2012 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Astor, Brad , Barr, R. Graham , Burke, Gregory L. , Daviglus, Martha , Detrano, Robert , Diez Roux, Ana V. , Folsom, Aaron , Gross, Myron , Jacobs, David , Kinney, Patrick L. , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Liu, Sally , Lumley, Thomas , Nyerges, Timothy , OLeary, Daniel , Saad, Mohammed , Sampson, Paul , Seixas, Noah , Shea, Steven , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Budoff, Matthew , Burke, Gregory L. , Daviglus, Martha , Diez Roux, Ana V. , Goldstein, James , Jacobs, David , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Navas-Acien, Ana , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Szpiro, Adam , Watson, Karol
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , The Johns Hopkins University , Tufts University , University of California - Los Angeles , University of Michigan , University of Minnesota , University of Vermont , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Ilacqua, Vito
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2011 through July 31,2012
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Health Effects , Particulate Matter , Air

Objective:

The goals of the Multi-Ethnic Study of Atherosclerosis and Air Pollution Study (MESA Air) are: 1) to prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposure (including PM2.5 and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multi-city, multi-ethnic cohort; and 2) to prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

During the eighth year of MESA Air, the research team has:

  • Developed likelihood-based exposure models for PM2.5, NOx and NO2 concentrations across the MESA Air study regions, and produced ambient exposure predictions for these pollutants for each MESA Air participant at 2-week resolution from 1999-2011.
  • Developed a likelihood-based exposure model for light absorbing carbon (LAC) that predicts long-term LAC concentration from 2006-2008 across the MESA Air study regions.
  • Employed season-specific infiltration models to generate residence-specific ambient-source indoor PM2.5 concentrations for each participant using residential history information obtained from the MESA Air Questionnaire.
  • Calculated individual-level exposure to ambient-source PM2.5 by time-weighting indoor and outdoor concentrations using participant-specific patterns of time-location.
  • Collaborated with MESA investigators to successfully complete MESA Exam 5, which included 4,859 MESA Air participants.  Of these, 96% completed MESA Air Questionnaires.
  • Supported the acquisition and interpretation of 3,624 carotid ultrasounds and 3,484 CT scans, representing 100% and 97%, respectively, of the study goals.
  • Published several key manuscripts, including a major overview paper describing the MESA Air cohort and methodology, method papers describing the infiltration modeling and a new spatially weighted scoring system for coronary artery calcium measurements, and a health analysis of the relationship between PM2.5 exposure and vascular response.

Future Activities:

During the next project period, we will complete the analysis of the relationship between air pollutants and subclinical progression of atherosclerosis, as measured by coronary artery calcium and intima-medial thickness, using the full 10-year period of progression, from MESA Exam 1 to Exam 5.  We will update our exposure models with new AQS air monitoring data as they are released, and will continue to acquire information on participants’ residential locations, residential characteristics, and time-location patterns for those participants who move or have other significant life changes.  This information will be collected as part of the MESA follow-up phone calls. We also will begin our analysis of clinical events, including development of our clinical events analysis plan and finalization of our clinical events dataset. 


Journal Articles on this Report : 23 Displayed | Download in RIS Format

Other project views: All 253 publications 134 publications in selected types All 133 journal articles
Type Citation Project Document Sources
Journal Article Adar SD, Kaufman JD. Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhalation Toxicology 2007;19(Suppl 1):135-149. R831697 (2008)
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  • Journal Article Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O'Neill MS, Shrager S, Barr RG, Siscovick DS, Daviglus ML, Sampson PD, Kaufman JD. Air pollution and the microvasculature: a cross-sectional assessment of in vivo retinal images in the population-based Multi-Ethnic Study of Atherosclerosis (MESA). PLoS Medicine 2010;7(11):e1000372 (11 pp.). R831697 (2010)
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  • Journal Article Allen RW, Davies H, Cohen MA, Mallach G, Kaufman JD, Adar SD. The spatial relationship between traffic-generated air pollution and noise in 2 US cities. Environmental Research 2009;109(3):334-342. R831697 (2010)
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  • Journal Article Allen RW, Criqui MH, Diez Roux AV, Allison M, Shea S, Detrano R, Sheppard L, Wong ND, Stukovsky KH, Kaufman JD. Fine particulate matter air pollution, proximity to traffic, and aortic atherosclerosis. Epidemiology 2009;20(2):254-264. R831697 (2009)
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  • Journal Article Allen RW, Adar SD, Avol E, Cohen M, Curl CL, Larson T, Liu L-JS, Sheppard L, Kaufman JD. Modeling the residential infiltration of outdoor PM2.5 in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Health Perspectives 2012;120(6):824-830. R831697 (2012)
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  • Journal Article Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff Jr. DC, Kaufman JD, O'Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2008;116(4):486-491. R831697 (2009)
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  • Journal Article Cohen MA, Adar SD, Allen RW, Avol E, Curl CL, Gould T, Hardie D, Ho A, Kinney P, Larson TV, Sampson P, Sheppard L, Stukovsky KD, Swan SS, Liu L-J, Kaufman JD. Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Science & Technology 2009;43(13):4687-4693. R831697 (2009)
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  • Journal Article Gill EA, Curl CL, Adar SD, Allen RW, Auchincloss AH, O’Neill MS, Park SK, Van Hee VC, Diez Roux AV, Kaufman JD. Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Progress in Cardiovascular Diseases 2011;53(5):353-360. R831697 (2011)
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  • Journal Article Jensen SS, Larson T, Deepti KC, Kaufman JD. Modeling traffic air pollution in street canyons in New York City for intra-urban exposure assessment in the US Multi-Ethnic Study of atherosclerosis and air pollution. Atmospheric Environment 2009;43(30):4544-4556. R831697 (2009)
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  • Journal Article Kim S-Y, Sheppard L, Kim H. Health effects of long-term air pollution:influence of exposure prediction methods. Epidemiology 2009;20(3):442-450. R831697 (2010)
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  • Journal Article Krishnan RM, Adar SD, Szpiro AA, Jorgensen NW, Van Hee VC, Barr RG, O’Neill MS, Herrington DM, Polak JF, Kaufman JD. Vascular responses to long-and short-term exposure to fine particulate matter:MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution). Journal of the American College of Cardiology 2012;60(21):2158-2166. R831697 (2012)
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  • Journal Article Liang CJ, Budoff MJ, Kaufman JD, Kronmal RA, Brown ER. An alternative method for quantifying coronary artery calcification:the Multi-Ethnic Study of Atherosclerosis (MESA). BMC Medical Imaging 2012;12:14. R831697 (2012)
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  • Journal Article Mercer LD, Szpiro AA, Sheppard L, Lindstrom J, Adar SD, Allen RW, Avol EL, Oron AP, Larson T, Liu L-JS, Kaufman JD. Comparing universal kriging and land-use regression for predicting concentrations of gaseous oxides of nitrogen (NOx) for the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Atmospheric Environment 2011;45(26):4412-4420. R831697 (2011)
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  • Journal Article O'Neill MS, Diez-Roux AV, Auchincloss AH, Shen M, Lima JA, Polak JF, Barr RG, Kaufman J, Jacobs Jr. DR. Long-term exposure to airborne particles and arterial stiffness: the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2011;119(6):844-851. R831697 (2011)
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  • Journal Article Park SK, Auchincloss AH, O'Neill MS, Prineas R, Correa JC, Keeler J, Barr RG, Kaufman JD, Diez Roux AV. Particulate air pollution, metabolic syndrome, and heart rate variability: the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(10):1406-1411. R831697 (2010)
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  • Journal Article Poplawski K, Gould T, Setton E, Allen R, Su J, Larson T, Henderson S, Brauer M, Hystad P, Lightowlers C, Keller P, Cohen M, Silva C, Buzzelli M. Intercity transferability of land use regression models for estimating ambient concentrations of nitrogen dioxide. Journal of Exposure Science & Environmental Epidemiology 2009;19(1):107-117. R831697 (2009)
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  • Journal Article Sampson PD, Szpiro AA, Sheppard L, Lindstrom J, Kaufman JD. Pragmatic estimation of a spatio-temporal air quality model with irregular monitoring data. Atmospheric Environment 2011;45(36):6593-6606. R831697 (2011)
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  • Journal Article Su JG, Larson T, Gould T, Cohen M, Buzzelli M. Transboundary air pollution and environmental justice:Vancouver and Seattle compared. GeoJournal 2010;75(6):595-608. R831697 (2010)
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  • Journal Article Szpiro AA, Sampson PD, Sheppard L, Lumley T, Adar SD, Kaufman JD. Predicting intra-urban variation in air pollution concentrations with complex spatio-temporal dependencies. Environmetrics 2010;21(6):606-631. R831697 (2010)
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  • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Diez Roux A, Bluemke DA, Sheppard L, Gill EA, Bahrami H, Wassel C, Sale MM, Siscovick DS, Rotter JI, Rich SS, Kaufman JD. Common genetic variation, residential proximity to traffic exposure, and left ventricular mass:the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2010;118(7):962-969. R831697 (2010)
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  • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Bluemke DA, Diez Roux AV, Gill EA, Sheppard L, Kaufman JD. Exposure to traffic and left ventricular mass and function:the Multi-Ethnic Study of Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 2009;179(9):827-834. R831697 (2009)
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  • Journal Article Van Hee VC, Szpiro AA, Prineas R, Neyer J, Watson K, Siscovick D, Kyun Park S, Kaufman JD. Association of long-term air pollution with ventricular conduction and repolarization abnormalities. Epidemiology 2011;22(6):773-780. R831697 (2011)
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  • Journal Article Wilton D, Szpiro A, Gould T, Larson T. Improving spatial concentration estimates for nitrogen oxides using a hybrid meteorological dispersion/land use regression model in Los Angeles, CA and Seattle, WA. Science of the Total Environment 2010;408(5):1120-1130. R831697 (2010)
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  • Supplemental Keywords:

    Epidemiology, health effects, human health, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, exposure, airborne particulate matter, atherosclerosis, cardiovascular vulnerability, ambient particle health effects, human exposure, epidemiological studies, aersol particles, cardiovascular disease

    Relevant Websites:

    http://depts.washington.edu/mesaair Exit

    Progress and Final Reports:

    Original Abstract
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2010 Progress Report
  • 2011 Progress Report
  • 2013 Progress Report
  • Final Report