Hepatocyte Metabolism Model for Xenobiotics

EPA Grant Number: R832721C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832721
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: New Jersey Research Center for Environmental Bioinformatics and Computational Toxicology
Center Director: Welsh, William J.
Title: Hepatocyte Metabolism Model for Xenobiotics
Investigators: Ierapetritou, Marianthi , Androulakis, Ioannis
Current Investigators: Ierapetritou, Marianthi , Androulakis, Ioannis , Floudas, Christodoulos , Georgopoulos, Panos G. , Rabitz, Herschel , Tong, Weida , Welsh, William J.
Institution: Rutgers, The State University of New Jersey
Current Institution: Rutgers, The State University of New Jersey , Princeton University , U.S. Food and Drug Administration , University of Medicine and Dentistry of New Jersey
EPA Project Officer: Pascual, Pasky
Project Period: October 1, 2005 through September 30, 2010
RFA: Computational Toxicology: Environmental Bioinformatics Research Center (2004) RFA Text |  Recipients Lists
Research Category: Computational Toxicology , Health , Safer Chemicals

Objective:

The aims of this project have not changed from the original application; original objectives for the report period have been met. However, specific collaborative case studies have been defined during the report period to facilitate testing and evaluating of the accomplishment of these aims.

Publications and Presentations:

Publications have been submitted on this subproject: View all 8 publications for this subprojectView all 301 publications for this center

Supplemental Keywords:

computational toxicology, toxicogenomics, bioinformatics, toxicoinformatics, proteomics, metabonomics, physiomics, cytomics, genomics, transcriptomics, enviroinformatics, cheminformatics, biologically based dose-response modeling, cross-species extrapolation, risk assessment,, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Geographic Area, State, Risk Assessments, Biochemistry, Environmental Monitoring, Biology, Risk Assessment, ecological risk assessment, risk, computational toxicology, toxicology, environmental risks, biopollution, chemical composition, New Jersey (NJ), human exposure, toxicologic assessment, bioinformatics, biochemical research, human health risk

Progress and Final Reports:

2006 Progress Report
2007 Progress Report


Main Center Abstract and Reports:

R832721    New Jersey Research Center for Environmental Bioinformatics and Computational Toxicology

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832721C001 Development and Application of the DORIAN (Dose-Response Information Analysis) System
R832721C002 Hepatocyte Metabolism Model for Xenobiotics
R832721C003 Development of Computational Tools for Optimal Identification of Biological Networks
R832721C004 Cheminformatics Tools for Toxicant Characterization
R832721C005 Optimization Tools for In Silico Structural Proteomics