2009 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Astor, Brad , Barr, R. Graham , Burke, Gregory L. , Daviglus, Martha , Detrano, Robert , Diez Roux, Ana V. , Folsom, Aaron , Gross, Myron , Jacobs, David , Kinney, Patrick L. , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Liu, Sally , Lumley, Thomas , Nyerges, Timothy , OLeary, Daniel , Saad, Mohammed , Sampson, Paul , Seixas, Noah , Shea, Steven , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Budoff, Matthew , Burke, Gregory L. , Daviglus, Martha , Diez Roux, Ana V. , Goldstein, James , Jacobs, David , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Navas-Acien, Ana , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Szpiro, Adam , Watson, Karol
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , The Johns Hopkins University , Tufts University , University of California - Los Angeles , University of Michigan , University of Minnesota , University of Vermont , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Ilacqua, Vito
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2008 through July 31,2009
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Health Effects , Particulate Matter , Air

Objective:

The goal of the Multi-Ethnic Study of Atherosclerosis and Air Pollution Study (MESA Air) is to prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposure (including PM2.5 and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multi-city, multi-ethnic cohort. MESA Air will also prospectively examine the relation between an individual level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

During the fifth year of MESA Air, the research team has:
·   Successfully concluded all exposure monitoring, including ending sampling at the fixed sites—a total of 6,470 active samples (measuring PM2.5, light absorbing carbon, and metals) and 8,886 passive samples (measuring NO, NO2, NOX, and SO2) were deployed, and all study Data Quality Objectives were met
·   Completed the first MESA Air followup call (MESA Followup 8), and made significant progress on the next two followup calls (Followups 9 and 10)—99% of MESA Air participants were called during Followup 8, and Air Questionnaires were readministered on 12% (due to reported residence or life changes). To date, 78% of MESA Air participants have been called as part of Followup 9; Air Questionnaires were readministered on 9%.
·   Planned for the integration of MESA Air activities into the next clinic visit (MESA Exam 5, 4/2010-10/2011),
·   Predicted infiltration factors based on indoor and outdoor monitoring and questionnaire responses and used these models to estimate indoor air concentrations at all MESA Air participants’ homes.
·   Utilized individual-level data on self-reported time-location patterns to weight individual exposures between estimated indoor and outdoor concentrations.
·   Observed relationships between individual-level estimates of air pollution exposure and novel health outcomes, including left ventricular mass.

Future Activities:

During the next reporting period, we will finalize all questionnaires and protocols for MESA Exam 5, including the CT and Ultrasound scanning protocols and revisions to the Air Questionnaire. We will conduct in-person training sessions for the Exam 5 sonographers and for the MESA interviewers who will administer the Air Questionnaire in Exam 5. This next reporting year will include 4 of the 18 exam months, and we hope to conduct approximately 800 CTs and Ultrasounds during these months. During this next reporting period, we will continue to refine and improve our outdoor exposure estimates, including new variables such as traffic counts and dispersion modeling results, and to finalize our infiltration estimates for all six cities. We also intend to integrate our revised outdoor estimates with our infiltration estimates for each participant using reported time-location data from the Air Questionnaires. We will use these new personal-level estimates to examine the relationship between cardiovascular disease and air pollution, and will continue to public manuscripts describing our findings. We will also continue to support the submission of ancillary study proposals and the use of MESA Air as a platform for such research.


Journal Articles on this Report : 9 Displayed | Download in RIS Format

Other project views: All 253 publications 134 publications in selected types All 133 journal articles
Type Citation Project Document Sources
Journal Article Adar SD, Kaufman JD. Cardiovascular disease and air pollutants: evaluating and improving epidemiological data implicating traffic exposure. Inhalation Toxicology 2007;19(Suppl 1):135-149. R831697 (2008)
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  • Journal Article Allen RW, Criqui MH, Diez Roux AV, Allison M, Shea S, Detrano R, Sheppard L, Wong ND, Stukovsky KH, Kaufman JD. Fine particulate matter air pollution, proximity to traffic, and aortic atherosclerosis. Epidemiology 2009;20(2):254-264. R831697 (2009)
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  • Abstract: Epidemiology - Abstract
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  • Journal Article Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff Jr. DC, Kaufman JD, O'Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA). Environmental Health Perspectives 2008;116(4):486-491. R831697 (2009)
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  • Journal Article Cohen MA, Adar SD, Allen RW, Avol E, Curl CL, Gould T, Hardie D, Ho A, Kinney P, Larson TV, Sampson P, Sheppard L, Stukovsky KD, Swan SS, Liu L-J, Kaufman JD. Approach to estimating participant pollutant exposures in the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Environmental Science & Technology 2009;43(13):4687-4693. R831697 (2009)
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  • Abstract: ES&T-Abstract
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  • Journal Article Diez Roux AV, Auchincloss AH, Franklin TG, Raghunathan T, Barr RG, Kaufman J, Astor B, Keeler J. Long-term exposure to ambient particulate matter and prevalence of subclinical atherosclerosis in the Multi-Ethnic Study of Atherosclerosis. American Journal of Epidemiology 2008;167(6):667-675. R831697 (2009)
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  • Journal Article Jensen SS, Larson T, Deepti KC, Kaufman JD. Modeling traffic air pollution in street canyons in New York City for intra-urban exposure assessment in the US Multi-Ethnic Study of atherosclerosis and air pollution. Atmospheric Environment 2009;43(30):4544-4556. R831697 (2009)
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  • Journal Article O'Neill MS, Diez-Roux AV, Auchincloss AH, Franklin TG, Jacobs Jr DR, Astor BC, Dvonch JT, Kaufman J. Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis. Occupational and Environmental Medicine 2008;65(8):534-540. R831697 (2009)
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    R827353 (Final)
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  • Journal Article Poplawski K, Gould T, Setton E, Allen R, Su J, Larson T, Henderson S, Brauer M, Hystad P, Lightowlers C, Keller P, Cohen M, Silva C, Buzzelli M. Intercity transferability of land use regression models for estimating ambient concentrations of nitrogen dioxide. Journal of Exposure Science & Environmental Epidemiology 2009;19(1):107-117. R831697 (2009)
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  • Journal Article Van Hee VC, Adar SD, Szpiro AA, Barr RG, Bluemke DA, Diez Roux AV, Gill EA, Sheppard L, Kaufman JD. Exposure to traffic and left ventricular mass and function:the Multi-Ethnic Study of Atherosclerosis. American Journal of Respiratory and Critical Care Medicine 2009;179(9):827-834. R831697 (2009)
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  • Supplemental Keywords:

    Epidemiology, health effects, human health, athersclerosis, cardiovascular disease, ambient particulate matter, air pollutants , RFA, Health, Scientific Discipline, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, cardiovascular vulnerability, exposure, airborne particulate matter, atherosclerosis, human exposure, ambient particle health effects, epidemiological studies, aersol particles, cardiovascular disease

    Relevant Websites:

    http://depts.washington.edu/mesaair

    Progress and Final Reports:

    Original Abstract
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • Final Report