2009 Progress Report: UC Davis Center for Children’s Environmental Health

EPA Grant Number: R833292
Center: UC Davis Center for Children’s Environmental Health
Center Director: Pessah, Isaac N.
Title: UC Davis Center for Children’s Environmental Health
Investigators: Pessah, Isaac N.
Current Investigators: Pessah, Isaac N. , Ashwood, Paul , Bennett, Deborah H. , Berman, Robert F. , Golub, Mari S. , Hansen, Robin , Hertz-Picciotto, Irva , Ozonoff, Sally , Van de Water, Judith , Walker, Cheryl
Institution: University of California - Davis
EPA Project Officer: Louie, Nica
Project Period: November 1, 2006 through October 31, 2011 (Extended to October 31, 2013)
Project Period Covered by this Report: September 1, 2008 through August 31,2009
Project Amount: $3,782,733
RFA: Centers for Children’s Environmental Health and Disease Prevention Research (2005) RFA Text |  Recipients Lists
Research Category: Health , Children's Health , Health Effects

Objective:

The principal concern of the UC Davis Center for Children’s Environmental Health (CCEH) is to identify and understand environmental, immunologic, and genetic risk factors contributing to the incidence and severity of childhood autism. Autism is a heterogeneous neurodevelopmental disorder defined by core deficits in social reciprocity, communication, and restrictive/repetitive patterns of interest and behavior. Generally accepted estimates of prevalence range from 1:750 for the narrowest diagnostic criteria, to 1:166 for autism spectrum disorder (ASD). The California Department of Developmental Services records on average approximately 700-750 autism diagnoses each quarter. Although autism may be one of the most heritable complex disorders, the defective genes conferring autism risk do not segregate in a simple Mendelian manner. The prevalence of autism is approximately four times higher in males than in females. Results from over 10 genome-wide autism screens indicate that potential susceptibility genes are spread across the entire genome. Estimates of the number of genes involved in autism range from 3-10 to 15 and up to 100. However, no single locus alone appears to be sufficient to cause the full clinical phenotype. Evaluation of a broader autistic phenotype that included communication and social disorders increased concordance from 60% to 92% in monozygotic twins and from 0% to 10% in dizygotic pairs. These results indicate that interactions among multiple genes are likely to contribute to autism, and that epigenetic factors and exposure to environmental modifiers may contribute significantly to variable expression of autism, and autism-related traits.

The mission of the CCEH is to promote daily interactions among a multidisciplinary team of scientists whose main research interest is to understand the complex web of etiologic factors that contribute to autism. The shared philosophy among Center participants is that a better understanding of the immunological and neurobiological mechanisms associated with this neurodevelopmental disorder can not only lead to a better understanding of the mechanisms that influence it but can also accelerate the discovery of effective intervention strategies.

Progress Summary:

Project 1 – Environmental Epidemiology

Description: Three epidemiological studies are being conducted: 1) The CHARGE (Childhood Autism Risks from Genetics and the Environment) Study, which was launched in the first 5-year period of the CCEH, continues in its second five-year funding cycle as a separately funded R01. By 2011, the study will include 1600 children and their families, the largest and most comprehensive study of environmental factors in autism. 2) The MARBLES (Markers of Autism Risk in Babies – Learning Early Signs) Study, a longitudinal cohort study of pregnancies of high-risk children was launched, after a pilot phase. The pilot phase began recruitment in July 2006, supported by funding from the M.I.N.D. Institute. 3) The CHARGE-BACK Study has recruited children and their immediate family members who participated in the CHARGE study in the first five years. The study is investigating whether immune function differences between study subject groups found in the first project period will be maintained over time. In addition, studies in the first project period were aimed at a broad analysis of immune function while the present study seeks to address the mechanisms responsible for the immune function anomalies.

Key findings:

Questionnaire results indicate that several food items and household furnishings treated with brominated flame retardants are associated with higher PBDEs. We published results showing that PBDE concentrations are related to food consumption, demonstrating that household furnishings are not the only major source in young children. Given the role of food, we hypothesize that the use of current plasma is not an adequate surrogate for prenatal exposures of the fetus, and hence more work is needed with better surrogates or actual measurements, as in the MARBLES study (Key Words: Persistent Organic Pollutants)

Our research on folic acid showed that mean folic acid intake was greater for mothers of typically developing children than for mothers of autistic children, especially in the month before and the first month of pregnancy. This difference was primarily due to a greater proportion of mothers of typically developing children consuming prenatal vitamins before and during the first month of pregnancy (adjusted for maternal). Women reporting the highest average intake of folic acid (800+ mcg) before and during the first month of pregnancy had the lowest risk of having children diagnosed with autism. (Key Words: Autism Nutritional Risk Factors)

Data from plasma specimens on close to 100 CHARGE study children showed no significant differences between cases and controls, but did show a correlation with several immune markers, including lower IgG, lower IgM and lower TGF-beta; all three of these immune outcomes were associated with case status in a larger sample of CHARGE children. (Key Words: Immune Impairments)

Analysis of mercury levels indicated no differences between affected and unaffected children, after controlling for intake from fish and other sources. (Key Word: Mercury)

We also published results from two analyses pertaining to statewide autism incidence (one addressing parental age; the other, spatial clustering). (Key Word: Autism Onset, Regression)

Genotyping of some vitamin D genes has been completed and we will begin analyses of vitamin D in the Environmental Exposure Questionnaire soon, along with measuring vitamin D in plasma samples and newborn blood spots. (Key Words: Autism Nutritional Risk Factors)

Also, we collaborated with Dr. Xin Zhang, who conducted a case-control study of prenatal and perinatal risk factors for autism in Tianjin, China, and published those findings. (Key Words: Persistent Organic Pollutants)

In conjunction with the CCEH Genetics/genomics core, we published results on suggesting that the relationship of gene expression to mercury and lead differs by case status. Analyses of metals do not show any differences with regard to regression vs. early onset, language delay, nor cognitive or adaptive function. (Key Word: Mercury)

Project 2 – Immunological Susceptibility of Autism

Description – The goal of this project is to examine the effects of environmental toxicants on immune function in children with autism. In addition, we are currently working on the identification of the autoantigens in both the maternal population and their offspring. We will bring back our subjects for a longitudinal analysis of their immune function parameters studied previously.

Key Findings:

Effects of in vitro BDE 49 exposure: Our studies indicate that BDE49 has greater effects on immune function, particularly in the autistic population, at much lower concentrations than BDE47. (Key Words: Persistent Organic Pollutants)

Maternal Autoantibodies: The presence of these antibodies in the plasma of some mothers of children with autism, as well as the differential findings between mothers of children with early onset and regressive autism may suggest an association between the transfer of autoantibodies during early neurodevelopment and the risk of developing autism in some children. We have now identified several proteins recognized by maternal antibodies and are in the final stages of confirmation of these antigens. In addition, we are testing our plasma bank for reactivity to the individual antigens for all maternal samples. (Key Words: Immune Impairments)

Cytokine production: We published our findings describing plasma cytokine profile of subjects with autism and typically developing controls. Increasing cytokine levels were associated with more impaired social interactions and communication as well as more aberrant behaviors. It was noted that the increased cytokine levels were predominantly in autistic children who had evidence of regression. These findings suggest that ongoing inflammatory responses may be linked to disturbances in behavior and require confirmation in a larger study. Characterization of immunological parameters in autism has important implications for diagnosis, the designing and monitoring of therapeutic treatments of autism, and may help to identify mechanisms that are important in the etiology of autism in a subgroup of subjects. The biological impact of increased cytokines in autism children and their association with more impaired behaviors is intriguing and warrants further consideration. (Key Words: Immune Impairments)

Project 3 - Neurodevelopmental Toxicology

Description - The overall goal is to determine if exposure to environmental toxicants early in development contributes to the etiology of neurodevelopmental disorders. A related goal is to determine whether susceptibility to autoimmune disease increases the neurotoxicity of environmental contaminants and increases risk for developmental neurotoxicity.

Key Findings:

Our data indicate that developmental exposure to chronic low-levels of BDE-47 result in significant bioaccumulation in target organs, including brain, and is associated with early motor deficits in exposed neonates. (Key Words: Animal Models of Autism)

A study on the neurodevelopmental toxicity of autoantibodies and the effects on behavior in mice showed increased anxiety in mouse pups exposed during gestation to IgG-AU, consistent with our hypothesis that autoantibodies in the serum of mothers of autistic children may alter normal behavioral development. (Key Words: Animal Models of Autism)

Our misoprostol study showed that there were no statistically significant effects between treatment groups in any of the parameters tested and does not support that early misoprostol exposure impairs normal brain development. (Key Words: Animal Models of Autism)

We identified mechanisms of developmental neurotoxicity of PCBs and PBDEs. (Key Words: Animal Models of Autism)

We showed how a non-coplanar PCB, PCB95, alters the structure and function of a major Ca2+ channel found in muscle and brain. PCB 95 has been found in significantly higher concentration is post-mortem brains from individuals with syndromic ASD than those obtained from unaffected controls. (Key Words: Animal Models of Autism; Persistent Organic Pollutants)

We found that developmental PCB exposure accelerated dendritic growth in untrained experimental animals when compared to untrained controls. The trained PCB-exposed animals, however, took longer to learn the water maze and showed reversal of dendritic growth in response to water-maze training, in contrast to controls that learning increases dendritic growth. The results are important because problems in dendritic growth and plasticity have previously been implicated in many neurodevelopmental disorders, including ASD. We also showed dysregulated expression of ryanodine receptors (RyR1 and RyR2) is a consequence of PCB exposure. We think PCBs are increasing the activity of these Ca2+ channels, which we know generate the signals needed for the extension and branching of dendrites. (Key Words: Animal Models of Autism)

References:

Ahn K. C., Zhao B., Chen J., Cherednichenko G., Sanmarti E., Denison M. S., Lasley B., Pessah I. N., Kültz D., Chang D. P., Gee S. J., Hammock B. D. (2008). In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens.  Environ. Health Perspect. 116, 1203-10.  PMCID PMC2535623.

Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen L, Ozonoff S, Pessah IN, and J Van de Water. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol 2008 Nov 15;204(1-2):149-53.  PMID 18762342. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, Van de Water J.  Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes.  J Neuroimmunol. 2008 Nov 15;204(1-2):149-53.  PMID 18762342. (Projects 1, 2, 3; Cores 1, 2, 5)

 

Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun. 2010 Aug 10. [Epub ahead of print] PMID: 20705131 [PubMed - as supplied by publisher]

Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Altered T cell responses in children with autism. Brain Behav Immun. 2010 Sep 16. [Epub ahead of print] PMID: 20833247 [PubMed - as supplied by publisher]

Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J (2007).  Brief report: Plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disorders (in press, 5-06; epub ahead of print) PMID: 17347881(Projects 1, 2, 3; Cores 1, 2,5)

Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J (2007).  Brief report: Plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disorders (in press, 5-06; epub ahead of print) PMID: 17347881(Projects 1, 2, 3; Cores 1, 2)

Ashwood, P., Enstrom, A., Krakowiak, P., Hertz-Picciotto, I., Hansen, R. L., Croen, L. A., Ozonoff, S., Pessah, I. N., and Van de Water, J.V.  (2008). Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes. J. Neuroimmunol. 204, 149-153.  PMID 18762342.

Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., Walker, W., Pessah, I.N., and Van de Water, J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J. Autism and Devel. Disorders, 38 (1):169-175, 2008. (E-pub ahead of print, 2007).  PMID 17347881. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., Walker, W., Pessah, I.N., and Van de Water, J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J. Autism and Devel. Disorders, March 9, (E-pub before print). PMID 17347881.

Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., Walker, W., Pessah, I. N., and Van de Water, J.  (2008). Brief report:  plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord 38(1):169-175.  PMID 17347881.

Ashwood, P., Schauer, J., Pessah, I. N., and Van de Water, J. Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J. Neuroimmunology, 208: 130-135, Feb 10, E-pub.  PMID 19211157. (Projects 2, 3; Cores 1, 4)

Ashwood, P., Schauer, J., Pessah, I. N., de Water, J. V. (2009). Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J. Neuroimmunol. 208, 130-135.  PMID 19211157.

Bannister RA, Pessah IN, Beam KG. The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol. 2009 Jan;133(1):79-91. PMID: 19114636 PMCID:  PMC2606935.

Barrientos G, Bose DD, Feng W, Padilla I, Pessah IN. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol. 2009 Sep;76(3):560-8. Epub 2009 Jun 9. PMID: 19509218. [PubMed - indexed for MEDLINE]

Berman RF, Pessah IN, Mouton PR, Mav D, Harry GJ. (2008) Modeling neonatal thimerosal exposure in mice. Toxicol Sci 2008 Jun;103(2):416.  PMID 18364365.

Berman, R. F., Pessah, I. N., Mouton, P., Mav, D., Harry, J.  (2008). Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101(2):294-309. PMID 17977901.

Berman, R.F., Koenig, C., Hunsaker, M.R., Pessah, I.N. & LaSalle, J.M. Neurodevelopmental Toxicology and Autism Spectrum Disorders, W. Slikker & C. Wang, (ed), Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms, Vol. 1, John Wiley & Sons, London. IN PRESS

Berman, R.F., Lawler, C., Harry, G.J. Effects of neonatal thimerosal exposure on SJL mice on measures of sensory gating, anxiety and sociability. Birth Defects Research, 75(5), 360, 2006. (abstract and presentation at the 2006 Teratology Society Meeting, Tucson, Arizona). . (Project  3; Cores  3,5)

Berman, R.F., Pessah, I.N., Mouton, P., Mav, D. and Harry, J.  Examination of thimerosal effects on neonatal SJL/J mice at vaccination-associated exposure levels.  Scheduled presentation at the 11th International Neurotoxicology Association Meeting, Pacific Grove, CA, June 10-15, 2007. (Project  3; Cores  3,5)

Berman, R.F., Pessah, I.N., Mouton, P., Mav, D. and Harry, J.  Low-level thimerosal exposure:  Further evaluation of altered neurotoxic potential in SJL mice.  Submitted for publication, 2007. (Project  3; Cores  3,5)

Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water JA (2008).  Maternally derived antibodies specific for fetal brain proteins.  Neurotoxicology 29(2):226-231. PMID: 18078998 (Projects 1, 2, 3; Cores 1, 2)

Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R, Croen,  L.A., Pessah, I.N., and Van de Water, J.  Autism: Maternally Derived Antibodies Specific For Fetal Brain Proteins, Neurotoxicology, 29 (2):226-231, E-Pub ahead of print (November 2007). PMID 18078998.

Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L. A., Pessah, I. N., and Van de Water, J. (2008). Autism:  maternally derived antibodies specific for fetal brain proteins.  Neurotoxicology 29(2):226-231.  PMID 18078998.

Bu, B., Ashwood, P. ,  Harvey, D. , King, I.B. , Van De Water, J. , and  L-W, Jin. Fatty acid compositions of red blood cell phospholipids in children with autism.  Prostaglandins, Leukotrienes & Essential Fatty Acids, 74:215-221. PMID 16581239.

Buck Louis GM, Gray LE Jr, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, Sippell W, Abbott DH, Soto A, Tyl RW, Bourguignon JP, Skakkebaek NE, Swan SH, Golub MS, Wabitsch M, Toppari J, Euling SY. Environmental factors and puberty timing: expert panel research needs. Pediatrics. 2008 Feb;121 Suppl 3:S192-207. PMID: 18245512 [PubMed - indexed for MEDLINE]

Buie, T. Campbell, D.B., Fuchs, G.F., Furuta, G.T., Levy, J, Van de Water, J, Whitaker, A.H., Atkins, D. Bauman, M.L., Beaudet, A.L., Carr, E.G., Gershon, M.D., Hyman, S.L., Jirapinyo, P., Jyonouchi, H., Kooros, K, Kushak, R., Levitt, P., Levy, S.E., Lewis, J.D., Murray, K.F., Natowicz, M.R., Sabra, A., Wershil, B.K., Weston, S.C., Zeltzer, L., and H. Winter. Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report. Pediatrics 125:supplement Jan 2010, S1-S18. (Project 2)

Burke, K., Cheng, Y., Li, B., Petrov, A., Joshi, P. Berman, R.F., Reuhl, K.R. and  Dicicco-Bloom, E.  Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E.  Neurotoxicology, (6): 970-81, 2006. PMID 17056119. (Project  3; Core 3)

Cabanlit, M., Maitland, D., Wilson, T., Simon, S., Wun, T., Gershwin, M. E., and Van de Water, J. Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. Macromol. Biosci. 7:48-55. PMID 17238230.

Cabanlit, M., Wills, S., Goines, P., Ashwood, P., and Van de Water, J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann. N.Y. Acad. Sci, 1107:92-103.  PMID 17804536. (Projects 2; Cores 1, 2)

Campbell MA, Golub MS, Iyer P, Kaufman FL, Li LH, Moran Messen F, Morgan JE, Donald JM. Reduced water intake: Implications for rodent developmental and reproductive toxicity studies. Birth Defects Res B Dev Reprod Toxicol. 2009 Jun;86(3):157-75. Review. PMID: 19455576 [PubMed - indexed for MEDLINE]

Chen Y, Tassone F, Berman RF, Hagerman PJ, Hagerman RJ, Willemsen R, Pessah IN. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet. 2010 Jan 1;19(1):196-208. Epub . PMID: 19846466 [PubMed - indexed for MEDLINE]

Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7636-41. Epub 2009 Apr 21. PMID: 19383796.  PMCID:  PMC2678594.

Christophe Morisseau, Oleg Merzlikin, Amy Lin, Guochun He, Wei Feng, Isela Padilla, Michael S. Denison, Isaac N. Pessah, and Bruce D. Hammock Toxicology in the Fast Lane: Application of High-Throughput Bioassays to Detect Modulation of Key Enzymes and Receptors. Environ Health Perspect. 2009 December; 117(12): 1867–1872. PMCID: PMC2799460

Croen, L.A., Braunschweig, D., Haapanen, L., Yoshida, D.K., Fireman, B., Grether, J.K., Kharrazi, M., Hansen, R.L., Ashwood, P., and Van de Water, J. Maternal mid-pregnancy autoantibodies to fetal brain protein: the Early Markers for Autism Study, Biological Psychiatry.

Croen, L.A., Goines, P., Braunschweig, D., Yolken, R., Yoshida, D.K., Fireman, B., Grether, J.K., Kharrazi, M., Hansen, R.L., Ashwood, P., and Van de Water, J. Brain-derived neurotrophic factor and autism: maternal and infant serum levels in the Early Markers for Autism (EMA) Study, Autism Research.

Eltit JM, Yang T, Li H, Molinski TF, Pessah IN, Allen PD, Lopez JR. RyR1-mediated Ca2+ leak and Ca2+ entry determine resting intracellular Ca2+ in skeletal myotubes. J Biol Chem. 2010 Apr 30;285(18):13781-7. Epub 2010 Mar 5. PMID: 20207743 [PubMed - in process]

Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood P.  Increased IgG4 levels in children with autism disorder.  Brain Behav Immun. 2009 Mar;23(3):389-95.  PMID 19136055. (Projects 1, 2, 3; Cores 1, 2, 4,5)

 

Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P (2007) Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism.  Amer J Biochem Biotechnol 4(2):121-129.  No PMID. (Projects 1, 2; Cores 1, 2)

Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P (2007).  Detection of IL-17 and IL-23 in plasma samples of children with autism.  Amer J Biochem Biotechnol 4:114-120.  (ISSN 1553-3468).  No PMID. (Projects 1, 2; Cores 1, 2)

Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P.  Altered gene expression and function of peripheral blood natural killer cells in children with autism.  Brain Behav Immun. 2009 Jan;23(1):124-33.  PMID 18762240. (Projects 1, 2, 3; Cores 1, 2, 4,5)

 

Enstrom AM, Onore CE, Van de Water JA, and Ashwood P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun 2010 Jan;24(1):64-71. PMID:19666104. No PMC (Projects 2; Cores 5)

Enstrom, A. M., Lit, L., Onore, C. E., Gregg, J. P., Hansen, R. L., Pessah, I. N., Hertz-Picciotto, I., Van de Water, J. A., Sharp, F. R., Ashwood, P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav. Immun. 23:124-33. PMID 18762240. (Projects 1, 2, 3; Cores 1, 2,4,5)

Enstrom, A. M., Lit, L., Onore, C. E., Gregg, J. P., Hansen, R. L., Pessah, I. N., Hertz-Picciotto, I., Van de Water, J. A., Sharp, F. R., and Ashwood , P.  (2009).   Altered gene expression and function of peripheral blood natural killer cells in children with autism.  Brain Behav. Immun. 23, 124-33.  PMID 18762240.

Enstrom, A. M., Van de Water, J. A., Ashwood, P. Autoimmunity in autism. Curr. Opin. Investig. Drugs. 5:463-473. PMID 19431079. (Projects 2; Cores 1)

Enstrom, A., Krakowiak, P., Onore, C., Pessah, I. N., Hertz-Picciotto, I., Hansen, R. L., Van de Water, J. A., Ashwood, P. (2009). Increased IgG4 levels in children with autism disorder. Brain Behav. Immun. 23, 389-395.  PMID 19136055.

Enstrom, A., Onore, C., Tarver, A., Hertz-Picciotto, I., Hansen, R., Croen, L., Van de Water, J., and Ashwood, P.  Peripheral Blood Leukocyte Production of BDNF following Mitogen Stimulation in Early Onset and Regressive Autism. American Journal of Biochemistry and Biotechnology 4 (2): 121-129. No PMID.

Enstrom, A., Onore, C., Tarver, A., Hertz-Picciotto, I., Hansen, R., Croen, L., Van de Water, J. and Ashwood, P. Detection of IL-17 and IL-23 in Plasma Samples of Children with Autism.  American Journal of Biochemistry and Biotechnology 4 (2): 114-120. No PMID.

Feng W, Cherednichenko G, Ward CW, Padilla IT, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN. Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochem Pharmacol. 2010 Aug 15;80(4):512-21. Epub 2010 May 22. PMID: 20471964 [PubMed - indexed for MEDLINE]

Goines, P. and Van de Water, J. A. The immune system's role in the biology of autism. Curr. Opin. Neurol. 2010 Apr;23(2):111-7.  PMID:  20160651.  No PMC. (Project 2)

Goines, P. Schauer, J., Heuer, L., Ashwood, P. and Van de Water. J.  Beta-2-microglobulin in autism spectrum disorders. Amer. J. Biotech. Biochem. 3:91-95.  No PMID.

Goines, P., Schauer, J., Heuer, L., Ashwood, P., and Van de Water, J.  Beta-2-microglobulin in autism spectrum disorders. Amer. J. Biotech. Biochem. 3:91-95. No PMID. (Project  2; Core  2)

Golub MS (2010). Recent studies of iron deficiency during brain development in nonhuman primates. Biofactors. 2010 Mar;36(2):111-6. PMID: 20336711 [PubMed - in process]

Golub MS, Collman GW, Foster PM, Kimmel CA, Rajpert-De Meyts E, Reiter EO, Sharpe RM, Skakkebaek NE, Toppari J. (Not reported in previous progress reports.) Public health implications of altered puberty timing. Pediatrics. 2008 Feb;121 Suppl 3:S218-30. Review. PMID: 18245514 [PubMed - indexed for MEDLINE]

Golub MS, Hogrefe CE, Widaman KF, Capitanio JP. Iron deficiency anemia and affective response in rhesus monkey infants. Dev Psychobiol. 2009 Jan;51(1):47-59. PMID: 18814183 [PubMed - indexed for MEDLINE]

Goth, S. R., Chu, R. A., and Pessah, I. N. Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. J. Immunol. Meth.  (308):  179-191, 2006.  PMID 16406060. . (Project  3; Cores  3,5)

Goth, S. R., Chu, R., Gregg, P. J., Cherednichenko, G., and Pessah, I. N. Uncoupling of ATP-mediated calcium signaling and dysregulation of IL-6 secretion in dendritic cells by nanomolar thimerosal. Env. Health Perspect. (114), 1083-109, 2006.  PMID 16835063. . (Project  3; Cores  3,5)

Gregg J, Lit L, Baron C, Hertz-Picciotto I, Walker W, Davis R, Croen LA, Ozonoff S, Hansen R, Pessah I, Sharp FR (2008).  Gene expression changes in children with autism.  Genomics 2008 Jan;91(1):22-9. PMID: 18006270 (Projects 1, 2, 3; Cores 1, 2, 4,5)

Gregg, J.P., Lit, L., Baron, C. A., Hertz-Picciotto, I., Walker, W., Davis, R. A., Croen, L. A., Ozonoff, S., Hansen, R., Pessah, I. N., and Sharp, F. R. (2008). Gene expression changes in children with autism. Genomics 91(1):22-29.  PMID 18006270.

Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW.  Animal models of autism spectrum disorders: information for neurotoxicologists.  Neurotoxicology. 2009 Sep;30(5):811-21. Epub 2009 Jul 9. PMID: 19596370 [PubMed - indexed for MEDLINE]

Hansen RL, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey LJ, Le D-N, Croen L, Hertz-Picciotto I (2008 Jan-Feb).  Regression in autism: prevalence and associated factors in the CHARGE Study.  Ambul Pediatr 8(1):25-31. PMID: 18191778  (Projects 1; Cores 1, 2)

Harry, G.L., Mouton, P., Golub, M., Lawler, C., Berman, R.F. Hippocampal morphology - effects of litter and neonatal thimerosal exposure in SJl/J mice. Birth Defects Research, 76(5), 361, 2006. (abstract and presentation at the 2006 Teratology Society Meeting, Tucson, Arizona). . (Project  3; Cores  3,5)

Hertz-Picciotto I, Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology. 2009 Jan;20(1):84-90.  PMID 19234401. Project 1

 

Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN (2010 Jan).  Blood mercury concentrations in CHARGE Study children with and without autism. Environ Health Persp: 118(1):161-6. PMCID: PMC2831962 (Projects 1, 3; Cores 1, 2, 3)

Hertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ.  A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio.  Environ Health. 2008 Jul 15;7:37.  PMCID PMC2483969.  

Hertz-Picciotto I, Park H-Y, Dostal M, Kočan A, Trnovec T, Šrám R (2008 Feb).  Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development.  Basic Clin Pharmacol Toxicol 102(2):146-54.  PMID:  18226068

Hertz-Picciotto, I., Croen, L. A., Hansen, R., Jones, C. R., Van de Water, J., and I.N. Pessah. The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect, 114:1119-1125. PMID 16835068.

Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J.  Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms.  Autism Res. 2008 Oct;1(5):275-83. PMCID PMC2663897. (Projects 1, 2, 3; Cores 1, 2, 5)

 

Heuer L, Ashwood P,, Schauer J, Goines P,, Krakowiak P, Hertz-Picciotto I, Hansen R,  Croen LA,  Pessah I N, and Van de Water J., Reduced Levels of Immunoglobulin in Children with Autism Correlates with Behavioral Symptoms. Autism Research,1:275-283 2008.  PMCID PMC2663897. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Heuer, L., Ashwood, P., Schauer, J., Goines, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L.A., Pessah, I. N., Van de Water, J. (2008). Reduced Levels of Immunoglobulin in Children With Autism Correlates With Behavioral Symptoms. Autism Res. 1, 275-283.  PMCID PMC2663897.

Irva Hertz-Picciotto, Peter G. Green, Lora Delwiche, Robin Hansen, Cheryl Walker, and Isaac N. Pessah (2010).  Blood Mercury Concentrations in CHARGE Study Children with and without Autism. Environ Health Perspect. 2010 January; 118(1): 161–166. PMCID: PMC2831962.

Jaubert, P.J., Golub, M.S., Lo, Y.Y., German, S.L., Dehoff, M.H., Worley, P.F., Kang, S.H., Schwartz, M.K., Seeburg, P.H. and  Berman, R.F.  Complex, multimodal behavioral profile of the Homer1 knockout mouse.  Genes, Brain and Behavior, (6):141-154, 2007. PMID 16734773. (Project  3; Cores  3,5)

Kenet, T., Froemcke, R. C., Schreiner, C. E., Pessah, I. N., and Merzenich, M. M. (2007). Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proc Natl Acad Sci USA 104(18):7646-51.  PMID 17460041.

Kenet, T., Froemcke, R., Schreiner, C., Pessah, I. N. and Merzenich, M.M. Abnormal auditory Cortex development in PCB exposed rats. Proc. Natl. Acad. Sci. USA (in press). (Project  3)

Kim, K. H., Inan, S. Y., Berman, R. F. and Pessah I. N.*  (2009) Differential patterns of excitotoxicity and ryanodine receptor modulation in the hippocampus by two ortho-substituted polychlorinated biphenyls. Toxicol. Appl. Pharmacol.  (in press)

Kim, K.H., Inan, S.Y., Berman, R.F. & Pessah, I.N.  Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicology & Applied Pharmacology 2009 Jun 1;237(2): 168-177.  Epub 2009 Mar 13. PMID:  19289137. [PubMed - indexed for MEDLINE]

Krakowiak, P, Goodlin-Jones B, Croen LA, Hertz-Picciotto I, Hansen RL.  Sleep problems in young children with autism spectrum disorder. J Sleep Research (In press/rejected 10-06 9-06). (Projects 1; Cores 1, 2)

Krakowiak, P, Hansen RL, Goodlin-Jones B, Croen LA, Hertz-Picciotto I.  Sleep problems in young children with autism spectrum disorder (in revision/rejected 10-06 9-06). (Projects 1; Cores 1, 2)

Lein, P.M., Kim, K.H., Berman, R.F. & Pessah, I.N.: Exposure of the developing brain to polychlorinated biphenyls influences the susceptibility of the adult brain to stress, W. Slikker, (ed), Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms.  IN PRESS

Martin, L. A. , Ashwood, P. , Braunschweig, D., Cabanlit, M., Van de Water, J., and Amaral, D.G.  Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism.  Brain Behavior and Immunity, E-Pub ahead of print (February 2008). PMID 18262386.

MECP2 promoter methylation and X-chromosome inactivation in autism. Autism Research 1(3):169-178. PMID  19132145        (Projects 1, 2, 3; Cores 1, 2, 4,5)

Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, Lasalle JM (2008.  

Nagarajan, R. P., Patzel, K. A., Martin, M., Yasui, D. H., Swanberg, S. E., Hertz-Picciotto, I., Hansen, R. L., Van de Water, J. A., Pessah, I. N., Jiang, R., Robinson, W.P., and LaSalle, J. M. (2008).  MECP2 promoter methylation and X chromosome inactivation in autism. Autism Res. 1, 169-178.  PMCID PMC2614877.

Nagarajan, R.P., Patzel, K.A., Martin, M., Yasui, D.H., Swanberg, S.E., Hertz-Picciotto, I., Hansen, R.L., Van de Water, J., Pessah, I.N., Jiang, R., Wendy P. Robinson, W.P., and LaSalle, J.M. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Research 1: 169-178. Published Online: Jul 9 2008.  PMCID PMC2614877. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Onore C, Enstrom A, Krakowiak P, Hansen R, Hertz-Picciotto I, Van de Water J (2009 Nov). Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J Neuroimmunol 216(1-2):126-9. .  PMID 19800697.  No PMC. (Projects 1, 2, 3; Cores 1, 2)

Onore C, Enstrom A, Krakowiak P, Hansen R, Hertz-Picciotto I, Van de Water J (2009 Nov). Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J Neuroimmunol 216(1-2):126-9. .  PMID 19800697.  No PMC.(Project 2)

Ozonoff S, Heung K, Byrd R, Hansen R, Hertz-Picciotto I.  The onset of autism: patterns of symptom emergence in the first years of life.  Autism Res. 2008 Dec;1(6):320-8. PMID 19360687. (Projects 1; Cores 1, 2)

 

Palkovičova L, Ursinyova M, Hladikova V, Yu Z, Hertz-Picciotto I (2008 May).  Maternal amalgam dental fillings as a major source of mercury in the developing fetus and newborn.  J Expos Science & Env Epidemiol 18(3):326-31. PMID: 17851449 http://www.nature.com/jes/journal/vaop/ncurrent/abs/7500606a.html;jsessionid=87AC0B7C7043E0215659818962050E50

Paul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology. 2010 May 10. [Epub ahead of print] PMID: 20466021 [PubMed - as supplied by publisher]

Pessah I. N., Seegal, R. F., Lein, P. J., Lasalle, J., Yee, B. K., Van De Water, J., Berman, R. F. (2008). Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29, 532-45.  PMCID PMC2475601.

Pessah IN, Cherednichenko G, Lein PJ.  Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacol Ther. 2010 Feb;125(2):260-85. Epub 2009 Nov 25. PMID: 19931307

Pessah IN, Seegal RF, Lein PJ, Lasalle J, Yee BK, Van de Water J, Berman RF. (2008) Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology, February 23, Epub ahead of print.  PMID 18394707.

Pessah, I. N., Hansen, L. G., Albertson, T. E., Garner, C. E., Ta, T. A., Do, Z., and Wong P. W. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem. Res. Toxicol. (19): 92-101, 2006. PMID 16411661. . (Project  3; Cores  3,5)

Pessah, I. N., Lehmler, H.-J., Robertson, L. W., Perez, C. F., Cabrales, E., Bose, D. D., and Feng, W. (2009). Enantiomeric specificity of (-)-2,2',3,3',6,6 -hexachlorobiphenyl ((-)-PCB 136) towards ryanodine receptor types 1 and 2. Chem. Res. Toxicol. 22, 201-207. PMID 18954145.

Pessah, I.N. and Lein, P. (2008). Evidence for Environmental Susceptibility in Autism. What We Know. What We Need to Know About Gene x Environment Interactions. In Autism: Current Theories and Evidence, Ed: A. W. Zimmerman. Humana Press, in press.

Pessah, I.N., Seegal, R.F., Lein, P.J., Lasalle, J., Yee, B.K., Van de Water, J., and Berman, R.F.  Immunologic and neurodevelopmental susceptibilities of autism.  Neurotoxicology, February 23, Epub ahead of print. PMID 18394707.

Rose M, Bennett DH, Bergman A, Fangstrom B, Pessah IN, Hertz-Picciotto I (2010 Apr). PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Env Sci Technol 44(7):2648-53. PMID: 20196589.  No PMC. (Projects 1, 3; Core 1)

Rose M, Bennett DH, Bergman A, Fängström B, Pessah IN, Hertz-Picciotto I. PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environ Sci Technol. 2010 Apr 1;44(7):2648-53. PMID: 20196589 [PubMed - in process]

Samso, M., Feng, W., Pessah, I. N., and Allen, P. D. (2009). Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating. PLoS Biol.  Published online April 14, 2009; 7(4):e85.  PMCID PMC2672603.

Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt L, Tancredi DJ, Tassone F, Hertz-Picciotto I. Maternal prenatal vitamin intake, functional gene variants in folate, methionine, and transmethylation pathways, and risk for autism in the CHARGE case-control study. Submitted 2010. (Project 1, Cores 2, 4)

Schmidt RJ, Hansen RL, Hertz-Picciotto I. Maternal periconceptional folic acid vitamin intake and risk of autism spectrum disorders in the CHARGE Study.  Submitted 2010. (Project 1, Cores 2, 4)

Shelton J, Tancredi DJ, Hertz-Picciotto I (2010 Feb). Independent and dependent contributions of advanced maternal and paternal ages for autism risk. Autism Res 3(1):30-39. [Epub ahead of print] PMID: 20143326.  No PMC. (Project 1)

Sonneborn D, Park HY, Babinska K, Palkovicova L, Trnovec T, Kocan A, Nguyen DV, Hertz-Picciotto I.  Serum PCB concentrations in relation to locally produced food items in eastern Slovakia.  J Expo Sci Environ Epidemiol. 2008 Nov;18(6):581-7.  PMID 18285840.

 

Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotoxicity Res November 2009. [Epub ahead of print].  PMID:  19937285.  No PMC. (Projects 1, 2, 3; Cores 1, 2, 3, 4, 5)

Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotoxicity Res November 2009. [Epub ahead of print].  PMID:  19937285.  No PMC. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations Between Gene Expression and Mercury Levels in Blood of Boys With and Without Autism. Neurotox Res. 2009 Nov 24. [Epub ahead of print] PMID: 19937285 [PubMed - as supplied by publisher]

Ta, T. A., and Pessah, I. N.  (2007). Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). Neurotoxicology 28(4):770-779. (Cover Article) PMID 17023049.

Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res 2009. [Epub ahead of print].  PMID:  19921347.  No PMC. (Projects 1, 2, 3; Cores 1, 2, 3, 4, 5)

Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotox Res 2009. [Epub ahead of print].  PMID:  19921347.  No PMC. (Projects 1, 2, 3; Cores 1, 2, 4,5)

Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of Gene Expression with Blood Lead Levels in Children with Autism Compared to Typically Developing Controls. Neurotox Res. 2009 Nov 17. [Epub ahead of print] PMID: 19921347 [PubMed - as supplied by publisher]

Van Meter KC, Christiansen LE, Delwiche, LD, Azari R, Carpenter TE, Hertz-Picciotto I (2010 Jan). Geographic Distribution of Autism in California: A Retrospective Birth Cohort Analysis. Autism Res 2010 Jan 4;3(1):19-29. [Epub ahead of print] PMID: 20049980.  No PMC. (Project 1)

Vogel C. F., Goth S. R., Dong B., Pessah I. N., Matsumura F. (2008).  Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase.  Biochem. Biophys. Res. Commun. 375, 331-5.  PMID 18694728.

Wiest MM, German JB, Harvey DJ, Watkins SM, Hertz-Picciotto I.  Plasma fatty acid profiles in autism: A case-control study.  Prostaglandins Leukot Essent Fatty Acids. 2009 Apr;80(4):221-7. PMID 19307110. (Project 1; Cores 1, 3)

 

Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D.G. and Van de Water, J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders, Brain Behavior and Immunity, 23:64-74 E-pub 2008. PMID 18706993. (Projects 2; Cores 1)

Yang, D., Kim, K. H., Phimister, A. V., Bachstetter, A., Ward, T., Stackman, R., Mervis, R., Wisniewski, A., Klein, S., Kodavanti, P., Anderson, Wayman, G., Pessah, I. N., and Lein, P. J. (2009). Developmental exposure to polychlorinated biphenyls (PCBs) interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling Rats Env. Health Perspect. 117, 426-435.  PMCID PMC2661913.

Zhang X, Lv C-C, Tian J, Miao RJ, Xi W, Hertz-Picciotto I, Qi  L (2010 Apr).  Prenatal and perinatal risk factors for autism in China. J Autism Dev Dis April 2010 [Epub ahead of print].  PMID: 20358271.  No PMC. (Project 1)

Zhu X, Rivera A, Golub MS, Peng J, Sha Q, Wu X, Song X, Kumarathasan P, Ho M, Redman CM, Lee S. Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am J Hematol. 2009 Aug;84(8):492-8. PMID: 19544475 [PubMed - indexed for MEDLINE] 

 

 

 

 

 

 

 

 

 


Journal Articles: 274 Displayed | Download in RIS Format

Other center views: All 471 publications 286 publications in selected types All 274 journal articles
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Journal Article Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kultz D, Chang DPY, Gee SJ, Hammock BD. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens:receptor-based bioassay screens. Environmental Health Perspectives 2008;116(9):1203-1210. R833292 (2009)
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  • Journal Article Ahn KC, Gee SJ, Tsai H-J, Bennett D, Nishioka MG, Blum A, Fishman E, Hammock BD. Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environmental Science & Technology 2009;43(20):7784-7790. R833292 (Final)
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  • Journal Article Ahn KC, Kim H-J, McCoy MR, Gee SJ, Hammock BD. Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides. Journal of Agricultural and Food Chemistry 2011;59(7):2792-2802. R833292 (Final)
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  • Journal Article Ahn KC, Gee SJ, Kim H-J, Aronov PA, Vega H, Krieger RI, Hammock BD. Immunochemical analysis of 3-phenoxybenzoic acid, a biomarker of forestry worker exposure to pyrethroid insecticides. Analytical and Bioanalytical Chemistry 2011;401(4):1285-1293. R833292 (Final)
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  • Journal Article Ahn KC, Kasagami T, Tsai H-J, Schebb NH, Gee SJ, Hammock BD. An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban. Environmental Science & Technology 2012;46(1):374-381. R833292 (Final)
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  • Journal Article Anderson PJ, Lango J, Carkeet C, Britten A, Krautler B, Hammock BD, Roth JR. One pathway can incorporate either adenine or dimethylbenzimidazole as an α-axial ligand of B12 cofactors in Salmonella enterica. Journal of Bacteriology 2008;190(4):1160-1171. R833292 (Final)
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  • Journal Article Angkustsiri K, Krakowiak P, Moghaddam B, Wardinsky T, Gardner J, Kalamkarian N, Hertz-Picciotto I, Hansen RL. Minor physical anomalies in children with autism spectrum disorders. Autism 2011;15(6):746-760. R833292 (2011)
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  • Journal Article Aronov PA, Hall LM , Dettmer K, Stephensen CB, Hammock BD. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2008;391(5):1917-1930. R833292 (Final)
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  • Journal Article Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P, Walker W, Pessah IN, Van de Water J. Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? Journal of Autism and Developmental Disorders 2008;38(1):169-175. R833292 (2007)
    R833292 (2008)
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  • Journal Article Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA, Ozonoff S, Pessah IN, Van de Water J. Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes. Journal of Neuroimmunology 2008;204(1-2):149-153. R833292 (2009)
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  • Journal Article Ashwood P, Schauer J, Pessah IN, Van de Water J. Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. Journal of Neuroimmunology 2009;208(1-2):130-135. R833292 (2009)
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  • Journal Article Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain, Behavior, and Immunity 2011;25(1):40-45. R833292 (2010)
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  • Journal Article Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Altered T cell responses in children with autism. Brain, Behavior, and Immunity 2011;25(5):840-849. R833292 (2010)
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  • Journal Article Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. Journal of Neuroimmunology 2011;232(1-2):196-199. R833292 (2011)
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  • Journal Article Bannister RA, Pessah IN, Beam KG. The skeletal L-type Ca2+ current is a major contributor to excitation-coupled Ca2+ entry. Journal of General Physiology 2009;133(1):79-91. R833292 (2009)
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  • Journal Article Barile D, Marotta M, Chu C, Mehra R, Grimm R, Lebrilla CB, German JB. Neutral and acidic oligosaccharides in Holstein-Friesian colostrum during the first 3 days of lactation measured by high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry. Journal of Dairy Science 2010;93(9):3940-3949. R833292 (Final)
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  • Journal Article Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
 Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes. Human Molecular Genetics 2006;15(6):853-869. R833292 (Final)
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  • Journal Article Baron CA, Liu SY, Hicks C, Gregg JP. Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autism. Journal of Autism and Developmental Disorders 2006;36(8):973-982. R833292 (Final)
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  • Journal Article Barrientos G, Bose DD, Feng W, Padilla I, Pessah IN. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Molecular Pharmacology 2009;76(3):560-568. R833292 (2009)
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  • Journal Article Bauman MD, Lavenex P, Mason WA, Capitanio JP, Amaral DG. The development of social behavior following neonatal amygdala lesions in rhesus monkeys. Journal of Cognitive Neuroscience 2004;16(8):1388-1411. R833292 (Final)
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  • Journal Article Bennett DH, Wu XM, Teague CH, Lee K, Cassady DL, Ritz B, Hertz-Picciotto I. Passive sampling methods to determine household and personal care product use. Journal of Exposure Science & Environmental Epidemiology 2012;22(2):148-160. R833292 (2012)
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  • Journal Article Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicological Sciences 2008;101(2):294-309. R833292 (2008)
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  • Journal Article Berman RF, Pessah IN, Mouton PR, Mav D, Harry GJ. Modeling neonatal thimerosal exposure in mice. Toxicological Sciences 2008;103(2):416. R833292 (2008)
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  • Journal Article Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J. Autism: maternally derived antibodies specific for fetal brain proteins. NeuroToxicology 2008;29(2):226-231. R833292 (2007)
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  • Journal Article Braunschweig D, Duncanson P, Boyce R, Hansen R, Ashwood P, Pessah IN, Hertz-Picciotto I, Van de Water J. Behavioral correlates of maternal antibody status among children with autism. Journal of Autism and Developmental Disorders 2012;42(7):1435-1445. R833292 (2011)
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  • Journal Article Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW.
 Fatty acid compositions of red blood cell phospholipids in children with autism.
 Prostaglandins, Leukotrienes and Essential Fatty Acids 2006;74(4):215-221. R833292 (2007)
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  • Journal Article Buchen L. Scientists and autism: when geeks meet. Nature 2011;479(7371):25-27. R833292 (2012)
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  • Journal Article Buck Louis GM, Gray Jr LE, Marcus M, Ojeda SR, Pescovitz OH, Witchel SF, Sippell W, Abbott DH, Soto A, Tyl RW, Bourguignon JP, Skakkebaek NE, Swan SH, Golub MS, Wabitsch M, Toppari J, Euling SY. Environmental factors and puberty timing: expert panel research needs. Pediatrics 2008;121(Suppl 3):S192-S207. R833292 (2009)
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  • Journal Article Buie T, Campbell DB, Fuchs III GJ, Furuta GT, Levy J, Van de Water J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics 2010;125(Suppl 1):S1-S18. R833292 (Final)
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  • Journal Article Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. NeuroToxicology 2006;27(6):970-981. R833292 (2009)
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  • Journal Article Cabanlit M, Maitland D, Wilson T, Simon S, Wun T, Gershwin ME, Van de Water J. Polyurethane shape-memory polymers demonstrate functional biocompatibility in vitro. Macromolecular Bioscience 2007;7(1):48-55. R833292 (2007)
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  • Journal Article Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific utoantibodies in the plasma of subjects with autistic spectrum disorder. Annals of the New York Academy of Sciences 2007;1107:92-103. R833292 (2007)
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  • Journal Article California Dental Association Foundation, American College of Obstetricians and Gynecologists District IX. Oral health during pregnancy and early childhood: evidence-based guidelines for health professionals. Journal of the California Dental Association 2010;38(6):391-403, 405-440. R833292 (2010)
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  • Journal Article Campbell MA, Golub MS, Iyer P, Kaufman FL, Li LH, Moran Messen F, Morgan JE, Donald JM. Reduced water intake: implications for rodent developmental and reproductive toxicity studies. Birth Defects Research Part B: Developmental and Reproductive Toxicology 2009; 86(3):157-175. R833292 (2009)
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  • Journal Article Cao Z, Hammock BD, McCoy M, Rogawski M, Lein PJ, Pessah IN. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABAA receptor-positive modulation. Toxicological Sciences 2012;130(2):362-372. R833292 (2012)
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  • Journal Article Careaga M, Van de Water J, Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 2010;7(3):283-292. R833292 (2011)
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  • Journal Article Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5694-5699. R833292 (Final)
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  • Journal Article Chaidez V, Hansen RL, Hertz-Picciotto I. Autism spectrum disorders in Hispanics and non-Hispanics. Autism: The International Journal of Research and Practice 2012;16(4):381-397. R833292 (2012)
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  • Journal Article Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB Journal 2006;20(2):329-330. R833292 (2007)
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  • Journal Article Chen Y, Tassone F, Berman RF, Hagerman PJ, Hagerman RJ, Willemsen R, Pessah IN. Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Human Molecular Genetics 2010;19(1):196-208. R833292 (Final)
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  • Journal Article Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14158-14163. R833292 (2012)
    R835432 (2013)
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  • Journal Article Chichlowski M, German JB, Lebrilla CB, Mills DA. The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas. Annual Review of Food Science and Technology 2011;2:331-351. R833292 (2012)
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  • Journal Article Croen LA, Goines P, Braunschweig D, Yolken R, Yoshida CK, Grether JK, Fireman B, Kharrazi M, Hansen RL, Van de Water J. Brain-derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study. Autism Research 2008;1(2):130-137. R833292 (2008)
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  • Journal Article Croen LA, Braunschweig D, Haapanen L, Yoshida CK, Fireman B, Grether JK, Kharrazi M, Hansen RL, Ashwood P, Van de Water J. Maternal mid-pregnancy autoantibodies to fetal brain protein: the Early Markers for Autism Study. Biological Psychiatry 2008;64(7):583-588. R833292 (2008)
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  • Journal Article Crofton KM, Mundy WR, Lein PJ, Bal-Price A, Coecke S, Coecke S, Seiler AEM, Knaut H, Buzanska L, Goldberg A. Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals. ALTEX 2011;28(1):9-15. R833292 (2012)
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  • Journal Article Dai JJ, Lieu L, Rocke D.
 Dimension reduction for classification with gene expression microarray data.
 Statistical Applications in Genetics and Molecular Biology 2006;5(1):Article 6. R833292 (Final)
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  • Journal Article Dallas DC, Martin WF, Strum JS, Zivkovic AM, Smilowitz JT, Underwood MA, Affolter M, Lebrilla CB, German JB. N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry. Journal of Agricultural and Food Chemistry 2011;59(8):4255-4263. R833292 (2012)
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  • Journal Article Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. Journal of Pharmacology and Experimental Therapeutics 2006;316(2):815-821. R833292 (Final)
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  • Journal Article Denning L, Anderson JA, Davis R, Gregg JP, Kuzdenyi J, Maselli RA.
 High throughput genetic analysis of congenital myasthenic syndromes using resequencing microarrays. PLoS One 2007;2(9):e918. R833292 (Final)
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  • Journal Article Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. 
Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory.
 Analytical and Bioanalytical Chemistry 2007;388(8):1643-1651. R833292 (Final)
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  • Journal Article Dettmer K, Aronov PA, Hammock BD. 
Mass spectrometry-based metabolomics.
 Mass Spectrometry Reviews 2007;26(1):51-78. R833292 (Final)
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  • Journal Article Dodds ED, German JB, Lebrilla CB. Enabling MALDI-FTICR-MS/MS for high-performance proteomics through combination of infrared and collisional activation. Analytical Chemistry 2007;79(24):9547-9556. R833292 (Final)
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  • Journal Article Du X, Tang Y, Xu H, Lit L, Walker W, Ashwood P, Gregg JP, Sharp FR. Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndrome. Genomics 2006;87(6):693-703. R833292 (Final)
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  • Journal Article Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN, Hertz-Picciotto I, Van de Water JA, Sharp FR, Ashwood P. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain, Behavior, and Immunity 2009:23(1):124-133. R833292 (2009)
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  • Journal Article Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Current Opinion in Investigational Drugs 2009;10(5):463-473. R833292 (Final)
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  • Journal Article Enstrom AM, Onore CE, Van de Water JA, Ashwood P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain, Behavior, and Immunity 2010;24(1):64-71. R833292 (2009)
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  • Journal Article Enstrom A, Onore C, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P. Detection of IL-17 and IL-23 in plasma samples of children with autism. American Journal of Biochemistry and Biotechnology 2008;4(2):114-120. R833292 (2007)
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  • Journal Article Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J, Ashwood P. Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology 2008;4(2):121-129. R833292 (2007)
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  • Journal Article Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL, Van de Water JA, Ashwood P. Increased IgG4 levels in children with autism disorder. Brain, Behavior, and Immunity 2009;23(3):389-395. R833292 (2009)
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  • Journal Article Esteve E, Smida-Rezgui S, Sarkozi S, Szegedi C, Regaya I, Chen L, Altafaj X, Rochat H, Allen P, Pessah IN, Marty I, Sabatier JM, Jona I, De Waard M, Ronjat M. Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells. Journal of Biological Chemistry 2003;278(39):37822-37831. R833292 (Final)
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  • Journal Article Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY-J, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor α by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 2005;314(1):260-270. R833292 (Final)
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  • Journal Article Feng W, Tu J, Pouliquin P, Cabrales E, Shen X, Dulhunty A, Worley PF, Allen PD, Pessah IN. Dynamic regulation of ryanodine receptor type 1 (RyR1) channel activity by Homer 1. Cell Calcium 2008;43(3):307-314. R833292 (2007)
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  • Journal Article Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN. Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Molecular Pharmacology 2011;79(3):420-431. R833292 (2012)
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  • Journal Article Froehlich JW, Dodds ED, Barboza M, McJimpsey EL, Seipert RR, Francis J, An HJ, Freeman S, German JB, Lebrilla CB. Glycoprotein expression in human milk during lactation. Journal of Agricultural and Food Chemistry 2010;58(10):6440-6448. R833292 (Final)
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  • Journal Article German JB, Smilowitz JT, Zivkovic AM. Lipoproteins: when size really matters. Current Opinion in Colloid & Interface Science 2006;11(2-3):171-183. R833292 (Final)
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  • Journal Article German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM. Lipidomics and lipid profiling in metabolomics.
 Current Opinion in Lipidology 2007;18(1):66-71. R833292 (Final)
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  • Journal Article German JB. Dietary lipids from an evolutionary perspective: sources, structures and functions. Maternal & Child Nutrition 2011;7(Suppl 2):2-16. R833292 (2012)
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  • Journal Article German JB, Zivkovic AM, Dallas DC, Smilowitz JT. Nutrigenomics and personalized diets: what will they mean for food? Annual Review of Food Science and Technology 2011;2:97-123. R833292 (2012)
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  • Journal Article Gibney MJ, Walsh M, Brennan L, Roche HM, German B, van Ommen B. Metabolomics in human nutrition: opportunities and challenges. American Journal of Clinical Nutrition 2005;82(3):497-503. R833292 (Final)
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  • Journal Article Giulivi C, Zhang Y-F, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I, Tassone F, Pessah IN. Mitochondrial dysfunction in autism. JAMA-Journal of the American Medical Association 2010;304(21):2389-2396. R833292 (2012)
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  • Journal Article Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, Allen PD, Pessah IN. Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice. Journal of Biological Chemistry 2011;286(1):99-113. R833292 (2012)
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  • Journal Article Goines PE, Croen LA, Braunschweig D, Yoshida, CK, Grether J, Hansen R, Kharrazi M, Ashwood P, Van de Water J. Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study. Molecular Autism 2011;2:13. R833292 (2011)
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  • Journal Article Goines P, Schauer J, Heuer L, Ashwood P, Van de Water J. Beta-2-microglobulin in autism spectrum disorders. American Journal of Biochemistry and Biotechnology 2007;3(2):87-91. R833292 (2007)
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  • Journal Article Goines P, Van de Water J. The immune system's role in the biology of autism. Current Opinion in Neurology 2010;23(2):111-117. R833292 (2009)
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  • Journal Article Goines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L, Hansen R, Hertz-Picciotto I, Ashwood P, Van de Water J. Autoantibodies to cerebellum in children with autism associate with behavior. Brain, Behavior, and Immunity 2011;25(3):514-523. R833292 (2011)
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  • Journal Article Goth SR, Chu RA, Pessah IN. Oxygen tension regulates the in vitro maturation of GM-CSF expanded murine bone marrow dendritic cells by modulating class II MHC expression. Journal of Immunological Methods 2006;308(1-2):179-191. R833292 (2007)
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  • Journal Article Goth SR, Chu RA, Gregg JP, Cherednichenko G, Pessah IN. Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosal. Environmental Health Perspectives 2006;114(7):1083-1091. R833292 (2007)
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  • Journal Article Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin L-W, Schumann C, Hagerman PJ, Hagerman RJ. Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Molecular Autism 2011;2(1):2 (13 pp.). R833292 (2012)
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  • Journal Article Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR. Gene expression changes in children with autism. Genomics 2008;91(1):22-29. R833292 (2008)
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  • Journal Article Hall LM, Kimlin MG, Aronov PA, Hammock BD, Slusser JR, Woodhouse LR, Stephensen CB. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. Journal of Nutrition 2010;140(3):542-550. R833292 (Final)
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  • Journal Article Halladay AK, Amaral D, Aschner M, Bolivar VJ, Bowman A, DiCicco-Bloom E, Hyman SL, Keller F, Lein P, Pessah I, Restifo L, Threadgill DW. Animal models of autism spectrum disorders: information for neurotoxicologists. NeuroToxicology 2009;30(5):811-821. R833292 (Final)
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  • Journal Article Hansen RL, Ozonoff S, Krakowiak P, Angkustsiri K, Jones C, Deprey LJ, Le D-N, Croen LA, Hertz-Picciotto I. Regression in autism: prevalence and associated factors in the CHARGE Study. Ambulatory Pediatrics 2008;8(1):25-31. R833292 (2008)
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  • Journal Article Herr CE, Dostal M, Ghosh R, Ashwood P, Lipsett M, Pinkerton KE, Sram R, Hertz-Picciotto I. Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths. Environmental Health 2010;9(46). R833292 (2010)
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  • Journal Article Herr CEW, Ghosh R, Dostal M, Skokanova V, Ashwood P, Lipsett M, Joad JP, Pinkerton KE, Yap P-S, Frost JD, Sram R, Hertz-Picciotto I. Exposure to air pollution in critical prenatal time windows and IgE levels in newborns. Pediatric Allergy and Immunology 2011;22(1 Pt 1):75-84. R833292 (2011)
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  • Journal Article Hertz-Picciotto I, Charles MJ, James RA, Keller JA, Willman E, Teplin S. In utero polychlorinated biphenyl exposures in relation to fetal and early childhood growth. Epidemiology 2005;16(5):648-656. R833292 (2007)
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  • Journal Article Hertz-Picciotto I, Croen LA, Hansen R, Jones CR, van de Water J, Pessah IN. The CHARGE Study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives 2006;114(7):1119-1125. R833292 (2007)
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  • Journal Article Hertz-Picciotto I, Baker RJ, Yap PS, Dostal M, Joad JP, Lipsett M, Greenfield T, Herr CE, Benes I, Shumway RH, Pinkerton KE, Sram R. Early childhood lower respiratory illness and air pollution. Environmental Health Perspectives 2007;115(10):1510-1518. R833292 (2007)
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  • Journal Article Hertz-Picciotto I, Park H-Y, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic & Clinical Pharmacology and Toxicology 2008;102(2):146-154. R833292 (2008)
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  • Journal Article Hertz-Picciotto I, Jusko TA, Willman EJ, Baker RJ, Keller JA, Teplin SW, Charles MJ. A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio. Environmental Health 2008;7:37. R833292 (2009)
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  • Journal Article Hertz-Picciotto I, Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology 2009;20(1):84-90. R833292 (2009)
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  • Journal Article Hertz-Picciotto I, Cassady D, Lee K, Bennett DH, Ritz B, Vogt R. Study of Use of Products and Exposure-Related Behaviors (SUPERB): study design, methods, and demographic characteristics of cohorts. Environmental Health 2010;9:54. R833292 (2010)
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  • Journal Article Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. Blood mercury concentrations in CHARGE Study children with and without autism. Environmental Health Perspectives 2010;118(1):161-166. R833292 (2009)
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  • Journal Article Hertz-Picciotto I, Bergman A, Fangstrom B, Rose M, Krakowiak P, Pessah I, Hansen R, Bennett DH. Polybrominated diphenyl ethers in relation to autism and developmental delay: a case-control study. Environmental Health 2011;10(1):1. R833292 (2011)
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  • Journal Article Heuer LS, Rose M, Ashwood P, Van de Water J. Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction. Journal of Neuroimmunology 2012;251(1-2):94-102. R833292 (2012)
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  • Journal Article Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA, Pessah IN, Van de Water J. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Research 2008;1(5):275-283. R833292 (2009)
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  • Journal Article Heuer L, Braunschweig D, Ashwood P, Van de Water J, Campbell DB. Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. Translational Psychiatry 2011;1:e48. R833292 (2011)
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  • Journal Article Hillyard SL, German JB. Non-essential dietary factors: from test tube to lifespan. Journal of the Science of Food and Agriculture 2007;87(10):1802-1805. R833292 (Final)
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  • Journal Article Hillyard SL, German JB. Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans. Journal of Agricultural and Food Chemistry 2009;57(8):3389-3396. R833292 (Final)
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  • Journal Article Horvathova M, Jahnova E, Palkovicova L, Trnovec T, Hertz-Picciotto I. Dynamics of lymphocyte subsets in children living in an area polluted by polychlorinated biphenyls. Journal of Immunotoxicology 2011;8(4):333-345. R833292 (2012)
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  • Journal Article Horvathova M, Jahnova E, Palkovicova L, Trnovec T, Hertz-Picciotto I. The kinetics of cell surface receptor expression in children perinatally exposed to polychlorinated biphenyls. Journal of Immunotoxicology 2011;8(4):367-380. R833292 (2012)
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  • Journal Article Howards PP, Hertz-Picciotto I. Invited commentary: Disinfection by-products and pregnancy loss—lessons. American Journal of Epidemiology 2006;164(11):1052-1055. R833292 (2007)
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  • Journal Article Hua S, Nwosu CC, Strum JS, Seipert RR, An HJ, Zivkovic AM, German JB, Lebrilla CB. Site-specific protein glycosylation analysis with glycan isomer differentiation. Analytical and Bioanalytical Chemistry 2012;403(5):1291-1302. R833292 (2012)
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  • Journal Article Huang H, Nishi K, Gee SJ, Hammock BD. Evaluation of chiral α-cyanoesters as general fluorescent substrates for screening enantioselective esterases. Journal of Agricultural and Food Chemistry 2006;54(3):694-699. R833292 (Final)
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  • Journal Article Hwang H-M, Park E-K, Young TM, Hammock BD. Occurrence of endocrine-disrupting chemicals in indoor dust. Science of the Total Environment 2008;404(1):26-35. R833292 (Final)
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  • Journal Article Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD.
 Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). 
Prostaglandins & Other Lipid Mediators 2007;82(1-4):42-49. R833292 (Final)
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  • Journal Article Jaubert PJ, Golub MS, Lo YY, Germann SL, Dehoff MH, Worley PF, Kang SH, Schwarz MK, Seeburg PH, Berman RF. Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes, Brain and Behavior 2007;6(2):141-154. R833292 (2007)
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    R829388C005 (2005)
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  • Journal Article Jusko TA, Koepsell TD, Baker RJ, Greenfield TA, Willman EJ, Charles MJ, Teplin SW, Checkoway H, Hertz-Picciotto I. Maternal DDT exposures in relation to fetal and 5-year growth. Epidemiology 2006;17(6):692-700. R833292 (2007)
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  • Journal Article Jusko TA, De Roos AJ, Schwartz SM, Lawrence BP, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Sonneborn D, Jahnova E, Kavanagh TJ, Trnovec T, Hertz-Picciotto I. A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age. Environmental Research 2010;110(4):388-395. R833292 (2010)
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  • Journal Article Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MHME, Lein PJ, Veng-Pedersen P, Lehmler H-J. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environmental Science & Technology 2012;46(20):11393-11401. R833292 (2012)
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  • Journal Article Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex.
 Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7646-7651. R833292 (2007)
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  • Journal Article Kim H-J, Ahn KC, Ma SJ, Gee SJ, Hammock BD.
 Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. Journal of Agricultural and Food Chemistry 2007;55(10):3750-3757. R833292 (Final)
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  • Journal Article Kim H-J, McCoy M, Gee SJ, Gonzalez-Sapienza GG, Hammock BD. Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules. Analytical Chemistry 2011;83(1):246-253. R833292 (2012)
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  • Journal Article Kim H-J, McCoy MR, Majkova Z, Dechant JE, Gee SJ, Tabares-da Rosa S, Gonzalez-Sapienza GG, Hammock BD. Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay. Analytical Chemistry 2012;84(2):1165-1171. R833292 (2012)
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  • Journal Article Kim H-J, Rossotti MA, Ahn KC, Gonzalez-Sapienza GG, Gee SJ, Musker R, Hammock BD. Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Analytical Biochemistry 2010;401(1):38-46. R833292 (Final)
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  • Journal Article Kim KH, Inan SY, Berman RF, Pessah IN. Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicology and Applied Pharmacology 2009;237(2):168-177. R833292 (Final)
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  • Journal Article Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environmental Health Perspectives 2011;119(4):519-526. R833292 (2012)
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  • Journal Article Kim KH, Pessah IN. Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. NeuroToxicology 2011;32(6):981-985. R833292 (2011)
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  • Journal Article Koenig CM, Walker CK, Qi L, Pessah IN, Berman RF. Lack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice. PLoS ONE 2012;7(6):e38911 (7 pp.). R833292 (2012)
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  • Journal Article Koenig CM, Lango J, Pessah IN, Berman RF. Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicology and Teratology 2012;34(6):571-580. R833292 (2012)
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  • Journal Article Krakowiak P, Goodlin-Jones B, Hertz-Picciotto I, Croen LA, Hansen RL.
Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. 
Journal of Sleep Research 2008;17(2):197-206. R833292 (2007)
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  • Journal Article Krakowiak P, Walker CK, Bremer AA, Baker AS, Ozonoff S, Hansen RL, Hertz-Picciotto I. Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders. Pediatrics 2012;129(5):e1121-e1128. R833292 (2012)
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  • Journal Article Lange MC, Lemay DG, German JB. A multi-ontology framework to guide agriculture and food towards diet and health. Journal of the Science of Food and Agriculture 2007;87(8):1427-1434. R833292 (Final)
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  • Journal Article Lee H, Lerno Jr. LA, Choe Y, Chu CS, Gillies LA, Grimm R, Lebrilla CB, German JB. Multiple precursor ion scanning of gangliosides and sulfatides with a reversed-phase microfluidic chip and quadrupole time-of-flight mass spectrometry. Analytical Chemistry 2012;84(14):5905-5912. R833292 (2012)
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  • Journal Article Lein PJ, Barnhart CD, Pessah IN. Acute hippocampal slice preparation and hippocampal slice cultures. Methods in Molecular Biology 2011;758:115-134. R833292 (Final)
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  • Journal Article Lemay DG, Neville MC, Rudolph MC, Pollard KS, German JB.
 Gene regulatory networks in lactation: identification of global principles using bioinformatics. BMC Systems Biology 2007;1:56 (24 pp.). R833292 (Final)
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  • Journal Article Lemay DG, Zivkovic AM, German JB.
 Building the bridges to bioinformatics in nutrition research. American Journal of Clinical Nutrition 2007;86(5):1261-1269. R833292 (Final)
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  • Journal Article Lemay DG, Lynn DJ, Martin WF, Neville MC, Casey TM, Rincon G, Kriventseva EV, Barris WC, Hinrichs AS, Molenaar AJ, Pollard KS, Maqbool NJ, Singh K, Murney R, Zdobnov EM, Tellam RL, Medrano JF, German JB, Rijnkels M. The bovine lactation genome: insights into the evolution of mammalian milk. Genome Biology 2009;10(4):R43 (18 pp.). R833292 (Final)
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  • Journal Article Li L. Survival prediction of diffuse large-B-cell lymphoma based on both clinical and gene expression information. Bioinformatics 2006;22(4):466-471. R833292 (Final)
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  • Journal Article Li N, Liu J-Y, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: insight gained using metabolomic approaches. Journal of Molecular and Cellular Cardiology 2009;47(6):835-845. R833292 (Final)
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  • Journal Article Li N, Liu J-Y, Qiu H, Harris TR, Sirish P, Hammock BD, Chiamvimonvat N. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congestive Heart Failure 2011;17(1):42-46. R833292 (Final)
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  • Journal Article Liu J, Koscielska KA, Cao Z, Hulsizer S, Grace N, Mitchell G, Nacey C, Githinji J, McGee J, Garcia-Arocena D, Hagerman RJ, Nolta J, Pessah IN, Hagerman PJ. Signaling defects in iPSC-derived fragile X premutation neurons. Human Molecular Genetics 2012;21(17):3795-3805. R833292 (2012)
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  • Journal Article Magby JP, Neal AP, Atchison WD, Pessah IP, Shafer TJ. Channelopathies: summary of the hot topic keynotes session. NeuroToxicology 2011;32(5):661-665. R833292 (2011)
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  • Journal Article Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain, Behavior, and Immunity 2008;22(6):806-816. R833292 (2008)
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  • Journal Article Masuno MN, Pessah IN, Olmstead MM, Molinski TF. Simplified cyclic analogues of bastadin-5. Structure-activity relationships for modulation of the RyR1/FKBP12 Ca2+ channel complex. Journal of Medicinal Chemistry 2006;49(15):4497-4511. R833292 (2007)
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  • Journal Article McCanlies EC, Fekedulegn D, Mnatsakanova A, Burchfiel CM, Sanderson WT, Charles LE, Hertz-Picciotto I. Parental occupational exposures and autism spectrum disorder. Journal of Autism and Developmental Disorders 2012;42(11):2323-2334. R833292 (2012)
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  • Journal Article Merin N, Young GS, Ozonoff S, Rogers SJ. Visual fixation patterns during reciprocal social interaction distinguish a subgroup of 6-month-old infants at-risk for autism from comparison infants. Journal of Autism and Developmental Disorders 2007;37(1):108-121. R833292 (2007)
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  • Journal Article Mitchell MM, Woods R, Chi L-H, Schmidt RJ, Pessah IN, Kostyniak PJ, LaSalle JM. Levels of select PCB and PBDE congeners in human postmortem brain reveal possible environmental involvement in 15q11-q13 duplication autism spectrum disorder. Environmental and Molecular Mutagenesis 2012;53(8):589-598. R833292 (2012)
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    R835432 (2013)
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  • Journal Article Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environmental Health Perspectives 2009;117(12):1867-1872. R833292 (2009)
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  • Journal Article Nadig AS, Ozonoff S, Young GS, Rozga A, Sigman M, Rogers SJ. A prospective study of response to name in infants at risk for autism. Archives of Pediatrics & Adolescent Medicine 2007;161(4):378-383. R833292 (2007)
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  • Journal Article Nagarajan RP, Patzel KA, Martin M, Yasui DH, Swanberg SE, Hertz-Picciotto I, Hansen RL, Van de Water J, Pessah IN, Jiang R, Robinson WP, LaSalle JM. MECP2 promoter methylation and X chromosome inactivation in autism. Autism Research 2008;1(3):169-178. R833292 (2008)
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  • Journal Article Newman JW, Kaysen GA, Hammock BD, Shearer GC. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. Journal of Lipid Research 2007;48(8):1792-1800. R833292 (Final)
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  • Journal Article Nguyen DV, Senturk D. Distortion diagnostics for covariate-adjusted regression: graphical techniques based on local linear modeling.
 Journal of Data Science 2007;5(4):471-490. R833292 (Final)
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  • Journal Article Nguyen DV, Senturk D, Carroll RJ. Covariate-adjusted linear mixed effects model with an application to longitudinal data. Journal of Nonparametric Statistics 20(6):459-481. R833292 (Final)
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  • Journal Article Ninonuevo MR, Park Y, Yin H, Zhang J, Ward RE, Clowers BH, German JB, Freeman SL, Killeen K, Grimm R, Lebrilla CB. A strategy for annotating the human milk glycome.
 Journal of Agricultural and Food Chemistry 2006;54(20):7471-7480. R833292 (Final)
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  • Journal Article Ninonuevo MR, Ward RE, LoCascio RG, German JB, Freeman SL, Barboza M, Mills DA, Lebrilla CB. 
Methods for the quantitation of human milk oligosaccharides in bacterial fermentation by mass spectometry.
 Analytical Biochemistry 2007;361(1):15-23. R833292 (Final)
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  • Journal Article Oberbauer AM, German JB, Murray JD. Growth hormone enhances arachidonic acid metabolites in a growth hormone transgenic mouse. Lipids 2011;46(6):495-504. R833292 (2012)
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  • Journal Article Onore CE, Nordahl CW, Young GS, Van de Water JA, Rogers SJ, P Ashwood P. Levels of soluble adhesion molecules PECAM-1 and P-selectin are decreased in children with autism spectrum disorder. Biological Psychiatry 2012;72(12):1020-1025. R833292 (2012)
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  • Journal Article Onore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Van de Water J, Ashwood P. Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. Journal of Neuroimmunology 2009;216(1-2):126-129. R833292 (2009)
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  • Journal Article Onore C, Careaga M, Ashwood P. The role of immune dysfunction in the pathophysiology of autism. Brain, Behavior, and Immunity 2012;26(3):383-392. R833292 (2011)
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  • Journal Article Ostrovskaya O, Goyal R, Osman N, McAllister CE, Pessah IN, Hume JR, Wilson SM. 
Inhibition of ryanodine receptors by 4-(2-aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in canine pulmonary arterial smooth muscle cells.
 Journal of Pharmacology and Experimental Therapeutics 2007;323(1):381-390. R833292 (2007)
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  • Journal Article Ozonoff S, Young GS, Goldring S, Greiss-Hess L, Herrera AM, Steele J, Macari S, Hepburn S, Rogers SJ. Gross motor development, movement abnormalities, and early identification of autism. Journal of Autism and Developmental Disorders 2008;38(4):644-656. R833292 (2007)
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  • Journal Article Ozonoff S, Heung K, Byrd R, Hansen R, Hertz-Picciotto I. The onset of autism: patterns of symptom emergence in the first years of life. Autism Research 2008;1(6):320-328. R833292 (2009)
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  • Journal Article Ozonoff S, Iosif A-M, Young GS, Hepburn S, Thompson M, Colombi C, Cook IC, Werner E, Goldring S, Baguio F, Rogers SJ. Onset patterns in autism: correspondence between home video and parent report. Journal of the American Academy of Child & Adolescent Psychiatry 2011;50(8):796-806.e1. R833292 (2012)
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  • Journal Article Ozonoff S. The first cut is the deepest: why do the reported effects of treatments decline over trials? Journal of Child Psychology and Psychiatry 2011;52(7):729-730 (editorial). R833292 (2012)
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  • Journal Article Palkovicova L, Ursinyova M, Masanova V, Yu Z, Hertz-Picciotto I. Maternal amalgam dental fillings as the source of mercury exposure in developing fetus and newborn. Journal of Exposure Science & Environmental Epidemiology 2008;18(3):326-331. R833292 (2007)
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  • Journal Article Park H-Y, Hertz-Picciotto I, Petrik J, Palkovicova L, Kocan A, Trnovec T.
 Prenatal PCB exposure and thymus size at birth in neonates in Eastern Slovakia.
 Environmental Health Perspectives 2008;116(1):104-109. R833292 (Final)
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  • Journal Article Park H-Y, Hertz-Picciotto I, Sovcikova E, Kocan A, Drobna B, Trnovec T. Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study. Environmental Health 2010;9:51. R833292 (2010)
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  • Journal Article Park H-Y, Park J-S, Sovcikova E, Kocan A, Linderholm L, Bergman A, Trnovec T, Hertz-Picciotto I. Exposure to hydroxylated polychlorinated biphenyls (OH-PCBs) in the prenatal period and subsequent neurodevelopment in Eastern Slovakia. Environmental Health Perspectives 2009;117(10):1600-1606. R833292 (Final)
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  • Journal Article Park J-S, Bergman A, Linderholm L, Athanasiadou M, Kocan A, Petrik J, Drobna B, Trnovec T, Charles MJ, Hertz-Picciotto I. Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia. Chemosphere 2008;70(9):1676-1684. R833292 (Final)
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  • Journal Article Paul R, Pessah IN, Gane L, Ono M, Hagerman PJ, Brunberg JA, Tassone F, Bourgeois JA, Adams PE, Nguyen DV, Hagerman R. Early onset of neurological symptoms in fragile X premutation carriers exposed to neurotoxins. Neurotoxicology 2010;31(4):399-402. R833292 (2009)
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  • Journal Article Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do Z, Kim KH, Wong PW. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chemical Research in Toxicology 2006;19(1):92-101. R833292 (2007)
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  • Journal Article Pessah IN, Seegal RF, Lein PJ, LaSalle J, Yee BK, Van de Water J, Berman RF. Immunologic and neurodevelopmental susceptibilities of autism. NeuroToxicology 2008;29(3):532-545. R833292 (2008)
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  • Journal Article Pessah IN, Lehmler HJ, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chemical Research in Toxicology 2009;22(1):201-207. R833292 (Final)
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  • Journal Article Pessah IN, Cherednichenko G, Lein PJ. Minding the calcium store: ryanodine receptor activation as a convergent mechanism of PCB toxicity. Pharmacology & Therapeutics 2010;125(2):260-285. R833292 (2009)
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  • Journal Article Phimister AJ, Lango J, Lee EH, Ernst-Russell MA, Takeshima H, Ma J, Allen PD, Pessah IN.
 Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.
 Journal of Biological Chemistry 2007;282(12):8667-8677. R833292 (2007)
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  • Journal Article Qi L, Wang Y-F, He Y. A comparison of multiple imputation and fully augmented weighted estimators for Cox regression with missing covariates. Statistics in Medicine 2010;29(25):2592-2604. R833292 (Final)
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  • Journal Article Qiu H, Li N, Liu J-Y, Harris TR, Hammock BD, Chiamvimonvat N. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovascular Therapeutics 2011;29(2):99-111. R833292 (Final)
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  • Journal Article Rose M, Bennett DH, Bergman A, Fangstrom B, Pessah IN, Hertz-Picciotto I. PBDEs in 2-5 year-old children from California and associations with diet and indoor environment. Environmental Science & Technology 2010;44(7):2648-2653. R833292 (2009)
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  • Journal Article Rossi CC, Van de Water J, Rogers SJ, Amaral DG. Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain, Behavior, and Immunity 2011;25(6):1123-1135. R833292 (2011)
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  • Journal Article Samso M, Feng W, Pessah IN, Allen PD. Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biology 2009;7(4):e1000085 (0980-0995). R833292 (2009)
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  • Journal Article Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13646-13651. R833292 (Final)
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  • Journal Article Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways.
 Environmental Health Perspectives 2006;114(9):1354-1360. R833292 (Final)
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  • Journal Article Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tancredi DJ, Tassone F, Hertz-Picciotto I. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology 2011;22(4):476-485. R833292 (2011)
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  • Journal Article Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, Hertz-Picciotto I. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. American Journal of Clinical Nutrition 2012;96(1):80-89. R833292 (2009)
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  • Journal Article Senturk D, Nguyen DV. Partial covariate adjusted regression. Journal of Statistical Planning and Inference 2009;139(2):454-468. R833292 (Final)
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  • Journal Article Shearer GC, Newman JW, Hammock BD, Kaysen GA. Graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology 2005;16(5):1309-1319. R833292 (Final)
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  • Journal Article Shelton JF, Tancredi DJ, Hertz-Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Research 2010;3(1):30-39. R833292 (2009)
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  • Journal Article Shelton JF, Hertz-Picciotto I, Pessah IN. Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environmental Health Perspectives 2012;120(7):944-951. R833292 (2012)
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  • Journal Article Smilowitz JT, Dillard CJ, German JB. Milk beyond essential nutrients: the metabolic food.
 Australian Journal of Dairy Technology 2005;60(2):77-83. R833292 (Final)
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  • Journal Article Sonneborn D, Park H-Y, Petrik J, Kocan A, Palkovicova L, Trnovec T, Nguyen D, Hertz-Picciotto I. Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight. Paediatric and Perinatal Epidemiology 2008;22(3):202-213. R833292 (Final)
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  • Journal Article Sonneborn D, Park H-Y, Babinska K, Palkovicova L, Trnovec T, Kocan A, Nguyen DV, Hertz-Picciotto I. Serum PCB concentrations in relation to locally produced food items in eastern Slovakia. Journal of Exposure Science & Environmental Epidemiology 2008;18(6):581-587. R833292 (2009)
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  • Journal Article Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczy P, Zhan X, Liu D-Z, Ander BP, Liao IH, Gregg JP, Turner RJ, Jickling GC, Lit L, Sharp FR. Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood. BMC Medical Genomics 2009;2:49. R833292 (Final)
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  • Journal Article Stamova BS, Tian Y, Nordahl CW, Shen MD, Rogers S, Amaral DG, Sharp FR. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Molecular Autism 2013;4:30 (16 pp.). R833292 (2012)
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  • Journal Article Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Teng J, Gregg JP, Ashwood P, Van de Water J, Sharp FR. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotoxicity Research 2011;19(1):31-48. R833292 (2009)
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  • Journal Article Ta TA, Feng W, Molinski TF, Pessah IN. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. Molecular Pharmacology 2006;69(2):532-538. R833292 (Final)
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  • Journal Article Ta TA, Pessah IN. Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,2',3,5',6-pentachlorobiphenyl (PCB 95). NeuroToxicology 2007;28(4):770-779. R833292 (2007)
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  • Journal Article Ta TA, Koenig CM, Golub MS, Pessah IN, Qi L, Aronov PA, Berman RF. Bioaccumulation and behavioral effects of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicology and Teratology 2011;33(3):393-404. R833292 (2011)
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  • Journal Article Tabares-da Rosa S, Rossotti M, Carleiza C, Carrion F, Pritsch O, Ahn KC, Last JA, Hammock BD, Gonzalez-Sapienza G. Competitive selection from single domain antibody libraries allows isolation of high-affinity antihapten antibodies that are not favored in the llama immune response. Analytical Chemistry 2011;83(18):7213-7220. R833292 (2012)
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  • Journal Article Tassone F, Qi L, Zhang W, Hansen RL, Pessah IN, Hertz-Picciotto I. MAOA, DΒH and SLC6A4 variants in CHARGE: a case-control study of autism spectrum disorders. Autism Research 2011;4(4):250-261. R833292 (2011)
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  • Journal Article Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R, Yang X, Gregg JP, Ashwood P, Jickling G, Van de Water J, Sharp FR. Correlations of gene expression with blood lead levels in children with autism compared to typically developing controls. Neurotoxicity Research 2011;19(1):1-13. R833292 (2009)
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  • Journal Article Trnovec T, Dedík L, Jusko TA, Lancz K, Palkovicova L, Kocan A, Sovcikova E, Wimmerova S, Tihanyi J, Patayova H, Hertz-Picciotto I. Assessment of exposure to PCB 153 from breast feeding and normal food intake in individual children using a system approach model. Chemosphere 2011;85(11):1687-1693. R833292 (2012)
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  • Journal Article Ulu A, Davis BB, Tsai H-J, Kim I-H, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein E-knockout mouse model. Journal of Cardiovascular Pharmacology 2008;52(4):314-323. R833292 (Final)
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  • Journal Article Van Meter KC, Christiansen LE, Hertz-Picciotto I, Azari R, Carpenter TE. A procedure to characterize geographic distributions of rare disorders in cohorts. International Journal of Health Geographics 2008;7:26. R833292 (Final)
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  • Journal Article Van Meter KC, Christiansen LE, Delwiche, LD, Azari R, Carpenter TE, Hertz-Picciotto I. Geographic distribution of autism in California: a retrospective birth cohort analysis. Autism Research 2010;3(1):19-29. R833292 (2009)
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  • Journal Article Verner MA, Sonneborn D, Lancz K, Muckle G, Ayotte P, Dewailly E, Kocan A, Palkovicova L, Trnovec T, Haddad S, Hertz-Picciotto I, Eggesbo M. Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies. Environmental Health Perspectives 2013;121(1):131-137. R833292 (2012)
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  • Journal Article Vogel CFA, Goth SR, Dong B, Pessah IN, Matsumura F. Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochemical and Biophysical Research Communications 2008;375(3):331-335. R833292 (Final)
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  • Journal Article Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell R. Residential proximity to freeways and autism in the CHARGE Study. Environmental Health Perspectives 2011;119(6):873-877. R833292 (2011)
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  • Journal Article Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Applied and Environmental Microbiology 2006;72(6):4497-4499. R833292 (Final)
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  • Journal Article Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria. Molecular Nutrition & Food Research 2007;51(11):1398-1405. R833292 (Final)
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  • Journal Article Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ. PCB 95 modulates calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environmental Health Perspectives 2012;120(7):1003-1009. R833292 (2012)
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  • Journal Article Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environmental Health Perspectives 2012;120(7):997-1002. R833292 (2012)
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  • Journal Article Wiest MM, German JB, Harvey DJ, Watkins SM, Hertz-Picciotto I. Plasma fatty acid profiles in autism: a case-control study. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2009;80(4):221-227. R833292 (2009)
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  • Journal Article Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD).
 Annals of the New York Academy of Sciences 2007;1107:79-91. R833292 (2007)
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  • Journal Article Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral DG, Van de Water J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain, Behavior, and Immunity 2009;23(1):64-74. R833292 (2008)
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  • Journal Article Wills S, Rossi CC, Bennett J, Martinez-Cerdeno V, Ashwood P, Amaral DG, Van de Water J. Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Molecular Autism 2011;2(5). R833292 (2011)
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  • Journal Article Woods R, Vallero RO, Golub MS, Suarez JK, Ta TA, Yasui DH, Chi LH, Kostyniak PJ, Pessah IN, Berman RF, LaSalle JM. Long-lived epigenetic interactions between perinatal PBDE exposure and Mecp2308 mutation. Human Molecular Genetics 2012;21(11):2399-2411. R833292 (2012)
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  • Journal Article Wu XM, Bennett DH, Lee K, Cassady DL, Ritz B, Hertz-Picciotto I. Feasibility of using web surveys to collect time-activity data. Journal of Exposure Science & Environmental Epidemiology 2012;22(2):116-125. R833292 (2012)
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  • Journal Article Wu X, Bennett DH, Lee K, Cassady DL, Ritz B, Hertz-Picciotto I. Longitudinal variability of time-location/activity patterns of population at different ages: a longitudinal study in California. Environmental Health 2011;10:80. R833292 (2012)
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  • Journal Article Yakes EA, Arsenault JE, Islam MM, Hossain MB, Ahmed T, German JB, Gillies LA, Rahman AS, Drake C, Jamil KM, Lewis BL, Brown KH. Intakes and breast-milk concentrations of essential fatty acids are low among Bangladeshi women with 24-48-month-old children. British Journal of Nutrition 2011;105(11):1660-1670. R833292 (2012)
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  • Journal Article Yakes EA, Arsenault JE, Islam MM, Ahmed T, German JB, Drake C, Hossain MB, Lewis BL, Rahman AS, Jamil KM, Brown KH. Dietary intake of polyunsaturated fatty acids among breast-feeding and non-breast-feeding 24- to 48-month-old children in Bangladesh. Journal of Pediatric Gastroenterology and Nutrition 2011;52(3):351-359. R833292 (2012)
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  • Journal Article Yang D, Kim KH, Phimister AV, Bachstetter AD, Ward TR, Stackman RW, Mervis RF, Wisniewski AB, Klein SL, Kodavanti PRS, Anderson KA, Wayman G, Pessah IN, Lein PJ. Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environmental Health Perspectives 2009;117(3):426-435. R833292 (Final)
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  • Journal Article Yang J, Dong H, Hammock BD. Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Current Opinion in Lipidology 2011;22(3):197-203. R833292 (2012)
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  • Journal Article Yang T, Riehl J, Esteve E, Matthaei KI, Goth S, Allen PD, Pessah IN, Lopez JR. Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse. Anesthesiology 2006;105(6):1164-1175. R833292 (2007)
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  • Journal Article Yang T, Allen PD, Pessah IN, Lopez JR. Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations. 
Journal of Biological Chemistry 2007;282(52):37471-37478. R833292 (2007)
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  • Journal Article Zerbo O, Iosif AM, Delwiche L, Walker C, Hertz-Picciotto I. Month of conception and risk of autism. Epidemiology 2011;22(4):469-475. R833292 (2011)
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  • Journal Article Zhang X, Lv CC, Tian J, Miao RJ, Xi W, Hertz-Picciotto I, Qi L. Prenatal and perinatal risk factors for autism in China. Journal of Autism and Developmental Disorders 2010;40(11):1311-1321. R833292 (2009)
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  • Journal Article Zivkovic AM, German JB, Esfandiari F, Halsted CH. Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. Alcoholism: Clinical & Experimental Research 2009;33(4):751-758. R833292 (Final)
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  • Journal Article Zivkovic AM, Wiest MM, Nguyen U, Nording ML, Watkins SM, German JB. Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach. Metabolomics 2009;5(2):209-218. R833292 (Final)
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  • Journal Article Zivkovic AM, German JB. Metabolomics for assessment of nutritional status. Current Opinion in Clinical Nutrition and Metabolic Care 2009;12(5):501-507. R833292 (Final)
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  • Journal Article Zivkovic AM, Telis N, German JB, Hammock BD. Dietary omega-3 fatty acids in the modulation of inflammation and metabolic health. California Agriculture 2011;65(3):106-111. R833292 (Final)
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  • Journal Article Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proceedings of the National Academy of Sciences of the United States of America 2011;108(Suppl 1):4653-4658. R833292 (2012)
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  • Journal Article Zivkovic AM, Barile D. Bovine milk as a source of functional oligosaccharides for improving human health. Advances in Nutrition 2011;2(3):284-289. R833292 (2012)
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  • Journal Article Eltit JM, Li H, Ward CW, Molinski T, Pessah IN, Allen PD, Lopez JR. Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proceedings of the National Academy of Sciences of the United States of America2011;108(17):7046-7051. R833292 (2012)
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  • Journal Article Nordahl CW, Lange N, Li DD, Barnett LA, Lee A, Buonocore MH, Simon TJ, Rogers S, Ozonoff S, Amaral DG. Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders. Proceedings of the National Academy of Sciences of the United States of America 2011;108(50):20195-20200. R833292 (2012)
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  • Journal Article Shumway S, Thurm A, Swedo SE, Deprey L, Barnett LA, Amaral DG, Rogers SJ, Ozonoff S. Brief report: symptom onset patterns and functional outcomes in young children with autism spectrum disorders. Journal of Autism and Developmental Disorders 2011;41(12):1727-1732. R833292 (2012)
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  • Journal Article Cunningham CL, Martinez Cerdeno V, Navarro Porras E, Prakash AN, Angelastro JM, Willemsen R, Hagerman PJ, Pessah IN, Berman RF, Noctor SC. Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Human Molecular Genetics 2011;20(1):64-79. R833292 (2012)
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  • Journal Article Jusko TA, De Roos AJ, Schwartz SM, Lawrence BP, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Jahnova E, Kavanagh TJ, Trnovec T, Hertz-Picciotto I. Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants. Journal of Immunotoxicology 2011;8(1):95-100. R833292 (2012)
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  • Journal Article Wu XM, Bennett DH, Ritz B, Frost J, Cassady D, Lee K, Hertz-Picciotto I. 
Residential insecticide usage in northern California homes with young children.
 Journal of Exposure Science & Environmental Epidemiology 2011;21(4):427-436. R833292 (2012)
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  • Journal Article Ghosh R, Amirian E, Dostal M, Sram RJ, Hertz-Picciotto I. Indoor coal use and early childhood growth. Archives of Pediatrics & Adolescent Medicine 2011;165(6):492-497. R833292 (2012)
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  • Journal Article Hunsaker MR, Greco CM, Tassone F, Berman RF, Willemsen R, Hagerman RJ, Hagerman PJ. Rare intranuclear inclusions in the brains of 3 older adult males with fragile X syndrome: implications for the spectrum of fragile X-associated disorders. Journal of Neuropathology & Experimental Neurology 2011;70(6):462-469. R833292 (2012)
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  • Journal Article Rozga A, Hutman T, Young GS, Rogers SJ, Ozonoff S, Dapretto M, Sigman M. Behavioral profiles of affected and unaffected siblings of children with autism: contribution of measures of mother-infant interaction and nonverbal communication. Journal of Autism and Developmental Disorders 2011;41(3):287-301. R833292 (2012)
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  • Journal Article Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren RL. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. Journal of Autism Developmental Disorders 2011;41(5):545-554. R833292 (2012)
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  • Journal Article Bookman EB, McAllister K, Gillanders E, Wanke K, Balshaw D, Rutter J, Reedy J, Shaughnessy D, Agurs-Collins T, Paltoo D, Atienza A, Bierut L, Kraft P, Fallin MD, Perera F, Turkheimer E, Boardman J, Marazita ML, Rappaport SM, Boerwinkle E, Suomi SJ, Caporaso NE, Hertz-Picciotto I, Jacobson KC, Lowe WL, Goldman LR, Duggal P, Gunnar MR, Manolio TA, Green ED, Olster DH, Birnbaum LS for the NIH G × E Interplay Workshop participants. Gene-environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop. Genetic Epidemiology 2011;35(4):217-225. R833292 (2012)
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  • Journal Article Vivanti G, McCormick C, Young GS, Abucayan F, Hatt N, Nadig A, Ozonoff S, Rogers SJ. Intact and impaired mechanisms of action understanding in autism. Developmental Psychology 2011;47(3):841-856. R833292 (2012)
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  • Journal Article Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, Miller J, Fedele A, Collins J, Smith K, Lotspeich L, Croen LA, Ozonoff S, Lajonchere C, Grether JK, Risch N. Genetic heritability and shared environmental factors among twin pairs with autism. JAMA Psychiatry (formerly Archives of General Psychiatry). 2011;68(11):1095-1102. R833292 (2012)
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  • Journal Article Young GS, Rogers SJ, Hutman T, Rozga A, Sigman M, Ozonoff S. Imitation from 12 to 24 months in autism and typical development: a longitudinal Rasch analysis. Developmental Psychology 2011;47(6):1565-1578. R833292 (2012)
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  • Journal Article Critchfield JW, van Hemert S, Ash M, Mulder L, Ashwood P. The potential role of probiotics in the management of childhood autism spectrum disorders. Gastroenterology Research and Practice 2011;2011:161358 (8 pp.). R833292 (2012)
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  • Journal Article Wu X, Apte MG, Maddalena R, Bennett DH. Volatile organic compounds in small- and medium-sized commercial buildings in California. Environmental Science & Technology 2011;45(20):9075-9083. R833292 (2012)
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  • Journal Article Hunsaker MR, Greco CM, Spath MA, Smits AP, Navarro CS, Tassone F, Kros JM, Severijnen LA, Berry-Kravis EM, Berman RF, Hagerman PJ, Willemsen R, Hagerman RJ, Hukema RK. Widespread non-central nervous system organ pathology in fragile X premutation carriers with fragile X-associated tremor/ataxia syndrome and CGG knock-in mice. Acta Neuropathologica 2011;122(4):467-479. R833292 (2012)
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  • Journal Article Hunsaker MR, von Leden RE, Ta BT, Goodrich-Hunsaker NJ, Arque G, Kim K, Willemsen R, Berman RF. Motor deficits on a ladder rung task in male and female adolescent and adult CGG knock-in mice. Behavioural Brain Research 2011;222(1):117-121. R833292 (2012)
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  • Journal Article Ozonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, Bryson S, Carver LJ, Constantino JN, Dobkins K, Hutman T, Iverson JM, Landa R, Rogers SJ, Sigman M, Stone WL. Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study. Pediatrics 2011;128(3):e488-e495. R833292 (2012)
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  • Journal Article Newschaffer CJ, Croen LA, Fallin MD, Hertz-Picciotto I, Nguyen DV, Lee NL, Berry CA, Farzadegan H, Hess HN, Landa RJ, Levy SE, Massolo ML, Meyerer SC, Mohammed SM, Oliver MC, Ozonoff S, Pandey J, Schroeder A, Shedd-Wise KM. Infant siblings and the investigation of autism risk factors. Journal of Neurodevelopmental Disorders 2012;4(1):7 (16 pp.). R833292 (2012)
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  • Journal Article Dutta SK, Mitra PS, Ghosh S, Zang S, Sonneborn D, Hertz-Picciotto I, Trnovec T, Palkovicova L, Sovcikova E, Ghimbovschi S, Hoffman EP. Differential gene expression and a functional analysis of PCB-exposed children: understanding disease and disorder development. Environment International 2012;40:143-154. R833292 (2012)
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  • Journal Article Jusko TA, Sonneborn D, Palkovicova L, Kocan A, Drobna B, Trnovec T, Hertz-Picciotto I. Pre- and postnatal polychlorinated biphenyl concentrations and longitudinal measures of thymus volume in infants. Environmental Health Prespectives 2012;120(4):595-600. R833292 (2012)
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  • Journal Article Hinde K, German JB. Food in an evolutionary context: insights from mother's milk. Journal of the Science of Food and Agriculture 2012;92(11):2219-2223. R833292 (2012)
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  • Journal Article van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology 2012;33(4):911-924. R833292 (2012)
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  • Journal Article Ghosh R, Joad J, Benes I, Dostal M, Sram RJ, Hertz-Picciotto I. Ambient nitrogen oxides exposure and early childhood respiratory illnesses. Environment International 2012;39(1):96-102. R833292 (2012)
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  • Journal Article Mitra PS, Ghosh S, Zang S, Sonneborn D, Hertz-Picciotto I, Trnovec T, Palkovicova L, Sovcikova E, Ghimbovschi S, Hoffman EP, Dutta SK. Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: correlations between gene expression and disease risk. Environment International 2012;39(1):188-199. R833292 (2012)
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  • Journal Article Diep AA, Hunsaker MR, Kwock R, Kim K, Willemsen R, Berman RF. Female CGG knock-in mice modeling the fragile X premutation are impaired on a skilled forelimb reaching task. Neurobiology of Learning and Memory 2012;97(2):229-234. R833292 (2012)
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  • Journal Article Barrientos GC, Feng W, Truong K, Matthaei KI, Yang T, Allen PD, Lopez JR, Pessah IN. Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle. The Journal of Biological Chemistry 2012;287(4):2863-2876. R833292 (2012)
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  • Journal Article Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN. Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone. Human Molecular Genetics 2012;21(13):2923-2935. R833292 (2012)
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  • Journal Article Borthwell RM, Hunsaker MR, Willemsen R, Berman RF. Spatiotemporal processing deficits in female CGG KI mice modeling the fragile X premutation. Behavioural Brain Research 2012;233(1):29-34. R833292 (2012)
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  • Journal Article Sundekilde UK, Barile D, Meyrand M, Poulsen NA, Larsen LB, Lebrilla CB, German JB, Bertram HC. Natural variability in bovine milk oligosaccharides from Danish Jersey and Holstein-Friesian breeds. Journal of Agricultural and Food Chemistry 2012;60(24):6188-6196. R833292 (2012)
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  • Journal Article Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL. Brief report: hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial. Journal of Autism Developmental Disorders 2012;42(6):1127-1132. R833292 (2012)
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  • Journal Article Lein PJ. Emerging concepts in neurotoxicology: models, mechanisms and modifying factors. NeuroToxicology 2012;33(3):516-517. R833292 (2012)
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  • Journal Article Yuen B, Boncompagni S, Feng W, Yang T, Lopez JR, Matthaei KI, Goth SR, Protasi F, Franzini-Armstrong C, Allen PD, Pessah IN. Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage. FASEB Journal 2012;26(3):1311-1322. R833292 (2012)
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  • Journal Article Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, López JR, Beam KG, Allen PD. Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):7923-7928. R833292 (2012)
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  • Journal Article Schebb NH, Ahn KC, Dong H, Gee SJ, Hammock BD. Whole blood is the sample matrix of choice for monitoring systemic triclocarban levels. Chemosphere 2012;87(7):825-827. R833292 (2012)
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  • Journal Article Braunschweig D, Golub MS, Koenig CM, Qi L, Pessah IN, Van de Water J, Berman RF. Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. Journal of Neuroimmunology 2012;15;252(1-2):56-65. R833292 (2012)
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  • Journal Article Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN. Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model. Journal of Neurochemistry 2012;123(4):613-621. R833292 (2012)
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  • Journal Article Coury DL, Ashwood P, Fasano A, Fuchs G, Geraghty M, Kaul A, Mawe G, Patterson P, Jones NE. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics 2012;130(Suppl 2):S160-S168. R833292 (2012)
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  • Journal Article Ozonoff S. Editorial perspective: autism spectrum disorders in DSM-5--an historical perspective and the need for change. Journal of Child Psychology and Psychiatry 2012;53(10):1092-1094. R833292 (2012)
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  • Journal Article Winarni TI, Chonchaiya W, Sumekar TA, Ashwood P, Morales GM, Tassone F, Nguyen DV, Faradz SM, Van de Water J, Cook K, Hamlin A, Mu Y, Hagerman PJ, Hagerman RJ. Immune-mediated disorders among women carriers of fragile X premutation alleles. American Journal of Medical Genetics Part A 2012;158A(10):2473-2481. R833292 (2012)
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  • Journal Article Kim IH, Nishi K, Kasagami T, Morisseau C, Liu JY, Tsai HJ, Hammock BD. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters 2012;22(18):5889-5892. R833292 (2012)
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  • Journal Article Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JP. Consensus paper: pathological role of the cerebellum in autism. Cerebellum 2012;11(3):777-807. R833292 (2012)
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  • Journal Article Ozonoff S. DSM-5 and autism spectrum disorders--two decades of perspectives from the JCPP. Journal of Child Psychology and Psychiatry 2012;53(9):e4-e6 (editorial). R833292 (2012)
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  • Journal Article Onore C, Van de Water J, Ashwood P. Decreased levels of EGF in plasma of children with autism spectrum disorder. Autism Research and Treatment 2012;2012:205362 (4 pp.). R833292 (2012)
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  • Journal Article Clifton MS, Wargo JP, Weathers WS, Colon M, Bennett DH, Tulve NS. Quantitative analysis of organophosphate and pyrethroid insecticides, pyrethroid transformation products, polybrominated diphenyl ethers and bisphenol A in residential surface wipe samples. Journal of Chromatography A 2013;1273:1-11. R833292 (2012)
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  • Journal Article Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic related air pollution, particulate matter, and autism. JAMA Psychiatry 2013;70(1):71-77. R833292 (2012)
    R835441 (2017)
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  • Journal Article Zerbo O, Iosif A-M, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto I. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study. Journal of Autism and Developmental Disorders 2013;43(1):25-33. R833292 (2012)
    R833292 (Final)
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  • Journal Article Breece E, Paciotti B, Nordahl CW, Ozonoff S, Van de Water JA, Rogers SJ, Amaral D, Ashwood P. Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain, Behavior, and Immunity 2013;31:69-75. R833292 (2012)
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  • Journal Article Tassone F, Choudhary NS, Tassone F, Durbin-Johnson B, Hansen R, Hertz-Picciotto I, Pessah I. Identification of expanded alleles of the FMR1 gene in the CHildhood Autism Risks from Genes and Environment (CHARGE) study. Journal of Autism and Developmental Disorders 2013;43(3):530-539. R833292 (2012)
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  • Journal Article Goines PE, Ashwood P. Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment. Neurotoxicology and Teratology 2013;36:67-81. R833292 (2012)
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  • Journal Article Schwartzer JJ, Koenig CM, Berman RF. Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions. Neurotoxicology and Teratology 2013;36:17-35. R833292 (2012)
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  • Supplemental Keywords:

    autism, genes, environment, mercury, PCBs, PBDEs, immune, autoimmune, neurodevelopment, developmental neurotoxicity, persistent organic pollutants, CHARGE, MARBLES, Scientific Discipline, Health, Risk Assessments, Health Risk Assessment, Biochemistry, Genetics, developmental neurotoxicology, autism, developmental effects, children's health, ecotoxicogenomics,, Health, Scientific Discipline, Genetics, Health Risk Assessment, Risk Assessments, Biochemistry, children's health, developmental neurotoxicology, ecotoxicogenomics, developmental effects, genetic analysis

    Progress and Final Reports:

    Original Abstract
    2007 Progress Report
    2008 Progress Report
    2010 Progress Report
    2011 Progress Report
    2012 Progress Report
    Final Report

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R833292C001 PROJECT 1: Environmental Epidemiology of Autism
    R833292C002 PROJECT 2: Immunological Susceptibility in Autism
    R833292C003 PROJECT 3: Models of Neurosusceptibility