Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes

EPA Grant Number: R832141C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R832141
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
Investigators: Rauh, Virginia , Davidson, Leslie , Greenhill, Larry , Perera, Frederica P. , Whyatt, Robin M.
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health

Objective:

The objectives of this research project are to: (1) quantify the impact of prenatal and postnatal exposures to air pollutants such as polycyclic aromatic hydrocarbons (PAHs), environmental tobacco smoke (ETS), and pesticides on neurobehavioral development through 7 years of age, after controlling for the effects of known determinants of child neurodevelopment and potential confounders; (2) refine the measurement of exposure to chronic social stressors in this population for the purpose of assessing the impact of chronic stressors on child neurobehavioral development at 5 and 7 years of age and testing interactions between environmental toxicants and stressors, by which some children are rendered more vulnerable than others to the toxic impact of pollutants; (3) investigate the modifying role of micronutrients and genetic polymorphisms on the association of toxic exposures (PAH and ETS) with fetal growth and neurodevelopment through 7 years of age, as determined in Objective 1; (4) collaborate with the Community Outreach, Translation and Application Core (COTAC) to translate research findings on neurodevelopmental risk associated with toxicant exposures and assist in developing interventions and policies to prevent such exposures; and (5) investigate associations between neurodevelopmental deficits and asthma morbidity at 5 and 7 years of age. We posit that children who exhibit asthma symptoms will be more likely to manifest neurodevelopment deficits as compared to children without symptoms (exploratory).

Publications and Presentations:

Publications have been submitted on this subproject: View all 3 publications for this subprojectView all 154 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 3 journal articles for this subprojectView all 139 journal articles for this center

Supplemental Keywords:

children’s health, children’s environmental health, genetics, health effects, health risk assessment, air pollutants, exposure assessment, national exposure, pesticides, PAHs, ETS, tobacco smoke,, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Genetics, Health Risk Assessment, Epidemiology, Biochemistry, Health Effects, Children's Health, Environmental Policy, Risk Assessment, asthma, prenatal exposure, environmental risks, genetic mechanisms, Human Health Risk Assessment, diesel exhaust, assessment of exposure, genetic risk factors, children's environmental health, exposure assessment, genetic susceptibility, maternal exposure

Progress and Final Reports:

2004 Progress Report
2005 Progress Report
2006 Progress Report
2007 Progress Report


Main Center Abstract and Reports:

R832141    Columbia Center for Children’s Environmental Health

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
R832141C003 Mechanistic Research Project
R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
R832141C005 Community Translation and Application Core (COTAC)
R832141C006 Exposure Assessment Facility Core
R832141C007 Data Management, Statistics and Community Impact Modeling Core
R832141C008 Administrative Core