Environmental Factors in the Etiology of Autism; Animal Models of Autism

EPA Grant Number: R829388C005
Subproject: this is subproject number 005 , established and managed by the Center Director under grant R829388
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Center Director: Pessah, Isaac N.
Title: Environmental Factors in the Etiology of Autism; Animal Models of Autism
Investigators: Amaral, David G. , Berman, Robert F. , Capitanio, John , Matsumura, Fumio
Current Investigators: Amaral, David G. , Berman, Robert F.
Institution: University of California - Davis
EPA Project Officer: Saint, Chris
Project Period: September 30, 2001 through September 29, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text |  Recipients Lists
Research Category: Health , Children's Health , Health Effects

Objective:

The goals of this project are to establish in vivo exposure models in mice and primates with which to study how relevant xenobiotics of concern to childhood autism influence the development of social behavior. The specific aims of the mouse studies were to: (1) develop a battery of behavioral probes to assess social behavior in developing and mature mice, (2) to evaluate the effects of prenatal and early postnatal exposure to thimerosal, methyl mercury and congeners of PCB on the emergence and quality of social behavior in mice, (3) to determine whether the expected toxicity of exposure to xenobiotics is altered in mice whose immune systems have been activated early in postnatal development by administration of bacterial endotoxin lipopolysaccaride (LPS), and (4) to examine selected brain regions (e.g., amygdala) in xenobiotic treated mice for morphological alterations that may be similar to those observed in neuropathological studies of autism.

The aim of the monkey studies were to use a battery of social testing to evaluate potential alterations of conspecific social behavior following early postnatal exposure of realistic levels of thimerosal, methyl mercury and congeners of PCB.

Publications and Presentations:

Publications have been submitted on this subproject: View all 3 publications for this subprojectView all 145 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 3 journal articles for this subprojectView all 132 journal articles for this center

Supplemental Keywords:

Autism, thimerosal, amygdala, hippocampus, neurodevelopmental toxicity, animal models,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Physical Processes, Children's Health, genetic susceptability, Biology, Risk Assessment, chemical exposure, neurotoxic, xenobiotics, biomarkers, neurodevelopment, gene-environment interaction, pesticides, exposure, halogenated aromatics, children, neurobehavioral, neurodevelopmental, neurotoxicity, etiology, susceptibility, neurobehavioral effects, autism, biological markers, mechanisms, exposure assessment, neurological development, biomarker, synergistic interactions

Progress and Final Reports:

2002 Progress Report
2003 Progress Report
2005 Progress Report


Main Center Abstract and Reports:

R829388    CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism