Research Grants/Fellowships/SBIR

Dendritic Cell Activation by Particulate Matter and Allergen

EPA Grant Number: R832139C004
Subproject: this is subproject number 004 , established and managed by the Center Director under grant R832139
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Center Director: Breysse, Patrick N.
Title: Dendritic Cell Activation by Particulate Matter and Allergen
Investigators: Georas, Steven
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health

Objective:

The overall goal of the research project is to examine the influence of airborne particulates and bioaerosols on airway immune responses associated with asthma. The specific objectives are to: (1) test the hypothesis that particulate matter (PM) influences dendritic cell (DC) maturation; and (2) test the hypothesis that PM interacts with allergen to induce a Th2-promoting DC phenotype.

Publications and Presentations:

Publications have been submitted on this subproject: View all 7 publications for this subprojectView all 113 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 7 journal articles for this subprojectView all 110 journal articles for this center

Supplemental Keywords:

airborne particulates, asthma, dendritic cells, allergens, particulate matter, PM, children’s health,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, HUMAN HEALTH, particulate matter, Genetics, Health Risk Assessment, Allergens/Asthma, Health Effects, Physical Processes, asthma, asthma triggers, children's health, air toxics, exposure, air pollution, children, airborne pollutants, human exposure, bioaerosols, air pollutant, PM, allergens

Progress and Final Reports:

2004 Progress Report
2005 Progress Report
2006 Progress Report
2007 Progress Report
Final Report


Main Center Abstract and Reports:

R832139    Johns Hopkins Center for Childhood Asthma in the Urban Environment

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen