2013 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Astor, Brad , Barr, R. Graham , Burke, Gregory L. , Daviglus, Martha , Detrano, Robert , Diez Roux, Ana V. , Folsom, Aaron , Gross, Myron , Jacobs, David , Kinney, Patrick L. , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Liu, Sally , Lumley, Thomas , Nyerges, Timothy , OLeary, Daniel , Saad, Mohammed , Sampson, Paul , Seixas, Noah , Shea, Steven , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Budoff, Matthew , Burke, Gregory L. , Daviglus, Martha , Diez Roux, Ana V. , Goldstein, James , Jacobs, David , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Navas-Acien, Ana , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Szpiro, Adam , Watson, Karol
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , The Johns Hopkins University , Tufts University , University of California - Los Angeles , University of Michigan , University of Minnesota , University of Vermont , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Ilacqua, Vito
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2012 through July 31,2013
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Health Effects , Particulate Matter , Air

Objective:

The goals of the Multi-Ethnic Study of Atherosclerosis and Air Pollution Study are to: 1) prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposure (including PM2.5 and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multi-city, multi-ethnic cohort; and 2) prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

 During the ninth year of MESA Air, the research team has:

  • Finalized a unified exposure prediction model that uses consistent data inputs and computer code to generate likelihood-based ambient outdoor exposure predictions for all of our primary air pollutants including fine particulate matter (PM2.5), oxides of nitrogen (both  NOX and NO2), and light absorbing, or black, carbon (BC).
  • Developed models of individual-level exposure to PM2.5 of ambient origin that incorporate information on residential infiltration rates and individual patterns of time-location, which also can be used in health analysis.
  • Created several health-related datasets for use in health analysis, including coronary artery calcium (CAC) and intima-medial thickness (IMT) measures, and inflammatory markers.
  • Continued to collect data on clinical cardiovascular disease events.
  • Furthered our understanding of the complex interplay between air pollution, socioeconomic and demographic factors and health, and published several new studies describing these relationships.
  • Published several new manuscripts describing our exposure modeling work and intermediate health analyses, and have begun drafting the manuscripts that will describe our primary analyses of the relationship between air pollution exposure and subclinical atherosclerosis.

Future Activities:

During the final year of MESA Air, we intend to publish major study results, including the main analysis of the effects of air pollution exposure on progression of atherosclerosis as assessed by repeated measurements of coronary artery calcium and carotid intima-medial thickness.  We also intend to publish the results of analyses of several other air pollution-health outcome relationships, papers describing aspects of our exposure modeling process, and results of additional analyses that evaluate the interplay between socioeconomic status, air pollution, neighborhood characteristics and health. In addition, we will continue to extend the temporal coverage of our air pollution exposure predictions as additional regulatory monitoring becomes available.  We also will continue to incorporate additional residential locations captured by ongoing MESA follow-up calls, and will utilize the update of the residential history questionnaire occurring on Follow Up Call 14 to verify and correct any errors in previous residential locations.


Journal Articles on this Report : 49 Displayed | Download in RIS Format

Other project views: All 253 publications 134 publications in selected types All 133 journal articles
Type Citation Project Document Sources
Journal Article Adar SD, Kaufman JD. Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhalation Toxicology 2007;19(Suppl 1):135-149. R831697 (2008)
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  • Journal Article Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O'Neill MS, Shrager S, Barr RG, Siscovick DS, Daviglus ML, Sampson PD, Kaufman JD. Air pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based Multi-Ethnic Study of Atherosclerosis (MESA). PLoS Medicine 2010;7(11):e1000372 (11 pp.). R831697 (2010)
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  • Journal Article Adar SD, Sheppard L, Vedal S, Polak JF, Sampson PD, Diez Roux AV, Budoff M, Jacobs Jr. DR, Barr RG, Watson K, Kaufman JD. Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the Multi-Ethnic Study of Atherosclerosis and air pollution. PLoS Medicine 2013;10(4):e1001430 (9 pp.). R831697 (2013)
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  • Journal Article Allen RW, Davies H, Cohen MA, Mallach G, Kaufman JD, Adar SD. The spatial relationship between traffic-generated air pollution and noise in 2 US cities. Environmental Research 2009;109(3):334-342. R831697 (2010)
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  • Journal Article Allen RW, Criqui MH, Diez Roux AV, Allison M, Shea S, Detrano R, Sheppard L, Wong ND, Stukovsky KH, Kaufman JD. Fine particulate matter air pollution, proximity to traffic, and aortic atherosclerosis. Epidemiology 2009;20(2):254-264. R831697 (2009)
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  • Journal Article Allen RW, Adar SD, Avol E, Cohen M, Curl CL, Larson T, Liu L-JS, Sheppard L, Kaufman JD. Modeling the residential infiltration of outdoor PM2.5 in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Health Perspectives 2012;120(6):824-830. R831697 (2012)
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  • Journal Article Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff Jr. DC, Kaufman JD, O'Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2008;116(4):486-491. R831697 (2009)
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  • Journal Article Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, Kaufman JD, Szpiro AA. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environmental Health Perspectives 2013;121(9):1017-1025. R831697 (2013)
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  • Journal Article Blondon M, Sachs M, Hoofnagle AN, Ix JH, Michos ED, Korcarz C, Gepner AD, Siscovick DS, Kaufman JD, Stein JH, Kestenbaum B, de Boer IH. 25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33(11):2639-2645. R831697 (2013)
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  • Journal Article Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D, Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S, Rotter JI, Smith LJ, Artigas MS, Tobin MD, Tsai MY, Watson K, White W, Young TR, Rich SS, Barr RG. APOM and high-density lipoprotein cholesterol are associated with lung function and percent emphysema. European Respiratory Journal 2014;43(4):1003-1017. R831697 (2013)
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  • Journal Article Cohen MA, Adar SD, Allen RW, Avol E, Curl CL, Gould T, Hardie D, Ho A, Kinney P, Larson TV, Sampson P, Sheppard L, Stukovsky KD, Swan SS, Liu L-J, Kaufman JD. Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Science & Technology 2009;43(13):4687-4693. R831697 (2009)
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  • Journal Article Donohue KM, Hoffman EA, Baumhauer H, Guo J, Budoff M, Austin JHM, Kalhan R, Kawut S, Tracy R, Barr RG. Cigarette smoking and airway wall thickness on CT scan in a multi-ethnic cohort: the MESA Lung Study. Respiratory Medicine 2012;106(12):1655-1664. R831697 (2013)
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  • Journal Article Genovese G, Handsaker RE, Li H, Altemose N, Lindgren AM, Chambert K, Pasaniuc B, Price AL, Reich D, Morton CC, Pollak MR, Wilson JG, McCarroll SA. Using population admixture to help complete maps of the human genome. Nature Genetics 2013;45(4):406-414. R831697 (2013)
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  • Journal Article Gepner AD, Korcarz CE, Colangelo LA, Hom EK, Tattersall MC, Astor BC, Kaufman JD, Liu K, Stein JH. Longitudinal effects of a decade of aging on carotid artery stiffness: the Multi-Ethnic Study of Atherosclerosis. Stroke 2014;45(1):48-53. R831697 (2013)
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  • Journal Article Gepner AD, Colangelo LA, Blondon M, Korcarz CE, de Boer IH, Kestenbaum B, Siscovick DS, Kaufman JD, Liu K, Stein JH. 25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2014;34(5):1102-1109. R831697 (2013)
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  • Journal Article Gill EA, Curl CL, Adar SD, Allen RW, Auchincloss AH, O’Neill MS, Park SK, Van Hee VC, Diez Roux AV, Kaufman JD. Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Progress in Cardiovascular Diseases 2011;53(5):353-360. R831697 (2011)
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  • Journal Article Hajat A, Diez-Roux AV, Adar SD, Auchincloss AH, Lovasi GS, O'Neill MS, Sheppard L, Kaufman JD. Air pollution and individual and neighborhood socioeconomic status:evidence from the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2013;121(11-12):1325-1333. R831697 (2013)
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  • Journal Article Hicken MT, Adar SD, Diez Roux AV, O'Neill MS, Magzamen S, Auchincloss AH, Kaufman JD. Do psychosocial stress and social disadvantage modify the association between air pollution and blood pressure? The Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2013;178(10):1550-1562. R831697 (2013)
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  • Journal Article Jensen SS, Larson T, Deepti KC, Kaufman JD. Modeling traffic air pollution in street canyons in New York City for intra-urban exposure assessment in the US Multi-Ethnic Study of atherosclerosis and air pollution. Atmospheric Environment 2009;43(30):4544-4556. R831697 (2009)
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  • Journal Article Kaufman JD, Adar SD, Allen RW, Barr RG, Budoff MJ, Burke GL, Casillas AM, Cohen MA, Curl CL, Daviglus ML, Diez Roux AV, Jacobs Jr. DR, Kronmal RA, Larson TV, Liu SL, Lumley T, Navas-Acien A, O'Leary DH, Rotter JI, Sampson PD, Sheppard L, Siscovick DS, Stein JH, Szpiro AA, Tracy RP. Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease:the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). American Journal of Epidemiology 2012;176(9):825-837. R831697 (2013)
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  • Journal Article Kim S-Y, Sheppard L, Kim H. Health effects of long-term air pollution:influence of exposure prediction methods. Epidemiology 2009;20(3):442-450. R831697 (2010)
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  • Journal Article Krishnan RM, Adar SD, Szpiro AA, Jorgensen NW, Van Hee VC, Barr RG, O’Neill MS, Herrington DM, Polak JF, Kaufman JD. Vascular responses to long-and short-term exposure to fine particulate matter:MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution). Journal of the American College of Cardiology 2012;60(21):2158-2166. R831697 (2012)
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  • Journal Article Liang CJ, Budoff MJ, Kaufman JD, Kronmal RA, Brown ER. An alternative method for quantifying coronary artery calcification:the Multi-Ethnic Study of Atherosclerosis (MESA). BMC Medical Imaging 2012;12:14. R831697 (2012)
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  • Journal Article Lindstrom J, Szpiro AA, Sampson PD, Oron AP, Richards M, Larson TV, Sheppard L. A flexible spatio-temporal model for air pollution with spatial and spatio-temporal covariates. Environmental and Ecological Statistics 2014;21(3):411-433. R831697 (2013)
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  • Journal Article Manichaikul A, Palmas W, Rodriguez CJ, Peralta CA, Divers J, Guo X, Chen WM, Wong Q, Williams K, Kerr KF, Taylor KD, Tsai MY, Goodarzi MO, Sale MM, Diez-Roux AV, Rich SS, Rotter JI, Mychaleckyj JC. Population structure of Hispanics in the United States: the Multi-Ethnic Study of Atherosclerosis. PLoS Genetics 2012;8(4):e1002640 (14 pp.). R831697 (2013)
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  • Journal Article Mercer LD, Szpiro AA, Sheppard L, Lindstrom J, Adar SD, Allen RW, Avol EL, Oron AP, Larson T, Liu L-JS, Kaufman JD. Comparing universal kriging and land-use regression for predicting concentrations of gaseous oxides of nitrogen (NOx) for the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Atmospheric Environment 2011;45(26):4412-4420. R831697 (2011)
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  • Journal Article Moore K, Diez Roux AV, Auchincloss A, Evenson KR, Kaufman J, Mujahid M, Williams K. Home and work neighbourhood environments in relation to body mass index: the Multi-Ethnic Study of Atherosclerosis (MESA). Journal of Epidemiology and Community Health 2013;67(10):846-853. R831697 (2013)
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  • Journal Article O'Neill MS, Diez-Roux AV, Auchincloss AH, Shen M, Lima JA, Polak JF, Barr RG, Kaufman J, Jacobs Jr. DR. Long-term exposure to airborne particles and arterial stiffness: the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2011;119(6):844-851. R831697 (2011)
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  • Journal Article Oelsner EC, Pottinger TD, Burkart KM, Allison M, Buxbaum SG, Hansel NN, Kumar R, Larkin EK, Lange LA, Loehr LR, London SJ, O'Connor GT, Papanicolaou G, Petrini MF, Rabinowitz D, Raghavan S, Redline S, Thyagarajan B, Tracy RP, Wilk JB, White WB, Rich SS, Barr RG. Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. Biomarkers 2013;18(3):196-203. R831697 (2013)
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  • Journal Article Pakbin P, Hudda N, Cheung KL, Moore KF, Sioutas C. Spatial and temporal variability of coarse (PM10-2.5) particulate matter concentrations in the Los Angeles area. Aerosol Science and Technology 2010;44(7):514-525. R831697 (2013)
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  • Journal Article Pakbin P, Ning Z, Shafer MM, Schauer JJ, Sioutas C. Seasonal and spatial coarse particle elemental concentrations in the Los Angeles area. Aerosol Science and Technology 2011;45(8):949-963. R831697 (2013)
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  • Journal Article Park SK, Auchincloss AH, O'Neill MS, Prineas R, Correa JC, Keeler J, Barr RG, Kaufman JD, Diez Roux AV. Particulate air pollution, metabolic syndrome, and heart rate variability: the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(10):1406-1411. R831697 (2010)
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  • Journal Article Poplawski K, Gould T, Setton E, Allen R, Su J, Larson T, Henderson S, Brauer M, Hystad P, Lightowlers C, Keller P, Cohen M, Silva C, Buzzelli M. Intercity transferability of land use regression models for estimating ambient concentrations of nitrogen dioxide. Journal of Exposure Science & Environmental Epidemiology 2009;19(1):107-117. R831697 (2009)
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  • Journal Article Sampson PD, Szpiro AA, Sheppard L, Lindstrom J, Kaufman JD. Pragmatic estimation of a spatio-temporal air quality model with irregular monitoring data. Atmospheric Environment 2011;45(36):6593-6606. R831697 (2011)
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  • Journal Article Sampson PD, Richards M, Szpiro AA, Bergen S, Sheppard L, Larson TV, Kaufman JD. A regionalized national universal kriging model using Partial Least Squares regression for estimating annual PM2.5 concentrations in epidemiology. Atmospheric Environment 2013;75:383-392. R831697 (2013)
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  • Journal Article Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope III CA, Brunekreef B. Confounding and exposure measurement error in air pollution epidemiology. Air Quality, Atmosphere & Health 2012;5(2):203-216. R831697 (2013)
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  • Journal Article Sturtz TM, Adar SD, Gould T, Larson TV. Constrained source apportionment of coarse particulate matter and selected trace elements in three cities from the Multi-Ethnic Study of Atherosclerosis. Atmospheric Environment 2014;84:65-77. R831697 (2013)
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  • Journal Article Su JG, Larson T, Gould T, Cohen M, Buzzelli M. Transboundary air pollution and environmental justice:Vancouver and Seattle compared. GeoJournal 2010;75(6):595-608. R831697 (2010)
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  • Journal Article Sun M, Kaufman JD, Kim S-Y, Larson TV, Gould TR, Polak JF, Budoff MJ, Diez Roux AV, Vedal S. Particulate matter components and subclinical atherosclerosis:common approaches to estimating exposure in a Multi-Ethnic Study of Atherosclerosis cross-sectional study. Environmental Health 2013;12:39. R831697 (2013)
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  • Journal Article Szpiro AA, Sampson PD, Sheppard L, Lumley T, Adar SD, Kaufman JD. Predicting intra-urban variation in air pollution concentrations with complex spatio-temporal dependencies. Environmetrics 2010;21(6):606-631. R831697 (2010)
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  • Journal Article Szpiro AA, Sheppard L, Lumley T. Efficient measurement error correction with spatially misaligned data. Biostatistics 2011;12(4):610-623. R831697 (2013)
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  • Journal Article Szpiro AA, Paciorek CJ, Sheppard L. Does more accurate exposure prediction necessarily improve health effect estimates? Epidemiology 2011;22(5):680-685. R831697 (2013)
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  • Journal Article Szpiro AA, Paciorek CJ. Measurement error in two-stage analyses, with application to air pollution epidemiology. Environmetrics 2013;24(8):501-517. R831697 (2013)
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  • Journal Article Szpiro AA, Sheppard L, Adar SD, Kaufman JD. Estimating acute air pollution health effects from cohort study data. Biometrics 2014;70(1):164-174. R831697 (2013)
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  • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Diez Roux A, Bluemke DA, Sheppard L, Gill EA, Bahrami H, Wassel C, Sale MM, Siscovick DS, Rotter JI, Rich SS, Kaufman JD. Common genetic variation, residential proximity to traffic exposure, and left ventricular mass:the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(7):962-969. R831697 (2010)
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  • Journal Article Van Hee VC, Szpiro AA, Prineas R, Neyer J, Watson K, Siscovick D, Kyun Park S, Kaufman JD. Association of long-term air pollution with ventricular conduction and repolarization abnormalities. Epidemiology 2011;22(6):773-780. R831697 (2011)
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  • Journal Article Wilton D, Szpiro A, Gould T, Larson T. Improving spatial concentration estimates for nitrogen oxides using a hybrid meteorological dispersion/land use regression model in Los Angeles, CA and Seattle, WA. Science of the Total Environment 2010;408(5):1120-1130. R831697 (2010)
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  • Journal Article Wojczynski MK, Li M, Bielak LF, Kerr KF, Reiner AP, Wong ND, Yanek LR, Qu L, White CC, Lange LA, Ferguson JF, He J, Young T, Mosley TH, Smith JA, Kral BG, Guo X, Wong Q, Ganesh SK, Heckbert SR, Griswold ME, O'Leary DH, Budoff M, Carr JJ, Taylor HA, Bluemke DA, Demissie S, Hwang S-J, Paltoo DN, Polak JF, Psaty BM, Becker DM, Province MA, Post WS, O'Donnell CJ, Wilson JG, Harris TB, Kavousi M, Cupples LA, Rotter JI, Fornage M, Becker LC, Peyser PA, Borecki IB, Reilly MP. Genetics of coronary artery calcification among African Americans, a meta-analysis. BMC Medical Genetics 2013;14:75. R831697 (2013)
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  • Supplemental Keywords:

    Epidemiology, health effects, human health, MESA Air, air pollution., RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, exposure, airborne particulate matter, atherosclerosis, cardiovascular vulnerability, ambient particle health effects, human exposure, epidemiological studies, aersol particles, cardiovascular disease

    Relevant Websites:

    http://depts.washington.edu/mesaair Exit

    Progress and Final Reports:

    Original Abstract
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • Final Report