Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDDEPA Grant Number: R831604
Title: Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDD
Investigators: Sweeney, Anne , Päpke, O. , del Junco, Deborah J.
Institution: Texas A & M University
EPA Project Officer: Deener, Kacee
Project Period: October 1, 2004 through September 30, 2005
Project Amount: $31,275
RFA: Issues in Human Health Risk Assessment (2001) RFA Text | Recipients Lists
Research Category: Human Health Risk Assessment , Health , Health Effects , Pesticides
Concerns have been raised recently regarding the validity and feasibility of using the chemically activated luciferase expression (CALUX) bioassay as a screening tool to measure dioxin exposure in large-scale epidemiologic studies. The objective of this research project was to validate the CALUX assay by comparison with the gold standard method, high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), in 105 blood samples obtained from male Vietnam veterans during the period from 2001-2002. This grant was a follow-on to STAR Grant No. R825817.