Final Report: Technology Development and Transfer Core

EPA Grant Number: R827353C017
Subproject: this is subproject number 017 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: EPA Harvard Center for Ambient Particle Health Effects
Center Director: Koutrakis, Petros
Title: Technology Development and Transfer Core
Investigators: Coull, Brent , Demokritou, Philip , Koutrakis, Petros , Lawrence, Joy , Schwartz, Joel , Wolfson, Mike
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air

Objective:

The Technology Core led by Dr. Koutrakis focused on implementation and integration of the new technologies into the work of researchers at Harvard and a number of other research centers.

Summary/Accomplishments (Outputs/Outcomes):

In conjunction with the analytical and facilities core, we supported a number of exposure assessment studies through the development and provision of state-of-the-art personal, microenvironmental, and outdoor particulate and gaseous samplers. This core also supported use of the instruments in toxicological studies by operating and servicing the concentrator and by developing new concentrator technologies. As new particle samplers and generating systems were developed, they were made available to other Centers and research groups. We published a number of research papers documenting the performance of these instruments (Demokritou, et al., 2003; Demokritou, et al., 2004a; Gupta, et al., 2004), and we assisted a number of research groups in installation and operation of these systems (Savage, et al., 2003). These studies have already substantially improved our understanding of particle health effects.

References:

Demokritou P, Lee SJ, Ferguson ST, Koutrakis P. A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. Journal of Aerosol Science 2004a;35(3):281-299.

Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development of a high-volume concentrated ambient particles system (caps) for human and animal inhalation toxicological studies. Inhalation Toxicology 2003;15(2):111-129.

Gupta T, Demokritou P, Koutrakis P. Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhalation Toxicology 2004;16(13):851-862.

Savage ST, Lawrence J, Katz T, Stearns RC, Coull BA, Godleski JJ. Does the Harvard/U.S. Environmental Protection Agency ambient particle concentrator change the toxic potential of particles? Journal of the Air & Waste Management Association 2003;53(9):1088-1097.


Journal Articles on this Report : 20 Displayed | Download in RIS Format

Other subproject views: All 20 publications 20 publications in selected types All 20 journal articles
Other center views: All 200 publications 198 publications in selected types All 197 journal articles
Type Citation Sub Project Document Sources
Journal Article Demokritou P, Kavouras IG, Harrison D, Koutrakis P. Development and evaluation of an impactor for a PM2.5 speciation sampler. Journal of the Air & Waste Management Association 2001;51(4):514-523. R827353 (Final)
R827353C017 (Final)
R833626 (Final)
  • Abstract from PubMed
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Journal Article Demokritou P, Kavouras IG, Ferguson ST, Koutrakis P. Development and laboratory performance evaluation of a personal multipollutant sampler for simultaneous measurements of particulate and gaseous pollutants. Aerosol Science and Technology 2001;35(3):741-752. R827353 (Final)
    R827353C017 (Final)
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Other: Academia-Full Text PDF
    Exit
  • Journal Article Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development and laboratory characterization of a prototype coarse particle concentrator for inhalation toxicological studies. Journal of Aerosol Science 2002;33(8):1111-1123. R827353 (Final)
    R827353C017 (Final)
    R825270 (2000)
    R825270 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Demokritou P, Gupta T, Koutrakis P. A high volume apparatus for the condensational growth of ultrafine particles for inhalation toxicological studies. Aerosol Science and Technology 2002;36(11):1061-1072. R827353 (Final)
    R827353C017 (Final)
    R825270 (2000)
    R825270 (Final)
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Journal Article Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development and laboratory performance evaluation of a personal cascade impactor. Journal of the Air & Waste Management Association 2002;52(10):1230-1237. R827353 (Final)
    R827353C017 (Final)
    R825270 (2000)
    R825270 (Final)
  • Abstract from PubMed
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Journal Article Demokritou P, Kavouras IG, Ferguson ST, Koutrakis P. Development of a high volume cascade impactor for toxicological and chemical characterization studies. Aerosol Science and Technology 2002;36(9):925-933. R827353 (Final)
    R827353C017 (Final)
    R825270 (2000)
    R825270 (Final)
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Journal Article Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development of a high-volume concentrated ambient particles system (CAPS) for human and animal inhalation toxicological studies. Inhalation Toxicology 2003;15(2):111-129. R827353 (Final)
    R827353C017 (Final)
  • Abstract from PubMed
  • Full-text: ResearchGate-Full Text PDF
    Exit
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Journal Article Demokritou P, Lee SJ, Koutrakis P. Development and evaluation of a high loading PM2.5 speciation sampler. Aerosol Science and Technology 2004;38(2):111-119. R827353 (Final)
    R827353C017 (Final)
  • Full-text: Taylor&Francis-Full Text HTML
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Other: Taylor&Francis-Full Text PDF
    Exit
  • Journal Article Demokritou P, Lee SJ, Ferguson ST, Koutrakis P. A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. Journal of Aerosol Science 2004;35(3):281-299. R827353 (Final)
    R827353C017 (Final)
  • Full-text: ScienceDIrect-Full Text HTML
    Exit
  • Abstract: ScienceDIrect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Ding Y, Koutrakis P. Development of a dichotomous slit nozzle virtual impactor. Journal of Aerosol Science 2000;31(12):1421-1431. R827353 (Final)
    R827353C017 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Franklin M, Zeka A, Schwartz J. Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. Journal of Exposure Science and Environmental Epidemiology 2007;17(3):279-287. R827353 (Final)
    R827353C017 (Final)
    R832416 (2008)
  • Abstract from PubMed
  • Full-text: Nature-Full Text HTML
    Exit
  • Abstract: Nature-Abstract
    Exit
  • Other: Nature-Full Text PDF
    Exit
  • Journal Article Gupta T, Demokritou P, Koutrakis P. Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhalation Toxicology 2004;16(13):851-862. R827353 (Final)
    R827353C017 (Final)
  • Abstract from PubMed
  • Full-text: ResearchGate-Abstract & Full Text
    Exit
  • Abstract: Taylor & Francis-Abstract
    Exit
  • Other: ResearchGate-Full Text PDF
    Exit
  • Journal Article Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. R827353 (Final)
    R827353C017 (Final)
    R827351 (Final)
    R827351C001 (Final)
    R827354 (Final)
    R827354C001 (Final)
    R827355 (Final)
    R827355C008 (Final)
    R832415 (2010)
    R832415 (2011)
    R832415 (Final)
  • Abstract from PubMed
  • Full-text: Nature-Full Text HTML
    Exit
  • Abstract: Nature-Abstract
    Exit
  • Other: Nature-Full Text PDF
    Exit
  • Journal Article Lee SJ, Demokritou P, Koutrakis P. Performance evaluation of commonly used impaction substrates under various loading conditions. Journal of Aerosol Science 2005;36(7):881-895. R827353 (Final)
    R827353C017 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Lee SJ, Demokritou P, Koutrakis P, Delgado-Saborit JM. Development and evaluation of personal respirable particulate sampler (PRPS). Atmospheric Environment 2006;40(2):212-224. R827353 (Final)
    R827353C017 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
  • Journal Article Liu Y, Sarnat JA, Coull BA, Koutrakis P, Jacob DJ. Validation of Multiangle Imaging Spectroradiometer (MISR) aerosol optical thickness measurements using Aerosol Robotic Network (AERONET) observations over the contiguous United States. Journal of Geophysical Research–Atmospheres 2004;109(D6):D06205 (9 pp.). R827353 (Final)
    R827353C017 (Final)
  • Full-text: Wiley-Full Text HTML
    Exit
  • Abstract: Wiley-Abstract
    Exit
  • Other: Wiley-Full Text PDF
    Exit
  • Journal Article Liu Y, Park RJ, Jacob DJ, Li Q, Kilaru V, Sarnat JA. Mapping annual mean ground-level PM2.5 concentrations using Multiangle Imaging Spectroradiometer aerosol optical thickness over the contiguous United States. Journal of Geophysical Research–Atmospheres 2004;109(D22):D22206. R827353 (Final)
    R827353C017 (Final)
  • Full-text: Wiley-Full Text HTML
    Exit
  • Abstract: Wiley-Abstract
    Exit
  • Other: Wiley-Full Text PDF
    Exit
  • Journal Article Liu Y, Sarnat JA, Kilaru V, Jacob DJ, Koutrakis P. Estimating ground-level PM2.5 in the eastern United States using satellite remote sensing. Environmental Science & Technology 2005;39(9):3269-3278. R827353 (Final)
    R827353C017 (Final)
  • Abstract from PubMed
  • Full-text: Harvard-Full Text PDF
    Exit
  • Abstract: ACS-Abstract
    Exit
  • Other: ACS-Full Text PDF
    Exit
  • Journal Article Liu Y, Franklin M, Kahn R, Koutrakis P. Using aerosol optical thickness to predict ground-level PM2.5 concentrations in the St. Louis area:a comparison between MISR and MODIS. Remote Sensing of Environment 2007;107(1-2):33-44. R827353 (Final)
    R827353C017 (Final)
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDIrect-Full Text PDF
    Exit
  • Journal Article Savage ST, Lawrence J, Katz T, Stearns RC, Coull BA, Godleski JJ. Does the Harvard/U.S. Environmental Protection Agency Ambient Particle Concentrator change the toxic potential of particles? Journal of the Air & Waste Management Association 2003;53(9):1088-1097. R827353 (Final)
    R827353C014 (Final)
    R827353C017 (Final)
  • Abstract from PubMed
  • Full-text: Taylor&Francis-Full Text PDF
    Exit
  • Abstract: Taylor&Francis-Abstract
    Exit
  • Other: Harvard-Full Text PDF
    Exit
  • Supplemental Keywords:

    RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Air Pollution Monitoring, particulate matter, Toxicology, air toxics, Environmental Chemistry, Epidemiology, Air Pollution Effects, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Environmental Microbiology, Environmental Monitoring, Health Effects, Physical Processes, Children's Health, genetic susceptability, indoor air, Atmospheric Sciences, Molecular Biology/Genetics, Biology, Risk Assessment, ambient air quality, interindividual variability, microbiology, molecular epidemiology, monitoring, particulates, sensitive populations, chemical exposure, air pollutants, cardiopulmonary responses, health risks, human health effects, indoor exposure, PM 2.5, ambient air monitoring, exposure and effects, ambient air, ambient measurement methods, exposure, lead, pulmonary disease, developmental effects, biological response, respiratory disease, air pollution, ambient monitoring, children, Human Health Risk Assessment, particle exposure, biological mechanism , cardiopulmonary response, human exposure, inhalation, pulmonary, susceptibility, particulate exposure, assessment of exposure, ambient particle health effects, human susceptibility, environmental health hazard, inhalation toxicology, cardiopulmonary, indoor air quality, inhaled particles, air quality, cardiovascular disease, dosimetry, exposure assessment, human health risk, respiratory

    Relevant Websites:

    http://www.hsph.harvard.edu/epacenter/epa_center_99-05/index.html Exit

    Progress and Final Reports:

    Original Abstract
  • 1999
  • 2000
  • 2001
  • 2002
  • 2003
  • 2004

  • Main Center Abstract and Reports:

    R827353    EPA Harvard Center for Ambient Particle Health Effects

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
    R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
    R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
    R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
    R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
    R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
    R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
    R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
    R827353C009 Assessing Deposition of Ambient Particles in the Lung
    R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
    R827353C011 Studies of Oxidant Mechanisms
    R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
    R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
    R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
    R827353C015 Research Coordination Core
    R827353C016 Analytical and Facilities Core
    R827353C017 Technology Development and Transfer Core