Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources

EPA Grant Number: R832415C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832415
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Rochester PM Center
Center Director: Oberdörster, Günter
Title: Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources
Investigators: Peters, Annette , Breitner, Susanne , Henneberger, Alexandra , Phipps, Richard , Rückerl, Regina , Stoelzel, M , Utell, Mark J. , Wichmann, Heinz-Erich , Zareba, Wojciech
Institution: GSF-National Research Center for Environment and Health , University of Rochester
EPA Project Officer: Hunt, Sherri
Project Period: October 1, 2005 through September 30, 2010 (Extended to September 30, 2012)
RFA: Particulate Matter Research Centers (2004) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

Our objective is to evaluate the role of key components of urban aerosol on acute phase reaction and prothrombotic states in the blood, endothelial dysfunction, cardiac function and classical cardiovascular risk factors in susceptible subgroups. We will focus on determining the effects of fresh ultrafine particles from specific sources such as traffic as well as aged aerosols in the accumulation mode which are mixtures of particles from different sources and secondary aerosols. We hypothesize that the following subgroups are susceptible to effects of ambient fine and ultrafine particles compared to control subjects: (a) Patients with coronary artery disease during rehabilitation, (b) myocardial infarction (MI) survivors, (c) diabetics, (d) individuals with enhanced inflammatory responses due to genetic polymorphisms in inflammation regulating pathways and/or in detoxifying pathways.

Approach:

In Rochester 80 patients taking part in a cardiac rehabilitation program will be studied. In Augsburg, panel studies enrolling a total of 400 subjects will be conducted including 100 subjects per group b-d. A random sample of the population of Augsburg will be screened for genetic predispositions for enhanced inflammatory responses and slower detoxification pathways to select participants with genetic polymorphisms as well as healthy controls. In a sub-study, data on 24 hour ECG Holter monitoring, a time-activity diary including traffic exposures and stress level, and continuous personal exposure to the total particle number concentrations will be collected in 30 participants of each group. Outcome measures will be determined by the Vascular & Inflammation Core and ECG parameters will be provided by the Cardiac Core. The number concentration of ultra fine particles, particle size distributions and continuous particle mass measurements are conducted in Rochester, NY. Ambient air pollution in Augsburg will include continuous particle mass measurements, particle size distributions separated into volatile and non-volatile fractions, particle surface, elemental and organic carbon, sulphates and nitrates. PM associated oxidative stress will be measured in Rochester and Augsburg by the Aerosol Generation and Analysis Core. In collaboration with Core 1 source apportionment analyses will be conducted.

Expected Results:

The studies will give evidence on health effects of key characteristics of the urban aerosol such as oxidative stress and on the role of sources in urban areas. In addition, they will assess the potential role of ambient air pollution concentrations on smaller time-scales than 24 hours.

Publications and Presentations:

Publications have been submitted on this subproject: View all 19 publications for this subprojectView all 169 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 18 journal articles for this subprojectView all 122 journal articles for this center

Supplemental Keywords:

Mechanisms, biomarker, gene-environment interaction, personal monitoring,, RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Physical Processes, atmospheric particulate matter, atmospheric particles, long term exposure, acute cardiovascular effects, airway disease, exposure, human exposure, ambient particle health effects, atmospheric aerosol particles, PM, aersol particles, cardiovascular disease

Progress and Final Reports:

2006 Progress Report
2007 Progress Report
2008 Progress Report
2009 Progress Report
2010 Progress Report
2011 Progress Report
Final Report


Main Center Abstract and Reports:

R832415    Rochester PM Center

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832415C001 Characterization and Source Apportionment
R832415C002 Epidemiological Studies on Extra Pulmonary Effects of Fresh and Aged Urban Aerosols from Different Sources
R832415C003 Human Clinical Studies of Concentrated Ambient Ultrafine and Fine Particles
R832415C004 Animal models: Cardiovascular Disease, CNS Injury and Ultrafine Particle Biokinetics
R832415C005 Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading To Altered Gene Expression in Relation to Particle Composition