Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core

EPA Grant Number: R829388C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R829388
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism
Center Director: Pessah, Isaac N.
Title: Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
Investigators: Hammock, Bruce , German, Bruce , Lango, Jozsef , Watkins, Steve
Current Investigators: Hammock, Bruce , Dettmer, Katja , German, Bruce , Green, Peter , Lango, Jozsef
Institution: University of California - Davis
EPA Project Officer: Saint, Chris
Project Period: September 30, 2001 through September 29, 2002
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2001) RFA Text |  Recipients Lists
Research Category: Health , Health Effects , Children's Health

Objective:

The two major goals of this core are to develop strategies to profile xenobiotics of concern to childhood neurodevelopment in biological fluids and provide support in metabolomics. The long-term approach is to establish a horizontally integrated database from the genome through the autistic phenotype to aid in developing and testing hypotheses regarding the disorder. Thus the core provides established analytical support for xenobiotic and proteomic profiling, and is currently developing tools to study the metabolome.

Our specific aims are: I.) Determine xenobiotics in serum, urine and food; II.) Determine levels of nutritional and structural lipids in serum samples; III.) Provide general analytical support for the project including the development of methods for possible biomarkers that are considered important.

Publications and Presentations:

Publications have been submitted on this subproject: View all 20 publications for this subprojectView all 145 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 18 journal articles for this subprojectView all 132 journal articles for this center

Supplemental Keywords:

Autism, metabolomics, lipids, proteomics, xenobiotics,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, ENVIRONMENTAL MANAGEMENT, Toxicology, Health Risk Assessment, Chemistry, Epidemiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Disease & Cumulative Effects, Physical Processes, Children's Health, genetic susceptability, Biology, Risk Assessment, chemical exposure, neurotoxic, xenobiotics, biomarkers, gene-environment interaction, neurodevelopment, pesticides, exposure, halogenated aromatics, children, neurobehavioral, neurodevelopmental, neurotoxicity, etiology, susceptibility, human exposure, neurobehavioral effects, autism, biological markers, mechanisms, exposure assessment, neurological development, biomarker, synergistic interactions, mercurials

Progress and Final Reports:

2002 Progress Report
2003 Progress Report
2004 Progress Report
2005 Progress Report


Main Center Abstract and Reports:

R829388    CECEHDPR - University of California at Davis Center for the Study of Environmental Factors in the Etiology of Autism

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R829388C001 Environmental Factors in the Etiology of Autism; Analytic Biomakers (xenobiotic) Core
R829388C002 Environmental Factors in the Etiology of Autism; Cell Activation/Signaling Core
R829388C003 Environmental Factors in the Etiology of Autism; Molecular Biomakers Core
R829388C004 Environmental Factors in the Etiology of Autism; Childhood Autism Risks from Genetics and the Environment (The CHARGE Study)
R829388C005 Environmental Factors in the Etiology of Autism; Animal Models of Autism
R829388C006 Environmental Factors in the Etiology of Autism; Molecular and Cellular Mechanisms of Autism