Genetics and Biochemistry Associated with Biodegradation of the Endocrine Disrupter OctylphenolEPA Grant Number: FP916439
Title: Genetics and Biochemistry Associated with Biodegradation of the Endocrine Disrupter Octylphenol
Investigators: Wise, Abigail E.
Institution: Cornell University
EPA Project Officer: Manty, Dale
Project Period: January 1, 2004 through December 31, 2006
Project Amount: $111,344
RFA: STAR Graduate Fellowships (2004) RFA Text | Recipients Lists
Research Category: Fellowship - Microbiology , Academic Fellowships , Biology/Life Sciences
The objectives of this project are to elucidate the mechanism by which octylphenol is degraded by aerobic microorganisms and to study the genetic components of the system to gain a better understanding of how to evaluate the biodegradation potential of octylphenol in the environment.
A combination of genetic and biochemical tools will provide a mechanism to examine how certain microorganisms are able to utilize octylphenol as a sole carbon source. As these will be laboratory-based, it also will be necessary to model the fate of octylphenol in the environment to gain a more accurate picture of in situ biodegradation rates. Because so little is known regarding the biodegradation of octylphenol, the final aspect of the project will be to test the estrogenicity of the metabolic intermediates.