The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children

EPA Grant Number: R828678C017
Subproject: this is subproject number 017 , established and managed by the Center Director under grant R824834
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mickey Leland National Urban Air Toxics Research Center (NUATRC)
Center Director: Beskid, Craig
Title: The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children
Investigators: Hammond, S. Katharine
Institution: University of California - Berkeley
EPA Project Officer: Chung, Serena
Project Period: January 2, 2001 through December 31, 2005 (Extended to December 31, 2008)
RFA: Targeted Research Center (2004) Recipients Lists
Research Category: Targeted Research

Objective:

The investigators are studying the relationship between exposure to vehicular polycyclic aromatic hydrocarbons (PAHs) and the short- and long-term respiratory effects on children who have well-characterized asthma. This research will complement an on-going study of 302 children with asthma, ages 6-11 at intake, in Fresno, CA, who are already recruited and for whom voluminous health and exposure data are available (the Fresno Asthmatic Children’s Environment Study-FACES). The investigators will test the following hypothesis:

Acute exposure to PAHs leads to acute increases in symptoms, increased medication use, and lung function declines. These adverse reactions to acute PAH exposures, when recurrent over 3-5 years, have the cumulative effects of more severe asthma and reduced lung function growth.

The investigators plan innovative approaches both to develop the exposure metrics and to conduct the epidemiologic analyses. The innovative exposure metric itself has two parts: first, the development of the underlying dataset of PAHs measured in two media, ambient air and pine needles, and secondly, the development of a model. FACES has been collecting data for 5 years under the sponsorship of the California Air Resources Board, and an R01 NIH proposal to extend the program for another 4.5 year recently received an excellent priority score (3.6 percentile), so the investigators have high hopes for continued funding.

Publications and Presentations:

Publications have been submitted on this subproject: View all 4 publications for this subprojectView all 144 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 3 journal articles for this subprojectView all 53 journal articles for this center

Supplemental Keywords:

RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, HUMAN HEALTH, particulate matter, air toxics, Environmental Chemistry, Health Risk Assessment, Exposure, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Physical Processes, genetic susceptability, copollutant exposures, sensitive populations, atmospheric particulate matter, cardiopulmonary responses, fine particles, morbidity, PM 2.5, long term exposure, inhaled pollutants, acute lung injury, acute cardiovascular effects, air pollution, susceptible subpopulations, cardiac arrest, cardiopulmonary response, chronic health effects, human exposure, lung inflammation, particulate exposure, time series analysis, National Cohort Studies, Acute health effects, inhaled, human susceptibility, cardiopulmonary, cardiotoxicity, mortality, acute exposure, air quality, cardiovascular disease, human health risk, toxics, environmental hazard exposures, air contaminant exposure

Progress and Final Reports:

  • 2001
  • 2002
  • 2003
  • 2004
  • 2005
  • 2006
  • 2007 Progress Report
  • Final Report

  • Main Center Abstract and Reports:

    R824834    Mickey Leland National Urban Air Toxics Research Center (NUATRC)

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R824834C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles - A Columbia-Harvard Study (TEACH)
    R824834C002 Cardiopulmonary Response to Particulate Exposure
    R824834C003 VOC Exposure in an Industry Impacted Community
    R824834C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
    R824834C005 Methods Development Project for a Study of Personal Exposures to Toxic Air Pollutants
    R824834C006 Relationship Between Indoor, Outdoor and Personal Air (RIOPA)
    R824834C007 Development of the "Leland Legacy" Air Sampling Pump
    R824834C008 Source Apportionment of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Residences
    R824834C009 Development of a Personal Cascade Impactor Sampler (PCIS)
    R824834C010 Testing the Metals Hypothesis in Spokane
    R828678C001 Air Toxics Exposures Among Teenagers in New York City and Los Angeles—A Columbia-Harvard Study (TEACH)
    R828678C002 Cardiopulmonary Effects of Metal-Containing Particulate Exposure
    R828678C003 VOC Exposure in an Industry Impacted Community
    R828678C004 A Study of Personal Exposure to Air Toxics Among a Subset of the Residential U.S. Population (VOC Project)
    R828678C005 Oxygenated Urban Air Toxics and Asthma Variability in Middle School Children: A Panel Study (ATAC–Air Toxics and Asthma in Children)
    R828678C006 Relationship between Indoor, Outdoor and Personal Air (RIOPA). Part II: Analyses of Concentrations of Particulate Matter Species
    R828678C007 Development of the “Leland Legacy” Air Sampling Pump
    R828678C008 Source Apportionment of Indoor PAHs in Urban Residences 98-03B
    R828678C009 Development of a Personal Cascade Impactor Sampler (PCIS)
    R828678C010 Testing the Metals Hypothesis in Spokane
    R828678C011 A Pilot Geospatial Analysis of Exposure to Air Pollutants (with Special Attention to Air Toxics) and Hospital Admissions in Harris County, Texas
    R828678C012 Impact of Exposure to Urban Air Toxics on Asthma Utilization for the Pediatric Medicaid Population in Dearborn, Michigan
    R828678C013 Field Validation of the Sioutas Sampler and Leland Legacy Pump – Joint Project with EPA’s Environmental Technology Validation Program (ETV)
    R828678C014 Performance Evaluation of the 3M Charcoal Vapor Monitor for Monitor Low Ambient Concentrations of VOCs
    R828678C015 RIOPA Database Development
    R828678C016 Contributions of Outdoor PM Sources to Indoor and Personal Exposures: Analysis of PM Species Concentrations” Focused on the PM Speciation and Apportioning of Sources
    R828678C017 The Short and Long-Term Respiratory Effects of Exposure to PAHs from Traffic in a Cohort of Asthmatic Children