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Modulation of Lymphocyte IL-2 Expression and Apoptosis by Estrogenic XenobioticsEPA Grant Number: U915917
Title: Modulation of Lymphocyte IL-2 Expression and Apoptosis by Estrogenic Xenobiotics
Investigators: Ndebele, Kenneth
Institution: Jackson State University
EPA Project Officer: Graham, Karen
Project Period: January 1, 2001 through January 1, 2004
Project Amount: $104,062
RFA: Minority Academic Institutions (MAI) Fellowships for Graduate Environmental Study (2001) RFA Text | Recipients Lists
Research Category: Ecological Indicators/Assessment/Restoration , Academic Fellowships , Fellowship - Environmental Science
The objective of this research project is to show that estrogen suppresses interleukin-2 (IL-2) production from activated peripheral blood T cells and CD4+ T cell lines at the transcriptional level.
IL-2 plays an important role in adaptive immune responses. These responses differ between females and males; this may be because of the sex steroid estrogen. In CD4+ Jurkat T cells, transcriptional suppression of IL-2 was associated with decreased nuclear binding of two important IL-2 positive transcriptional binding factors, NFK and AP-1. The decreased nuclear binding of NFK occurred in the setting of estrogen-induced increases in IK–Ba protein levels, an important inhibitor of NFK nuclear translocation. Moreover, estrogen also was shown to inhibit IL-2 receptor (IL2-R) expression in activated peripheral blood T cells. Estrogen-induced suppression of IL-2 and its receptor may have many ramifications for our understanding of immune and autoimmune sexual dichotomies, immune responses during pregnancy, and potential therapeutic intervention with hormone agonists and antagonists.