2006 Progress Report: Growing Up Healthy in East Harlem (Community-Based Participatory Research)

EPA Grant Number: R831711C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R831711
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Mount Sinai Center for Children’s Health and the Environment
Center Director: Wolff, Mary S.
Title: Growing Up Healthy in East Harlem (Community-Based Participatory Research)
Investigators: Brenner, Barbara , Galvez, Maida
Current Investigators: Brenner, Barbara , Galvez, Maida , Teitelbaum, Susan , Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2005 through August 23,2006
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Health

Objective:

This community-based participatory research (CBPR) project is studying childhood obesity in relation to structural features and endocrine disruptor (ED) exposures in the urban built environment of East Harlem. The specific objective of this project is to assess accessibility to physical activity resources and to healthy foods.

Progress Summary:

This project continues apace, with a manuscript submitted and one in preparation that describe features of the built environment and children in East Harlem. Our children are at great risk for overweight and obesity. A recently completed 6-month study to evaluate biomarker protocols in 34 6–8 year-old children of phthalates, phenols, and phytoestrogens shows high levels of urinary metabolites in the phthalate, phytoestrogen, and phenol families of EDs. Levels were quite stable over time, indicating that spot urines are useful to examine general exposures. We now plan to examine relationships of urine levels with specific products to identify sources of EDs. Phase 2 of the 3-year longitudinal study has begun to evaluate risk prospectively for obesity in relation to built environment factors and ED exposures.

Future Activities:

As the longitudinal study continues to collect data on exposures and obesity outcomes, we are planning to publish the study on temporal variability and reliability of the EDs that was completed last year, and we will continue to examine ED exposure levels and their relationship to diet, physical activity level, and weight, and to compare availability, proximity, and density of resources (GIS data) with individual level factors (neighborhood questionnaire) such as access, knowledge, utilization, dietary quality, and physical activity level. A modification to the protocol is being submitted for Institutional Review Board (IRB) review to add the collection of saliva/cheek cells from all children (boys) in the study in order to measure common genetic polymorphisms that may influence the body’s ability to metabolize chemical substances including phthalates and bisphenol A.


Journal Articles on this Report : 49 Displayed | Download in RIS Format

Other subproject views: All 91 publications 56 publications in selected types All 51 journal articles
Other center views: All 253 publications 140 publications in selected types All 118 journal articles
Type Citation Sub Project Document Sources
Journal Article Anderson HA, Wolff MS. Special fish contaminants issue. Environmental Research 2005;97(2):125-126 (introductory commentary). R831711 (2004)
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  • Journal Article Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. R831711 (2004)
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  • Journal Article Berkowitz GS, Wetmur JG, Birman-Deych E, Obel J, Lapinski RH, Godbold JH, Holzman IR, Wolff MS. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives 2004;112(3):388-391. R831711 (2004)
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  • Journal Article Borrell LN, Factor-Litvak P, Wolff MS, Susser E, Matte TD. Effect of socioeconomic status on exposures to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) among pregnant African-American women. Archives of Environmental Health 2004;59(5):250-255. R831711 (2005)
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  • Journal Article Braganza SF, Galvez MP, Mencin AA, Ozuah PO. Weighting the appropriate uses of supplemental zinc. Contemporary Pediatrics 2006;23(7):66-74. R831711 (2005)
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  • Journal Article Braganza SF, Galvez MP, Ozuah PO. When parents ask about diet therapy for ADHD. Contemporary Pediatrics 2006;23(5):47-49. R831711 (2005)
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  • Journal Article Brenner BL, Markowitz S, Rivera M, Romero H, Weeks M, Sanchez E, Deych E, Garg A, Godbold J, Wolff MS, Landrigan PJ, Berkowitz G. Integrated pest management in an urban community: a successful partnership for prevention. Environmental Health Perspectives 2003;111(13):1649-1653. R831711 (2004)
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  • Journal Article Britton JA, Wolff MS, Lapinski R, Forman J, Hochman S, Kabat GC, Godbold J, Larson S, Berkowitz GS. Characteristics of pubertal development in a multi-ethnic population of nine-year-old girls. Annals of Epidemiology 2004;14(3):179-187. R831711 (2005)
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  • Journal Article Chen J, Kumar M, Chan W, Berkowitz G, Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environmental Health Perspectives 2003;111(11):1403-1409. R831711 (2005)
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  • Journal Article Chen J, Chan W, Wallenstein S, Berkowitz G, Wetmur JG. Haplotype-phenotype relationships of paraoxonase-1. Cancer Epidemiology Biomarkers & Prevention 2005;14(3):731-734. R831711 (2005)
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  • Journal Article Claudio L. Breast cancer takes center stage. Environmental Health Perspectives 2004;112(2):A92-A95 (NIEHS News). R831711 (2004)
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  • Journal Article Claudio L, Stingone JA, Godbold J. Prevalence of childhood asthma in urban communities: the impact of ethnicity and income. Annals of Epidemiology 2006;16(5):332-340. R831711 (2005)
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  • Journal Article Edwards ES, Green N, Henry CJ, Landrigan PJ, Swartz D. Tracking children's health to age 21. Science 2003;302(5646):781 (letter comment on Science 2003;301(5630):162-163). R831711 (2005)
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  • Journal Article Engel SM, Levy B, Liu Z, Kaplan D, Wolff MS. Xenobiotic phenols in early pregnancy amniotic fluid. Reproductive Toxicology 2006;21(1):110-112. R831711 (2005)
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  • Journal Article Engel SM, Olshan AF, Siega-Riz AM, Savitz DA, Chanock SJ. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth. American Journal of Obstetrics and Gynecology 2006;195(5):1231.e1-1231.e11. R831711 (2005)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R831711 (2005)
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  • Journal Article Etzel RA, Crain EF, Gitterman BA, Oberg C, Scheidt P, Landrigan PJ. Pediatric environmental health competencies for specialists. Ambulatory Pediatrics 2003;3(1):60-63. R831711 (2004)
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  • Journal Article Etzel RA, Balk SJ, Reigart JR, Landrigan PJ. Environmental health for practicing pediatricians. Indian Pediatrics 2003;40(9):853-860. R831711 (2005)
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  • Journal Article Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. R831711 (2004)
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  • Journal Article Fewtrell LJ, Pruss-Ustun A, Landrigan P, Ayuso-Mateos JL. Estimating the global burden of disease of mild mental retardation and cardiovascular diseases from environmental lead exposure. Environmental Research 2004;94(2):120-133. R831711 (2005)
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  • Journal Article Galvez MP, Frieden TR, Landrigan PJ. Obesity in the 21st century. Environmental Health Perspectives 2003;111(13):A684-A685 (editorial). R831711 (2005)
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  • Journal Article Galvez MP, Peters R, Graber N, Forman J. Effective risk communication in children's environmental health:lessons learned from 9/11. Pediatric Clinics of North America 2007;54(1):33-46. R831711 (2005)
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  • Journal Article Galvez M, Vanable L, Forman JA, Landrigan PJ, Akeredolu E, Leighton J, Nagin D. Childhood lead poisoning from commercially manufactured French ceramic dinnerware-New York City, 2003. Morbidity and Mortality Weekly Reports 2004;53(26):584-586. R831711 (2005)
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  • Journal Article Goldman L, Falk H, Landrigan PJ, Balk SJ, Reigart JR, Etzel RA. Environmental pediatrics and its impact on government health policy. Pediatrics 2004;113(Suppl 3):1146-1157. R831711 (2005)
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  • Journal Article Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. R831711 (2005)
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  • Journal Article Lamb MR, Taylor S, Liu X, Wolff MS, Borrell L, Matte TD, Susser ES, Factor-Litvak P. Prenatal exposure to polychlorinated biphenyls and postnatal growth: a structural analysis. Environmental Health Perspectives 2006;114(5):779-785. R831711 (2005)
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  • Journal Article Landrigan PJ, Kimmel CA, Correa A, Eskenazi B. Children's health and the environment:public health issues and challenges for risk assessment. Environmental Health Perspectives 2004;112(2):257-265. R831711 (2005)
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  • Journal Article Landrigan PJ. Children as a vulnerable population. International Journal of Occupational Medicine and Environmental Health 2004;17(1):175-177. R831711 (2005)
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  • Journal Article Landrigan PJ, Sonawane B, Butler RN, Trasande L, Callan R, Droller D. Early environmental origins of neurodegenerative disease in later life. Environmental Health Perspectives 2005;113(9):1230-1233. R831711 (2005)
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  • Journal Article Landrigan PJ, Newman B. Children and other high-risk workers as a special challenge to occupational health services. SJWEH Supplements 2005;1:43-45. R831711 (2005)
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  • Journal Article Landrigan PJ, Tamburlini G. Children’s health and the environment: a transatlantic dialogue. Environmental Health Perspectives 2005;113(10):A646-A647 (editorial). R831711C001 (2006)
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  • Journal Article Landrigan PJ. Environmental pediatrics and the ecological imperative. EcoHealth 2006;3(2):75-76 (editorial). R831711 (2005)
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  • Journal Article Landrigan PJ, Trasande L, Thorpe LE, Gwynn C, Lioy PJ, D'Alton ME, Lipkind HS, Swanson J, Wadhwa PD, Clark EB, Rauh VA, Perera FP, Susser E. The National Children's Study:a 21-year prospective study of 100,000 American children. Pediatrics 2006;118(5):2173-2186. R831711 (2005)
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  • Journal Article Landrigan P, Garg A, Droller DBJ. Assessing the effects of endocrine disruptors in the National Children's Study. Environmental Health Perspectives 2003;111(13):1678-1682. R831711 (2005)
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  • Journal Article Longnecker MP, Wolff MS, Gladen BC, Brock JW, Grandjean P, Jacobson JL, Korrick SA, Rogan WJ, Weisglas-Kuperus N, Hertz-Picciotto I, Ayotte P, Stewart P, Winneke G, Charles MJ, Jacobson SW, Dewailly E, Boersma ER, Altshul LM, Heinzow B, Pagano JJ, Jensen AA. Comparison of polychlorinated biphenyl levels across studies of human neurodevelopment. Environmental Health Perspectives 2003;111(1):65-70. R831711 (2004)
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  • Journal Article Needleman HL, Landrigan PJ. What level of lead in blood is toxic for a child? American Journal of Public Health 2004;94(1):8. R831711 (2005)
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  • Journal Article Salama J, Chakraborty TR, Ng L, Gore AC. Effects of polychlorinated biphenyls on estrogen receptor-β expression in the anteroventral periventricular nucleus. Environmental Health Perspectives 2003;111(10):1278-1282. R831711 (2005)
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  • Journal Article Suk WA, Ruchirawat KM, Balakrishnan K, Berger M, Carpenter D, Damstra T, Pronczuk de Garbino J, Koh D, Landrigan PJ, Makalinao I, Sly PD, Xu Y, Zheng BS. Environmental threats to children's health in Southeast Asia and the western Pacific. Environmental Health Perspectives 2003;111(10):1340-1347. R831711 (2005)
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  • Journal Article Trasande L, Landrigan PJ. The National Children's Study: a critical national investment. Environmental Health Perspectives 2004;112(14):A789-A790. R831711 (2005)
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  • Journal Article Trasande L, Boscarino J, Graber N, Falk R, Schechter C, Galvez M, Dunkel G, Geslani J, Moline J, Kaplan-Liss E, Miller RK, Korfmacher K, Carpenter D, Forman J, Balk SJ, Laraque D, Frumkin H, Landrigan P. The environment in pediatric practice: a study of New York pediatricians' attitudes, beliefs, and practices towards children's environmental health. Journal of Urban Health 2006;83(4):760-772. R831711 (2005)
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  • Journal Article Trasande L, Schapiro ML, Falk R, Haynes KA, Behrmann A, Vohmann M, Stremski ES, Eisenberg C, Evenstad C, Anderson HA, Landrigan PJ. Pediatrician attitudes, clinical activities, and knowledge of environmental health in Wisconsin. Wisconsin Medical Journal 2006;105(2):45-49. R831711 (2005)
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    R831711C002 (2006)
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  • Abstract from PubMed
  • Full-text: Wisconsin Medical Journal-Full Text PDF
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  • Journal Article Trasande L, Cronk CE, Leuthner SR, Hewitt JB, Durkin MS, McElroy JA, Anderson HA, Landrigan PJ. The National Children's Study and the children of Wisconsin. Wisconsin Medical Journal 2006;105(2):50-54. R831711 (2005)
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  • Journal Article Wallenstein S, Chen J, Wetmur JG. Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Molecular Genetics and Metabolism 2006;89(3):270-273. R831711 (2005)
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  • Journal Article Wetmur JG, Kumar M, Zhang L, Palomeque C, Wallenstein S, Chen J. Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes. Nucleic Acids Research 2005;33(8):2615-2619. R831711 (2005)
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  • Abstract: Oxford Journals-Abstract
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  • Journal Article Wolff MS, Deych E, Ojo F, Berkowitz GS. Predictors of organochlorines in New York City pregnant women, 1998-2001. Environmental Research 2005;97(2):170-177. R831711 (2004)
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  • Abstract: ScienceDirect-Abstract
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  • Journal Article Wolff MS, Britton JA, Russo JC. TCDD and puberty in girls. Environmental Health Perspectives 2005;113(1):A17. R831711 (2005)
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  • Journal Article Wolff MS. Endocrine disruptors: challenges for environmental research in the 21st Century. Annals of the New York Academy of Sciences 2006;1076:228-238. R831711 (2006)
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  • Abstract: Wiley Online-Abstract
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  • Journal Article Wolff MS, Engel S, Berkowitz G, Teitelbaum S, Siskind J, Barr DB, Wetmur J. Prenatal pesticide and PCB exposures and birth outcomes. Pediatric Research 2007;61(2):243-250. R831711 (2005)
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  • Full-text: Nature-Full Text HTML
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  • Abstract: Nature-Abstract
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  • Other: Nature-Full Text PDF
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  • Journal Article Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, Chelimo C, Godbold J, Biro F, Kushi LH, Pfeiffer CM, Calafat AM. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environmental Health Perspectives 2007;115(1):116-121. R831711 (2005)
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    R831711C001 (2006)
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    R831711C003 (2006)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Supplemental Keywords:

    lipase, paraoxonase, fast food, obesity, endocrine disruptors, neurodevelopment, ENVIRONMENTAL MANAGEMENT, Health, POLLUTANTS/TOXICS, RFA, Scientific Discipline, Biochemistry, Chemicals, Children's Health, Endocrine Disruptors - Environmental Exposure & Risk, Endocrine Disruptors - Human Health, Environmental Chemistry, Health Risk Assessment, Risk Assessment, endocrine disruptors, Human Health Risk Assessment, childhood development, childhood obesity, children's environmental health, children’s vulnerability, community-based intervention, dietary factors, endocrine disrupting chemicals, environmental health, exposure pathways, exposure studies, neurodevelopmental toxicity,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, POLLUTANTS/TOXICS, Environmental Chemistry, Health Risk Assessment, Chemicals, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Biochemistry, Children's Health, Endocrine Disruptors - Human Health, Risk Assessment, environmental health, community-based intervention, childhood development, phtalates, endocrine disrupting chemicals, exposure studies, Human Health Risk Assessment, childhood obesity, children's vulnerablity, neurodevelopmental toxicity, children's environmental health, exposure pathways

    Relevant Websites:

    http://www.mssm.edu/cpm/dept_research.shtml Exit

    Progress and Final Reports:

    Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2007 Progress Report
  • 2008
  • 2009
  • Final Report

  • Main Center Abstract and Reports:

    R831711    Mount Sinai Center for Children’s Health and the Environment

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R831711C001 Growing Up Healthy in East Harlem (Community-Based Participatory Research)
    R831711C002 Pesticides, Endocrine Disruptors, Childhood Growth and Development (Birth Cohort)
    R831711C003 Genetics of Phthalate and Bisphenol A Risk in Minority Populations (Individual Susceptibility)