Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers

EPA Grant Number: R834510
Center: Mechanisms of Asthma-Dietary Interventions against Environmental Triggers - Johns Hopkins University
Center Director: Diette, Greg
Title: Mechanisms of Asthma -- Dietary Interventions against Environmental Triggers
Investigators: Diette, Greg , Anderson, Cheryl , Biswal, Shyam , Breysse, Patrick N. , Gittelsohn, Joel , Hansel, Nadia , Matsui, Elizabeth C. , McCormack, Meredith , Peng, Roger D. , Rand, Cynthia , Sharma, Sangita , Shreffler, Wayne G.
Institution: The Johns Hopkins University
EPA Project Officer: Louie, Nica
Project Period: August 1, 2009 through July 31, 2015
Project Amount: $4,107,128
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009) RFA Text |  Recipients Lists
Research Category: Children's Health , Health

Objective:

The long-term goal of the ASTHMA-DIET Program is to understand how diet influences the asthmatic response to indoor and outdoor airborne pollutants and allergens, with the expectation of translating these findings into practical dietary strategies to improve pediatric asthma health. The ASTHMA-DIET Center’s overall hypothesis is that a low anti-oxidant, pro-inflammatory diet impairs the capacity to respond to oxidative stressors, thereby increasing susceptibility to pollutant and allergen exposures. The aims of our Center proposal are focused on the mechanistic underpinnings of airway inflammation, oxidative stress and respiratory morbidity in predominantly African-American children with asthma, living in the inner city of Baltimore.

Approach:

We will use an interdisciplinary program directed to address these goals, using one mechanistic and two clinically-oriented research projects: Project 1 (Urban dietary effects on the asthmatic response to pollutants ) is an observational field study, using a panel design with repeated measures of pollutants, allergens, dietary intake and indicators of asthma morbidity, inflammation and oxidative stress. Project 2 (Dietary interventions in asthma treatment )includes two experiments, testing the capacity of 1) broccoli sprout supplementation and 2) a Mediterranean-style diet (OmniHeart) to ameliorate the response to inhaled allergens. Project 3 (Dissecting the diet-asthma relationship in mice models of asthma )uses an experimental approach in mice, using controlled diet, pollutant and allergen exposure to elucidate mechanisms by which dietary factors can modify susceptibility to pollutants and allergens.

Expected Results:

At the conclusion of this program we expect 1) to have a better understanding of the mechanisms by which diet affects susceptibility of asthmatics to inhaled pollutants and allergens, 2) to understand the extent to which the composition of the inner city diet contributes to vulnerability to pollutants and allergens, and 3) whether certain specific dietary manipulations can improve health of asthmatics, by protecting against inflammation and oxidative stress induced by pollutants and allergens.


Journal Articles: 77 Displayed | Download in RIS Format

Other center views: All 77 publications 77 publications in selected types All 77 journal articles
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Journal Article Ahluwalia SK, Peng RD, Breysse PN, Diette GB, Curtin-Brosnan J, Aloe C, Matsui EC. Mouse allergen is the major allergen of public health relevance in Baltimore City. The Journal of Allergy and Clinical Immunology 2013;132(4):830-835.e2. R834510 (2014)
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  • Journal Article Ahluwalia S, Matsui EC. The indoor environment and its effects on childhood asthma. Current Opinion in Allergy and Clinical Immunology 2011;11(2):137-143. R834510 (2012)
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  • Journal Article Arbes Jr. SJ, Matsui EC. Can oral pathogens influence allergic disease? The Journal of Allergy and Clinical Immunology 2011;127(5):1119-1127. R834510 (2012)
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  • Journal Article Bose S, Breysse PN, McCormack MC, Hansel NN, Rusher RR, Matsui E, Peng R, Curtin-Brosnan J, Diette GB; Center for Childhood Asthma in the Urban Environment. Outdoor exposure and vitamin D levels in urban children with asthma. Nutrition Journal 2013;12:81. R834510 (2014)
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  • Journal Article Breysse PN, Diette GB, Matsui EC, Butz AM, Hansel NN, McCormack MC. Indoor air pollution and asthma in children. Proceedings of the American Thoracic Society 2010;7(2):102-106. R834510 (2010)
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  • Journal Article Brigham EP, Kolahdooz F, Hansel N, Breysse PN, Davis M, Sharma S, Matsui EC, Diette G, McCormack MC. Association between Western diet pattern and adult asthma:a focused review. Annals of Allergy, Asthma & Immunology 2015;114(4):273-280. R834510 (Final)
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  • Journal Article Brigham EP, McCormack MC, Takemoto CM, Matsui EC. Iron status is associated with asthma and lung function in US women. PLoS One 2015;10(2):e0117545. R834510 (Final)
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  • Journal Article Butz AM, Matsui EC, Breysse P, Curtin-Brosnan J, Eggleston P, Diette G, Williams D, Yuan J, Bernert JT, Rand C. A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Archives of Pediatrics & Adolescent Medicine 2011;165(8):741-748. R834510 (2011)
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  • Journal Article Butz AM, Breysse P, Rand C, Curtin-Brosnan J, Eggleston P, Diette GB, Williams D, Bernert JT, Matsui EC. Household smoking behavior:effects on indoor air quality and health of urban children with asthma. Maternal and Child Health Journal 2011;15(4):460-468. R834510 (2010)
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  • Journal Article Chong LK, Ong MJ, Curtin-Brosnan J, Matsui EC. Skin test sensitivity to mouse predicts allergic symptoms to nasal challenge in urban adults. Asthma and Allergy Proceedings 2010;31(6):472-476. R834510 (2011)
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  • Journal Article Curtin-Brosnan J, Paigen B, Hagberg KA, Langley S, O’Neil EA, Krevans M, Eggleston PA, Matsui EC. Occupational mouse allergen exposure among non-mouse handlers. Journal of Occupational and Environmental Hygiene 2010;7(12):726-734. R834510 (2010)
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  • Journal Article Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. A multi-allergen standard for calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy: European Journal of Allergy and Clinical Immunology 2012; 67(2):235-241. R834510 (2011)
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  • Journal Article Filep S, Tsay A, Vailes LD, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard. The Journal of Allergy and Clinical Immunology 2012;129(5):1408-1410. R834510 (2012)
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  • Journal Article Fujimura KE, Rauch M, Matsui E, Iwai S, Calatroni A, Lynn H, Mitchell H, Johnson CC, Gern JE, Togias A, Boushey HA, Kennedy S, Lynch SV. Development of a standardized approach for environmental microbiota investigations related to asthma development in children. Journal of Microbiological Methods 2012;91(2):231-239. R834510 (2013)
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  • Journal Article Gergen PJ, Teach SJ, Mitchell HE, Freishtat RF, Calatroni A, Matsui E, Kattan M, Bloomberg GR, Liu AH, Kercsmar C, O'Connor G, Pongracic J, Rivera-Sanchez Y, Morgan WJ, Sorkness CA, Binkley N, Busse W. Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. American Journal of Clinical Nutrition 2013;97(6):1228-1234. R834510 (2013)
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  • Journal Article Gruchalla RS, Sampson HA, Matsui E, David G, Gergen PJ, Calatroni A, Brown M, Liu AH, Bloomberg GR, Chmiel JF, Kumar R, Lamm C, Smartt E, Sorkness CA, Steinbach SF, Stone KD, Szefler SJ, Busse WW. Asthma morbidity among inner-city adolescents receiving guidelines-based therapy:role of predictors in the setting of high adherence. Journal of Allergy and Clinical Immunology 2009;124(2):213-221. R834510 (2010)
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  • Journal Article Hackstadt AJ, Matsui EC, Williams DL, Diette GB, Breysse PN, Butz AM, Peng RD. Inference for environmental intervention studies using principal stratification. Statistics in Medicine 2014;33(28):4919‐4933. R834510 (2014)
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  • Journal Article Hansel NN, Matsui EC, Rusher R, McCormack MC, Curtin-Brosnan J, Peng RD, Mazique D, Breysse PN, Diette GB. Predicting future asthma morbidity in preschool inner-city children. Journal of Asthma 2011;48(8):797-803. R834510 (2011)
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  • Journal Article Hansel NN, McCormack MC, Belli AJ, Matsui EC, Peng RD, Aloe C, Paulin L, Williams DL, Diette GB, Breysse PN. In-home air pollution is linked to respiratory morbidity in former smokers with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 2013;187(10):1085-1090. R834510 (2013)
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  • Journal Article Jassal MS, Diette GB, Dowdy DW. Cost-consequence analysis of multimodal interventions with environmental components for pediatric asthma in the state of Maryland. Journal of Asthma 2013;50(6):672-680. R834510 (2014)
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  • Journal Article Kaji DA, Belli AJ, McCormack MC, Matsui EC, Williams DL, Paulin L, Putcha N, Peng RD, Diette GB, Breysse PN, Hansel NN. Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD. BMC Pulmonary Medicine 2014;14:147. R834510 (2014)
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  • Journal Article Kattan M, Kumar R, Bloomberg GR, Mitchell HE, Calatroni A, Gergen PJ, Kercsmar CM, Visness CM, Matsui EC, Steinbach SF, Szefler SJ, Sorkness CA, Morgan WJ, Teach SJ, Gan VN. Asthma control, adiposity, and adipokines among inner-city adolescents. Journal of Allergy and Clinical Immunology 2010;125(3):584-592. R834510 (2010)
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  • Journal Article Keet CA, Matsui EC, Dhillon G, Lenehan P, Paterakis M, Wood RA. The natural history of wheat allergy. Annals of Allergy, Asthma, and Immunology 2009;102(5):410-415. R834510 (2010)
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  • Journal Article Keet CA, McCormack MC, Peng RD, Matsui EC. Age-and atopy-dependent effects of vitamin D on wheeze and asthma. The Journal of Allergy and Clinical Immunology 2011:128(2):414-416.e5. R834510 (2011)
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  • Journal Article Keet CA, Wood RA, Matsui EC. Personal and parental nativity as risk factors for food sensitization. The Journal of Allergy and Clinical Immunology 2012;129(1):169-175.e5. R834510 (2012)
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  • Journal Article Keet CA, Matsui EC, Savage JH, Neuman-Sunshine DL, Skripak J, Peng RD, Wood RA. Potential mechanisms for the association between fall birth and food allergy. Allergy: European Journal of Allergy and Clinical Immunology 2012;67(6):775-782. R834510 (2012)
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  • Journal Article Keet CA, Wood RA, Matsui EC. Limitations of reliance on specific IgE for epidemiologic surveillance of food allergy. The Journal of Allergy and Clinical Immunology 2012;130(5):1207-1209.e10. R834510 (2013)
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  • Journal Article Kolahdooz F, Butler JL, Christiansen K, Diette GB, Breysse PN, Hansel NN, McCormack MC, Sheehy T, Gittelsohn J, Sharma S. Food and nutrient intake in African American children and adolescents aged 5 to 16 years in Baltimore City. Journal of the American College of Nutrition 2015;35(3):205-216. R834510 (Final)
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  • Journal Article Krishan JA, Lemanske Jr. RF, Canino GJ, Elward KS, Kattan M, Matsui EC, Mitchell H, Sutherland ER, Minnicozzi M. Asthma outcomes: symptoms. The Journal of Allergy and Clinical Immunology 2012;129(3 Suppl):S124-S135. R834510 (2013)
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  • Journal Article Kumar S, Singh BK, Arya P, Malhotra S, Thimmulappa R, Prasad AK, Van der Eycken E, Olsen CE, DePass AL, Biswal S, Parmar VS, Ghosh B. Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells. European Journal of Medicinal Chemistry 2011;46(11):5498-5511. R834510 (2012)
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  • Journal Article Kumar S, Reddy CS, Kumar Y, Kumar A, Singh BK, Kumar V, Malhotra S, Pandey MK, Jain R, Thimmulappa R, Sharma SK, Prasad AK, Biswal S, Van der Eycken E, DePass AL, Malhotra SV, Ghosh B, Parmar VS. Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: structure-activity analysis. Archiv der Pharmazie 2012;345(5):368-377. R834510 (2012)
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  • Journal Article Kumar S, Singh BK, Prasad AK, Parmar VS, Biswal S, Ghosh B. Ethyl 3',4',5'-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors. European Journal of Pharmacology 2013;700(1-3):32-41. R834510 (2013)
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  • Journal Article Kumar V, Kumar S, Hassan M, Wu H, Thimmulappa RK, Kumar A, Sharma SK, Parmar VS, Biswal S, Malhotra SV. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. Journal of Medicinal Chemistry 2011:54(12):4147-4159. R834510 (2011)
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  • Journal Article Lin JH, Matsui W, Aloe C, Peng RD, Diette GB, Breysse PN, Matsui EC. Relationships between folate and inflammatory features of asthma.The Journal of Allergy and Clinical Immunology 2013;131(3):918-920.e6. R834510 (2013)
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  • Journal Article Little FF, Delgado DM, Wexler PJ, Oppenheim FG, Mitchell P, Feldman JA, Walt DR, Peng RD, Matsui EC. Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma. PLoS One 2014;9(1):e84449 (10 pp.). R834510 (2014)
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  • Journal Article Lu KD, Breysse PN, Diette GB, Curtin-Brosnan J, Aloe C, Williams DL, Peng RD, McCormack MC, Matsui EC. Being overweight increases susceptibility to indoor pollutants among urban children with asthma. The Journal of Allergy and Clinical Immunology 2013;131(4):1017-1023.e3. R834510 (2013)
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  • Journal Article Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research 2010;38(17):5718-5734. R834510 (2011)
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  • Journal Article Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Feller-Kopman D, Wise R, Barnes PJ, Biswal S. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. Journal of Clinical Investigation 2011;121(11):4289-4302 (ARTICLE WAS RETRACTED). R834510 (2014)
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  • Journal Article Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PMA, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KC. A genome-wide association study on African-ancestry populations for asthma. The Journal of Allergy and Clinical Immunology 2010;125(2):336-346. R834510 (2010)
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  • Journal Article Matsui EC, Matsui W. Higher serum folate levels are associated with a lower risk of atopy and wheeze. Journal of Allergy and Clinical Immunology 2009;123(6):1253-1259. R834510 (2010)
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  • Journal Article Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, Gergen PJ, Bloomberg GR, Chmiel JF, Liu AH, Kattan M, Sorkness CA, Steinbach SF, Story RE, Visness CM. Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma. Allergy 2010;65(11):1414-1422. R834510 (2010)
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  • Journal Article Matsui EC, Ahluwalia S. The impact of an urban environment on a child's lungs. Expert Review of Respiratory Medicine 2011;5(4):465-468. R834510 (2012)
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  • Journal Article Matsui EC. Respiratory symptoms in asthma: the view through a wide-angle lens. The Journal of Allergy and Clinical Immunology 2012;130(2):408-409. R834510 (2013)
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  • Journal Article Matsui EC. Role of environmental control in the management of asthma and allergy. The Journal of Allergy and Clinical Immunology 2012;129(1):271-272.e3. R834510 (2012)
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  • Journal Article Matsui EC. Environmental control for asthma: recent evidence. Current Opinion in Allergy and Clinical Immunology 2013;13(4):417‐425. R834510 (2014)
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  • Journal Article Matsui EC. Management of rodent exposure and allergy in the pediatric population. Current Allergy and Asthma Reports 2013;13(6):681‐686. R834510 (2014)
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  • Journal Article Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, Liu AH. Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. American Journal of Respiratory and Critical Care Medicine 2013;188(10):1210-1215. R834510 (2014)
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  • Journal Article Mazique D, Diette GB, Breysse PN, Matsui EC, McCormack MC, Curtin-Brosnan J, Williams DL, Peng RD, Hansel NN. Predictors of airborne endotoxin concentrations in inner city homes. Environmental Research 2011;111(4):614-617. R834510 (2011)
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  • Journal Article McCormack MC, Breysse PN, Matsui EC, Hansel NN, Williams D, Curtin-Brosnan J, Eggleston P, Diette GB. In-home particle concentrations and childhood asthma morbidity. Environmental Health Perspectives 2009;117(2):294-298. R834510 (2010)
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  • Journal Article McCormack MC, Breysse PN, Matsui EC, Hansel NN, Peng RD, Curtin-Brosnan J, Williams DL, Wills-Karp M, Diette GB, Center for Childhood Asthma in the Urban Environment. Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Annals of Allergy, Asthma and Immunology 2011;106(4):308-315. R834510 (2011)
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  • Journal Article McCormack MC, Aloe C, Curtin‐Brosnan J, Diette GB, Breysse PN, Matsui EC. Guideline-recommended fractional exhaled nitric oxide is a poor predictor of health-care use among inner-city children and adolescents receiving usual asthma care. Chest 2013;144(3):923‐929. R834510 (2013)
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  • Journal Article Mudd K, Paterakis M, Curtin-Brosnan J, Matsui E, Wood RA. Predicting outcome of repeat milk, egg, or peanut oral food challenges. Journal of Allergy and Clinical Immunology 2009;124(5):1115-1116. R834510 (2010)
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  • Journal Article Narisety SD, Skripak JM, Steele P, Hamilton RG, Matsui EC, Burks AW, Wood RA. Open label maintenance after milk oral immunotherapy for IgE-mediated cow’s milk allergy. Journal of Allergy and Clinical Immunology 2009;124(3):610-612. R834510 (2010)
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  • Journal Article Neuman-Sunshine DL, Eckman JA, Keet CA, Matsui EC, Peng RD, Lenehan PJ, Wood RA. The natural history of persistent peanut allergy. Annals of Allergy, Asthma, and Immunology 2012;108(5):326-331.e3. R834510 (2012)
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  • Journal Article Noel S, Saams J, Ong MJC, Breysse P, Diette G, Biswal S, Matsui EC. Opposing effects of nasal epithelial NAD(P)H dehydrogenase quinine 1 and heme oxygenase 1 expression on upper and lower airway symptoms in adolescents with asthma. The Journal of Allergy and Clinical Immunology 2011;128(2):422-424.e3. R834510 (2011)
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  • Journal Article Okelo SO, Eakin MN, Patino CM, Teodoro AP, Bilderback AL, Thompson DA, Loiaza-Martinez A, Rand CS, Thyne S, Diette GB, Riekert KA. The Pediatric Asthma Control and Communication Instrument asthma questionnaire: for use in diverse children of all ages. The Journal of Allergy and Clinical Immunology 2013;132(1):55-62.e10. R834510 (2014)
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  • Journal Article Okelo SO, Butz AM, Sharma R, Diette GB, Pitts SI, King TM, Linn ST, Reuben M, Chelladurai Y, Robinson KA. Interventions to modify health care provider adherence to asthma guidelines: a systematic review. Pediatrics 2013;132(3):517-534. R834510 (2014)
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  • Journal Article Okelo SO, Riekert KA, Eakin MN, Bilderback AL, Diette GB, Rand CS, Yenokyan G. Pediatrician qualifications and asthma management behaviors and their association with patient race/ethnicity. Journal of Asthma 2014;51(2):155-161. R834510 (2014)
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  • Journal Article Okelo SO, Eakin MN, Riekert KA, Teodoro AP, Bilderback AL, Thompson DA, Loiaza-Martinez A, Rand CS, Thyne S, Diette GB, Patino CM. Validation of parental reports of asthma trajectory, burden, and risk by using the pediatric asthma control and communication instrument. The Journal of Allergy and Clinical Immunology: In Practice 2014;2(2):186-192.e7. R834510 (2014)
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  • Journal Article Okupa AY, Lemanske Jr. RF, Jackson DJ, Evans MD, Wood RA, Matsui EC. Early-life folate levels are associated with incident allergic sensitization. The Journal of Allergy and Clinical Immunology 2013;131(1):226-228.e2. R834510 (2013)
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  • Journal Article Pandey MK, Kumar S, Thimmulappa RK, Parmar VS, Biswal S, Watterson AC. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. European Journal of Pharmaceutical Science 2011;43(1-2):16-24. R834510 (2011)
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  • Journal Article Paulin LM, Williams D, Oberweiser C, Diette GB, Breysse PN, McCormack MM, Matsui EC, Peng R, Metts TA, Hansel NN. Indoor air quality in central Appalachia homes impacted by wood and coal use. Journal of Environmental Protection 2013;4(1):67-71. R834510 (2013)
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  • Journal Article Paulin LM, Diette GB, Scott M, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, Kidd-Taylor A, Shea M, Breysse PN, Hansel NN. Home interventions are effective at decreasing indoor nitrogen dioxide concentrations. Indoor Air 2014;24(4):416-424. R834510 (2014)
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  • Journal Article Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, Benson C, Shreffler WG, Matsui EC. Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility. Journal of Allergy and Clinical Immunology 2011;128(2):390-396.e7. R834510 (2011)
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  • Journal Article Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, Bernstein D, Blessing-Moore J, Cox L, Khan D, Lang D, Nicklas R, Oppenheimer J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Sublett J, Bernstein J, Grimes C, Miller JD, Seltzer J, Joint Task Force on Practice Parameters. Environmental assessment and exposure reduction of rodents: a practice parameter. Annals of Allergy, Asthma, and Immunology 2012;109(6):375-387. R834510 (2013)
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  • Journal Article Portnoy JM, Kennedy K, Sublett JL, Phipatanakul W, Matsui E, Barnes C, Grimes C, Miller JD, Seltzer JM, Williams PB, Bernstein JA, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J. Environmental assessment and exposure control: a practice parameter—furry animals. Annals of Allergy, Asthma, and Immunology 2012;108(4):223.e1-223.e15. R834510 (2013)
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  • Journal Article Rivera-Mariani FE, Matsui EC, Breysse PN. Performance of the halogen immunoassay to assess airborne mouse allergen-containing particles in a laboratory animal facility. Journal of Exposure Science & Environmental Epidemiology 2014;24(1):3-8. R834510 (2013)
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  • Journal Article Sandford AJ, Malhotra D, Boezen HM, Siedlinski M, Postma DS, Wong V, Akhabir L, He JQ, Connett JE, Anthonisen NR, Pare PD, Biswal S. NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. Physiological Genomics 2012;44(15):754-763. R834510 (2013)
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  • Journal Article Savage JH, Kaeding AJ, Matsui EC, Wood RA. The natural history of soy allergy. Journal of Allergy and Clinical Immunology 2010;125(3):683-686. R834510 (2010)
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  • Journal Article Savage JH, Matsui EC, Wood RA, Keet CA. Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. The Journal of Allergy and Clinical Immunology 2012;130(2):453-460.e7. R834510 (2013)
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  • Journal Article Sharma S, Zhou X, Thibault DM, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson Jr. NF Jr, Avila L, Soto-Quiros M, Barraza-Villareal A, Lemanske Jr. RF, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K, London SJ, Martinez F, Ober C, Celedon JC, Carey VJ, Weiss ST, Raby BA. A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes. The Journal of Allergy and Clinical Immunology 2014;134(5):1153-1162. R834510 (2014)
    R834510 (Final)
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  • Journal Article Sheehan WJ, Rangsithienchai PA, Wood RA, Rivard D, Chinratanapisit S, Perzanowski MS, Chew GL, Seltzer JM, Matsui EC, Phipatanakul W. Pest and allergen exposure and abatement in inner-city asthma:a work group report of the American Academy of Allergy, Asthma & Immunology Indoor Allergy/Air Pollution Committee. Journal of Allergy and Clinical Immunology 2010;125(3):575-581. R834510 (2010)
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  • Journal Article Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S. Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. American Journal of Physiology: Lung Cellular and Molecular Physiology 2015;309(1):L27-L36. R834510 (Final)
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  • Journal Article Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S. Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke. Biochemical and Biophysical Research Communications 2012;426(2):253-259. R834510 (2013)
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  • Journal Article Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedon JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske Jr. RF, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ, Gilliland FD, Burchard EG, Martinez FD, Weiss ST, Williams LK, Barnes KC, Ober C, Nicolae DL. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nature Genetics 2011;43(9):887-892. R834510 (2012)
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  • Journal Article Torjusen EN, Diette GB, Breysse PN, Curtin-Brosnan J, Aloe C, Matsui EC. Dose-response relationships between mouse allergen exposure and asthma morbidity among urban children and adolescents. Indoor Air 2013;23(4):268-274. R834510 (2013)
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  • Journal Article Sudini K, Diette GB, Breysse PN, McCormack MC, Bull D, Biswal S, Zhai S, Brereton N, Peng RD,Matsui EC. A randomized controlled trial of the effect of broccoli sprouts on antioxidant gene expression and airway inflammation in asthmatics. The Journal of Allergy and Clinical Immunology:In Practice 2016 Apr 27. [Epub ahead of print] doi:10.1016/j.jaip.2016.03.012. R834510 (Final)
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  • Supplemental Keywords:

    air, ambient air, indoor air, exposure, risk, health effects, human health, metabolism, vulnerability, sensitive populations, animal, population, children, race, diet, sex, ethnic groups, susceptibility, particulates, nitrogen oxides, community-based, observation, engineering, epidemiology, biology, monitoring, measurement methods, Mid-Atlantic, Maryland, MD,, Health, Scientific Discipline, Health Risk Assessment, Epidemiology, Allergens/Asthma, Biology, asthma triggers, asthma indices, air pollution, children, airway inflammation, diet, oxidant stress

    Progress and Final Reports:

    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    2013 Progress Report
    2014 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R834510C001 Urban Dietary Effects on the Asthmatic Response to Pollutants
    R834510C002 Dietary Interventions in Asthma Treatment
    R834510C003 Dissecting the Diet-Asthma Relationship in Mice Models of Asthma