Johns Hopkins Particulate Matter Research Center

EPA Grant Number: R832417
Center: Johns Hopkins Particulate Matter Research Center
Center Director: Samet, Jonathan M.
Title: Johns Hopkins Particulate Matter Research Center
Investigators: Samet, Jonathan M. , Breysse, Patrick N. , Chillrud, Steven , Dominici, Francesca , Garcia, Joe , Ondov, John M.
Institution: The Johns Hopkins University , Columbia University (Lamont Doherty Earth Observatory) (JHPMRC) , University of Chicago , University of Maryland , Yale University
EPA Project Officer: Chung, Serena
Project Period: October 1, 2005 through September 30, 2010
Project Amount: $7,993,275
RFA: Particulate Matter Research Centers (2004) RFA Text |  Recipients Lists
Research Category: Health Effects , Air

Objective:

The Johns Hopkins PM Research Center brings together a multidisciplinary research team: biostatisticians, epidemiologists, exposure assessors, lung biologists and respiratory toxicologists, pulmonary clinicians, and atmospheric scientists to address the most critical gap in current understanding of health and particulate matter (PM) the physical and chemical characteristics that determine risk to human health. The Center's conceptual foundation lies in mapping health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then using the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.

Approach:

The Center's three-phase agenda builds progressively from mapping the health risks in the first phase. During this first phase, we will also explore patterns of PM characteristics across the United States using existing data; we will develop protocols for detailed PM monitoring and collection of sufficient materials for bioassays; adapt existing in vitro and in vivo bioassays for assessing the comparative toxicity of the PM samples; and develop relevant microarray approaches. In the second phase, we will monitor and collect PM from 10 sites, selected from the higher and lower extremes of the effects of PM on human health; we will then assess the comparative toxicity of the PM samples in the bioassay battery. The third phase is likely to involve assessment of risks of more toxic particles in susceptible populations, source-related relative risk characterization, exposure assessment studies, and more focused studies of mechanisms of injury by these particles. The Center will have three discipline-based Research Projects and two scientific cores, the Data Base Core and the PM Collection, Sampling & Analysis Core. The Administrative Core will be the focal point for interdisciplinary interactions.

Expected Results:

The Center will map health risks of PM across the US, based on analysis of national databases on air pollution, mortality, and hospitalization, and then use the maps to guide detailed monitoring and collection of PM samples for physical, chemical, and biological characterization in assays relevant to pulmonary and cardiovascular outcomes.


Journal Articles: 63 Displayed | Download in RIS Format

Other center views: All 88 publications 65 publications in selected types All 63 journal articles
Type Citation Sub Project Document Sources
Journal Article Anderson BG, Bell ML. Weather-related mortality: how heat, cold, and heat waves affect mortality in the United States. Epidemiology 2009;20(2):205-213. R832417 (Final)
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  • Journal Article Anderson GB, Bell ML. Heat waves in the United States: mortality risk during heat waves and effect modification by heat wave characteristics in 43 U.S. communities.Environmental Health Perspectives 2011;119(2):210-218. R832417 (Final)
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  • Journal Article Anderson GB, Bell ML. Lights out: impact of the August 2003 power outage on mortality in New York, NY. Epidemiology 2012;23(2):189-193. R832417 (Final)
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  • Journal Article Barr CD, Dominici F. Comment on article by Craigmile et al. Bayesian Analysis 2009;4(1):37-40. R832417C001 (2009)
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  • Journal Article Barr CD, Dominici F. Cap and trade legislation for greenhouse gas emissions: public health benefits from air pollution mitigation. JAMA-Journal of the American Medical Association 2010;303(1):69-70. R832417 (Final)
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  • Journal Article Barr CD, Diez DM, Wang Y, Dominici F, Samet JM. Comprehensive smoking bans and acute myocardial infarction among Medicare enrollees in 387 US counties:1999–2008. American Journal of Epidemiology 2012;176(7):642-648. R832417 (Final)
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  • Journal Article Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environmental Health Perspectives 2006;114(4):532-536. R832417 (Final)
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  • Journal Article Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environmental Health Perspectives 2007;115(7):989-995. R832417 (Final)
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  • Journal Article Bell ML, Kim JY, Dominici F. Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies. Environmental Health Perspectives 2007;115(11):1591-1595. R832417 (Final)
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  • Journal Article Bell ML, Dominici F. Effect modification by community characteristics on the short-term effects of ozone exposure and mortality in 98 US communities. American Journal of Epidemiology 2008;167(8):986-997. R832417 (Final)
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  • Journal Article Bell ML, Ebisu K, Peng RD, Walker J, Samet JM, Zeger SL, Dominici F. Seasonal and regional short-term effects of fine particles on hospital admissions in 202 US counties, 1999-2005. American Journal of Epidemiology 2008;168(11):1301-1310. R832417 (2008)
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  • Journal Article Bell ML, Ebisu K, Peng RD, Samet JM, Dominici F. Hospital admissions and chemical composition of fine particle air pollution. American Journal of Respiratory and Critical Care Medicine 2009;179(12):1115-1120. R832417 (Final)
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  • Journal Article Bell ML, Peng RD, Dominici F, Samet JM. Emergency hospital admissions for cardiovascular diseases and ambient levels of carbon monoxide: results for 126 United States urban counties, 1999-2005. Circulation 2009;120(11):949-955. R832417 (Final)
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  • Journal Article Bell ML, Ebisu K, Peng RD, Dominici F. Adverse health effects of particulate air pollution: modification by air conditioning. Epidemiology 2009;20(5):682-686. R832417 (Final)
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  • Journal Article Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP. Prenatal exposure to fine particulate matter and birth weight: variations by particulate constituents and sources. Epidemiology 2010;21(6):884-891. R832417 (Final)
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  • Journal Article Bell ML, Ebisu K, Peng RD. Community-level spatial heterogeneity of chemical constituent levels of fine particulates and implications for epidemiological research. Journal of Exposure Science & Environmental Epidemiology 2011;21(4):372-384. R832417 (Final)
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  • Journal Article Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012;117:83-89. R832417 (Final)
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  • Journal Article Bobb JF, Dominici F, Peng RD. A Bayesian model averaging approach for estimating the relative risk of mortality associated with heat waves in 105 U.S. cities. Biometrics 2011;67(4):1605-1616. R832417 (Final)
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  • Journal Article Chang HH, Peng RD, Dominici F. Estimating the acute health effects of coarse particulate matter accounting for exposure measurement error. Biostatistics 2011;12(4):637-652. R832417 (Final)
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  • Journal Article Crainiceanu CM, Dominici F, Parmigiani G. Adjustment uncertainty in effect estimation. Biometrika 2008;95(3):635-651. R832417 (Final)
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  • Journal Article Datta S, Rule AM, Mihalic JN, Chillrud SN, Bostick BC, Ramos-Bonilla JP, Han I, Polyak LM, Geyh AS, Breysse PN. Use of X-ray absorption spectroscopy to speciate manganese in airborne particulate matter from five counties across the United States. Environmental Science & Technology 2012;46(6):3101-3109. R832417 (Final)
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  • Journal Article Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA-Journal of the American Medical Association 2006;295(10):1127-1134. R832417 (Final)
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  • Journal Article Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspectives 2007;115(12):1701-1703. R832417 (Final)
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  • Journal Article Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Dominici et al. respond to "Heterogeneity of particulate matter health risks." American Journal of Epidemiology 2007;166(8):892-893. R832417 (2008)
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  • Journal Article Dominici F, Peng RD, Zeger SL, White RH, Samet JM. Particulate air pollution and mortality in the United States: did the risks change from 1987 to 2000? American Journal of Epidemiology 2007;166(8):880-888. R832417 (Final)
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  • Journal Article Dominici F, Wang C, Crainiceanu C, Parmigiani G. Model selection and health effect estimation in environmental epidemiology. Epidemiology 2008;19(4):558-560. R832417 (2008)
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  • Journal Article Dominici F, Peng RD, Barr CD, Bell ML. Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach. Epidemiology 2010;21(2):187-194. R832417 (Final)
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  • Journal Article Eftim SE, Samet JM, Janes H, McDermott A, Dominici F. Fine particulate matter and mortality: a comparison of the six cities and American Cancer Society cohorts with a Medicare cohort. Epidemiology 2008;19(2):209-216. R832417 (2008)
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  • Journal Article Greven S, Dominici F, Zeger S. An approach to the estimation of chronic air pollution effects using spatio-temporal information. Journal of the American Statistical Association 2011;106(494):396-406. R832417 (Final)
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  • Journal Article Han I, Ramos-Bonilla JP, Rule AM, Mihalic JN, Polyak LM, Breysse PN, Geyh AS. Comparison of spatial and temporal variations in p-PAH, BC, and p-PAH/BC ratio in six US counties. Atmospheric Environment 2011;45(40):7644-7652. R832417 (Final)
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  • Journal Article Han I, Mihalic JN, Ramos-Bonilla JP, Rule AM, Polyak LM, Peng RD, Geyh AS, Breysse PN. Assessment of heterogeneity of metal composition of fine particulate matter collected from eight U.S. counties using principal component analysis. Journal of the Air & Waste Management Association 2012;62(7):773-782. R832417 (Final)
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  • Journal Article Heaton MJ, Peng RD. Flexible distributed lag models using random functions with application to estimating mortality displacement from heat-related deaths. Journal of Agricultural Biological and Environmental Statistics 2012;17(3):313-331. R832417 (Final)
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  • Journal Article Janes H, Dominici F, Zeger S. Partitioning evidence of association between air pollution and mortality. Epidemiology 2007;18(4):427-428. R832417 (2008)
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  • Journal Article Janes H, Dominici F, Zeger SL. Trends in air pollution and mortality: an approach to the assessment of unmeasured confounding. Epidemiology 2007;18(4):416-423. R832417 (Final)
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  • Journal Article Janes H, Dominici F, Zeger S. On quantifying the magnitude of confounding. Biostatistics 2010;11(3):572-582. R832417 (Final)
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  • Journal Article Krall JR, Anderson GB, Dominici F, Bell ML, Peng RD. Short-term exposure to particulate matter constituents and mortality in a national study of U.S. urban communities. Environmental Health Perspectives 2013;121(10):1148-1153. R832417 (Final)
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  • Journal Article Levy JI, Diez D, Dou Y, Barr CD, Dominici F. A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents. American Journal of Epidemiology 2012;175(11):1091-1099. R832417 (Final)
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  • Journal Article Peng RD, Dominici F, Louis TA. Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Society Series A-Statistics in Society 2006;169(2):179-203. R832417 (Final)
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  • Journal Article Peng RD, Dominici F, Zeger SL. Reproducible epidemiological research. American Journal of Epidemiology 2006;163(9):783-789. R832417 (Final)
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  • Journal Article Peng RD, Chang HH, Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. Coarse particulate matter air pollution and hospital admissions for cardiovascular and respiratory diseases among Medicare patients. JAMA-Journal of the American Medical Association 2008;299(18):2172-2179. R832417 (2008)
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  • Journal Article Peng RD. A Method for Visualizing Multivariate Time Series Data. Journal of Statistical Software 2008;25(Code Snippet 1):1-17 R832417 (2008)
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    Journal Article Peng RD, Dominici F, Welty LJ. A Bayesian hierarchical distributed lag model for estimating the time course of risk of hospitalization associated with particulate matter air pollution. Journal of the Royal Statistical Society Series C--Applied Statistics 2009;58(1):3-24. R832417 (2008)
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  • Journal Article Peng RD, Bell ML, Geyh AS, McDermott A, Zeger SL, Samet JM, Dominici F. Emergency admissions for cardiovascular and respiratory diseases and the chemical composition of fine particle air pollution. Environmental Health Perspectives 2009;117(6):957-963. R832417 (Final)
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  • Journal Article Peng RD, Bell ML. Spatial misalignment in time series studies of air pollution and health data. Biostatistics 2010;11(4):720-740. R832417 (Final)
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  • Journal Article Peng RD, Bobb JF, Tebaldi C, McDaniel L, Bell ML, Dominici F. Toward a quantitative estimate of future heat wave mortality under global climate change. Environmental Health Perspectives 2011;119(5):701-706. R832417 (Final)
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  • Journal Article Ramos-Bonilla JP, Breysse PN, Dominici F, Geyh A, Tankersley CG. Ambient air pollution alters heart rate regulation in aged mice. Inhalation Toxicology 2010;22(4):330-339. R832417 (Final)
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  • Journal Article Rava M, White RH, Dominici F. Does attainment status for the PM10 National Air Ambient Quality Standard change the trend in ambient levels of particulate matter? Air Quality, Atmosphere & Health 2011;4(2):133-143. R832417 (Final)
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  • Journal Article Rule AM, Geyh AS, Ramos-Bonilla JP, Mihalic JN, Margulies JD, Polyak LM, Kesavan J, Breysse PN. Design and characterization of a sequential cyclone system for the collection of bulk particulate matter. Journal of Environmental Monitoring 2010;12(10):1807-1814. R832417 (Final)
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  • Journal Article Samet JM. Air pollution risk estimates: Determinants of heterogeneity. Journal of Toxicology and Environmental Health-Part A-Current Issues 2008;71(9-10):578-582 R832417 (2008)
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    Journal Article Symons JM, Wang L, Guallar E, Howell E, Dominici F, Schwab M, Ange BA, Samet J, Ondov J, Harrison D, Geyh A. A case-crossover study of fine particulate matter air pollution and onset of congestive heart failure symptom exacerbation leading to hospitalization. American Journal of Epidemiology 2006;164(5):421-433. R832417 (Final)
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  • Journal Article Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwartz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. Journal of Toxicology and Environmental Health-Part A 2007;70(3-4):311-315. R832417 (Final)
    R832417C001 (2007)
    R832417C001 (2008)
    R832417C001 (2009)
    R832417C001 (Final)
    R830548 (Final)
    R831861 (2005)
  • Abstract from PubMed
  • Abstract: Taylor&Francis-Abstract
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  • Journal Article Venturini S, Dominici F, Parmigiani G. Gamma shape mixtures for heavy-tailed distributions. The Annals of Applied Statistics 2008;2(2):756-776. R832417 (2007)
  • Full-text: Project Euclid PDF
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  • Abstract: Project Euclid
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  • Journal Article Wang C, Parmigiani G, Dominici F. Bayesian effect estimation accounting for adjustment uncertainty. Biometrics 2012;68(3):661-671. R832417 (Final)
    R832416 (Final)
    R833622 (Final)
    R834798 (2012)
    R834798 (2013)
    R834798 (2014)
    R834798 (Final)
    R834798C005 (2012)
    R834798C005 (2013)
    R834798C005 (Final)
    R834894 (2012)
    R834894 (2013)
  • Abstract from PubMed
  • Full-text: ResearchGate-Full Text PDF
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  • Abstract: Wiley-Abstract
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  • Other: Harvard-Full Text PDF
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  • Journal Article Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JGN. Murine lung responses to ambient particulate matter:genomic analysis and influence on airway hyperresponsiveness. Environmental Health Perspectives 2008;116(11):1500-1508. R832417 (2008)
    R832417 (Final)
    R832417C003 (2008)
    R832417C003 (2009)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JGN. Particulate matter disrupts human lung endothelial barrier integrity via ROS-and p38 MAPK-dependent pathways. American Journal of Respiratory Cell and Molecular Biology 2010;42(4):442-449. R832417 (Final)
    R832417C003 (2009)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: AJRCMB-Full-Text HTML
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  • Abstract: AJRCMB-Abstract
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  • Other: AJRCMB-Full Text PDF
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  • Journal Article Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakarz NR, Garcia JGN. Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. American Journal of Respiratory Cell and Molecular Biology 2012;46(4):524-531. R832417 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ATS-Full Text HTML
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  • Other: ATS-Full Text PDF
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  • Journal Article Wang T, Wang L, Moreno-Vinasco L, Lang GD, Siegler JH, Mathew B, Usatyuk PV, Samet JM, Geyh AS, Breysse PN, Natarajan V, Garcia JGN. Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Particle and Fibre Toxicology 2012;9:35 (12 pp.). R832417 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: BMC-Full Text HTML
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  • Other: BMC-Full Text PDF
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  • Journal Article Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG. Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. American Journal of Respiratory Cell and Molecular Biology 2012;47(4):491-496. R832417 (Final)
    R832417C003 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: AJRCMB-Full Text HTML
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  • Abstract: AJRCMB-Abstract
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  • Other: AJRCMB-Full Text PDF
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  • Journal Article Welty LJ, Peng RD, Zeger SL, Dominici F. Bayesian distributed lag models: estimating effects of particulate matter air pollution on daily mortality. Biometrics 2009;65(1):282-291. R832417 (2008)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (Final)
  • Abstract from PubMed
  • Full-text: JohnsHopkins-Full Text PDF
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  • Abstract: Wiley-Abstract
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  • Journal Article Zeger SL, Dominici F, McDermott A, Samet JM. Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000–2005). Environmental Health Perspectives 2008;116(12):1614-1619. R832417 (2008)
    R832417 (2009)
    R832417 (Final)
    R832417C001 (2009)
    R832417C001 (Final)
    R833622 (2008)
    R833622 (2009)
    R833622 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: EHP-Full Text PDF
  • Abstract: EHP-Abstract & Full Text HTML
  • Journal Article Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T, Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JGN, Natarajan V. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 2009;40(1):19-30. R832417 (2008)
    R832417 (Final)
    R832417C003 (2008)
    R832417C003 (2009)
  • Abstract from PubMed
  • Full-text: AJRCMB-Full Text HTML
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  • Abstract: AJRCMB-Abstract
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  • Other: AJRCMB-Full Text PDF
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  • Journal Article Zhou Y, Dominici F, Louis TA. Racial disparities in risks of mortality in a sample of the US Medicare population. Journal of the Royal Statistical Society: Series C (Applied Statistics) 2010;59(2):319-339. R832417 (2007)
  • Abstract: Wiley Online-Abstract
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  • Other: Prepublication paper
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  • Journal Article Zigler CM, Dominici F, Wang Y. Estimating causal effects of air quality regulations using principal stratification for spatially correlated multivariate intermediate outcomes. Biostatistics 2012;13(2):289-302. R832417 (Final)
    R833622 (Final)
    R834798 (2012)
    R834798 (2013)
    R834798 (2014)
    R834798C005 (2012)
    R834798C005 (2013)
    R834894 (2012)
    R834894 (2013)
  • Full-text from PubMed
  • Abstract from PubMed
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  • Full-text: Oxford Journals-Full Text HTML
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-Full Text PDF
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  • Supplemental Keywords:

    PM Components, susceptible populations, human health risks, toxicological and genomic bioassays,, RFA, Health, Scientific Discipline, Air, particulate matter, Environmental Chemistry, Health Risk Assessment, Risk Assessments, atmospheric particulate matter, cardiopulmonary responses, chemical characteristics, epidemiology, human health effects, toxicology, lung epithelial cells, cardiovascular vulnerability, exposure, airborne particulate matter, pulmonary toxicity, particle exposure, biological mechanisms, endothelial function, pariculate matter, cardiopulmonary mechanisms, human exposure, particulate exposure, ambient particle health effects, ultrafine particulate matter, respiratory impact, PM, cardiotoxicity, particulate matter components, cardiovascular disease, human health risk

    Progress and Final Reports:

  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • Final Report
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R832417C001 Estimation of the Risks to Human Health of PM and PM Components
    R832417C002 PM Characterization and Exposure Assessment (Project 2)
    R832417C003 Biological Assessment of the Toxicity of PM and PM Components