2008 Progress Report: Assessment of Perinatal PBDE Exposure and Related Child Behavioral and Cognitive Developmental Effects

EPA Grant Number: R832736
Title: Assessment of Perinatal PBDE Exposure and Related Child Behavioral and Cognitive Developmental Effects
Investigators: Daniels, J L , Evenson, Kelly , Goldman, B , Herring, Amy H. , Savitz, David A. , Siega-Riz, Anna Maria
Institution: University of North Carolina at Chapel Hill
EPA Project Officer: Callan, Richard
Project Period: March 15, 2006 through March 14, 2009 (Extended to March 14, 2011)
Project Period Covered by this Report: March 15, 2008 through March 14,2009
Project Amount: $749,990
RFA: Early Indicators of Environmentally Induced Disease (2004) RFA Text |  Recipients Lists
Research Category: Health Effects , Health


We will assess correlation in the classification of PBDE exposure between the home exposure assessment, levels in breast milk, and levels in house dust. We also will identify factors in the home and diet that predict maternal PBDE levels in breast milk. We will estimate the change in cognitive and behavioral developmental scores relative to total PBDE level and PBDE composition using random effects models and generalized estimating equations, accounting for the correlation in development over time and adjusting for important confounding factors. This study will efficiently estimate contemporary PBDE levels from the largest human sample to date in North America, correlate household sources of exposure with levels measured in dust and in humans, and provide the first results of an investigation of the effects of PBDEs on early human development. These data will provide information about potential risks to development associated with exposure to PBDEs.

Progress Summary:

Data collection for the study has been administered in the field at four subsequent time points, 3 months, 12 months, 24 months, and 36 months postpartum. Breast milk specimens have been analyzed by the CDC laboratory (n = 389). Analysis of first- and third-year postpartum household dust specimens is planned by the CDC laboratory. Data collection was completed in December 2008, with the completion of 206 environmental questionnaires and 341 developmental assessments at age 36 months. These environmental data have been merged with existing data from the PIN pregnancy and PIN postpartum studies. Analyses and manuscript preparation are underway.

Future Activities:

Data analysis and preparation of presentations and publications during 2009 and 2010.

Supplemental Keywords:

epidemiology, environmental health, exposure assessment, longitudinal, human milk biomarkers, PBDE, persistent organic pollutants;, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Biochemistry, Children's Health, Environmental Policy, Risk Assessment, childhood learning, behavioral effects, developmental neurotoxicity, perinatal exposure, neurodevelopment, flame retardants, PBDE, Human Health Risk Assessment, assessment of exposure, cognitive development, developmental disorders

Progress and Final Reports:

Original Abstract
  • 2006 Progress Report
  • 2007 Progress Report
  • 2009
  • Final