. The event was hosted by staff from both our research office and our field office, which created a familiar and inclusive atmosphere.
  • Youth Community Forum (YCF): The theme of this year'’s event was sustainable agriculture. The YCF was held at ALBA, a local organic farmer training program located 10 minutes south of Salinas. At the event, the 33 children who attended broke up into four groups and participated in four activities or stations. Each of the stations was visited for 30 minutes. At the first station, the members of the Youth Community Council presented their Photovoice project, at the second station there was an interactive presentation and jeopardy game on CHAMACOS Study results. At the third station, there was a presentation from farmers from ALBA on sustainable agriculture. At the fourth station there was an activity by California Alliance for Family Farmers on nutrition where the children learned to read food labels.
  • Newsletter: We are publishing our newsletter La Semilla twice a year, doubling production to have more frequent communication with our participant families. Our June edition focused on our research with Flame Retardants and included information on where these chemicals are found, why we are studying them, and how to prevent exposure. This edition also had a feature on our long time community outreach worker Jose Camacho. Our November edition had an overview on our study looking at methyl bromide exposure of pregnant mothers and had a summary of our Indoor Air Quality in Childcare Centers Study. Both editions also had a children’s Fun” section in the back where there was a word search for children to get involved.
  • Electronic Newsletter: We have sent out email announcements regularly about our new publications and activities of the COTC. The newsletter has grown from efforts to sign up individuals at presentations and workshops, both to research audiences and to community members in the Salinas Valley. Visitors to the CERCH website also can sign up for newsletters through a button on our homepage. Our email list is comprised of researchers, students, farmworkers, advocates, health professionals, growers, and other community members.
  • Dissemination to larger community and targeted groups: We continued our efforts to share Center research findings with the Salinas Valley community through targeted meetings with community groups and key stakeholders, participation in community events, and media interviews about our work. Mostly in the Salinas Valley, we conducted nearly 87 meetings with targeted groups in the community to discuss recent Center findings and other environmental health issues. Center staff also participated in several local health-related events such as health fairs and town hall meetings to talk about Center research. Through these efforts we made contact with 764 children, 2,059 women, and 1,015 men from July 1, 2012 to May 31, 2013.
  • Dissemination to the scientific community: A list of pertinent scientific publications is listed for each Core in their respective progress reports, along with a list of presentations at scientific meetings. We also have presented our findings at other local meetings and universities, including briefings with senior scientific and management staff at the California Department of Pesticide Regulation.
  • Website: On our website, www.cerch.org Exit, we have developed an Online Resource Center (ORC) where specific audience groups can access information on environmental health hazards, and how they can protect themselves including parents, families, young children and teens, community groups, and health professionals. As new resources are developed by our Center, they are posted to the ORC to facilitate rapid access by these audience groups. To expand our online outreach efforts we recently have started a CERCH Facebook page where interested individuals can hear about breaking news related to the Center on their Facebook Newsfeed.

2. To increase awareness about children'’s environmental health among low-income Latino communities, clinicians, and service providers through widespread dissemination of innovative outreach and educational programs.

  • Outreach to pregnant women: The Prenatal Environmental Health Kiosk has been updated to reach a wider audience. The Prenatal Kiosk now is available on the internet, on both PC and Mac platforms, and in both English and Spanish. We also have added new slides on emerging chemical exposures for pregnant women including: BPA, Phthalates, and Flame Retardants. All versions of the Kiosk now are available in the CERCH Online Resource Center. Also, on February 20, 2013, the Prenatal Kiosk was presented to the Monterey County Comprehensive Perinatal Services Program (CPSP) to encourage CPSP workers to share the resource with their clients
  • Outreach to childcare providers: In collaboration with the California Childcare Health Program (CCHP), we continue to conduct our workshop on healthy environments in childcare settings. We have presented 14 such trainings in Monterey County reaching 306 childcare providers and parents. Dr. Bradman and Jose Camacho also worked with the UCSF and UCI PEHSU and Region IX EPA to conduct a successful training on environmental health in schools and childcare in Imperial County, CA.
  • Outreach to social service organizations: Over the past year, Center staff has continued to provide presentations to community groups in Monterey County on the following topics: Preventing Pesticide Exposure, CHAMACOS Findings Overview, Healthy Homes, and Heat Illness Prevention. With support from an EPA Children'’s Center grant, we have conducted two Train-the-Trainers workshops to prepare community leaders to give pesticide safety training presentations. The workshop was given once to farmworker parent leaders from the Migrant Education program, and then again to local community health workers.
  • Outreach to farmworkers: We have maintained a Farmworker Council of former and current farmworkers in the Salinas Valley. We will be meeting with this group in June 2013 to discuss outreach strategies, and facilitate farmworker input into Center research and health promotion activities. We share Spanish-language summaries of our research with this group before the results are published. Additionally, we continue to provide many presentations and trainings to members of the public in the Salinas Valley, many of whom are farmworkers.
  • Outreach to growers and the agricultural industry: We continue to have a relationship with our Agricultural Council, including the sharing of study summaries of abstracts with this group before they are released and phone conferences with members. We also have made ourselves available to talk with them if they have questions related to new publications. Our CAB continues to include membership from local leaders of the agricultural industry.

3. To build the capacity of Salinas Valley youth to promote healthy environmental policies in their community.

We have maintained the CHAMACOS Youth Community Council (YCC), whose goal it is to build youth capacity to promote healthy environmental policies in Salinas. The YCC now consists of 20 youth from Salinas, CA, and we meet with them twice per month. We continue to build on the Photovoice project that was conducted by the youth in 2011. One of the themes that came from the Photovoice project was lack of safe space to get physical activity in Salinas. To learn more about this built environment issue, the youth conducted a Walkability Survey to learn what prevented community members from walking as much as they would like. Youth were involved in all phases of the survey including designing the survey instrument, conducting interviews, entering data, and analyzing the data. A report currently is being written to share the results of the survey, and will support efforts to bring safer spaces to get physical activity to Salinas.The YCC also has been involved in a new project funded by the California Breast Cancer Research Fund to investigate exposure to endocrine disruptors in Latina adolescents. The study will measure endocrine disruptors in 100 adolescent girls of Salinas, then ask them to use low-chemical personal care products for 3 days. After the 3 days, we will measure their endocrine disruptors once again. The YCC are again involved in all phases of the project including, designing questionnaires and recruitment; they also will be involved in study interviewing, and data analysis. The project is titled the HERMOSA Study, an acronym for Health and Environmental Research in Make-up Of Salinas Adolescents. The word also translates to “beautiful” in Spanish. For more on the HERMOSA Study, see: www.cerch.org/hermosastudy Exit.

4. To educate policy makers at the local, state, and national levels about Center research findings and children'’s environmental health priorities.

On June 26, 2012, Dr. Kim Harley was invited to speak to the California State Assembly Environmental Safety and Toxic Materials Committee on the health effects of flame retardants. This talk followed a four-part series by the Chicago Tribune that ignited interest in the California flammability standard. On January 16, 2013, Dr. Bradman was invited to speak at the Symposium on Cumulative Impacts and Children's Environmental Health for the California Office of Environmental Health Hazard Assessment on the “Application of a Cumulative Impact Framework to Understand Environmental Exposures and Social Stressors in an Agricultural Community.” Legislative aides for state representatives attended the talk. On April 24, Dr. Bradman was invited to speak to the California State Assembly Environmental Safety and Toxic Materials Committee at a meeting on Fumigant Alternatives. At the meeting he fielded many questions related to a recent publication in EHP on methyl bromide and birth outcomes.

Significance: COTC activities are vital to our Community-University partnership. The COTC permits Center scientists and community partners to communicate study findings in a culturally appropriate manner, to raise awareness of children’'s environmental health within and beyond the Salinas Valley, and to mobilize groups toward actions that will improve the health of low-income Latino residents in Monterey County. By increasing the capacity of community members and professionals in the Salinas Valley to address environmental health issues, we are supporting efforts to reduce environmental exposures to children.

Project-Generated Resources

The COTC core has received funds from U.S. EPA to expand outreach activities by building capacity to reduce children’'s environmental health exposures. With this supplementary funding and COTC Core funding, we have developed the following resources:

  • Online Resource Center (ORC) at www.cerch.org Exit tailored to distinct audience groups.
  • Update of the Prenatal Environmental Health Kiosk. Now available on PC and Mac platforms, in English and Spanish, and with new sections on emerging exposures including phthalates, bisphenol-a, and flame retardants. We also have developed a flyer that health workers can give to their patients to educate them about environmental health hazards to be aware of during pregancy. Available at www.cerch.org/kiosk Exit in English, and at www.cerch.org/kiosco Exit in Spanish.
  • Train-the-Trainer Curriculum——a guide for other community based organizations that are interested in building capacity among lay health workers on pesticide exposure reducing tecniques.
  • Puppet show video and script——we have developed a puppet show for children ages 4-8 years old to learn about pesticides alongside the puppets Lola, Lupe, and Beto. In the puppet show, audience members learn the following about pesticides: (1) What are they? (2) Why are they dangerous?, and (3) How can they be avoided? A video of the puppet show in both English and Spanish is available on our website. Also, for childcare programs and others who work with children who would like to replicate the puppet show, we have posted the script in English and Spanish on our website.
  • Trainings to build environmental health awareness and capacity to prevention exposures in child settings including: Environmental Quality in Childcare Centers and Healthy Homes. The environmental quality in Childcare Centers training focuses on pesticides and integrated pest management strategies, as well as a broad range of environmental health concerns in childcare facilities. Healthy Homes training prepares parents to prevent exposures associated with poor housing quality. By learning to take a holistic approach to identifying and resolving housing problems that affect the health of residents, parents leave with the tools to understand and apply healthy homes intervention strategies.

Future Activities:

Project A (R834513C001)

In year 5, we will complete the 11¼-year and 12-year assessments, and will complete as many 12¾ visits as we are able before funding expires. We will complete data entry and cleaning of the 10½-year questionnaire and neurodevelopment data, as well as for age 9¾, 10½, and 11¼ Tanner data. We anticipate that PBPK models to back-extrapolate levels during pregnancy for CHAM2 will be completed by March 2014. Statistical analyses of prenatal PBDEs and DDT/E exposure in CHAM2 study participants (Aims 2 and 3) will begin when these PBPK models are available.

Project B (R834513C002)

In the next year, measurements of Mn in hair will be completed. We will complete analyses of predictors of Mn in house dust and correlates of PBDE and DDT/E exposure. We expect to publish at least four manuscripts this year, one on predictors of Mn in dust, one examining the interrelationships of Mn in biological samples, one on the best method to back-estimate maternal PBDE and DDT/E levels in adult women, and another on correlates of PBDE’s and DDT/E in 9-year-old boys.

Project C (R834513C003)

In the next year, we will finalize analyses of available Illumina 450K data using newly developed ASMN methodology, both genome-wide and site-specific. Recent publications also have suggested filtering for potentially biased probes (i.e., sex linked probes and those containing SNP). Therefore, we will re-examine sites differentially methylated by sex, age, puberty, and environmental exposures. We will complete the analyses of ontogenetic changes in DNA methylation as soon as 12-year-old samples are collected. We also will expand on the analyses of the relationship of epigenetic changes with hormones and puberty onset using complete global methylation data for Alu and LINE-1 assays.

COTC Core (R834513C004)

Dissemination of Center research findings: We plan to hold a Youth Community Forum in the summer of 2013 for CHAMACOS children participants and a Participant Community Forum in December 2013 for all study participants. We will continue targeted outreach to community groups, and respond to invitations for presentations. We will be holding a meeting of our Community Advisory Board and Farmworker Councils. We will continue to communicate with the members of our Agricultural Council, although we will need to redevelop the structure and protocol of our interaction with this group. We also will continue our dissemination to the scientific community.

Education on children’'s environmental health: We have completed the revisions to the Prenatal Environmental Health Kiosk. Next, we will develop a guide for its use in health clinics and social service agencies. Environmental education to childcare providers and community groups will continue.

Youth Community Council: Over the summer, the YCC will engage with the participatory research project to investigate exposure to endocrine disruptors from personal care products. They will be involved in all phases of the research project. After the project, they will take part in actions to reduce exposure of Latina adolescents to these personal care projects. This project was funded by the California Breast Cancer Research Fund based on the strength of the previous 2 years of work of the YCC.


Journal Articles: 137 Displayed | Download in RIS Format

Other center views: All 666 publications 138 publications in selected types All 137 journal articles
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Journal Article Alkon A, Boyce WT, Davis NV, Eskenazi B. Developmental changes in autonomic nervous system resting and reactivity measures in Latino children from 6 to 60 months of age. Journal of Developmental and Behavioral Pediatrics 2011;32(9):668-677. R834513 (2012)
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  • Journal Article Alkon A, Boyce WT, Tran L, Harley KG, Neuhaus J, Eskenazi B. Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLoS One 2014;9(1):e86283. R834513 (2012)
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  • Journal Article Alkon A, Harley KG, Neilands TB, Tambellini K, Lustig RH, Boyce WT, Eskenazi B. Latino children's body mass index at 2-3.5 years predicts sympathetic nervous system activity at 5 years. Childhood Obesity 2014;10(3):214-224. R834513 (2012)
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  • Journal Article Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith D. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environmental Science & Technology 2012;46(9):5118-5125. R834513 (Final)
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  • Journal Article Arora M, Bradman A, Austin C, Vedar M, Holland N, Eskenazi B, Smith DR. Determining fetal manganese exposure from mantle dentine of deciduous teeth. Environmental Science & Technology 2012;46(9):5118-5125. R834513 (2010)
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  • Journal Article Audelo J, Kogut K, Harley KG, Rosas LG, Stein L, Eskenazi B. Maternal depression and childhood overweight in the CHAMACOS Study of Mexican-American children. Maternal and Child Health Journal 2016;20(7):1405-1414. R834513 (2014)
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  • Journal Article AugsJoost B, Jerman P, Deardorff J, Harley K, Constantine NA. Factors associated with parent support for condom education and availability. Health Education & Behavior 2014;41(2):207-215. R834513 (2014)
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  • Journal Article Austin C, Smith TM, Bradman A, Hinde K, Joannes-Boyau R, Bishop D, Hare DJ, Doble P, Eskenazi B, Arora M. Barium distributions in teeth reveal early-life dietary transitions in primates. Nature 2013;498(7453):216-219. R834513 (2013)
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  • Journal Article Beamer PI, Canales RA, Bradman A, Leckie JO. Farmworker children’s residential non-dietary exposure estimates from micro-level activity time series. Environment International 2009;35(8):1202-1209. R834513 (2010)
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  • Journal Article Beamer PI, Canales RA, Ferguson AC, Leckie JO, Bradman A. Relative pesticide and exposure route contribution to aggregate and cumulative dose in young farmworker children. International Journal of Environmental Research and Public Health 2012;9(1):73-96. R834513 (2013)
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  • Journal Article Beamer P, Canales RA, Leckie JO. Developing probability distributions for transfer efficiencies for dermal exposure. Journal of Exposure Science and Environmental Epidemiology 2009;19(3):274-283. R834513 (2010)
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  • Journal Article Bouchard MF, Chevrier J, Harley KG, Kogut K, Vedar M, Calderon N, Trujillo C, Johnson C, Bradman A, Barr DB, Eskenazi B. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental Health Perspectives 2011;119(8):1189-1195. R834513 (2010)
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  • Journal Article Bradman A, Fenster L, Sjodin A, Jones RS, Patterson Jr DG, Eskenazi B. Polybrominated diphenyl ether levels in the blood of pregnant women living in an agricultural community in California. Environmental Health Perspectives 2007;115(1):71-74. R834513 (2010)
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  • Journal Article Bradman A, Castorina R, Barr DB, Chevrier J, Harnly ME, Eisen EA, McKone TE, Harley K, Holland N, Eskenazi B. Determinants of organophosphorus pesticide urinary metabolite levels in young children living in an agricultural community. International Journal of Environmental Research and Public Health 2011;8(4):1061-1083. R834513 (2010)
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  • Journal Article Bradman A, Castorina R, Sjodin A, Fenster L, Jones RS, Harley KG, Chevrier J, Holland NT, Eskenazi B. Factors associated with serum polybrominated diphenyl ether (PBDE) levels among school-age children in the CHAMACOS cohort. Environmental Science & Technology 2012;46(13):7373-7381. R834513 (2012)
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  • Journal Article Bradman A, Kogut K, Eisen EA, Jewell NP, Quiros-Alcala L, Castorina R, Chevrier J, Holland NT, Barr DB, Kavanagh-Baird G, Eskenazi B. Variability of organophosphorous pesticide metabolite levels in spot and 24-hr urine samples collected from young children during 1 week. Environmental Health Perspectives 2013;121(1):118-124. R834513 (2011)
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  • Journal Article Bradman A, Castorina R, Gaspar F, Nishioka M, Colon M, Weathers W, Egeghy PP, Maddalena R, Williams J, Jenkins PL, McKone TE. Flame retardant exposures in California early childhood education environments. Chemosphere 2014;116:61-66. R834513 (2014)
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  • Journal Article Bradman A, Quiros-Alcala L, Castorina R, Schall RA, Camacho J, Holland NT, Barr DB, Eskenazi B. Effect of organic diet intervention on pesticide exposures in young children living in low-income urban and agricultural communities. Environmental Health Perspectives 2015;123(10):1086-1093. R834513 (2014)
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  • Journal Article Castorina R, Bradman A, Fenster L, Barr DB, Bravo R, Vedar MG, Harnly ME, McKone TE, Eisen EA, Eskenazi B. Comparison of current-use pesticide and other toxicant urinary metabolite levels among pregnant women in the CHAMACOS cohort and NHANES. Environmental Health Perspectives 2010;118(6):856-863. R834513 (2010)
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  • Journal Article Castorina R, Bradman A, Stapleton HM, Butt C, Avery D, Harley KG, Gunier RB, Holland N, Eskenazi B. Current-use flame retardants: maternal exposure and neurodevelopment in children of the CHAMACOS cohort. Chemosphere 2017;189:574-580. R834513 (Final)
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  • Journal Article Castorina R, Butt C, Stapleton HM, Avery D, Harley KG, Holland N, Eskenazi B, Bradman A. Flame retardants and their metabolites in the homes and urine of pregnant women residing in California (the CHAMACOS cohort). Chemosphere 2017;179:159-166. R834513 (Final)
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  • Journal Article Chadwick LH, Sawa A, Yang IV, Baccarelli A, Breakefield XO, Deng H-W, Dolinoy DC, Fallin MD, Holland NT, Houseman EA, Lomvardas S, Rao M, Satterlee JS, Tyson FL, Vijayanand P, Greally JM. New insights and updated guidelines for epigenome-wide association studies. Neuroepigenetics 2015;1:14-19. R834513 (2014)
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  • Journal Article Chevrier J, Harley KG, Bradman A, Gharbi M, Sjodin A, Eskenazi B. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environmental Health Perspectives 2010;118(10):1444-1449. R834513 (2010)
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  • Journal Article Chevrier J, Harley KG, Kogut K, Holland N, Johnson C, Eskenazi B. Maternal thyroid function during the second half of pregnancy and child neurodevelopment at 6, 12, 24, and 60 months of age. Journal of Thyroid Research 2011;2011:426427 (13 pp.). R834513 (2011)
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  • Journal Article Chevrier J, Gunier RB, Bradman A, Holland NT, Calafat AM, Eskenazi B, Harley KG. Maternal urinary bisphenol A during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environmental Health Perspectives 2013;121(1):138-144. R834513 (2012)
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  • Journal Article Chevrier J, Warner M, Gunier RB, Brambilla P, Eskenazi B, Mocarelli P. Serum dioxin concentrations and thyroid hormone levels in the Seveso Women’s Health Study. American Journal of Epidemiology 2014;180(5):490-498. R834513 (2014)
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  • Journal Article Chopra V, Harley K, Lahiff M, Eskenazi B. Association between phthalates and attention deficit disorder and learning disability in U.S. children, 6-15 years. Environmental Research 2014;128:64-69. R834513 (2014)
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  • Journal Article Coker E, Gunier R, Bradman A, Harley K, Kogut K, Molitor J, Eskenazi B. Association between Pesticide Profiles Used on Agricultural Fields near Maternal Residences during Pregnancy and IQ at Age 7 Years. International Journal of Environmental Research and Public Health 2017;14(5):506 (20 pp.). R834513 (Final)
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  • Journal Article Dannemiller KC, Mendell MJ, Macher JM, Kumagai K, Bradman A, Holland N, Harley K, Eskenazi B, Peccia J. Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development. Indoor Air 2014;24(3):236-247. R834513 (2014)
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  • Journal Article Dave V, Yousefi P, Huen K, Volberg V, Holland N. Relationship between expression and methylation of obesity-related genes in children. Mutagenesis 2015;30(3):411-420. R834513 (2013)
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  • Journal Article Dave V, Street K, Francis S, Bradman A, Riley L, Eskenazi B, Holland N. Bacterial microbiome of breast milk and child saliva from low-income Mexican-American women and children. Pediatric Research 2016;79(6):846-854. R834513 (Final)
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  • Journal Article Duramad P, Holland NT. Biomarkers of immunotoxicity for environmental and public health research. International Journal of Environmental Research and Public Health 2011;8(5):1388-1401. R834513 (2010)
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  • Journal Article Eastman RR, Jursa TP, Benedetti C, Lucchini RG, Smith DR. Hair as a biomarker of environmental manganese exposure. Environmental Science & Technology 2013;47(3):1629-1637. R834513 (2012)
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  • Journal Article Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glucose levels in women without diabetes or gestational diabetes and childhood cardiometabolic risk at 7 years of age. Journal of Pediatrics 2012;161(6):1016-1021. R834513 (2012)
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  • Journal Article Ehrlich SF, Rosas LG, Ferrara A, King JC, Abrams B, Harley KG, Hedderson MM, Eskenazi B. Pregnancy glycemia in Mexican-American women without diabetes or gestational diabetes and programming for childhood obesity. American Journal of Epidemiology 2013;177(8):768-775. R834513 (2012)
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  • Journal Article Engel SM, Bradman A, Wolff MS, Rauh VA, Harley KG, Yang JH, Hoepner LA, Barr DB, Yolton K, Vedar MG, Xu Y, Hornung RW, Wetmur JG, Chen J, Holland NT, Perera FP, Whyatt RM, Lanphear BP, Eskenazi B. Prenatal organophosphorus pesticide exposure and child neurodevelopment at 24 months: an analysis of four birth cohorts. Environmental Health Perspectives 2016;124(6):822-830. R834513 (2014)
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  • Journal Article Erkin-Cakmak A, Harley KG, Chevrier J, Bradman A, Kogut K, Huen K, Eskenazi B. In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS Study. Environmental Health Perspectives 2015;123(6):636-642. R834513 (2015)
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  • Journal Article Eskenazi B, Huen K, Marks A, Harley KG, Bradman A, Barr DB, Holland N. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environmental Health Perspectives 2010;118(12):1775-1781. R834513 (2010)
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  • Journal Article Eskenazi B, Fenster L, Castorina R, Marks AR, Sjodin A, Rosas LG, Holland N, Guerra AG, Lopez-Carrillo L, Bradman A. A comparison of PBDE serum concentrations in Mexican and Mexican-American children living in California. Environmental Health Perspectives 2011;119(10):1442-1448. R834513 (2010)
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  • Journal Article Eskenazi B, Chevrier J, Rauch SA, Kogut K, Harley KG, Johnson C, Trujillo C, Sjodin A, Bradman A. In utero and childhood polybrominated diphenyl ether (PBDE) exposures and neurodevelopment in the CHAMACOS study. Environmental Health Perspectives 2013;121(2):257-262. R834513 (2012)
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  • Journal Article Eskenazi B, Bradman A, Finkton D, Purwar M, Noble JA, Pang R, Burnham O, Cheikh Ismail L, Farhi F, Barros FC, Lambert A, Papageorghiou AT, Carvalho M, Jaffer YA, Bertino E, Gravett MG, Altman DG, Ohuma EO, Kennedy SH, Bhutta ZA, Villar J, International Fetal and Newborn Growth Consortium for the 21st Century. A rapid questionnaire assessment of environmental exposures to pregnant women in the INTERGROWTH-21st Project. BJOG: An International Journal of Obstetrics & Gynaecology 2013;120(Suppl 2):129-138. R834513 (2014)
    R834513C002 (2014)
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  • Journal Article Eskenazi B, Warner M, Sirtori M, Fuerst T, Rauch SA, Brambilla P, Mocarelli P, Rubinacci A. Serum dioxin concentrations and bone density and strucure in the Seveso Women’s Health Study. Environmental Health Perspectives 2014;122(1):51-57. R834513 (2014)
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  • Journal Article Eskenazi B, Quiros-Alcala L, Lipsitt JM, Wu LD, Kruger P, Ntimbane T, Nawn JB, Bornman R, Seto E. mSpray: a mobile phone technology to improve malaria control efforts and monitor human exposure to malaria control pesticides in Limpopo, South Africa. Environment International 2014;68:219-226. R834513 (2014)
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  • Journal Article Eskenazi B, Kogut K, Huen K, Harley KG, Bouchard M, Bradman A, Boyd-Barr D, Johnson C, Holland N. Organophosphate pesticide exposure, PON1, and neurodevelopment in school-age children from the CHAMACOS study. Environmental Research 2014;134:149-157. R834513 (2014)
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  • Journal Article Eskenazi B, Rauch SA, Tenerelli R, Huen K, Holland NT, Lustig RH, Kogut K, Bradman A, Sjödin A, Harley KG. In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: the CHAMACOS study. International Journal of Hygiene and Environmental Health 2017;220(2 Pt B):364-372. R834513 (Final)
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  • Journal Article Gaspar FW, Castorina R, Maddalena RL, Nishioka MG, McKone TE, Bradman A. Phthalate exposure and risk assessment in California child care facilities. Environmental Science & Technology 2014;48(13):7593-7601. R834513 (2014)
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  • Journal Article Gaspar FW, Harley KG, Kogut K, Chevrier J, Mora AM, Sjodin A, Eskenazi B. Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort. Environment International 2015;85:206-212. R834513 (2014)
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  • Journal Article Gemmill A, Gunier RB, Bradman A, Eskenazi B, Harley KG. Residential proximity to methyl bromide use and birth outcomes in an agricultural population in California. Environmental Health Perspectives 2013;121(6):737-743. R834513 (2013)
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  • Journal Article Gomez N, Guendelman S, Harley KG, Gomez SL. Nativity and neighborhood characteristics and cervical cancer stage at diagnosis and survival outcomes among Hispanic women in California. American Journal of Public Health 2015;105(3):538-545. R834513 (Final)
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  • Journal Article Guerrero J, Madrigal DS, Minkler M. What is…?: a research ethics Jeopardy™ game to help community partners understand human subjects protections and their importance. Progress in Community Health Partnerships: Research, Education, and Action 2014;8(3):405-411. R834513 (2014)
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  • Journal Article Gunier RB, Bradman A, Jerrett M, Smith DR, Harley KG, Austin C, Vedar M, Arora M, Eskenazi B. Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community. Environmental Science & Technology 2013;47(19):11249-11257. R834513 (2013)
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  • Journal Article Gunier RB, Mora AM, Smith D, Arora M, Austin C, Eskenazi B, Bradman A. Biomarkers of manganese exposure in pregnant women and children living in an agricultural community in California. Environmental Science & Technology 2014;48(24):14695-14702. R834513 (2011)
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  • Journal Article Gunier RB, Jerrett M, Smith DR, Jursa T, Yousefi P, Camacho J, Hubbard A, Eskenazi B, Bradman A. Determinants of manganese levels in house dust samples from the CHAMACOS cohort. Science of the Total Environment 2014;497-498:360-368. R834513 (2012)
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  • Journal Article Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B. Manganese in teeth and neurodevelopment in young Mexican-American children. Environmental Research 2015;142:688-695. R834513 (2014)
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  • Journal Article Gunier RB, Bradman A, Harley KG, Eskenazi B. Will buffer zones around schools in agricultural areas be adequate to protect children from the potential adverse effects of pesticide exposure? PLoS Biology 2017;15(12):e2004741 (7 pp.). R834513 (Final)
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  • Journal Article Gunier RB, Bradman A, Harley KG, Kogut K, Eskenazi B. Prenatal residential proximity to agricultural pesticide use and IQ in 7-year-old children. Environmental Health Perspectives 2017;125(5):057002 (8 pp.). R834513 (Final)
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  • Journal Article Gunier RB, Bradman A, Castorina R, Holland NT, Avery D, Harley KG, Eskenazi B. Residential proximity to agricultural fumigant use and IQ, attention and hyperactivity in 7-year old children. Environmental Research 2017;158:358-365. R834513 (Final)
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  • Journal Article Gunier RB, Raanan R, Castorina R, Holland NT, Harley KG, Balmes JR, Fouquette L, Eskenazi B, Bradman A. Residential proximity to agricultural fumigant use and respiratory health in 7-year old children. Environmental Research. 2018;164:93-99. R834513 (Final)
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  • Journal Article Harley KG, Marks AR, Chevrier J, Bradman A, Sjodin A, Eskenazi B. PBDE concentrations in women’s serum and fecundability. Environmental Health Perspectives 2010;118(5):699-704. R834513 (2010)
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  • Journal Article Harley KG, Huen K, Aguilar Schall R, Holland NT, Bradman A, Barr DB, Eskenazi B. Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PLoS ONE 2011;6(8):e23923 (10 pp.). R834513 (2010)
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  • Journal Article Harley KG, Chevrier J, Schall RA, Sjodin A, Bradman A, Eskenazi B. Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight. American Journal of Epidemiology 2011;174(8):885-892. R834513 (2010)
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  • Journal Article Harley KG, Aguilar Schall R, Chevrier J, Tyler K, Aguirre H, Bradman A, Holland NT, Lustig RH, Calafat AM, Eskenazi B. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(4):514-520. R834513 (2012)
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  • Journal Article Harley KG, Gunier RB, Kogut K, Johnson C, Bradman A, Calafat AM, Eskenazi B. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environmental Research 2013;126:43-50. R834513 (2014)
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  • Journal Article Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphate pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. R834513 (2014)
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  • Journal Article Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. R834513 (Final)
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  • Journal Article Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environmental Health Perspectives 2016;124(10):1600-1607. R834513 (Final)
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  • Journal Article Harley KG, Rauch SA, Chevrier J, Kogut K, Parra KL, Trujillo C, Lustig RH, Greenspan LC, Sjodin A, Bradman A, Eskenazi B. Association of prenatal and childhood PBDE exposure with timing of puberty in boys and girls. Environment International 2017;100:132-138. R834513 (2014)
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  • Journal Article Harley KG, Berger K, Rauch S, Kogut K, Henn BC, Calafat AM, Huen K, Eskenazi B, Holland N. Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity. Pediatric Research 2017;82(3):405-415. R834513 (Final)
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  • Journal Article Harnly ME, Bradman A, Nishioka M, McKone TE, Smith D, McLaughlin R, Kavanagh-Baird G, Castorina R, Eskenazi B. Pesticides in dust from homes in an agricultural area. Environmental Science & Technology 2009;43(23):8767-8774. R834513 (2010)
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  • Journal Article Heggeseth B, Harley K, Warner M, Jewell N, Eskenazi B. Detecting associations between early-life DDT exposures and childhood growth patterns: a novel statistical approach. PLoS ONE 2015;10(6):e0131443 (13 pp.). R834513 (2015)
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  • Journal Article Holland N, Lizarraga D, Huen K. Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health. Current Opinion in Pediatrics 2015;27(2):240-247. R834513 (2013)
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  • Journal Article Holland N, Huen K, Tran V, Street K, Nguyen B, Bradman A, Eskenazi B. Urinary phthalate metabolites and biomarkers of oxidative stress in a Mexican-American cohort: variability in early and late pregnancy. Toxics 2016;4(1):7 (18 pp.). R834513 (Final)
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  • Journal Article Huen K, Richter R, Furlong C, Eskenazi B, Holland N. Validation of PON1 enzyme activity assays for longitudinal studies. Clinica Chimica Acta 2009;402(1-2):67-74. R834513 (2010)
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  • Journal Article Huen K, Harley K, Brooks J, Hubbard A, Bradman A, Eskenazi B, Holland N. Developmental changes in PON1 enzyme activity in young children and effects of PON1 polymorphisms. Environmental Health Perspectives 2009;117(10):1632-1638. R834513 (2010)
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  • Journal Article Huen K, Harley K, Bradman A, Eskenazi B, Holland N. Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes. Toxicology and Applied Pharmacology 2010;244(2):181-189. R834513 (2010)
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  • Journal Article Huen K, Barcellos L, Beckman K, Rose S, Eskenazi B, Holland N. Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children. Environmental and Molecular Mutagenesis 2011;52(2):105-116. R834513 (2010)
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  • Journal Article Huen K, Bradman A, Harley K, Yousefi P, Boyd Barr D, Eskenazi B, Holland N. Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community. Environmental Research 2012;117:8-16. R834513 (2010)
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  • Journal Article Huen K, Harley K, Beckman K, Eskenazi B, Holland N. Associations of PON1 and genetic ancestry with obesity in early childhood. PLoS One 2013;8(5):e62565. R834513 (2013)
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  • Journal Article Huen K, Yousefi P, Bradman A, Yan L, Harley KG, Kogut K, Eskenazi B, Holland N. Effects of age, sex, and persistent organic pollutants on DNA methylation in children. Environmental and Molecular Mutagenesis 2014;55(3):209-222. R834513 (2012)
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  • Journal Article Huen K, Yousefi P, Street K, Eskenazi B, Holland N. PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genes. Environmental Epigenetics 2015;1(1):dvv003. R834513 (2015)
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  • Journal Article Huen K, Calafat AM, Bradman A, Yousefi P, Eskenazi B, Holland N. Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children. Environmental Research 2016;148:55-62. R834513 (Final)
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  • Journal Article Huen K, Harley K, Kogut K, Rauch S, Eskenazi B, Holland N. DNA methylation of LINE-1 and Alu repetitive elements in relation to sex hormones and pubertal timing in Mexican-American children. Pediatric Research 2016;79(6):855-862. R834513 (2014)
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  • Journal Article Johnson M, Deardorff J, Davis EL, Martinez W, Eskenazi B, Alkon A. The relationship between maternal responsivity, socioeconomic status, and resting autonomic nervous system functioning in Mexican American children. International Journal of Psychophysiology 2017;116:45-52. R834513 (Final)
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  • Journal Article Lizarraga D, Huen K, Combs M, Escudero-Fung M, Eskenazi B, Holland N. miRNAs differentially expressed by next-generation sequencing in cord blood buffy coat samples of boys and girls. Epigenomics 2016;8(12):1619-1635. R834513 (Final)
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  • Journal Article Lopez-Espinosa M-J, Mondal D, Armstrong BG, Eskenazi B, Fletcher T. Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6-9 years of age: a cross-sectional analysis within the C8 Health Project. Environmental Health Perspectives 2016;124(8):1269-1275. R834513 (2014)
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  • Journal Article Macher JM, Mendell MJ, Kumagai K, Holland NT, Camacho JM, Harley KG, Eskenazi B, Bradman A. Higher measured moisture in California homes with qualitative evidence of dampness. Indoor Air 2016;26(6):892-902. R834513 (Final)
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  • Journal Article Madrigal DS, Salvatore A, Casillas G, Casillas C, Vera I, Eskenazi B, Minkler M. Health in my community: conducting and evaluating PhotoVoice as a tool to promote environmental health and leadership among Latino/a youth. Progress in Community Health Partnerships: Research, Education, and Action 2014;8(3):317-329. R834513 (2014)
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  • Journal Article Marks AR, Harley K, Bradman A, Kogut K, Barr DB, Johnson C, Calderon N, Eskenazi B. Organophosphate pesticide exposure and attention in young Mexican-American children: the CHAMACOS Study. Environmental Health Perspectives 2010;118(12):1768-1774. R834513 (2010)
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  • Journal Article Mora AM, van Wendel de Joode B, Mergler D, Cordoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Lundh T, Lindh CH, Bradman A, Eskenazi B. Blood and hair manganese concentrations in pregnant women from the Infants’ Environmental Health Study (ISA) in Costa Rica. Environmental Science & Technology 2014;48(6):3467-3476. R834513 (2014)
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  • Journal Article Mora AM, van Wendel de Joode B, Mergler D, Cordoba L, Cano C, Quesada R, Smith DR, Menezes-Filho JA, Eskenazi B. Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica. Environmental Research 2015;136:47-56. R834513 (2014)
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  • Journal Article Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernandez-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5 years in the CHAMACOS cohort. Environment International 2015;84:39-54. R834513 (2014)
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  • Journal Article Payne-Sturges D, Cohen J, Castorina R, Axelrad DA, Woodruff TJ. Evaluating cumulative organophosphorus pesticide body burden of children: a national case study. Environmental Science & Technology 2009;43(20):7924-7930. R834513 (2010)
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  • Journal Article Quiros-Alcala L, Bradman A, Nishioka M, Harnly ME, Hubbard A, McKone TE, Eskenazi B. Concentrations and loadings of polybrominated diphenyl ethers in dust from low-income households in California. Environment International 2011;37(3):592-596. R834513 (2010)
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  • Journal Article Quiros-Alcala L, Bradman A, Nishioka M, Harnly ME, Hubbard A, McKone TE, Ferber J, Eskenazi B. Pesticides in house dust from urban and farmworker households in California: an observational measurement study. Environmental Health 2011;10:19 (15 pp.). R834513 (2010)
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  • Journal Article Quiros-Alcala L, Alkon AD, Boyce WT, Lippert S, Davis NV, Bradman A, Barr DB, Eskenazi B. Maternal prenatal and child organophosphate pesticide exposures and children's autonomic function. NeuroToxicology 2011;32(5):646-655. R834513 (2010)
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  • Journal Article Quiros-Alcala L, Bradman A, Smith K, Weerasekera G, Odetokun M, Barr DB, Nishioka M, Castorina R, Hubbard AE, Nicas M, Hammond SK, McKone TE, Eskenazi B. Organophosphorous pesticide breakdown products in house dust and children's urine. Journal of Exposure Science & Environmental Epidemiology 2012;22(6):559-568. R834513 (2012)
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  • Journal Article Quiros-Alcala L, Eskenazi B, Bradman A, Ye X, Calafat AM, Harley K. Determinants of urinary bisphenol A concentrations in Mexican/Mexican-American pregnant women. Environment International 2013;59:152-160. R834513 (2013)
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  • Journal Article Quiros-Alcala L, Mehta S, Eskenazi B. Pyrethroid pesticide exposure and parental report of learning disability and attention deficit/hyperactivity disorder in U.S. children: NHANES 1999-2002. Environmental Health Perspectives 2014;122(12):1336-1342. R834513 (2014)
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  • Journal Article Raanan R, Harley KG, Balmes JR, Bradman A, Lipsett M, Eskenazi B. Early-life exposure to organophosphate pesticides and pediatric respiratory symptoms in the CHAMACOS cohort. Environmental Health Perspectives 2015;123(2):179-185. R834513 (2010)
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  • Journal Article Raanan R, Balmes JR, Harley KG, Gunier RB, Magzamen S, Bradman A, Eskenazi B. Decreased lung function in 7-year-old children with early-life organophosphate exposure. Thorax 2016;71(2):148-153. R834513 (2015)
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  • Journal Article Raanan R, Gunier RB, Balmes JR, Beltran AJ, Harley KG, Bradman A, Eskenazi B. Elemental sulfur use and associations with pediatric lung function and respiratory symptoms in an agricultural community (California, USA). Environmental Health Perspectives 2017;125(8):087007 (8 pp.). R834513 (Final)
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  • Journal Article Rosas LG, Harley K, Fernald LC, Guendelman S, Mejia F, Neufeld LM, Eskenazi B. Dietary associations of household food insecurity among children of Mexican descent: results of a binational study. Journal of the American Dietetic Association 2009;109(12):2001-2009. R834513 (2010)
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  • Journal Article Rosas LG, Harley KG, Guendelman S, Fernald LC, Mejia F, Eskenazi B. Maternal perception of child weight among Mexicans in California and Mexico. Maternal and Child Health Journal 2010;14(6):886-894. R834513 (2010)
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  • Journal Article Rosas LG, Guendelman S, Harley K, Fernald LC, Neufeld L, Mejia F, Eskenazi B. Factors associated with overweight and obesity among children of Mexican descent:results of a binational study. Journal of Immigrant and Minority Health 2011;13(1):169-180. R834513 (2010)
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  • Journal Article Rosas LG, Trujillo C, Camacho J, Madrigal D, Bradman A, Eskenazi B. Acceptability of health information technology aimed at environmental health education in a prenatal clinic. Patient Education and Counseling 2014;97(2):244-247. R834513 (2014)
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  • Journal Article Rowe C, Gunier R, Bradman A, Harley KG, Kogut K, Parra K, Eskenazi B. Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children. Environmental Research 2016;150:128-137. R834513 (2015)
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  • Journal Article Sagiv SK, Kogut K, Gaspar FW, Gunier RB, Harley KG, Parra K, Villasenor D, Bradman A, Holland N, Eskenazi B. Prenatal and childhood polybrominated diphenyl ether (PBDE) exposure and attention and executive function at 9-12 years of age. Neurotoxicology and Teratology 2015:52(Pt B):151-161. R834513 (2014)
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  • Journal Article Salvatore AL, Chevrier J, Bradman A, Camacho J, Lopez J, Kavanagh-Baird G, Minkler M, Eskenazi B. A community-based participatory worksite intervention to reduce pesticide exposures to farmworkers and their families. American Journal of Public Health 2009;99(Suppl 3):S578-S581. R834513 (2010)
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  • Journal Article Salvatore AL, Castorina R, Camacho J, Morga N, Lopez J, Nishioka M, Barr DB, Eskenazi B, Bradman A. Home-based community health worker intervention to reduce pesticide exposures to farmworkers’ children: a randomized-controlled trial. Journal of Exposure Science & Environmental Epidemiology 2015;25(6):608-615. R834513 (2014)
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  • Journal Article Scholtz, RI, McLaughlin KR, Cirillo PM, Petreas M, Park J-S, Wolff MS, Factor-Litvak P, Eskenazi B, Krigbaum N, Cohn BA. Assaying organochlorines in archived serum for a large, long-term cohort:implications of combining assay results from multiple laboratories over time. Environment International 2011;37(4):709-714. R834513 (2010)
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  • Journal Article Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges Jr. E, Lotti F, Steegers-Theunissen RPM, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Levy R, Czernichow S. BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human Reproduction Update 2013;19(3):221-231. R834513 (2014)
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  • Journal Article Sjodin A, Jones RS, Gunier RB, Wong LY, Holland N, Eskenazi B, Bradman, A. Polybrominated diphenyl ethers, polychlorinated biphenyls, and 2,2-Bis(4-chlorophenyl)-1,1-dichloroethene in 7-and 9-year-old children and their mothers in the Center for the Health Assessment of Mothers and Children of Salinas Cohort. Environmental Science & Technology 2018;52(4):2287-2294. R834513 (Final)
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  • Journal Article Sly PD Eskenazi B, Pronczuk J, Sram R, Diaz-Barriga F, Machin DG, Carpenter DO, Surdu S, Meslin EM. Ethical issues in measuring biomarkers in children's environmental health. Environmental Health Perspectives 2009;117(8):1185-1190. R834513 (2010)
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  • Journal Article Solomon O, Yousefi P, Huen K, Gunier RB, Escudero-Fung M, Barcellos LF, Eskenazi B, Holland N. Prenatal phthalate exposure and altered patterns of DNA methylation in cord blood. Environmental and Molecular Mutagenesis 2017;58(6):398-410. R834513 (Final)
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  • Journal Article Stein LJ, Gunier RB, Harley K, Kogut K, Bradman A, Eskenazi B. Early childhood adversity potentiates the adverse association between prenatal organophosphate pesticide exposure and child IQ: the CHAMACOS cohort. Neurotoxicology 2016;56:180-187. R834513 (2015)
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  • Journal Article Torres JM, Deardorff J, Gunier RB, Harley KG, Alkon A, Kogut K, Eskenazi B. Worry about deportation and cardiovascular disease risk factors among adult women: the Center for the Health Assessment of Mothers and Children of Salinas Study. Annals of Behavioral Medicine 2018;52(2):186-193. R834513 (Final)
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  • Journal Article Tran V, Tindula G, Huen K, Bradman A, Harley K, Kogut K, Calafat AM, Nguyen B, Parra K, Ye X, Eskenazi B, Holland N. Prenatal phthalate exposure and 8-isoprostane among Mexican-American children with high prevalence of obesity. Journal of Developmental Origins of Health and Disease 2017;8(2):196-205. R834513 (Final)
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  • Journal Article van Wendel de Joode B, Mora AM, Cordoba L, Cano JC, Quesada R, Faniband M, Wesseling C, Ruepert C, Oberg M, Eskenazi B, Mergler D, Lindh CH. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants’ Environmental Health Study (ISA). Environmental Health Perspectives 2014;122(12):1321-1328. R834513 (2014)
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  • Journal Article Verner M-A, Gaspar FW, Chevrier J, Gunier RB, Sjodin A, Bradman A, Eskenazi B. Increasing sample size in prospective birth cohorts:back-extrapolating prenatal levels of persistent organic pollutants in newly enrolled children. Environmental Science & Technology 2015;49(6):3940-3948. R834513 (2014)
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  • Journal Article Volberg V, Harley KG, Aguilar RS, Rosas LG, Huen K, Yousefi P, Dave V, Phan N, Lustig RH, Eskenazi B, Holland N. Associations between perinatal factors and adiponectin and leptin in 9-year-old Mexican-American children. Pediatric Obesity 2013;8(6):454-463. R834513 (2013)
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  • Journal Article Volberg V, Heggeseth B, Harley K, Huen K, Yousefi P, Dave V, Tyler K, Vedar M, Eskenazi B, Holland N. Adiponectin and leptin trajectories in Mexican-American children from birth to 9 years of age. PLoS One 2013;8(10):e77964 (8 pp.). R834513 (2014)
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  • Journal Article Volberg V, Harley K, Calafat AM, Dave V, McFadden J, Eskenazi B, Holland N. Maternal bisphenol A exposure during pregnancy and its association with adipokines in Mexican-American children. Environmental and Molecular Mutagenesis 2013;54(8):621-628. R834513 (2014)
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  • Journal Article Warner M, Mocarelli P, Brambilla P, Wesselink A, Samuels S, Signorini S, Eskenazi B. Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso Women's Health Study. Environmental Health Perspectives 2013;121(8):906-911. R834513 (2013)
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  • Journal Article Warner M, Schall RA, Harley KG, Bradman A, Barr D, Eskenazi B. In utero DDT and DDE exposure and obesity status of 7-year-old Mexican-American children in the CHAMACOS cohort. Environmental Health Perspectives 2013;121(5):631-636. R834513 (2013)
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    R834513C001 (2014)
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  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text-HTML
  • Abstract: EHP-Abstract
  • Other: EHP-Full Text-PDF
  • Journal Article Warner M, Wesselink A, Harley KG, Bradman A, Kogut K, Eskenazi B. Prenatal exposure to dichlorodiphenyltrichloroethane and obesity at 9 years of age in the CHAMACOS Study cohort. American Journal of Epidemiology 2014;179(11):1312-1322. R834513 (2014)
    R834513C001 (2014)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Oxford Journals-Full Text HTML
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-Full Text PDF
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  • Journal Article Warner M, Mocarelli P, Brambilla P, Wesselink A, Patterson Jr. DG, Turner WE, Eskenazi B. Serum TCDD and TEQ concentrations among Seveso women, 20 years after the explosion. Journal of Exposure Science & Environmental Epidemiology 2014;24(6):588-594. R834513 (2014)
    R834513C002 (2014)
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  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Nature-Abstract
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  • Other: Italian Minstry of Health-Abstract
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  • Journal Article Warner M, Ye M, Harley K, Kogut K, Bradman A, Eskenazi B. Prenatal DDT exposure and child adiposity at 12 years of age in the CHAMACOS cohort. Environmental Research 2017;159:606-612. R834513 (Final)
  • Abstract from PubMed
  • Full-text: ScienceDirect-Full Text-HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text-PDF
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  • Journal Article Waters SF, Boyce WT, Eskenazi B, Alkon A. The impact of maternal depression and overcrowded housing on associations between autonomic nervous system reactivity and externalizing behavior problems in vulnerable Latino children. Psychophysiology 2016;53(1):97-104. R834513 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: WIley-Abstract
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  • Journal Article Weerasekera G, Smith KD, Quiros-Alcala L, Fernandez C, Bradman A, Eskenazi B, Needham LL, Barr DB. A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice. Journal of Environmental Monitoring 2009;11(7):1345-1351. R834513 (2010)
    R834513 (2011)
    R834513 (Final)
    R831710 (Final)
  • Abstract from PubMed
  • Full-text: ResearchGate-Full Text PDF
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  • Abstract: RSC Publishing-Abstract
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  • Journal Article Weldon RH, Webster M, Harley KG, Bradman A, Fenster L, Davis MD, Hubbard A, Barr DB, Holland N, Eskenazi B. Serum persistent organic pollutants and duration of lactation among Mexican-American women. Journal of Environmental and Public Health 2010;2010:861757 (11 pp.). R834513 (2010)
    R834513 (2011)
    R834513 (2012)
    R834513 (2013)
    R834513 (2015)
    R834513 (Final)
    R834513C001 (2010)
    R834513C001 (2011)
    R834513C002 (2010)
    R834513C002 (2011)
    R834513C003 (2010)
    R834513C003 (2011)
    R831710 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: Hindawi-Full Text HTML
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  • Abstract: Hindawi-Abstract
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  • Other: Hindawi-Full Text PDF
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  • Journal Article Weldon RH, Barr DB, Trujillo C, Bradman A, Holland N, Eskenazi B. A pilot study of pesticides and PCBs in the breast milk of women residing in urban and agricultural communities of California. Journal of Environmental Monitoring 2011;13(11):3136-3144. R834513 (2011)
    R834513 (2012)
    R834513 (2013)
    R834513 (Final)
    R834513C001 (2012)
    R834513C002 (2012)
  • Abstract from PubMed
  • Full-text: ResearchGate-Full Text-PDF
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  • Abstract: RSC Publishing-Abstract
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  • Journal Article Wesselink A, Warner M, Samuels S, Parigi A, Brambilla P, Mocarelli P, Eskenazi B. Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environment International 2014;63:143-148. R834513 (2014)
    R834513C001 (2014)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
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  • Abstract: ScienceDirect-Abstract
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  • Other: ScienceDirect-Full Text PDF
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  • Journal Article Yousefi P, Huen K, Schall RA, Decker A, Elboudwarej E, Quach H, Barcellos L, Holland N. Considerations for normalization of DNA methylation data by Illumina 450K BeadChip assay in population studies. Epigenetics 2013;8(11):1141-1152. R834513 (2012)
    R834513 (2013)
    R834513 (2014)
    R834513 (2015)
    R834513 (Final)
    R834513C003 (2012)
    R834513C003 (2013)
    R834513C003 (2014)
    R834513C003 (2015)
  • Abstract from PubMed
  • Full-text: Taylor & Francis-Full Text-HTML
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  • Abstract: Taylor & Francis-Abstract
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  • Other: Taylor & Francis-Full Text-PDF
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  • Journal Article Yousefi P, Huen K, Quach H, Motwani G, Hubbard A, Eskenazi B, Holland N. Estimation of blood cellular heterogeneity in newborns and children for epigenome-wide association studies. Environmental and Molecular Mutagenesis 2015;56(9):751-758. R834513 (2015)
    R834513C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ResearchGate-Abstract & Full Text-PDF
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  • Abstract: Wiley-Abstract
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  • Journal Article Yousefi P, Huen K, Dave V, Barcellos L, Eskenazi B, Holland N. Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. BMC Genomics 2015;16:911. R834513C003 (2015)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: BioMed Central-Full Text-HTML
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  • Abstract: BioMed Central-Abstract
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  • Other: BioMed Central-Full Text-PDF
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  • Supplemental Keywords:

    DDT, DDE, PBDEs, flame retardants, manganese, maneb, puberty, neurodevelopment, behavior, children's health, CHAMACOS, mancozeb, pesticides, exposure assessment, biomonitoring, house dust, dust loading, teeth, blood, urine measurements, epigenetics, methylation, community outreach and translation, community-based research, environmental justice

    Relevant Websites:

    Center for Environmental Research and Children's Health Exit
    CHAMACOS Study, 15 Years in the Fields [Video] Exit
    Environmental Quality in California Child Care Exit
    Green Cleaning Toolkit Exit

    Progress and Final Reports:

    Original Abstract
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2014 Progress Report
  • 2015 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834513C001 CHAMACOS Cohort Project: Pesticides and PBDE on Neurobehavior and Puberty
    R834513C002 Project B: Exposure Project: Mn, DDT/E and PBDE Exposure to Farmworker Children
    R834513C003 Epigenetics Project
    R834513C004 Community Outreach and Translation Core