2006 Progress Report: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)

EPA Grant Number: R831697
Title: Prospective Study of Atherosclerosis, Clinical Cardiovascular Disease, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (MESA Air)
Investigators: Kaufman, Joel D. , Astor, Brad , Barr, R. Graham , Burke, Gregory L. , Daviglus, Martha , Detrano, Robert , Diez Roux, Ana V. , Folsom, Aaron , Gross, Myron , Jacobs, David , Kinney, Patrick L. , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Liu, Sally , Lumley, Thomas , Nyerges, Timothy , OLeary, Daniel , Saad, Mohammed , Sampson, Paul , Seixas, Noah , Shea, Steven , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Wang, Yinhai
Current Investigators: Kaufman, Joel D. , Adar, Sara D. , Barr, R. Graham , Budoff, Matthew , Burke, Gregory L. , Daviglus, Martha , Diez Roux, Ana V. , Goldstein, James , Jacobs, David , Kronmal, Richard , Larson, Timothy V. , Liu, Kiang J. , Navas-Acien, Ana , Sampson, Paul , Sheppard, Lianne (Elizabeth) A. , Siscovick, David , Szpiro, Adam , Watson, Karol
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , The Johns Hopkins University , Tufts University , University of California - Los Angeles , University of Michigan , University of Minnesota , University of Vermont , Wake Forest University
Current Institution: University of Washington , Columbia University in the City of New York , Northwestern University , Tellus Institute , The Johns Hopkins University , University of California - Los Angeles , University of Michigan , University of Minnesota
EPA Project Officer: Ilacqua, Vito
Project Period: August 1, 2004 through July 31, 2014
Project Period Covered by this Report: August 1, 2005 through July 31, 2006
Project Amount: $32,999,090
RFA: Epidemiologic Research on Health Effects of Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants (2003) RFA Text |  Recipients Lists
Research Category: Air Quality and Air Toxics , Health Effects , Particulate Matter , Air

Objective:

The objective of the Multi-Ethnic Study of Atherosclerosis (MESA) Air study is to prospectively examine the relation between an individual-level assessment of long-term ambient air pollution exposures (including fine particulate matter and gaseous co-pollutants) and the progression of subclinical cardiovascular disease in a multicity, multiethnic cohort.  The MESA Air study also will prospectively examine the relation between an individual-level assessment of long-term ambient air pollution exposures and the incidence of cardiovascular disease, including myocardial infarction and cardiovascular death.

Progress Summary:

Work efforts in Year 2 of the MESA Air project concentrated on recruiting individuals into the study and initiating air pollution monitoring in the communities of the study participants and at their homes.  Activities included:  

  • Recruitment of participants from the main MESA cohort, the MESA Family cohort, and de novo recruits from California and New York.
  • Collection of health outcomes on subclinical cohort including coronary computed tomography (CT), aortic CT, ultrasound, and questionnaires.
  • Establishment of fixed air sampling sites and continuous sampling at all Field Center locations.
  • Monitoring indoor and outdoor locations at participant homes.
  • Sampling of traffic-related gases simultaneously throughout each MESA Air community
  • Completion of an internal data quality audit.
  • Presentation of project status and discussion regarding existing issues with our External Scientific Advisory Committee in January 2005.

Future Activities:

Recruitment activities and new health examinations will continue through the spring of 2007.  Event and exposure follow-up questionnaires also will be conducted via telephone throughout the year.  Air pollution monitoring will continue at all of our existing fixed sites as well as new and existing home sites.  Personal monitoring also will commence in all of the study areas, and the final two rounds of the community co-pollutant sampling will be completed.  Based on the exposure monitoring results, work will be conducted on the spatio-temporal model to create preliminary exposure estimates.

Journal Articles:

No journal articles submitted with this report: View all 253 publications for this project

Supplemental Keywords:

epidemiology, health effects, human health,, RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, particulate matter, Health Risk Assessment, Epidemiology, Risk Assessments, Biochemistry, Physical Processes, ambient aerosol, lung injury, long term exposure, lung disease, airway disease, exposure, airborne particulate matter, atherosclerosis, cardiovascular vulnerability, ambient particle health effects, human exposure, epidemiological studies, aersol particles, cardiovascular disease

Relevant Websites:

http://depts.washington.edu/mesaair

Progress and Final Reports:

Original Abstract
  • 2005 Progress Report
  • 2007 Progress Report
  • 2008 Progress Report
  • 2009 Progress Report
  • 2010 Progress Report
  • 2011 Progress Report
  • 2012 Progress Report
  • 2013 Progress Report
  • Final Report