Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDD

EPA Grant Number: R831604
Title: Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDD
Investigators: Sweeney, Anne , PƤpke, O. , del Junco, Deborah J.
Institution: Texas A & M University
EPA Project Officer: Deener, Kacee
Project Period: October 1, 2004 through September 30, 2005
Project Amount: $31,275
RFA: Issues in Human Health Risk Assessment (2001) RFA Text |  Recipients Lists
Research Category: Human Health Risk Assessment , Health , Health Effects , Pesticides

Description:

Concerns have been raised recently regarding the validity and feasibility of using the chemically activated luciferase expression (CALUX) bioassay as a screening tool to measure dioxin exposure in large-scale epidemiologic studies. The objective of this research project was to validate the CALUX assay by comparison with the gold standard method, high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), in 105 blood samples obtained from male Vietnam veterans during the period from 2001-2002. This grant was a follow-on to STAR Grant No. R825817.

Supplemental Keywords:

risk assessment, exposure, dioxin, PCDD, PCDF, TCDD, epidemiology,, RFA, Health, Scientific Discipline, Toxics, PESTICIDES, Genetics, Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, genetic susceptability, Biology, Pesticide Types, dioxin, sensitive populations, Vietnam veterans, P450 genes, exposure, genetic polymorphisms, human exposure, environmentally caused disease, human susceptibility, bioassay, reproductive health, herbicides, dioxin exposure, genetic susceptibility, environmental hazard exposures

Progress and Final Reports:

Final Report