2006 Progress Report: Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)

EPA Grant Number: R831711C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R831711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mount Sinai Center for Children’s Health and the Environment
Center Director: Wolff, Mary S.
Title: Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)
Investigators: Wetmur, James G.
Current Investigators: Wetmur, James G. , Chen, Jia , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2005 through August 23,2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health

Objective:

The objective of this research project is to study seven genetic polymorphisms in the enzymes that activate and detoxify organophosphates and other pesticides in the population of mothers and infants enrolled in project R831711C002.

Progress Summary:

Project 3 has completed genotyping for a variant related to bisphenol A metabolism and analysis of those data is in progress. Genotypes and phenotypes of PON1 have been assessed in 656 samples, including maternal and cord bloods. Genotype/haplotype-phenotype associations of PON1 were found to vary by allele, to be independent of race/ethnicity, and to be stronger for infants than for mothers.

Future Activities:

We shall continue to collaborate with Project 2 to examine PON1 genotype and phenotype effects on developmental outcomes. We will complete the predictor paper on UGT2B7 genotype and maternal phenols in urine. We will also examine associations of the common UGT2B7 gene variant with birth outcomes and neurodevelopment with Project 2. The UGT2B7 promoters of our African-American population will be resequenced. The lipase/amylase data collection will continue.


Journal Articles on this Report : 49 Displayed | Download in RIS Format

Other subproject views: All 93 publications 57 publications in selected types All 52 journal articles
Other center views: All 253 publications 140 publications in selected types All 118 journal articles
Type Citation Sub Project Document Sources
Journal Article Anderson HA, Wolff MS. Special fish contaminants issue. Environmental Research 2005;97(2):125-126 (introductory commentary). R831711 (2004)
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  • Journal Article Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. R831711 (2004)
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  • Journal Article Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, Holzman IR, Wolff MS. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives 2004;112(3):388-391. R831711 (2004)
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  • Journal Article Borrell LN, Factor-Litvak P, Wolff MS, Susser E, Matte TD. Effect of socioeconomic status on exposures to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) among pregnant African-American women. Archives of Environmental Health 2004;59(5):250-255. R831711 (2005)
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  • Journal Article Braganza SF, Galvez MP, Mencin AA, Ozuah PO. Weighting the appropriate uses of supplemental zinc. Contemporary Pediatrics 2006;23(7):66-74. R831711 (2005)
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  • Journal Article Braganza SF, Galvez MP, Ozuah PO. When parents ask about diet therapy for ADHD. Contemporary Pediatrics 2006;23(5):47-49. R831711 (2005)
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  • Journal Article Brenner BL, Markowitz S, Rivera M, Romero H, Weeks M, Sanchez E, Deych E, Garg A, Godbold J, Wolff MS, Landrigan PJ, Berkowitz G. Integrated pest management in an urban community: a successful partnership for prevention. Environmental Health Perspectives 2003;111(13):1649-1653. R831711 (2004)
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  • Journal Article Britton JA, Wolff MS, Lapinski R, Forman J, Hochman S, Kabat GC, Godbold J, Larson S, Berkowitz GS. Characteristics of pubertal development in a multi-ethnic population of nine-year-old girls. Annals of Epidemiology 2004;14(3):179-187. R831711 (2005)
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  • Journal Article Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environmental Health Perspectives 2003;111(11):1403-1409. R831711 (2005)
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  • Journal Article Chen J, Chan W, Wallenstein S, Berkowitz G, Wetmur JG. Haplotype-phenotype relationships of paraoxonase-1. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):731-734. R831711 (2005)
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  • Journal Article Claudio L. Breast cancer takes center stage. Environmental Health Perspectives 2004;112(2):A92-A95 (NIEHS News). R831711 (2004)
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  • Journal Article Claudio L, Stingone JA, Godbold J. Prevalence of childhood asthma in urban communities: the impact of ethnicity and income. Annals of Epidemiology 2006;16(5):332-340. R831711 (2005)
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  • Journal Article Edwards ES, Green N, Henry CJ, Landrigan PJ, Swartz D. Tracking children's health to age 21. Science 2003;302(5646):781 (letter comment on Science 2003;301(5630):162-163). R831711 (2005)
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  • Journal Article Engel SM, Levy B, Liu Z, Kaplan D, Wolff MS. Xenobiotic phenols in early pregnancy amniotic fluid. Reproductive Toxicology 2006;21(1):110-112. R831711 (2005)
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  • Journal Article Engel SM, Olshan AF, Siega-Riz AM, Savitz DA, Chanock SJ. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth. American Journal of Obstetrics and Gynecology 2006;195(5):1231.e1-1231.e11. R831711 (2005)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R831711 (2005)
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  • Journal Article Etzel RA, Crain EF, Gitterman BA, Oberg C, Scheidt P, Landrigan PJ. Pediatric environmental health competencies for specialists. Ambulatory Pediatrics 2003;3(1):60-63. R831711 (2004)
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  • Journal Article Etzel RA, Balk SJ, Reigart JR, Landrigan PJ. Environmental health for practicing pediatricians. Indian Pediatrics 2003;40(9):853-860. R831711 (2005)
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  • Journal Article Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. R831711 (2004)
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  • Journal Article Fewtrell LJ, Pruss-Ustun A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environmental Research 2004;94(2):120-133. R831711 (2005)
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  • Journal Article Galvez MP, Frieden TR, Landrigan PJ. Obesity in the 21st century. Environmental Health Perspectives 2003;111(13):A684-A685 (editorial). R831711 (2005)
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  • Journal Article Galvez MP, Peters R, Graber N, Forman J. Effective risk communication in children's environmental health:lessons learned from 9/11. Pediatric Clinics of North America 2007;54(1):33-46. R831711 (2005)
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  • Journal Article Galvez M, Vanable L, Forman JA, Landrigan PJ, Akeredolu E, Leighton J, Nagin D. Childhood lead poisoning from commercially manufactured French ceramic dinnerware-New York City, 2003. Morbidity and Mortality Weekly Reports 2004;53(26):584-586. R831711 (2005)
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  • Journal Article Goldman L, Falk H, Landrigan PJ, Balk SJ, Reigart JR, Etzel RA. Environmental pediatrics and its impact on government health policy. Pediatrics 2004;113(Suppl 3):1146-1157. R831711 (2005)
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  • Journal Article Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. R831711 (2005)
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  • Journal Article Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L, Matte TD, Susser ES, Factor-Litvak P. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environmental Health Perspectives 2006;114(5):779-785. R831711 (2005)
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  • Journal Article Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children's health and the environment:public health issues and challenges for risk assessment. Environmental Health Perspectives 2004;112(2):257-265. R831711 (2005)
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  • Journal Article Landrigan PJ. Children as a vulnerable population. International Journal of Occupational Medicine and Environmental Health 2004;17(1):175-177. R831711 (2005)
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  • Journal Article Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113(9):1230-1233. R831711 (2005)
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  • Journal Article Landrigan PJ, Newman B. Children and other high-risk workers as a special challenge to occupational health services. SJWEH Supplements 2005;1:43-45. R831711 (2005)
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  • Journal Article Landrigan PJ, Tamburlini G. Children’s health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647 (editorial). R831711C001 (2006)
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  • Journal Article Landrigan PJ. Environmental pediatrics and the ecological imperative. EcoHealth 2006;3(2):75-76 (editorial). R831711 (2005)
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  • Journal Article Landrigan PJ, Trasande L, Thorpe LE, Gwynn C, Lioy PJ, D'Alton ME, Lipkind HS, Swanson J, Wadhwa PD, Clark EB, Rauh VA, Perera FP, Susser E. The National Children's Study:a 21-year prospective study of 100,000 American children. Pediatrics 2006;118(5):2173-2186. R831711 (2005)
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  • Journal Article Landrigan P, Garg A, Droller DBJ. Assessing the effects of endocrine disruptors in the National Children's Study. Environmental Health Perspectives 2003;111(13):1678-1682. R831711 (2005)
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  • Journal Article Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ, Jensen AA. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environmental Health Perspectives 2003;111(1):65-70. R831711 (2004)
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  • Journal Article Needleman HL, Landrigan PJ. What level of lead in blood is toxic for a child? American Journal of Public Health 2004;94(1):8. R831711 (2005)
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  • Journal Article Salama J, Chakraborty TR, Ng L, Gore AC. Effects of polychlorinated biphenyls on estrogen receptor-β expression in the anteroventral periventricular nucleus. Environmental Health Perspectives 2003;111(10):1278-1282. R831711 (2005)
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  • Journal Article Suk WA, Ruchirawat KM, Balakrishnan K, Berger M, Carpenter D, Damstra T, Pronczuk de Garbino J, Koh D, Landrigan PJ, Makalinao I, Sly PD, Xu Y, Zheng BS. Environmental threats to children's health in Southeast Asia and the western Pacific. Environmental Health Perspectives 2003;111(10):1340-1347. R831711 (2005)
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  • Journal Article Trasande L, Landrigan PJ. The National Children's Study: a critical national investment. Environmental Health Perspectives 2004;112(14):A789-A790. R831711 (2005)
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  • Journal Article Trasande L, Boscarino J, Graber N, Falk R, Schechter C, Galvez M, Dunkel G, Geslani J, Moline J, Kaplan-Liss E, Miller RK, Korfmacher K, Carpenter D, Forman J, Balk SJ, Laraque D, Frumkin H, Landrigan P. The environment in pediatric practice: a study of New York pediatricians' attitudes, beliefs, and practices towards children's environmental health. Journal of Urban Health 2006;83(4):760-772. R831711 (2005)
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  • Journal Article Trasande L, Schapiro ML, Falk R, Haynes KA, Behrmann A, Vohmann M, Stremski ES, Eisenberg C, Evenstad C, Anderson HA, Landrigan PJ. Pediatrician attitudes, clinical activities, and knowledge of environmental health in Wisconsin. Wisconsin Medical Journal 2006;105(2):45-49. R831711 (2005)
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  • Journal Article Trasande L, Cronk CE, Leuthner SR, Hewitt JB, Durkin MS, McElroy JA, Anderson HA, Landrigan PJ. The National Children's Study and the children of Wisconsin. Wisconsin Medical Journal 2006;105(2):50-54. R831711 (2005)
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  • Journal Article Wallenstein S, Chen J, Wetmur JG. Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Molecular Genetics and Metabolism 2006;89(3):270-273. R831711 (2005)
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  • Journal Article Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J. Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes. Nucleic Acids Research 2005;33(8):2615-2619. R831711 (2005)
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  • Journal Article Wolff MS, Deych E, Ojo F, Berkowitz GS. Predictors of organochlorines in New York City pregnant women, 1998-2001. Environmental Research 2005;97(2):170-177. R831711 (2004)
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  • Journal Article Wolff MS, Britton JA, Russo JC. TCDD and puberty in girls. Environmental Health Perspectives 2005;113(1):A17. R831711 (2005)
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  • Journal Article Wolff MS. Endocrine disruptors: challenges for environmental research in the 21st Century. Annals of the New York Academy of Sciences 2006;1076:228-238. R831711 (2006)
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  • Journal Article Wolff MS, Engel S, Berkowitz G, Teitelbaum S, Siskind J, Barr DB, Wetmur J. Prenatal pesticide and PCB exposures and birth outcomes. Pediatric Research 2007;61(2):243-250. R831711 (2005)
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  • Journal Article Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, Chelimo C, Godbold J, Biro F, Kushi LH, Pfeiffer CM, Calafat AM. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environmental Health Perspectives 2007;115(1):116-121. R831711 (2005)
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  • Supplemental Keywords:

    lipase, paraoxonase, pesticides, haplotyping technology, polymorphisms, endocrine disruptors, EDs, neurodevelopment, minority populations, ENVIRONMENTAL MANAGEMENT, Health, POLLUTANTS/TOXICS, RFA, scientific Discipline, Biochemistry, Chemicals, Children’s Health, Endocrine Disruptors - Environmental Exposure & Risk, Endocrine Disruptors - Human Health, Environmental Chemistry, Health Risk Assessment, Risk Assessment, endocrine disruptors, Human Health Risk Assessment, childhood development, children’s environmental health, children’s vulnerability, endocrine disrupting chemicals, environmental health, exposure pathways, exposure studies, genetic polymorphisms, neurodevelopmental toxicity, pesticide exposure, pesticides, phthalates,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, POLLUTANTS/TOXICS, Environmental Chemistry, Health Risk Assessment, Chemicals, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Biochemistry, Children's Health, Endocrine Disruptors - Human Health, Risk Assessment, environmental health, pesticide exposure, childhood development, pesticides, phtalates, endocrine disrupting chemicals, exposure studies, Human Health Risk Assessment, children's vulnerablity, neurodevelopmental toxicity, genetic polymorphisms, children's environmental health, exposure pathways

    Relevant Websites:

    http://www.mssm.edu/cpm/dept_research.shtml Exit
    http://www.childenvironment.org Exit

    Progress and Final Reports:

    Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2007 Progress Report
  • 2008
  • 2009
  • Final Report

  • Main Center Abstract and Reports:

    R831711    Mount Sinai Center for Children’s Health and the Environment

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R831711C001 Growing Up Healthy in East Harlem (Community-Based Participatory Research)
    R831711C002 Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
    R831711C003 Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)