Final Report: Columbia Center for Children's Environmental Health

EPA Grant Number: R832141
Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Columbia Center for Children's Environmental Health
Investigators: Perera, Frederica P. , Andrews, Howard F. , Barr, R. Graham , Chew, Ginger , Davidson, Leslie , Evans, David , Fullilove, Mindy , Garfinkel, Robin S. , Goldstein, Inge , Hatzis, Dimitrios , Kinney, Patrick L. , Lederman, Sally Ann , Matseoane, Stephen , Miller, Rachel L. , Orjuela, Manuela , Perzanowski, Matt , Rauh, Virginia , Rothman, Paul B. , Sheares, Beverley , Shepard, Peggy , Tang, Deliang , Tsai, Wei-Tann , Watkins, Beverly , Whyatt, Robin M. , Zivin, Joshua
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Amount: $4,435,198
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Health Effects , Human Health , Health

Objective:

The Center's three overall specific aims flow logically from prior achievements and address key policy questions. They have been developed with the Center's community partners to respond to community concerns.

Aim 1:  To determine the relationships between prenatal and/or postnatal exposures and health effects by:

  1. Assessing the effects of prenatal vs. postnatal exposures and their cumulative impacts on the risk of adverse developmental and respiratory health outcomes through elementary school age
  2. Evaluating the effects of combined exposures:  the impact of multiple pollutants, including additive vs. synergistic or antagonistic effects
  3. Determining the time course of impairment and disease:  determination of delayed vs. immediate effects of exposure, reversibility of effects, and early predictors of developmental disorders and asthma through school age
  4. Identifying the mechanisms by which prenatal exposures lead to antigen-specific sensitization and asthma

Aim 2:  To determine the modulation of risks by susceptibility factors, including:

  1. Psychosocial stressors due to social adversity, such as residence in low-quality housing, measured at the individual and community levels
  2. Genetic polymorphisms
  3. Antioxidant micronutrient status

Aim 3:  To translate research findings to prevention through:

  1. Community-based intervention with integrated pest management (IPM) and other strategies to make housing healthier
  2. Education of local residents, physicians, and policy makers to increase awareness of environmental health issues in their communities
  3. Community empowerment training to build the capacity of local individuals and organizations to advocate effectively for policy reforms and improved practices to reduce harmful community-wide exposures
  4. Translation of data through risk assessment and policy analysis

Conclusions:

Growth & Development Project:  Neurotoxic effects of prenatal exposure to CPF have been evaluated in 254 children through the first 3 years of life (Rauh, et al., 2006). A previous report showed widespread prenatal CPF exposure and significant adverse impacts on birth weight and birth length.

This project examined cognitive and motor development at 12, 24, and 36 months on the Bayley Scales of Infant Development as a function of CPF levels in umbilical cord plasma collected from newborns at delivery. Models were adjusted for race/ethnicity, sex, length of gestation, maternal education, maternal IQ, prenatal secondhand smoke exposure, and quality of the home environment. Using clinically defined cut-points for developmental delay, we found that children prenatally exposed to high CPF levels (greater than 6.17 picograms/gram [pg/g] plasma) were significantly more likely than children exposed to low levels of CPF to experience delay in both psychomotor (p=0.002) and cognitive (p=0.024) development at 36 months of age. In addition, highly exposed children were significantly more likely than less-exposed children to manifest attention problems (p=0.009), symptoms of attention deficit/hyperactivity disorder (ADHD; p=0.046), and symptoms of pervasive developmental problems (p=0.025) at 3 years of age, based on parental reports using the Child Behavior Checklist. Similarly, prenatal PAH exposure was associated with significantly lower mental development index (MDI) scores and delayed mental development at age 3 after adjusting for potential confounders (Perera, et al., 2006).

Asthma Project:  The frequency of sensitization to cockroach and dust mite is increasing substantially between ages 2-7 years. Allergic immune response to cockroach and mouse, allergens implicated in inner-city asthma, can occur by age 2 years. Respiratory symptoms and probable asthma are common. Airway obstruction was measured in 26% of 4-year-olds, 17% of 5-year-olds, and 36% of 6-year-olds. There was no difference in the patterns of lung function according to ethnicity.

Combined prenatal exposure to PAHs and postnatal exposure to environmental tobacco smoke was associated with respiratory symptoms and possible asthma at ages 1 and 2 (Miller, et al., 2004). Children born in the winter did not have increased levels of indoor allergen-induced cord blood mononuclear cell (CBMC) proliferation or Th cytokines. An association between winter birth and greater cockroach IL-5 production was seen (p=0.019), however. Higher prenatal levels of cockroach and mouse allergen were not associated with greater CBMC proliferation or Th cytokine production. A modest correlation was observed between mouse allergen and cord blood IgE levels (r=0.149; p=0.021).

Among those children who were sensitized to cockroach, a strong correlation between measured cockroach allergen levels in home dust and anti-cockroach IgE levels by age 2-3 years was present (bed dust:  Spearman’s Rho 0.762, p < 0.001). Children with wheeze had a higher average anti-cockroach and anti-mouse IgE than children without wheeze on Mann Whitney U analysis. Children with higher IgE to mouse were more likely to develop eczema and rhinitis than children with lower IgE class (test for trend p=0.002 for eczema, p=0.03 for rhinitis). Children with higher IgE class to cockroach were more likely to develop eczema, but not rhinitis, when compared to children with lower cockroach IgE class (test for trend p <0.001 for eczema, not significant for rhinitis).

Cat ownership was a significant risk factor for developing anti-cat IgE antibodies by age 2 (RR 6.4 [1.9-22]) but not for incidence of anti-cat IgE between ages 2 and 5 (RR 0.88 [0.24-2.3]). Wheeze was significantly more common among those children with anti-cat IgE at ages 3 (RR 3.5 [2.1-6.0]) and 5 (RR 3.4 [2.3-4.9]). Cat ownership was inversely associated with wheeze at age 5 among children without anti-cat IgE (RR 0.26 [0.083-0.81], p=0.007). Among children with anti-cat IgE a similar trend was observed (RR 0.57 [0.32-1.03], p=0.044), but the association was of borderline statistical significance. A significant association was found between a polymorphism in Glutathione-S-Transferase Theta 2-02 (GSTT2-02) and the development of wheeze or asthma by age 3 years in the Dominican children in the cohort from the first n=318 children analyzed.

Mechanistic Research Project:  In early studies, exposure of female mice to A. fumigatus led to a two-fold reduction in IgE production in the offspring (p=0.029). The effect appears to be more pronounced when examining the effects on the third generation offspring. Grandparental exposure to A. fumigatus both at high (1.25 mg; Figure 1) and medium (62.5 micrograms) doses resulted in repeatable reductions in IgE levels in the third generation mice. Effects on airway hyprreactivity are less consistent. The effects of prenatal exposure to diesel exhaust particles are less consistent. Prenatal exposure of female mice to A. fumigatus at 62.5 micrograms in combination with prenatal exposure to daily diesel induces variable immune responses in the offspring.

Experiments are being repeated to determine true effects in our model system. In additional experiments, we hypothesized that diesel exhaust particles (DEP) would induce hypermethylation of the IFNg promoter and hypomethylation of IL-4 in CD4+ T cells among mice sensitized to A. fumigatus. We also hypothesized that DEP-induced methylation changes would affect immunoglobulin (Ig) E regulation. Balb/c mice were exposed to a 3-week course of inhaled DEP exposure while undergoing intranasal sensitization to A. fumigatus. Purified DNA from splenic CD4+ cells underwent bisulfite treatment, PCR amplification, and pyrosequencing. Sera IgE levels were compared to methylation levels at several CpG sites in the IL-4 and IFNg promoter. Total IgE production was increased following intranasal sensitization to A. fumigatus. IgE production was augmented further following combined exposure to A. fumigatus and DEP exposure. Inhaled DEP exposure and intranasal A. fumigatus induced hypermethylation at CpG- 45, CpG-53, and CpG-205 sites of the IFNg promoter and hypomethylation at CpG-408 of the IL-4 promoter. Altered methylation of promoters of both genes was correlated with changes in IgE levels.

Community-Based Participatory Research (CBPR) Intervention Project:  All data collection for our baseline, 3- and 6-month, and long-term follow-up IPM evaluation at both sites is complete. We enrolled 324 apartments at baseline, 264 at 3-month follow-up, and 264 at 6-month follow-up, retaining 81% of participants. The final apartment was enrolled in Bushwick, Brooklyn, in Spring 2006. We collected follow-up data on 134 apartments. There were 65 apartments that were ineligible for follow-up due to an NYCHA error in scheduling the interventions. Multi-level modeling, controlling for baseline, buildings (as buildings were assigned to treatment and control), and senior- versus mixed-age buildings were used in the analyses of allergen and pest variables using SAS Proc Mixed. IPM apartments did better than control apartments in controlling cockroaches and mice according to every measure of effectiveness we assessed. There was a clearer impact on cockroaches than mice, and it was stronger at 3 months compared to 6 months.

IPM was significantly more successful than control apartments in reducing cockroach counts by 25%, 50%, and 75% at the 3-month follow-up (p<0.05; Evans, et al., in preparation). IPM apartments had, on average, between 6 and 24 fewer cockroaches trapped per week than control apartments, which had between 10 and 100 cockroaches trapped per week. We found statistically significant reductions in the cockroach allergen levels in the intervention (IPM) apartments compared to the control apartments (traditional pest control services of NYCHA) both in the kitchen (p=.05) and in the bedroom (p=.013) 6 months after the baseline. The reduction in kitchen cockroach allergen levels also was statistically significant at 3 months (p=.02); however, the bedroom cockroach allergens were not statistically significantly reduced. Cockroaches were detected in 77% of all apartments. Mice were found in only 13% of the apartments and therefore did not show a strong allergen reduction effect attributable to IPM treatment.

Summary of Progress from Cores

Exposure Assessment and Biomarker Core:  Personal air monitoring is being conducted over 48 hours during the 3rd trimester of pregnancy; samples have been analyzed for 702 women. 2 week integrated indoor air samples have been collected from a subset of the homes (n=337 samples from 102 homes) beginning during the 32nd week of gestation and continuing through delivery. The personal and indoor air samples have been analyzed for PAH and NPP. Simultaneous indoor/outdoor monitoring has also been completed on 103 homes at postnatal age 12 months.

PM filters have been analyzed for reflectance and transformed into absorption coefficients. Multiple dust samples have been collected from the homes during pregnancy (n=760), at child’s ages 12 (n=489), 36 (n=348), and at 60 months (n=289) and are being analyzed for allergens (cockroach, rodent, dust mite, dog and cat), endotoxins and mold. To date, dust samples from beds and kitchens have been analyzed for cockroach allergen (Bla g 2, n=2,981), mouse allergen (MUP, n=2,966), and dust mite allergen (Der f 1,n=1,586). The number of dust mite allergen analyses is lower because measurements are only made using bed samples (a location that has soft textile furnishings where dust mites can be found) and not kitchen samples.

The following biologic samples have been collected: maternal blood at delivery (n=720); umbilical cord blood (n=571); blood from the child at 24 months (n=405), 36 months (n=410), 60 months (n=324). 84 months (n=176) and 108 months (n=13). Meconium samples have been collected from a subset of the newborns at delivery (n=409). Urine samples have also been collected from the mother during pregnancy (n=734) and from the child at ages 3 (n=356), 5 (n=333), 7 (n=191) and 9 (n=13) years.

Biologic samples are analyzed for NPP, plasma cotinine, PAH-DNA adducts (mother (n=450) child (n=302)), lead, mercury, organochlorines, and antioxidants. We have measured a number of genes in 520 maternal blood samples and 373 blood samples collected from the newborn. We have also measured micronutrient levels in 404 maternal and 254 cord blood samples.

Between 1998-2006, we gathered information on pesticide use from 639 of the women; 87% reported using pest control during pregnancy and 46% reported using higher toxicity methods (cans sprays, sprays by exterminator and bombs). Pest problems and pesticide use increased significantly with the level of housing disrepair reported (p<0.01). As seen from Figure 1 above, there has been a significant increase over time in the use of the higher toxicity methods among women in the cohort. The organophosphates chlorpyrifos and diazinon and the carbamate propoxur were the insecticides detected most frequently: in 99% - 100% of personal (n=628) and indoor air samples (n=337) during pregnancy. There was little within-home variability and no significant difference in indoor air concentrations within homes over time (p< 0.2); between home variability accounted for 88% of the variance in the indoor air levels of propoxur, 92% in chlorpyrifos, 94% in diazinon (p<0.001). Indoor and maternal personal air insecticide levels were highly correlated (r=0.7-0.9, p<0.001).

Chlorpyrifos and diazinon exposures decreased significantly following the U.S. Environmental Protection Agency 2001-02 ban on their residential use. Detection frequencies of piperonyl butoxide (PBO, a synergist added to many pyrethroid formulations) and cis- and trans- permethrin in personal air samples increased over time from 2001- 05; the increase was significant for cis-permethrin (p<0.01, Chi-squared test), suggesting that the pyrethroids insecticides may be replacing the organophosphates for residential use in this cohort. Levels of PBO were significantly higher among mothers reporting use of high toxicity pesticides (ANCOVA, p<0.01). We have recently initiated a survey in collaboration with our lead community partner, WE ACT, to determine which pesticide products are currently being sold in stores in these inner-city communities.

Eight PAHs have been measured in 702 personal air samples collected from the mother during pregnancy; levels averaged 3.4±6.6 ng/m3. We are developing a land-use regression model to estimate concentrations of traffic-related fine particulate matter and absorbance, a surrogate for diesel exhaust particles, using various land-use and traffic-related predictors. Between October 1999 and March 2006, two 48-hour PM2.5 measurements were made at 103 home locations at the child’s age 12 months. PM filters were subsequently analyzed for reflectance and transformed into absorption coefficients. PM2.5 concentrations ranged from 0.47-160.23μg/m3, averaging 22.31 μg/m3, with corresponding absorption coefficients ranging from 0-9.47 m-1x10-5 and averaging 1.36 m-1x10-5.

Variables describing each sampling site, including road area, number of intersections and bus stops within various distance buffers, average building height on block, distances to nearest intersection, nearest trucking route and nearest body of water, average daily traffic, sampling height, as well as central site data and meteorological measures are being generated in a Geographic Information System and tested for predictability. Between May 2003 and October 2004, we analyzed Aspergillus/Penicillium extracellular polysaccharide (Asp/Pen EPS) in a total of 310 mother’s bed dust samples (230 prenatal and 80 12-month samples). There was a significant correlation between Asp/Pen EPS and Cockroach (Bla g 2) in the dust both at the prenatal (n=75, r=0.39, p<0.001) and 12 months (n=52, r=0.37, p=0.021) sampling times. A significant correlation between Asp/Pen EPS and MUP in the dust was found at the prenatal (n=70, r=0.31, p=0.009) but not at 12 months (n=40, r=0.18, p=0.26) sampling time.

Community Outreach, Translation, and Application Core (COTAC):

Study Newsletters: CCCEH remains a leader in the field of communicating results of its research to lowliterate, bilingual, and/or immigrant adults. COTAC developed useful items for families in the Mothers & Newborns Study that reinforced one health message from each newsletter. The first item was a refrigerator magnet that gives ten tips for safely cleaning up a small mercury spill. The second item was a writing notepad for grocery items that lists the safest fish for pregnant and breastfeeding women to eat. The current item being developed is a tool-kit that will reinforce the key message for Integrated Pest Management for the women in the study.

Broad Community Medical Education Initiative: CCCEH effectively shares its children’s environmental health research findings with the public. COTAC is currently developing educational posters to be displayed in free clinics, OB/GYN, pediatrician, and family doctor’s offices, as well as to community and service organizations working with parents, other caregivers, and families throughout Northern Harlem and the South Bronx. The posters repackage content from the newsletters with an emphasis on descriptive graphics for a low- literate audience. COTAC will be continuing this work over the next year, developing posters that coincide with the Healthy Home, Healthy Child newsletters.

Program Evaluation: COTAC has begun testing the quality and effectiveness of the community education materials with the Mothers & Newborns Study cohort. Dissemination: As the Center generates additional research findings, COTAC has continued to share new results through regular mailings of key scientific papers to local physicians, public interest groups, and community organizations working with parents, other caregivers of young children, youth, and families. Investigators also continue to present their latest research results and findings in the field of children’s environmental health at Grand Rounds for OB/GYN and pediatric residents.

Community Trainings on Housing and Health: CCCEH’s lead community partner, WE ACT for Environmental Justice, informs the broad local community about children’s environmental health and the Center’s work by speaking regularly at community board meetings, borough presidents’ cabinet meetings, and neighborhood health fairs. Recently, members of the Healthy Homes Street Team have been involved in a survey with CCCEH to determine the availability of harmful pesticides in Harlem, Washington Heights, Inwood and South Bronx..

Policy Initiatives: Members of CCCEH initiated a collaboration with Project THRIVE, a non-profit organization that is part of the National Center for Children in Poverty and is dedicated to the translation of research into effective policies to improve child health.

Data Management, Statistics, and Community Modeling Core (DSM): The Data Management, Statistics, and Community Modeling (DSM) Core has supported all the Center’s scientific projects by ensuring the highest quality of stored cohort research information, and facilitating the availability of cohort data for statistical analysis and translational activities. Over the past five years, the DSM Core has maintained a comprehensive quality assurance program; established and ensured adherence to standardized protocols for electronic data submission from participating projects and laboratories; used SIR/XS relational database management software to create a self-documenting central database capable of producing analytic-ready statistical files with appropriate content, format and internal documentation for statistical analysis; established mechanisms for coordinating all project publication efforts and publication review; and provided the Center with expertise in statistical analysis and community modeling. Working in collaboration with partners WE ACT and the Institute for Social and Economic Research and Policy (ISERP), the DSM core members continue to build the GIS infrastructure for mapping and spatial analysis of data. By pooling resources that would otherwise be used for data entry and data management by individual projects, the DSM Core has enhanced available expertise, training, and specialization, increased the continuity of experienced data entry and programming staff, and maintained cost efficiencies.

Administrative Core:  The Core Director is Frederica P. Perera, DrPH, (Professor, Department of Environmental Sciences) who is also the Director of the CCCEH.  The Administrative Core has provided overall coordination and guidance for all administrative and financial aspects of the Center. This includes facilitating regular and ad hoc internal and external communications. This Core set in motion interactions with the Community Advisory Board and the Scientific Advisory Board, which also helps to monitor and ensure that the CCCEH is progressing appropriately towards its goals.  Core staff scheduled, attended and led monthly Executive Committee meetings, weekly meetings of project leaders, Advisory Board meetings, and supervised Center administrative and financial activities.  Members of this Core also collaborated with the COTC staff in translating and disseminating research findings for best clinical practices to physicians, health educators, community practice settings, and community groups.  The responsibilities of the Core have also included administering the prospective cohort study of women and infants, assisting with progress reports, grant proposals, IRB applications, and general correspondence, overseeing  personnel,  planning  meetings  and   events,   and   preparing  manuscripts  for publication.  Staff also regularly reported financial progress to the Center director and project leaders, and funding agencies, and tracked and overseen all spending, ensuring compliance with funder and university regulations and policies.  The Administrative Core’s modus operandi during the past 10 years has resulted in synergestic productivity, and effective problem solving.

 


Journal Articles: 139 Displayed | Download in RIS Format

Other center views: All 154 publications 142 publications in selected types All 139 journal articles
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Journal Article Adibi JJ, Perera FP, Jedrychowski W, Camaan DE, Barr D, Jacek R, Whyatt RM. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environmental Health Perspectives 2003;111(14):1719-1722. R832141 (2005)
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  • Journal Article Adibi JJ, Hauser R, Williams PL, Whyatt RM, Calafat AM, Nelson H, Herrick R, Swan SH. Maternal urinary metabolites of di-(2-ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. American Journal of Epidemology 2009;169(8):1015-1024. R832141 (Final)
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  • Journal Article Adibi JJ, Hauser R, Williams PL, Whyatt RM, Thaker HM, Nelson H, Herrick R, Bhat HK. Placental biomarkers of phthalate effects on mRNA transcription: application in epidemiologic research. Environmental Health 2009;8:20 (11 pp.). R832141 (Final)
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  • Journal Article Adibi JJ, Whyatt RM, Hauser R, Bhat HK, Davis BJ, Calafat AM, Hoepner LA, Perera FP, Tang D, Williams PL. Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure. Environmental Health Perspectives 2010;118(2):291-296. R832141 (2007)
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  • Journal Article Arbuckle TE, Hauser R, Swan SH, Mao CS, Longnecker MP, Main KM, Whyatt RM, Mendola P, Legrand M, Rovet J, Till C, Wade M, Jarrell J, Matthews S, Van Vliet G, Bornehag C-G, Mieusset R. Meeting report:measuring endocrine-sensitive endpoints within the first years of life. Environmental Health Perspectives 2008;116(7):948-951. R832141 (Final)
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  • Journal Article Bocskay KA, Tang D, Orjuela MA, Liu X, Warburton DP, Perera FP. Chromosomal aberrations in cord blood are associated with prenatal exposure to carcinogenic polycyclic aromatic hydrocarbons. Cancer Epidemiology, Biomarkers & Prevention 2005;14(2):506-511. R832141 (2006)
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  • Journal Article Bocskay KA, Orjuela MA, Tang D, Liu X, Warburton D, Perera FP. Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement. Environmental and Molecular Mutagenesis 2007;48(2):114-123. R832141 (2007)
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  • Journal Article Bradman A, Whyatt RM. Characterizing exposures to nonpersistent pesticides during pregnancy and early childhood in the National Children's Study: a review of monitoring and measurement methodologies. Environmental Health Perspectives 2005;113(8):1092-1099. R832141 (2006)
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  • Journal Article Carlton EJ, Moats HL, Feinberg M, Shepard P, Garfinkel R, Whyatt R, Evans D. Pesticide sales in low-income, minority neighborhoods. Journal of Community Health 2004;29(3):231-244. R832141 (2005)
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  • Journal Article Chang C, Gauvey-Kern K, Johnson A, Kelvin EA, Chew GL, Perera F, Miller RL. Cord blood versus age 5 mononuclear cell proliferation on IgE and asthma. Clinical and Molecular Allergy 2010;8:11. R832141 (Final)
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  • Journal Article Chew GL, Perzanowski MS, Miller RL, Correa JC, Hoepner LA, Jusino CM, Becker MG, Kinney PL. Distribution and determinants of mouse allergen exposure in low-income New York City apartments. Environmental Health Perspectives 2003;111(10):1348-1351. R832141 (2005)
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  • Journal Article Chew GL, Carlton EJ, Kass D, Hernandez M, Clarke B, Tiven J, Garfinkel R, Nagle S, Evans D. Determinants of cockroach and mouse exposure and associations with asthma in families and elderly individuals living in New York City public housing. Annals of Allergy, Asthma & Immunology 2006;97(4):502-513. R832141 (2007)
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  • Journal Article Choi H, Jedrychowski W, Spengler J, Camann DE, Whyatt RM, Rauh V, Tsai WY, Perera FP. International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth. Environmental Health Perspectives 2006;114(11):1744-1750. R832141 (2006)
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  • Journal Article Choi H, Rauh V, Garfinkel R, Tu Y, Perera FP. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction. Environmental Health Perspectives 2008;116(5):658-665. R832141 (2007)
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  • Journal Article Choi H, Perera F, Pac A, Wang L, Flak E, Mroz E, Jacek R, Chai-Onn T, Jedrychowski W, Masters E, Camann D, Spengler J. Estimating individual-level exposure to airborne polycyclic aromatic hydrocarbons throughout the gestational period based on personal, indoor, and outdoor monitoring. Environmental Health Perspectives 2008;116(11):1509-1518. R832141 (2007)
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  • Journal Article Choi H, Perera FP. Sources of greater fetal vulnerability to airborne polycyclic aromatic hydrocarbons among African Americans. Journal of Epidemiology and Community Health 2012;66(2):121-126. R832141 (Final)
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  • Journal Article Chow JC, Watson JG, Chen L-WA, Ho SSH, Koracin D, Zielinska B, Tang D, Perera F, Cao J, Lee SC. Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological study. Journal of Environmental Science and Health Part A, Toxic/Hazardous Substances and Environmental Engineering 2006;41(4):517-542. R832141 (2007)
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  • Journal Article Chung EK, Miller RL, Wilson MT, McGeady SJ, Culhane JF. Antenatal risk factors, cytokines and the development of atopic disease in early childhood. Archives of Disease in Childhood. Fetal and Neonatal Edition 2007;92(1):F68-F73. R832141 (Final)
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  • Journal Article Corson L, Zhu H, Quan C, Grunig G, Ballaney M, Jin X, Perera FP, Factor PH, Chen L-C, Miller RL. Prenatal allergen and diesel exhaust exposure and their effects on allergy in adult offspring mice. Allergy, Asthma and Clinical Immunology 2010;6(1):7. R832141 (2007)
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  • Journal Article Dietrich KN, Eskenazi B, Schantz S, Yolton K, Rauh VA, Johnson CB, Alkon A, Canfield RL, Pessah IN, Berman RF. Principles and practices of neurodevelopmental assessment in children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1437-1446. R832141 (2006)
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  • Journal Article Donohue KM, Al-alem U, Perzanowski MS, Chew GL, Johnson A, Divjan A, Kelvin EA, Hoepner LA, Perera FP, Miller RL. Anti-cockroach and anti-mouse IgE are associated with early wheeze and atopy in an inner-city birth cohort. Journal of Allergy and Clinical Immunology 2008;122(5):914-920. R832141 (2007)
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  • Journal Article Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. R832141 (2006)
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  • Journal Article Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. R832141 (2005)
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  • Journal Article Fenske RA, Bradman A, Whyatt RM, Wolff MS, Barr DB. Lessons learned for the assessment of children's pesticide exposure: critical sampling and analytical issues for future studies. Environmental Health Perspectives 2005;113(10):1455-1462. R832141 (2006)
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  • Journal Article Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. R832141 (2006)
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    R832139 (2006)
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  • Journal Article Goldstein IF, Perzanowski MS, Lendor C, Garfinkel RS, Hoepner LA, Chew GL, Perera FP, Miller RL. Prevalence of allergy symptoms and total IgE in a New York City cohort and their association with birth order. International Archives of Allergy and Immunology 2005;137(3):249-257. R832141 (2006)
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  • Journal Article Green L, Fullilove M, Evans D, Shepard P. “Hey, Mom, thanks!”: use of focus groups in the development of place-specific materials for a community environmental action campaign. Environmental Health Perspectives 2002;110(Suppl 2):265-269. R832141 (2007)
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  • Journal Article Herbstman JB, Sjodin A, Kurzon M, Lederman SA, Jones RS, Rauh V, Needham LL, Tang D, Niedzwiecki M, Wang RY, Perera F. Prenatal exposure to PBDEs and neurodevelopment. Environmental Health Perspectives 2010;118(5):712-719. R832141 (2007)
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  • Journal Article Jedrychowksi W, Galas A, Pac A, Flak E, Camman D, Rauh V, Perera F. Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. European Journal of Epidemiology 2005;20(9):775-782. R832141 (2005)
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  • Journal Article Jedrychowski WA, Perera FP, Pac A, Jacek R, Whyatt RM, Spengler JD, Dumyahn TS, Sochacka-Tatara E. Variability of total exposure to PM2.5 related to indoor and outdoor pollution sources: Krakow study in pregnant women. Science of the Total Environment 2006;366(1):47-54. R832141 (2005)
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  • Journal Article Jedrychowski W, Whyatt RM, Camann DE, Bawle UV, Peki K, Spengler JD, Dumyahn TS, Penar A, and Perera FP. Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data. International Journal of Occupational Medicine and Environmental Health 2003;16(1):21-29. R832141 (2005)
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  • Journal Article Jedrychowski W, Bendkowska I, Flak E, Penar A, Jacek R, Kaim I, Spengler JD, Camann D, Perera FP. Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environmental Health Perspectives 2004;112(14):1398-1402. R832141 (2005)
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  • Journal Article Jedrychowski W, Whyatt RM, Perera FP, Flak E, Pabian W, Kaim I, Mroz E. Dose response relationship between maternal involuntary tobacco smoking and various birth outcomes. Central European Journal of Occupational and Environmental Medicine 2004;10(4):283-294. R832141 (2005)
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  • Journal Article Jedrychowski W, Jankowski J, Flak E, Skarupa A, Mroz E, Sochacka-Tatara E, Lisowska-Miszczyk I, Szpanowska-Wohn A, Rauh V, Skolicki Z, Kaim I, Perera FP. Effects of prenatal exposure to mercury on cognitive and psychomotor function in one-year-old infants: epidemiologic cohort study in Poland. Annals of Epidemiology 2006;16(6):439-447. R832141 (2005)
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  • Journal Article Jedrychowski W, Flak E, Mroz E, Rauh V, Caldwell K, Jones R, Skolicki Z, Kaim I, Perera F. Exposure to environmental tobacco smoke in pregnancy and lead level in maternal blood at delivery. International Journal of Occupational Medicine and Environmental Health 2006;19(4):205-210. R832141 (2007)
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  • Journal Article Jedrychowski W, Galas A, Whyatt R, Perera F. The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study. International Journal of Occupational Medicine and Environmental Health 2006;19(1):70-76. R832141 (2007)
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  • Journal Article Jedrychowski W, Maugeri U, Zembala M, Perzanowski MS, Hajto B, Flak E, Mroz E, Jacek R, Sowa A, Perera FP. Risk of wheezing associated with house-dust mite allergens and indoor air quality among three-year-old children. Krakow inner city study. International Journal of Occupational Medicine and Environmental Health 2007;20(2):117-126. R832141 (2007)
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  • Journal Article Jedrychowski W, Masters E, Choi H, Sochacka E, Flak E, Mroz E, Pac A, Jacek R, Kaim I, Skolicki Z, Spengler JD, Perera F. Pre-pregnancy dietary vitamin A intake may alleviate the adverse birth outcomes associated with prenatal pollutant exposure:epidemiologic cohort study in Poland. International Journal of Occupational and Environmental Health 2007;13(2):175-180. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Jankowski J, Rauh V, Flak E, Caldwell KL, Jones RL, Pac A, Lisowska-Miszczyk I. Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life:Krakow epidemiologic study. Environment International 2007;33(8):1057-1062. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Rauh V, Flak E, Mroz E, Pac A, Skolicki Z, Kaim I. Fish intake during pregnancy and mercury level in cord and maternal blood at delivery: an environmental study in Poland. International Journal of Occupational Medicine and Environmental Health 2007;20(1):31-37. R832141 (2007)
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  • Journal Article Jedrychowski W, Pac A, Choi H, Jacek R, Sochacka-Tatara E, Dumyahn TS, Spengler JD, Camann DE, Perera FP. Personal exposure to fine particles and benzo[a]pyrene. Relation with indoor and outdoor concentrations of these pollutants in Krakow. International Journal of Occupational Medicine and Environmental Health 2007;20(4):339-348. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Jankowski J, Rauh V, Flak E, Caldwell KL, Jones RL, Pac A, Lisowska-Miszczyk I. Prenatal low-level lead exposure and developmental delay of infants at age 6 months (Krakow inner city study). International Journal of Hygiene and Environmental Health 2008;211(3-4):345-351. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Mroz E, Edwards S, Flak E, Rauh V, Pac A, D. Budzyn-Mrozek, Musial A. Prenatal exposure to passive smoking and duration of breastfeeding in nonsmoking women: Krakow inner city prospective cohort study. Archives of Gynecology and Obstetrics 2008;278(5):411-417. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera FP, Maugeri U, Mroz E, Flak E, Mrozek-Budzyn D, Edwards S, Musial A. Length at birth and effect of prenatal and postnatal factors on early wheezing phenotypes. Krakow epidemiologic cohort study. International Journal of Occupational Medicine and Environmental Health 2008;21(2):111-119. R832141 (2007)
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  • Journal Article Jedrychowski W, Flak E, Mroz E, Pac A, Jacek R, Sochacka-Tatara E, Spengler J, Rauh V, Perera F. Modulating effects of maternal fish consumption on the occurrence of respiratory symptoms in early infancy attributed to prenatal exposure to fine particles. Annals of Nutrition and Metabolism 2008;52(1):8-16. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera FP, Jankowski J, Mrozek-Budzyn D, Mroz E, Flak E, Edwards S, Skarupa A, Lisowska-Miszczyk I. Very low prenatal exposure to lead and mental development of children in infancy and early childhood: Krakow prospective cohort study. Neuroepidemiology 2009;32(4):270-278. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera FP, Maugeri U, Mrozek-Budzyn D, Mroz E, Flak E, Edwards S, Spengler JD, Jacek R, Sowa A, Musial A. Early wheezing phenotypes and severity of respiratory illness in very early childhood: study on intrauterine exposure to fine particle matter. Environment International 2009;35(6):877-884. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Jankowski J, Mrozek-Budzyn D, Mroz E, Flak E, Edwards S, Skarupa A, Lisowska-Miszczyk I. Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: the prospective cohort study in three-year olds. Early Human Development 2009;85(8):503-510. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Mroz E, Edwards S, Flak E, Bernert JT, Mrozek-Budzyn D, Sowa A, Musial A. Fetal exposure to secondhand tobacco smoke assessed by maternal self-reports and cord blood cotinine: prospective cohort study in Krakow. Maternal and Child Health Journal 2009;13(3):415-423. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Mrozek-Budzyn D, Mroz E, Flak E, Spengler JD, Edwards S, Jacek R, Kaim I, Skolicki Z. Gender differences in fetal growth of newborns exposed prenatally to airborne fine particulate matter. Environmental Research 2009;109(4):447-456. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera FP, Jankowski J, Maugeri U, Mrozek-Budzyn D, Mroz E, Flak E, Skarupa A, Edwards S, Lisowska-Miszczyk I. Early wheezing phenotypes and cognitive development of 3-yr-olds. Community-recruited birth cohort study. Pediatric Allergy and Immunology 2010;21(3):550-556. R832141 (2007)
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  • Journal Article Jedrychowski WA., Perera FP, Maugeri U, Mroz E, Klimaszewska-Rembiasz M, Flak E, Edwards S, Spengler JD. Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers. Paediatric and Perinatal Epidemiology 2010;24(5):492-501. R832141 (2007)
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  • Journal Article Jedrychowski W, Perera F, Mrozek-Budzyn D, Flak E, Mroz E, Sochacka-Tatara E, Jacek R, Kaim I, Skolicki Z, Spengler JD. Higher fish consumption in pregnancy may confer protection against the harmful effect of prenatal exposure to fine particulate matter. Annals of Nutrition and Metabolism 2010;56(2):119-126. R832141 (2007)
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  • Journal Article Jung KH, Yan B, Chillrud SN, Perera FP, Whyatt R, Camann D, Kinney PL, Miller RL. Assessment of benzo(a)pyrene-equivalent carcinogenicity and mutagenicity of residential indoor versus outdoor polycyclic aromatic hydrocarbons exposing young children in New York City. International Journal of Environmental Research and Public Health 2010;7(5):1889-1900. R832141 (2007)
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  • Journal Article Jung KH, Patel MM, Moors K, Kinney PL, Chillrud SN, Whyatt R, Hoepner L, Garfinkel R, Yan B, Ross J, Camann D, Perera FP, Miller RL. Effects of heating season on residential indoor and outdoor polycyclic aromatic hydrocarbons, black carbon, and particulate matter in an urban birth cohort. Atmospheric Environment 2010;44(36):4545-4552. R832141 (Final)
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  • Journal Article Kass D, McKelvey W, Carlton E, Hernandez M, Chew G, Nagle S, Garfinkel R, Clarke B, Tiven J, Espino C, Evans D. Effectiveness of an integrated pest management intervention in controlling cockroaches, mice, and allergens in New York City public housing. Environmental Health Perspectives 2009;117(8):1219-1225. R832141 (2007)
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  • Journal Article Kelvin EA, Edwards S, Jedrychowski W, Schleicher RL, Camann D, Tang D, Perera FP. Modulation of the effect of prenatal PAH exposure on PAH-DNA adducts in cord blood by plasma antioxidants. Cancer Epidemiology, Biomarkers and Prevention 2009;18(8):2262-2268. R832141 (2007)
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  • Journal Article Landrigan PJ, Lioy PJ, Thurston G, Berkowitz G, Chen LC, Chillrud SN, Gavett SH, Georgopoulos PG, Geyh AS, Levin S, Perera F, Rappaport SM, Small C, NIEHS World Trade Center Working Group. Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 2004;112(6):731-739. R832141 (2005)
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  • Journal Article Landrigan PJ, Trasande L, Thorpe LE, Gwynn C, Lioy PJ, D'Alton ME, Lipkind HS, Swanson J, Wadhwa PD, Clark EB, Rauh VA, Perera FP, Susser E. The National Children's Study:a 21-year prospective study of 100,000 American children. Pediatrics 2006;118(5):2173-2186. R832141 (2007)
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  • Journal Article Lederman SA, Rauh VA, Weiss L, Stein JL, Hoepner LA, Becker M, Perera FP. The effects of the World Trade Center event on birth outcomes among term deliveries at three lower Manhattan hospitals. Environmental Health Perspectives 2004;112(17):1772-1778. R832141 (2005)
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  • Journal Article Lederman SA, Becker M, Sheets S, Stein J, Tang D, Weiss L, Perera FP. Modeling exposure to air pollution from the WTC disaster based on reports of perceived air pollution. Risk Analysis 2008;28(2):287-301. R832141 (2007)
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  • Journal Article Lederman SA, Jones RL, Caldwell KL, Rauh V, Sheets SE, Tang D, Viswanathan S, Becker M, Stein JL, Wang RY, Perera FP. Relation between cord blood mercury levels and early child development in a World Trade Center cohort. Environmental Health Perspectives 2008;116(8):1085-1091. R832141 (2007)
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  • Journal Article Lendor C, Johnson A, Perzanowski M, Chew GL, Goldstein IF, Kelvin E, Perera F, Miller RL. Effects of winter birth season and prenatal cockroach and mouse allergen exposure on indoor allergen-specific cord blood mononuclear cell proliferation and cytokine production. Annals of Allergy, Asthma and Immunology 2008;101(2):193-199. R832141 (2007)
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  • Journal Article Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, Chen LC, Miller RL. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicological Sciences 2008;102(1):76-81. R832141 (2007)
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  • Journal Article Lovasi GS, Quinn JW, Rauh VA, Perera FP, Andrews HF, Garfinkel R, Hoepner L, Whyatt R, Rundle A. Chlorpyrifos exposure and urban residential environment characteristics as determinants of early childhood neurodevelopment. American Journal of Public Health 2011;101(1):63-70. R832141 (Final)
    R834509 (2011)
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  • Journal Article Masters ET, Jedrychowski W, Schleicher RL, Tsai W-Y, Tu Y-H, Camann D, Tang D, Perera FP. Relation between prenatal lipid-soluble micronutrient status, environmental pollutant exposure, and birth outcomes. American Journal of Clinical Nutrition 2007;86(4):1139-1145. R832141 (2007)
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  • Journal Article Mense SM, Sengupta A, Lan C, Zhou M, Bentsman G, Volsky DJ, Whyatt RM, Perera FP, Zhang L. The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicological Sciences 2006;93(1):125-135. R832141 (2006)
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  • Journal Article Meyer IH, Whyatt RM, Perera FP, Ford JG. Risk for asthma in 1-year-old infants residing in New York City high-risk neighborhoods. Journal of Asthma 2003;40(5):545-550. R832141 (2005)
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  • Journal Article Miller RL, Garfinkel R, Horton M, Camann D, Perera FP, Whyatt RM, Kinney PL. Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Chest 2004;126(4):1071-1078. R832141 (2006)
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    R832141C002 (2004)
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  • Journal Article Miller RL, Ho S-M. Environmental epigenetics and asthma:current concepts and call for studies. American Journal of Respiratory and Critical Care Medicine 2008;177(6):567-573. R832141 (Final)
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  • Journal Article Miller RL. Prenatal maternal diet affects asthma risk in offspring. Journal of Clinical Investigation 2008;118(10):3265-3268. R832141 (Final)
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  • Journal Article Miller RL, Ho S-M. Epigenetic studies should focus on specific cell types. American Journal of Respiratory and Critical Care Medicine 2008;178(8):883. R832141 (Final)
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  • Journal Article Miller RL, Garfinkel R, Lendor C, Hoepner L, Li Z, Romanoff L, Sjodin A, Needham L, Perera FP, Whyatt RM. Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort. Pediatric Allergy and Immunology 2010;21(2 Pt 1):260-267. R832141 (2007)
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  • Journal Article Miller T, Rauh VA, Glied SA, Hattis D, Rundle A, Andrews H, Perera F. The economic impact of early life environmental tobacco smoke exposure: early intervention for developmental delay. Environmental Health Perspectives 2006;114(10):1585-1588. R832141 (2006)
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  • Journal Article Millman A, Tang D, Perera FP. Air pollution threatens the health of children in China. Pediatrics 2008;122(3):620-628. R832141 (2007)
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  • Journal Article Mooney LA, Madsen AM, Tang D, Orjuela MA, Tsai W-Y, Garduno ER, Perera FP. Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. Cancer Epidemiology, Biomarkers & Prevention 2005;14(1):237-242. R832141 (2005)
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  • Journal Article Narvaez RF, Hoepner L, Chillrud SN, Yan B, Garfinkel R, Whyatt R, Camann D, Perera FP, Kinney PL, Miller RL. Spatial and temporal trends of polycyclic aromatic hydrocarbons and other traffic-related airborne pollutants in New York City. Environmental Science & Technology 2008;42(19):7330-7335. R832141 (2007)
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  • Journal Article Narvaez R, Moors K, Miller RL, Ramirez M. Risks in using nonrigorous Spanish translations of asthma questionnaires. Chest 2007;131(4):1271-1272. R832141 (2007)
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  • Journal Article Needham LL, Ozkaynak H, Whyatt RM, Barr DB, Wang RY, Naeher L, Akland G, Bahadori T, Bradman A, Fortmann R, Liu L-JS, Morandi M, O'Rourke MK, Thomas K, Quackenboss J, Ryan PB, Zartarian V. Exposure assessment in the National Children's Study: Introduction. Environmental Health Perspectives 2005;113(8):1076-1082. R832141 (2006)
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  • Journal Article Ozkaynak H, Whyatt R, Needham LL, Akland G, Quackenboss J. Exposure assessment implications for the design and implementation of the National Children's Study. Environmental Health Perspectives 2005;113(8):1108-1115. R832141 (2005)
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  • Journal Article Patel MM, Miller RL. Air pollution and childhood asthma:recent advances and future directions. Current Opinion in Pediatrics 2009;21(2):235-242. R832141 (Final)
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  • Journal Article Patel MM, Hoepner L, Garfinkel R, Chillrud S, Reyes A, Quinn JW, Perera F, Miller RL. Ambient metals, elemental carbon, and wheeze and cough in New York City children through 24 months of age. American Journal of Respiratory and Critical Care Medicine 2009;180(11):1107-1113. R832141 (2007)
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  • Journal Article Perera FP, Rauh V, Tsai W-Y, Kinney P, Camann D, Barr D, Bernert T, Garfinkel R, Tu Y-H, Diaz D, Dietrich J, Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environmental Health Perspectives 2003;111(2):201-205. R832141 (2005)
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  • Journal Article Perera FP, Rauh V, Whyatt RM, Tsai W-Y, Bernert JT, Tu Y-H, Andrews H, Ramirez J, Qu L, Tang D. Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population. Environmental Health Perspectives 2004;112(5):626-630. R832141 (2005)
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  • Journal Article Perera FP, Tang D, Tu Y-H, Cruz LA, Borjas M, Bernert T, Whyatt RM. Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. Environmental Health Perspectives 2004;112(10):1133-1136. R832141 (2007)
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  • Journal Article Perera FP, Rauh V, Whyatt RM, Tang D, Tsai WY, Bernert JT, Tu YH, Andrews H, Barr DB, Camann DE, Diaz D, Dietrich J, Reyes A, Kinney PL. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures. NeuroToxicology 2005;26(4):573-587. R832141 (2006)
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  • Journal Article Perera FP, Tang D, Rauh VA, Lester K, Tsai WY, Tu YH, Weiss L, Hoepner L, King J, Del Priore G, Lederman SA. Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth. Environmental Health Perspectives 2005;113(8):1062-1067. R832141 (2005)
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  • Journal Article Perera FP, Rauh V, Whyatt RM, Tsai W-Y, Tang D, Diaz D, Hoepner L, Barr D, Tu Y-H, Camann D, Kinney P. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environmental Health Perspectives 2006;114(8):1287-1292. R832141 (2006)
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  • Journal Article Perera FP, Tang D, Brandt-Rauf P, Santella RM, Mooney LVA, Tu Y-H, Bendkowska I, Bell DA. Lack of associations between cancer and albumin adducts, ras p21 oncoprotein levels, and CYP1A1, CYP2D6, NAT1, and NAT2 in a nested case-control study of lung cancer within the Physicians' Health Study. Cancer Epidemiology, Biomarkers and Prevention 2006;15(7):1417-1419. R832141 (2007)
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  • Journal Article Perera FP, Tang D, Rauh V, Tu YH, Tsai WY, Becker M, Stein JL, King J, Del Priore G, Lederman SA. Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center cohort. Environmental Health Perspectives 2007;115(10):1497-1502. R832141 (2007)
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  • Journal Article Perera FP. Children are likely to suffer most from our fossil fuel addiction. Environmental Health Perspectives 2008;116(8):987-990. R832141 (2007)
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  • Journal Article Perera FP, Herbstman JB. Emerging technology in molecular epidemiology:what epidemiologists need to know. Epidemiology 2008;19(2):350-352. R832141 (2007)
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  • Journal Article Perera FP, Li Z, Whyatt R, Hoepner L, Wang S, Camann D, Rauh V. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 2009;124(2):e195-e202. R832141 (Final)
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  • Journal Article Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu YZ, Santella R, Albertini R, O'Neill JP. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiology Biomarkers & Prevention 2002;11(10 Pt 1):1134-1137. R832141 (2007)
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  • Journal Article Perera F, Rundle A. Correspondence re:Gammon et al, Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. 11, 677-685, 2002. Cancer Epidemiology, Biomarkers and Prevention 2003;12(1):75. R832141 (2007)
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  • Journal Article Perera F, Tang D, Whyatt R, Lederman SA, Jedrychowski W. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center area, Poland, and China. Cancer Epidemiology, Biomarkers & Prevention 2005;14(3):709-714. R832141 (2006)
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  • Journal Article Perera F, Viswanathan S, Whyatt R, Tang D, Miller RL, Rauh V. Children's environmental health research–highlights from the Columbia Center for Children's Environmental Health. Annals of the New York Academy of Science 2006;1076:15-28. R832141 (2007)
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  • Journal Article Perera F, Li T-Y, Zhou Z-J, Yuan T, Chen Y-H, Qu L, Rauh VA, Zhang Y, Tang D. Benefits of reducing prenatal exposure to coal-burning pollutants to children's neurodevelopment in China. Environmental Health Perspectives 2008;116(10):1396-1400. R832141 (2007)
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  • Journal Article Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, Ho SM. Relation of DNA methylation of 5’-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE 2009;4(2):e4488. R832141 (Final)
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  • Journal Article Perzanowski MS, Miller RL, Thorne PS, Barr RG, Divjan A, Sheares BJ, Garfinkel RS, Perera FP, Goldstein IF, Chew GL. Endotoxin in inner-city homes: associations with wheeze and eczema in early childhood. Journal of Allergy and Clinical Immunology 2006;117(5):1082-1089. R832141 (2005)
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  • Journal Article Perzanowski MS, Chew GL, Divjan A, Johnson A, Goldstein IF, Garfinkel RS, Hoepner LA, Platts-Mills TAE, Perera FP, Miller RL. Cat ownership is a risk factor for the development of anti-cat IgE but not current wheeze at age 5 years in an inner-city cohort. Journal of Allergy and Clinical Immunology 2008;121(4):1047-1052. R832141 (2007)
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  • Journal Article Perzanowski MS, Rosa MJ, Divjan A, Johnson A, Jacobson JS, Miller RL. Modifications improve an offline exhaled nitric oxide collection device for use with young children. Journal of Allergy and Clinical Immunology 2008;122(1):213. R832141 (Final)
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  • Journal Article Perzanowski MS, Miller RL, Tang D, Ali D, Garfinkel RS, Chew GL, Goldstein IF, Perera FP, Barr RG. Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. Thorax 2010;65(2):118-123. R832141 (2007)
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  • Journal Article Rastogi D, Wang C, Mao X, Lendor C, Rothman PB, Miller RL. Antigen-specific immune responses to influenza vaccine in utero. Journal of Clinical Investigation 2007;117(6):1637-1646. R832141 (2007)
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  • Journal Article Rauh VA, Parker FL, Garfinkel RS, Perry J, Andrews HF. Biological, social, and community influences on third-grade reading levels of minority Head Start children:a multilevel approach. Journal of Community Psychology 2003;31(3):255-278. R832141 (2005)
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  • Journal Article Rauh VA, Whyatt RM, Garfinkel R, Andrews H, Hoepner L, Reyes A, Diaz D, Camann D, Perera FP. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicology and Teratology 2004;26(3):373-385. R832141 (2005)
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  • Journal Article Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB, Whitehead R, Tang D, Whyatt RW. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 three years of life among inner-city children. Pediatrics 2006;118(6):e1845-e1859. R832141 (2007)
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  • Journal Article Rauh VA, Landrigan PJ, Claudio L. Housing and health:intersection of poverty and environmental exposures. Annals of the New York Academy of Sciences 2008;1136:276-288. R832141 (Final)
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  • Journal Article Reardon AM, Perzanowski MS, Whyatt RM, Chew GL, Perera FP, Miller RL. Associations between prenatal pesticide exposure and cough, wheeze, and IgE in early childhood. Journal of Allergy and Clinical Immunology 2009;124(4):852-854. R832141 (2007)
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  • Journal Article Ricceri F, Godschalk RW, Peluso M, Phillips DH, Agudo A, Georgiadis P, Loft S, Tjonneland A, Raaschou-Nielsen O, Palli D, Perera F, Vermeulen R, Taioli E, Sram RJ, Munnia A, Rosa F, Allione A, Matullo G, Vineis P. Bulky DNA adducts in white blood cells:a pooled analysis of 3,600 subjects. Cancer Epidemiology, Biomarkers & Prevention 2010;19(12):3174-3181. R832141 (Final)
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  • Journal Article Rosa MJ, Divjan A, Hoepner L, Sheares BJ, Diaz D, Gauvey-Kern K, Perera FP, Miller RL, Perzanowski MS. Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children. Pediatric Pulmonology 2011;46(1):83-91. R832141 (Final)
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  • Journal Article Rundle AG, Orjuela M, Mooney L, Tang D, Kim M, Calcagnotto A, Richie Jr. JP, Perera F. Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. Biomarkers 2005;10(5):390-400. R832141 (2007)
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  • Journal Article Rundle A, Tang D, Mooney L, Grumet S, Perera F. The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissue. Cancer Epidemiology, Biomarkers and Prevention 2003;12(9):911-914. R832141 (2007)
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  • Journal Article Rundle A, Madsen A, Orjuela M, Mooney L, Tang D, Kim M, Perera F. The association between benzo[a]pyrene-DNA adducts and body mass index, calorie intake and physical activity. Biomarkers 2007;12(2):123-132. R832141 (2007)
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  • Journal Article Rundle A, Hagins M, Orjuela M, Mooney L, Kim M, Perera F. Traditional physical activity indexes derived from the Harvard alumni activity survey have low construct validity in a lower income, urban population. Journal of Urban Health 2007;84(5):722-732. R832141 (2007)
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  • Journal Article Rundle A, Richards C, Tang D, Perera F. Lack of association between physical activity in smokers and plasma glutathione peroxidase levels. Cancer Epidemiology, Biomarkers and Prevention 2008;17(4):1004-1006. R832141 (2007)
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  • Journal Article Sax SN, Bennett DH, Chillrud SN, Kinney PL, Spengler JD. Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles. Journal of Exposure Analysis and Environmental Epidemiology 2004;14(Suppl 1):S95-S109. R832141 (2006)
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  • Journal Article Tang D, Rundle A, Mooney L, Cho S, Schnabel F, Estabrook A, Kelly A, Levine R, Hibshoosh H, Perera F. Sulfotransferase 1A1 (SULT1A1) polymorphism, PAH-DNA adduct levels in breast tissue and breast cancer risk in a case-control study. Breast Cancer Research and Treatment 2003;78(2):217-222. R832141 (2007)
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  • Journal Article Tang D, Li T-Y, Liu JJ, Chen Y-H, Qu L, Perera F. PAH-DNA adducts in cord blood and fetal and child development in a Chinese cohort. Environmental Health Perspectives 2006;114(8):1297-1300. R832141 (2006)
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  • Journal Article Tang D, Li T-y, Liu JJ, Zhou Z-j, Yuan T, Chen Y-h, Rauh VA, Xie J, Perera F. Effects of prenatal exposure to coal-burning pollutants on children's development in China. Environmental Health Perspectives 2008;116(5):674-679. R832141 (2007)
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  • Journal Article Tonne CC, Whyatt RM, Camann DE, Perera FP, Kinney PL. Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City. Environmental Health Perspectives 2004;112(6):754-759. R832141 (2005)
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  • Journal Article Ugolini D, Puntoni R, Perera FP, Schulte PA, Bonassi S. A bibliometric analysis of scientific production in cancer molecular epidemiology. Carcinogenesis 2007;28(8):1774-1779. R832141 (2007)
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  • Journal Article Vasquez VB, Minkler M, Shepard P. Promoting environmental health policy through community based participatory research:a case study from Harlem, New York. Journal of Urban Health 2006;83(1):101-110. R832141 (2006)
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    R832141C005 (2006)
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  • Journal Article Veglia F, Loft S, Matullo G, Peluso M, Munnia A, Perera F, Phillips DH, Tang D, Autrup H, Raaschou-Nielsen O, Tjonneland A, Vineis P. DNA adducts and cancer risk in prospective studies:a pooled analysis and meta-analysis. Carcinogenesis 2008;29(5):932-936. R832141 (2007)
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  • Journal Article Vineis P, Perera F. Molecular epidemiology and biomarkers in etiologic cancer research:the new in light of the old. Cancer Epidemiology, Biomarkers and Prevention 2007;16(10):1954-1965. R832141 (2007)
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  • Journal Article Wallace D, Wallace R, Rauh V. Community stress, demoralization and body mass index: evidence for social signal transduction. Social Science and Medicine 2003;56(12):2467-2478. R832141 (2005)
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  • Journal Article Wallace R, Wallace RG. Adaptive chronic infection, structured stress, and medical magic bullets: do reductionist cures select for holistic diseases? Biosystems 2004;77(1-3):93-108. R832141 (2006)
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  • Journal Article Wallace R. Comorbidity in psychiatric and chronic physical disease:autocognitive developmental disorders of structured psychosocial stress. Acta Biotheoretica 2004;52(2):71-93. R832141 (2006)
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  • Journal Article Wang S, Chanock S, Tang D, Li Z, Jedrychowski W, Perera FP. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. Cancer Epidemiology, Biomarkers and Prevention 2008;17(2):405-413. R832141 (2007)
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  • Journal Article Wang S, Zheng T, Chanock S, Jedrychowski W, Perera FP. Methods for detecting interactions between genetic polymorphisms and prenatal environment exposure with a mother-child design. Genetic Epidemiology 2010;34(2):125-132. R832141 (2007)
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  • Journal Article Wang S, Chanock S, Tang D, Li Z, Edwards S, Jedrychowski W, Perera FP. Effect of gene-environment interactions on mental development in African American, Dominican, and Caucasian mothers and newborns. Annals of Human Genetics 2010;74(1):46-56. R832141 (2007)
    R832141 (Final)
    R834509 (2013)
    R834509 (2014)
    R834509 (Final)
    R834509C002 (Final)
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  • Journal Article Whyatt RM, Barr DB, Camann DE, Kinney PL, Barr JR, Andrews HF, Hoepner LA, Garfinkel R, Hazi Y, Reyes A, Ramirez J, Cosme Y, Perera FP. Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental Health Perspectives 2003;111(5):749-756. R832141 (2005)
    R832141 (2006)
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    R827027 (2002)
    R828609 (2002)
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  • Journal Article Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, Hoepner LA, Diaz D, Dietrich J, Reyes A, Tang D, Kinney PL, Perera FP. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environmental Health Perspectives 2004;112(10):1125-1132. R832141 (2005)
    R832141 (2006)
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    R828609 (2004)
    R828609 (Final)
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  • Journal Article Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, Garfinkel R, Andrews H, Hoepner L, Barr DB. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicology and Applied Pharmacology 2005;206(2):246-254. R832141 (2005)
    R832141 (2006)
    R832141 (2007)
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    R827027 (2002)
    R828609 (2004)
    R828609 (Final)
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  • Journal Article Whyatt RM, Garfinkel R, Hoepner LA, Holmes D, Borjas M, Williams MK, Reyes A, Rauh V, Perera FP, Camann DE. Within-and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City. Environmental Health Perspectives 2007;115(3):383-389. R832141 (2007)
    R832141 (Final)
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  • Journal Article Whyatt RM, Garfinkel R, Hoepner LA, Andrews H, Holmes D, Williams MK, Reyes A, Diaz D, Perera FP, Camann DE, Barr DB. A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy. Environmental Health Perspectives 2009;117(4):559-567. R832141 (2007)
    R832141 (Final)
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  • Journal Article Williams MK, Barr DB, Camann DE, Cruz LA, Carlton EJ, Borjas M, Reyes A, Evans D, Kinney PL, Whitehead Jr RD, Perera FP, Matsoanne S, Whyatt RM. An intervention to reduce residential insecticide exposure during pregnancy among an inner-city cohort. Environmental Health Perspectives 2006;114(11):1684-1689. R832141 (2006)
    R832141 (2007)
    R832141 (Final)
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  • Journal Article Williams MK, Rundle A, Holmes D, Reyes M, Hoepner LA, Barr DB, Camann DE, Perera FP, Whyatt RM. Changes in pest infestation levels, self-reported pesticide use, and permethrin exposure during pregnancy after the 2000-2001 U.S. Environmental Protection Agency restriction of organophosphates. Environmental Health Perspectives 2008;116(12):1681-1688. R832141 (2007)
    R832141 (Final)
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  • Abstract from PubMed
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  • Supplemental Keywords:

    child, environment, environmental health, asthma, development, growth, mechanistic, exposure, exposure assessment, outreach, translation, community-based intervention, RFA, Health, Scientific Discipline, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Genetics, Health Risk Assessment, Biochemistry, Health Effects, Children's Health, Environmental Policy, Risk Assessment, asthma, African American, prenatal exposure, environmental risks, latino, diesel exhaust, Human Health Risk Assessment, genetic mechanisms, assessment of exposure, genetic risk factors, children's environmental health, exposure assessment, genetic susceptibility, maternal exposure

    Relevant Websites:

    http://www.ccceh.org/ Exit

    Progress and Final Reports:

    Original Abstract
  • 2004 Progress Report
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008
  • 2009
  • Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
    R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
    R832141C003 Mechanistic Research Project
    R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
    R832141C005 Community Translation and Application Core (COTAC)
    R832141C006 Exposure Assessment Facility Core
    R832141C007 Data Management, Statistics and Community Impact Modeling Core
    R832141C008 Administrative Core