A longitudinal assessment study of human exposure to pesticides due to variations of dietary consumption patternsEPA Grant Number: R832244
Title: A longitudinal assessment study of human exposure to pesticides due to variations of dietary consumption patterns
Investigators: Lu, Chensheng (Alex)
Current Investigators: Sarnat, Jeremy , Lu, Chensheng (Alex)
Institution: Emory University
EPA Project Officer: Hahn, Intaek
Project Period: February 1, 2005 through January 31, 2009
Project Amount: $1,883,248
RFA: Aggregate Exposure Assessment: Longitudinal Surveys of Human Exposure - Related Behavior (2003) RFA Text | Recipients Lists
Research Category: Health , Health Effects
There are three objectives for this proposed study. First, this study is designed to collect multi-year qualitative (food consumption) and quantitative (pesticide residue levels in food samples) dietary information from a stratified probability pool of individuals using a state-of-the-art sampling device. Second, this study will determine whether short-term dietary consumption data gathered from a smaller geographic region is representative of and can be used to predict longterm food consumption patterns for a much larger population. Third, this study will measure intra- and inter-individual variability, as well as temporal variation for dietary consumption of OP pesticides among individuals. We will use these complementary approaches to characterize the variation in dietary consumption patterns and pesticide body burden resulting from the dietary exposures in a longitudinal manner.
The study design for this project has four components. First, a pool of probability-base stratified subjects who will be representative of the residents in the State of Washington in terms of age, gender, and ethnic background will be recruited. A subject attrition reduction method will be implemented to minimize the loss of subject during the study period. Second, a food diary embedded in a personal digital assistant (PDA) will be developed to facilitate the collection, storage and transmission of daily food consumption data electronically and remotely from the subjects. Third, a weekly dietary consumption data will be collected from subject in each month for 24-consecutive months using a PDA. The last component of this study is to assess the body burden of pesticides resulting from the dietary exposures by measuring the pesticide levels in saliva.
The most significant benefit that may come from this study is to provide a complete set of data from a pool of statistically representative individuals regarding their dietary consumption patterns, dietary exposure to pesticides, and the body burden of pesticides resulting from the dietary intake over a 2-year period. This regional data set will be validated using USDA CSFII and USDA PDP database to determine whether it can be used to predict longer-term dietary consumption patterns and resulting pesticide exposure among individuals nationwide. Also, by collaborating with laboratories with the best quality in this country, the data generated from this study will not only have the highest accuracy and precision, but will also be comparable to other national databases. We believe the nature of this study and the expected results have strong scientific merits and are cost effective, and will improve the quality of risk assessment for OP pesticide exposure through dietary consumption.